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Entry version 148 (05 Jun 2019)
Sequence version 2 (26 Sep 2001)
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Protein

Kelch-like protein 4

Gene

KLHL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kelch-like protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KLHL4
Synonyms:KIAA1687
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6355 KLHL4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300348 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9C0H6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000102271

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30145

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KLHL4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
17378645

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001191041 – 718Kelch-like protein 4Add BLAST718

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9C0H6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9C0H6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9C0H6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9C0H6

PeptideAtlas

More...
PeptideAtlasi
Q9C0H6

PRoteomics IDEntifications database

More...
PRIDEi
Q9C0H6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
80044
80045 [Q9C0H6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9C0H6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9C0H6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in adult fibroblasts and in a range of fetal tissues including tongue, palate, and mandible.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000102271 Expressed in 111 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9C0H6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9C0H6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA029192

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121035, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q9C0H6, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362206

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9C0H6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini182 – 249BTBPROSITE-ProRule annotationAdd BLAST68
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati430 – 476Kelch 1Add BLAST47
Repeati477 – 523Kelch 2Add BLAST47
Repeati525 – 570Kelch 3Add BLAST46
Repeati571 – 617Kelch 4Add BLAST47
Repeati619 – 670Kelch 5Add BLAST52
Repeati671 – 717Kelch 6Add BLAST47

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4441 Eukaryota
ENOG410XNX8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159818

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230814

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9C0H6

KEGG Orthology (KO)

More...
KOi
K10442

Identification of Orthologs from Complete Genome Data

More...
OMAi
HFQANED

Database of Orthologous Groups

More...
OrthoDBi
709680at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9C0H6

TreeFam database of animal gene trees

More...
TreeFami
TF329218

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.80, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011705 BACK
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117281 SSF117281, 2 hits
SSF54695 SSF54695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50097 BTB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9C0H6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVSGKKEFD VKQILRLRWR WFSHPFQGST NTGSCLQQEG YEHRGTPVQG
60 70 80 90 100
RLKSHSRDRN GLKKSNSPVH HNILAPVPGP APAHQRAVQN LQQHNLIVHF
110 120 130 140 150
QANEDTPKSV PEKNLFKEAC EKRAQDLEMM ADDNIEDSTA RLDTQHSEDM
160 170 180 190 200
NATRSEEQFH VINHAEQTLR KMENYLKEKQ LCDVLLIAGH LRIPAHRLVL
210 220 230 240 250
SAVSDYFAAM FTNDVLEAKQ EEVRMEGVDP NALNSLVQYA YTGVLQLKED
260 270 280 290 300
TIESLLAAAC LLQLTQVIDV CSNFLIKQLH PSNCLGIRSF GDAQGCTELL
310 320 330 340 350
NVAHKYTMEH FIEVIKNQEF LLLPANEISK LLCSDDINVP DEETIFHALM
360 370 380 390 400
QWVGHDVQNR QGELGMLLSY IRLPLLPPQL LADLETSSMF TGDLECQKLL
410 420 430 440 450
MEAMKYHLLP ERRSMMQSPR TKPRKSTVGA LYAVGGMDAM KGTTTIEKYD
460 470 480 490 500
LRTNSWLHIG TMNGRRLQFG VAVIDNKLYV VGGRDGLKTL NTVECFNPVG
510 520 530 540 550
KIWTVMPPMS THRHGLGVAT LEGPMYAVGG HDGWSYLNTV ERWDPEGRQW
560 570 580 590 600
NYVASMSTPR STVGVVALNN KLYAIGGRDG SSCLKSMEYF DPHTNKWSLC
610 620 630 640 650
APMSKRRGGV GVATYNGFLY VVGGHDAPAS NHCSRLSDCV ERYDPKGDSW
660 670 680 690 700
STVAPLSVPR DAVAVCPLGD KLYVVGGYDG HTYLNTVESY DAQRNEWKEE
710
VPVNIGRAGA CVVVVKLP
Length:718
Mass (Da):80,245
Last modified:September 26, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD7385BAAD63B150A
GO
Isoform 2 (identifier: Q9C0H6-2) [UniParc]FASTAAdd to basket
Also known as: KLHL4c

