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Entry version 156 (16 Oct 2019)
Sequence version 4 (28 Mar 2018)
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Protein

SRC kinase signaling inhibitor 1

Gene

SRCIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9C0H9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SRC kinase signaling inhibitor 1Curated
Alternative name(s):
SNAP-25-interacting protein
Short name:
SNIP1 Publication
p130Cas-associated protein
p140Cap
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SRCIN1Imported
Synonyms:KIAA1684, P1401 Publication, SNIP1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29506 SRCIN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610786 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9C0H9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80725

Open Targets

More...
OpenTargetsi
ENSG00000277363

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165432823

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9C0H9

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2150836

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SRCIN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452948

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000720111 – 1183SRC kinase signaling inhibitor 1Add BLAST1183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei13PhosphoserineBy similarity1
Modified residuei18PhosphoserineBy similarity1
Modified residuei45PhosphoserineCombined sources1
Modified residuei52PhosphothreonineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Modified residuei64PhosphoserineCombined sources1
Modified residuei143PhosphoserineBy similarity1
Modified residuei165PhosphoserineBy similarity1
Modified residuei169PhosphoserineBy similarity1
Modified residuei179PhosphoserineBy similarity1
Modified residuei225PhosphoserineBy similarity1
Modified residuei241PhosphotyrosineBy similarity1
Modified residuei298PhosphoserineBy similarity1
Modified residuei307PhosphoserineBy similarity1
Modified residuei324PhosphoserineBy similarity1
Modified residuei329Omega-N-methylarginineBy similarity1
Modified residuei336Omega-N-methylarginineBy similarity1
Modified residuei343PhosphoserineBy similarity1
Modified residuei362PhosphoserineBy similarity1
Modified residuei364PhosphoserineCombined sources1
Modified residuei396PhosphotyrosineBy similarity1
Modified residuei493PhosphoserineBy similarity1
Modified residuei496PhosphoserineBy similarity1
Modified residuei500PhosphoserineBy similarity1
Modified residuei501Omega-N-methylarginineBy similarity1
Modified residuei503PhosphoserineBy similarity1
Modified residuei513PhosphoserineBy similarity1
Modified residuei515PhosphoserineBy similarity1
Modified residuei517PhosphoserineBy similarity1
Modified residuei522PhosphoserineBy similarity1
Modified residuei598PhosphoserineBy similarity1
Modified residuei621PhosphoserineBy similarity1
Modified residuei624PhosphothreonineBy similarity1
Modified residuei637PhosphothreonineBy similarity1
Modified residuei844PhosphoserineBy similarity1
Modified residuei857PhosphoserineCombined sources1
Modified residuei866PhosphoserineCombined sources1
Modified residuei884PhosphothreonineCombined sources1
Modified residuei987PhosphoserineBy similarity1
Modified residuei1043PhosphoserineBy similarity1
Modified residuei1060PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9C0H9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9C0H9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9C0H9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9C0H9

PeptideAtlas

More...
PeptideAtlasi
Q9C0H9

PRoteomics IDEntifications database

More...
PRIDEi
Q9C0H9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80047 [Q9C0H9-2]
80048 [Q9C0H9-4]
80049 [Q9C0H9-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9C0H9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9C0H9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000277363 Expressed in 130 organ(s), highest expression level in C1 segment of cervical spinal cord

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9C0H9 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA009701
HPA063795

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the N-terminal coiled-coil region of SNAP25 (By similarity).

Interacts with BCAR1/p130Cas and SRC through its C-terminal domain.

Interacts with CSK, CTTN, SORBS3/vinexin, SYP and MAPRE3/EB3.

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123275, 14 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9C0H9

Protein interaction database and analysis system

More...
IntActi
Q9C0H9, 6 interactors

Molecular INTeraction database

More...
MINTi
Q9C0H9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000484715

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9C0H9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni647 – 697Interaction with SNAP25By similarityAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili654 – 674Sequence analysisAdd BLAST21
Coiled coili726 – 746Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi471 – 504Pro-richAdd BLAST34
Compositional biasi956 – 1014Pro-richAdd BLAST59

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SRCIN1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHFG Eukaryota
ENOG410XTBA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157961

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293351

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9C0H9

KEGG Orthology (KO)

More...
KOi
K19930

Database of Orthologous Groups

More...
OrthoDBi
65773at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9C0H9

TreeFam database of animal gene trees

More...
TreeFami
TF332255

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022782 AIP3-like_C
IPR026727 Srcin1

