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Protein

Serine-rich coiled-coil domain-containing protein 1

Gene

CCSER1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-rich coiled-coil domain-containing protein 1
Alternative name(s):
Coiled-coil serine-rich protein 1
Gene namesi
Name:CCSER1
Synonyms:FAM190A, KIAA1680
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000184305.14
HGNCiHGNC:29349 CCSER1
neXtProtiNX_Q9C0I3

Pathology & Biotechi

Organism-specific databases

DisGeNETi401145
OpenTargetsiENSG00000184305
PharmGKBiPA165663936

Polymorphism and mutation databases

BioMutaiCCSER1
DMDMi205815669

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003492921 – 900Serine-rich coiled-coil domain-containing protein 1Add BLAST900

Proteomic databases

MaxQBiQ9C0I3
PaxDbiQ9C0I3
PeptideAtlasiQ9C0I3
PRIDEiQ9C0I3
ProteomicsDBi80053
80054 [Q9C0I3-2]

PTM databases

iPTMnetiQ9C0I3
PhosphoSitePlusiQ9C0I3

Expressioni

Gene expression databases

BgeeiENSG00000184305
ExpressionAtlasiQ9C0I3 baseline and differential
GenevisibleiQ9C0I3 HS

Organism-specific databases

HPAiHPA041880
HPA054709

Interactioni

Protein-protein interaction databases

BioGridi134948, 4 interactors
ELMiQ9C0I3
IntActiQ9C0I3, 4 interactors
STRINGi9606.ENSP00000329482

Structurei

3D structure databases

ProteinModelPortaliQ9C0I3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili673 – 707Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 69Ser-richAdd BLAST66
Compositional biasi495 – 498Poly-Ser4

Sequence similaritiesi

Belongs to the CCSER family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEYT Eukaryota
ENOG410YA7F LUCA
GeneTreeiENSGT00730000111248
HOGENOMiHOG000113174
InParanoidiQ9C0I3
OMAiYHSVVSC
OrthoDBiEOG091G0340
PhylomeDBiQ9C0I3
TreeFamiTF331021

Family and domain databases

InterProiView protein in InterPro
IPR029627 CCSER
IPR029628 CCSER1
PANTHERiPTHR22461 PTHR22461, 1 hit
PTHR22461:SF1 PTHR22461:SF1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C0I3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDSGSRRST LVSRLPIFRR SINRRHDSLP SSPSSSNTVG VHSSSPSSTN
60 70 80 90 100
SSSGSTGKRR SIFRTPSISF HHKKGSEPKQ EPTNQNLSIS NGAQPGHSNM
110 120 130 140 150
QKLSLEEHIK TRGRHSVGFS SSRNKKITRS LTEDFEREKE HSTNKNVFIN
160 170 180 190 200
CLSSGKSEGD DSGFTEDQTR RSVKQSTRKL LPKSFSSHYK FSKPVLQSQS
210 220 230 240 250
ISLVQQSEFS LEVTQYQERE PVLVRASPSC SVDVTERAGS SLQSPLLSAD
260 270 280 290 300
LTTAQTPSEF LALTEDSVSE MDAFSKSGSM ASHCDNFGHN DSTSQMSLNS
310 320 330 340 350
AAVTKTTTEL TGTVPCAIMS PGKYRLEGQC STESNSLPET SAANQKEVLL
360 370 380 390 400
QIAELPATSV SHSESNLPAD SEREENIGLQ NGETMLGTNS PRKLGFYEQH
410 420 430 440 450
KAIAEHVKGI HPISDSKIIP TSGDHHIFNK TSHGYEANPA KVLASSLSPF
460 470 480 490 500
REGRFIERRL RSSSEGTAGS SRMILKPKDG NIEEVNSLRK QRAGSSSSKM
510 520 530 540 550
NSLDVLNNLG SCELDEDDLM LDLEFLEEQS LHPSVCREDS YHSVVSCAAV
560 570 580 590 600
VLTPMEPMIE MKKREEPEFP EPSKQNLSLK LTKDVDQEAR CSHISRMPNS
610 620 630 640 650
PSADWPLQGV EENGGIDSLP FRLMLQDCTA VKTLLLKMKR VLQESADMSP
660 670 680 690 700
ASSTTSLPVS PLTEEPVPFK DIMKDECSML KLQLKEKDEL ISQLQEELGK
710 720 730 740 750
VRHLQKAFAS RVDKSTQTEL LCYDGLNLKR LETVQGGREA TYRNRIVSQN
760 770 780 790 800
LSTRDRKAIH TPTEDRFRYS AADQTSPYKN KTCQLPSLCL SNFLKDKELA
810 820 830 840 850
EVIKHSRGTY ETLTSDVTQN LRATVGQSSL KPTAKTEGLS TFLEKPKDQV
860 870 880 890 900
ATARQHSTFT GRFGQPPRGP ISLHMYSRKN VFLHHNLHST ELQTLGQQDG
Length:900
Mass (Da):99,510
Last modified:September 2, 2008 - v2
Checksum:i9F47FA3E08D2CDF7
GO
Isoform 2 (identifier: Q9C0I3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     671-677: DIMKDEC → TTYPREF
     678-900: Missing.

Note: No experimental confirmation available.
Show »
Length:677
Mass (Da):74,288
Checksum:iE7783D204718F516
GO

Sequence cautioni

The sequence BAB21771 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059336382G → S. Corresponds to variant dbSNP:rs12647859Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_035318671 – 677DIMKDEC → TTYPREF in isoform 2. 1 Publication7
Alternative sequenceiVSP_035319678 – 900Missing in isoform 2. 1 PublicationAdd BLAST223

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051467 mRNA Translation: BAB21771.1 Different initiation.
AC093729 Genomic DNA Translation: AAY41009.1
AC004054 Genomic DNA No translation available.
AC019188 Genomic DNA No translation available.
AC074124 Genomic DNA No translation available.
AC079301 Genomic DNA No translation available.
AC093781 Genomic DNA No translation available.
AC093793 Genomic DNA No translation available.
AC096897 Genomic DNA No translation available.
AC097524 Genomic DNA No translation available.
AC098593 Genomic DNA No translation available.
AC107049 Genomic DNA No translation available.
AC110774 Genomic DNA No translation available.
AC110796 Genomic DNA No translation available.
AC114787 Genomic DNA No translation available.
BC051694 mRNA Translation: AAH51694.1
CCDSiCCDS47099.1 [Q9C0I3-1]
CCDS47100.1 [Q9C0I3-2]
RefSeqiNP_001138537.1, NM_001145065.1 [Q9C0I3-1]
NP_997374.1, NM_207491.2 [Q9C0I3-2]
UniGeneiHs.654735

Genome annotation databases

EnsembliENST00000432775; ENSP00000389283; ENSG00000184305 [Q9C0I3-2]
ENST00000509176; ENSP00000425040; ENSG00000184305 [Q9C0I3-1]
GeneIDi401145
KEGGihsa:401145
UCSCiuc003hsv.5 human [Q9C0I3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCCSE1_HUMAN
AccessioniPrimary (citable) accession number: Q9C0I3
Secondary accession number(s): Q4W5M0, Q86V57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: July 18, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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