The sequence of this isoform differs from the canonical sequence as follows:
     700-718: EVPVNIGRAGACVVVVKLP → SMQELLQNFYTTQKLKETLGH

Show »
Length:720
Mass (Da):80,835
Checksum:i9746972C5B276C00
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14199 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB21778 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002818700 – 718EVPVN…VVKLP → SMQELLQNFYTTQKLKETLG H in isoform 2. 2 PublicationsAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF284765 mRNA Translation: AAK49441.1
AF284766 mRNA Translation: AAK49442.1
AB051474 mRNA Translation: BAB21778.1 Different initiation.
AL832514 mRNA Translation: CAI46201.1
AL035424 Genomic DNA No translation available.
Z95400 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98553.1
BC140839 mRNA Translation: AAI40840.1
BC140840 mRNA Translation: AAI40841.1
AK022715 mRNA Translation: BAB14199.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14456.1 [Q9C0H6-2]
CCDS14457.1 [Q9C0H6-1]

NCBI Reference Sequences

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RefSeqi
NP_061990.2, NM_019117.4 [Q9C0H6-1]
NP_476503.1, NM_057162.2 [Q9C0H6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373114; ENSP00000362206; ENSG00000102271 [Q9C0H6-2]
ENST00000373119; ENSP00000362211; ENSG00000102271 [Q9C0H6-1]
ENST00000652270; ENSP00000498718; ENSG00000102271 [Q9C0H6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
56062

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:56062

UCSC genome browser

More...
UCSCi
uc004efa.3 human [Q9C0H6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284765 mRNA Translation: AAK49441.1
AF284766 mRNA Translation: AAK49442.1
AB051474 mRNA Translation: BAB21778.1 Different initiation.
AL832514 mRNA Translation: CAI46201.1
AL035424 Genomic DNA No translation available.
Z95400 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98553.1
BC140839 mRNA Translation: AAI40840.1
BC140840 mRNA Translation: AAI40841.1
AK022715 mRNA Translation: BAB14199.1 Different initiation.
CCDSiCCDS14456.1 [Q9C0H6-2]
CCDS14457.1 [Q9C0H6-1]
RefSeqiNP_061990.2, NM_019117.4 [Q9C0H6-1]
NP_476503.1, NM_057162.2 [Q9C0H6-2]

3D structure databases

SMRiQ9C0H6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121035, 3 interactors
IntActiQ9C0H6, 3 interactors
STRINGi9606.ENSP00000362206

PTM databases

iPTMnetiQ9C0H6
PhosphoSitePlusiQ9C0H6

Polymorphism and mutation databases

BioMutaiKLHL4
DMDMi17378645

Proteomic databases

EPDiQ9C0H6
jPOSTiQ9C0H6
MaxQBiQ9C0H6
PaxDbiQ9C0H6
PeptideAtlasiQ9C0H6
PRIDEiQ9C0H6
ProteomicsDBi80044
80045 [Q9C0H6-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373114; ENSP00000362206; ENSG00000102271 [Q9C0H6-2]
ENST00000373119; ENSP00000362211; ENSG00000102271 [Q9C0H6-1]
ENST00000652270; ENSP00000498718; ENSG00000102271 [Q9C0H6-1]
GeneIDi56062
KEGGihsa:56062
UCSCiuc004efa.3 human [Q9C0H6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56062

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KLHL4
HGNCiHGNC:6355 KLHL4
HPAiHPA029192
MIMi300348 gene
neXtProtiNX_Q9C0H6
OpenTargetsiENSG00000102271
PharmGKBiPA30145

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00940000159818
HOGENOMiHOG000230814
InParanoidiQ9C0H6
KOiK10442
OMAiHFQANED
OrthoDBi709680at2759
PhylomeDBiQ9C0H6
TreeFamiTF329218

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
56062

Protein Ontology

More...
PROi
PR:Q9C0H6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000102271 Expressed in 111 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ9C0H6 baseline and differential
GenevisibleiQ9C0H6 HS

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR011705 BACK
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 6 hits
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 6 hits
SUPFAMiSSF117281 SSF117281, 2 hits
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKLHL4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C0H6
Secondary accession number(s): B2RTW2, Q9Y3J5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: June 5, 2019
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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