The PANTHER Classification System

More...
PANTHERi
PTHR22741:SF5 PTHR22741:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03915 AIP3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9C0H9-5) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNAPSQDPE RSSPPMLSAD DAEYPREYRT LGGGGGGGSG GRRFSNVGLV
60 70 80 90 100
HTSERRHTVI AAQSLEALSG LQKADADRKR DAFMDHLKSK YPQHALALRG
110 120 130 140 150
QQDRMREQPN YWSFKTRSSR HTQGAQPGLA DQAAKLSYAS AESLETMSEA
160 170 180 190 200
ELPLGFSRMN RFRQSLPLSR SASQTKLRSP GVLFLQFGEE TRRVHITHEV
210 220 230 240 250
SSLDTLHALI AHMFPQKLTM GMLKSPNTAI LIKDEARNVF YELEDVRDIQ
260 270 280 290 300
DRSIIKIYRK EPLYAAFPGS HLTNGDLRRE MVYASRESSP TRRLNNLSPA
310 320 330 340 350
PHLASGSPPP GLPSGLPSGL QSGSPSRSRL SYAGGRPPSY AGSPVHHAAE
360 370 380 390 400
RLGGAPAAQG VSPSPSAILE RRDVKPDEDL ASKAGGMVLV KGEGLYADPY
410 420 430 440 450
GLLHEGRLSL AAAAGDPFAY PGAGGLYKRG SVRSLSTYSA AALQSDLEDS
460 470 480 490 500
LYKAAGGGGP LYGDGYGFRL PPSSPQKLAD VAAPPGGPPP PHSPYSGPPS
510 520 530 540 550
RGSPVRQSFR KDSGSSSVFA ESPGGKTRSA GSASTAGAPP SELFPGPGER
560 570 580 590 600
SLVGFGPPVP AKDTETRERM EAMEKQIASL TGLVQSALLR GSEPETPSEK
610 620 630 640 650
IEGSNGAATP SAPCGSGGRS SGATPVSGPP PPSASSTPAG QPTAVSRLQM
660 670 680 690 700
QLHLRGLQNS ASDLRGQLQQ LRKLQLQNQE SVRALLKRTE AELSMRVSEA
710 720 730 740 750
ARRQEDPLQR QRTLVEEERL RYLNDEELIT QQLNDLEKSV EKIQRDVSHN
760 770 780 790 800
HRLVPGPELE EKALVLKQLG ETLTELKAHF PGLQSKMRVV LRVEVEAVKF
810 820 830 840 850
LKEEPQRLDG LLKRCRGVTD TLAQIRRQVD EGVWPPPNNL LSQSPKKVTA
860 870 880 890 900
ETDFNKSVDF EMPPPSPPLN LHELSGPAEG ASLTPKGGNP TKGLDTPGKR
910 920 930 940 950
SVDKAVSVEA AERDWEEKRA ALTQYSAKDI NRLLEETQAE LLKAIPDLDC
960 970 980 990 1000
ASKAHPGPAP TPDHKPPKAP HGQKAAPRTE PSGRRGSDEL TVPRYRTEKP
1010 1020 1030 1040 1050
SKSPPPPPPR RSFPSSHGLT TTRTGEVVVT SKKDSAFIKK AESEELEVQK
1060 1070 1080 1090 1100
PQVKLRRAVS EVARPASTPP IMASAIKDED DEDRIIAELE SGGGSVPPMK
1110 1120 1130 1140 1150
VVTPGASRLK AAQGQAGSPD KSKHGKQRAE YMRIQAQQQA TKPSKEMSGS
1160 1170 1180
NETSSPVSEK PSASRTSIPV LTSFGARNSS ISF
Length:1,183
Mass (Da):127,105
Last modified:March 28, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i52BF566E715EF6FF
GO
Isoform 2Curated (identifier: Q9C0H9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-180: MGNAPSQDPE...SASQTKLRSP → MRGAWVHLHS...SDSEGGVSFA
     1141-1183: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,012
Mass (Da):107,997
Checksum:i0B1EEB2BFB499E47
GO
Isoform 3 (identifier: Q9C0H9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-694: Missing.
     910-951: AAERDWEEKR...LKAIPDLDCA → VLGPGIVGGA...FFLGGGGPVP
     952-1183: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:257
Mass (Da):28,590
Checksum:iFA12D8010D0C52D4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X165A0A087X165_HUMAN
SRC kinase-signaling inhibitor 1
SRCIN1
1,217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVV7A0A087WVV7_HUMAN
SRC kinase-signaling inhibitor 1
SRCIN1
928Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WU33A0A087WU33_HUMAN
SRC kinase-signaling inhibitor 1
SRCIN1
473Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTE6A0A087WTE6_HUMAN
SRC kinase-signaling inhibitor 1
SRCIN1
306Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti177L → P in BAD03968 (Ref. 1) Curated1
Sequence conflicti442Missing AA sequence (PubMed:14657239).Curated1
Sequence conflicti609T → I in BAC86634 (PubMed:14702039).Curated1
Sequence conflicti720L → I AA sequence (PubMed:14657239).Curated1
Sequence conflicti833V → M AA sequence (PubMed:14657239).Curated1
Sequence conflicti841 – 842LS → IN AA sequence (PubMed:14657239).Curated2
Sequence conflicti971H → E AA sequence (PubMed:14657239).Curated1
Sequence conflicti978R → K AA sequence (PubMed:14657239).Curated1
Sequence conflicti995Y → R AA sequence (PubMed:14657239).Curated1
Sequence conflicti1086I → L AA sequence (PubMed:14657239).Curated1
Sequence conflicti1115Q → P AA sequence (PubMed:14657239).Curated1
Sequence conflicti1122S → G AA sequence (PubMed:14657239).Curated1
Sequence conflicti1140A → V in BAC86634 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0594501 – 694Missing in isoform 3. Add BLAST694
Alternative sequenceiVSP_0594511 – 180MGNAP…KLRSP → MRGAWVHLHSGAASSLRPCR CGAGAAPKSSPRSPGGRRGD GSSDSEGGVSFA in isoform 2. Add BLAST180
Alternative sequenceiVSP_059452910 – 951AAERD…DLDCA → VLGPGIVGGAMSQVHTFLRP SFLEWGVPILWVFFLGGGGP VP in isoform 3. Add BLAST42
Alternative sequenceiVSP_059453952 – 1183Missing in isoform 3. Add BLAST232
Alternative sequenceiVSP_0594541141 – 1183Missing in isoform 2. Add BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB127405 mRNA Translation: BAD03968.1
AK126665 mRNA Translation: BAC86634.1
AC006449 Genomic DNA No translation available.
AC115090 Genomic DNA No translation available.
AC129916 Genomic DNA No translation available.
AC244153 Genomic DNA No translation available.
KC877653 Genomic DNA No translation available.
BC033233 mRNA Translation: AAH33233.1
AB051471 mRNA Translation: BAB21775.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45660.1 [Q9C0H9-5]

NCBI Reference Sequences

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RefSeqi
NP_079524.2, NM_025248.2 [Q9C0H9-5]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80725

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80725

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB127405 mRNA Translation: BAD03968.1
AK126665 mRNA Translation: BAC86634.1
AC006449 Genomic DNA No translation available.
AC115090 Genomic DNA No translation available.
AC129916 Genomic DNA No translation available.
AC244153 Genomic DNA No translation available.
KC877653 Genomic DNA No translation available.
BC033233 mRNA Translation: AAH33233.1
AB051471 mRNA Translation: BAB21775.1
CCDSiCCDS45660.1 [Q9C0H9-5]
RefSeqiNP_079524.2, NM_025248.2 [Q9C0H9-5]

3D structure databases

SMRiQ9C0H9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi123275, 14 interactors
ELMiQ9C0H9
IntActiQ9C0H9, 6 interactors
MINTiQ9C0H9
STRINGi9606.ENSP00000484715

Chemistry databases

ChEMBLiCHEMBL2150836

PTM databases

iPTMnetiQ9C0H9
PhosphoSitePlusiQ9C0H9

Polymorphism and mutation databases

BioMutaiSRCIN1
DMDMi296452948

Proteomic databases

EPDiQ9C0H9
jPOSTiQ9C0H9
MassIVEiQ9C0H9
PaxDbiQ9C0H9
PeptideAtlasiQ9C0H9
PRIDEiQ9C0H9
ProteomicsDBi80047 [Q9C0H9-2]
80048 [Q9C0H9-4]
80049 [Q9C0H9-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
80725

Genome annotation databases

GeneIDi80725
KEGGihsa:80725

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80725
DisGeNETi80725

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SRCIN1
HGNCiHGNC:29506 SRCIN1
HPAiHPA009701
HPA063795
MIMi610786 gene
neXtProtiNX_Q9C0H9
OpenTargetsiENSG00000277363
PharmGKBiPA165432823

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHFG Eukaryota
ENOG410XTBA LUCA
GeneTreeiENSGT00940000157961
HOGENOMiHOG000293351
InParanoidiQ9C0H9
KOiK19930
OrthoDBi65773at2759
PhylomeDBiQ9C0H9
TreeFamiTF332255

Enzyme and pathway databases

SIGNORiQ9C0H9

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SRCIN1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80725
PharosiQ9C0H9

Protein Ontology

More...
PROi
PR:Q9C0H9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000277363 Expressed in 130 organ(s), highest expression level in C1 segment of cervical spinal cord
ExpressionAtlasiQ9C0H9 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR022782 AIP3-like_C
IPR026727 Srcin1
PANTHERiPTHR22741:SF5 PTHR22741:SF5, 1 hit
PfamiView protein in Pfam
PF03915 AIP3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSRCN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C0H9
Secondary accession number(s): Q75T46, Q8N4W8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: March 28, 2018
Last modified: October 16, 2019
This is version 156 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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