UniProtKB - Q9C0H5 (RHG39_HUMAN)
Protein
Rho GTPase-activating protein 39
Gene
ARHGAP39
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- GTPase activator activity Source: GO_Central
GO - Biological processi
- postsynapse organization Source: SynGO
- regulation of small GTPase mediated signal transduction Source: Reactome
- signal transduction Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | Q9C0H5 |
Reactomei | R-HSA-194840, Rho GTPase cycle R-HSA-428543, Inactivation of CDC42 and RAC1 |
SignaLinki | Q9C0H5 |
SIGNORi | Q9C0H5 |
Names & Taxonomyi
Protein namesi | Recommended name: Rho GTPase-activating protein 39 |
Gene namesi | Name:ARHGAP39 Synonyms:KIAA1688 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29351, ARHGAP39 |
MIMi | 615880, gene |
neXtProti | NX_Q9C0H5 |
VEuPathDBi | HostDB:ENSG00000147799.11 |
Subcellular locationi
Nucleus
- Nucleus Curated
Cytoskeleton
- cytoskeleton Source: InterPro
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
- glutamatergic synapse Source: SynGO
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 80728 |
OpenTargetsi | ENSG00000147799 |
PharmGKBi | PA165585391 |
Miscellaneous databases
Pharosi | Q9C0H5, Tbio |
Genetic variation databases
BioMutai | ARHGAP39 |
DMDMi | 28380079 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000076092 | 2 – 1083 | Rho GTPase-activating protein 39Add BLAST | 1082 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 169 | PhosphoserineCombined sources | 1 | |
Modified residuei | 286 | PhosphoserineCombined sources | 1 | |
Modified residuei | 384 | PhosphoserineBy similarity | 1 | |
Modified residuei | 388 | PhosphoserineCombined sources | 1 | |
Modified residuei | 406 | PhosphoserineCombined sources | 1 | |
Modified residuei | 407 | PhosphoserineCombined sources | 1 | |
Modified residuei | 604 | PhosphoserineCombined sources | 1 | |
Modified residuei | 690 | PhosphoserineCombined sources | 1 | |
Modified residuei | 715 | PhosphoserineBy similarity | 1 | |
Modified residuei | 726 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | Q9C0H5 |
MassIVEi | Q9C0H5 |
MaxQBi | Q9C0H5 |
PaxDbi | Q9C0H5 |
PeptideAtlasi | Q9C0H5 |
PRIDEi | Q9C0H5 |
ProteomicsDBi | 80042 [Q9C0H5-1] 80043 [Q9C0H5-2] |
PTM databases
iPTMneti | Q9C0H5 |
PhosphoSitePlusi | Q9C0H5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000147799, Expressed in sural nerve and 162 other tissues |
Genevisiblei | Q9C0H5, HS |
Organism-specific databases
HPAi | ENSG00000147799, Tissue enhanced (testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 123278, 26 interactors |
IntActi | Q9C0H5, 30 interactors |
STRINGi | 9606.ENSP00000366522 |
Miscellaneous databases
RNActi | Q9C0H5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 58 | WW 1PROSITE-ProRule annotationAdd BLAST | 34 | |
Domaini | 63 – 97 | WW 2PROSITE-ProRule annotationAdd BLAST | 35 | |
Domaini | 722 – 879 | MyTH4PROSITE-ProRule annotationAdd BLAST | 158 | |
Domaini | 890 – 1078 | Rho-GAPPROSITE-ProRule annotationAdd BLAST | 189 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 234 – 367 | Pro-richAdd BLAST | 134 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QR6X, Eukaryota |
GeneTreei | ENSGT00390000003161 |
HOGENOMi | CLU_005171_0_0_1 |
InParanoidi | Q9C0H5 |
OMAi | QDDAMSW |
OrthoDBi | 1123653at2759 |
PhylomeDBi | Q9C0H5 |
TreeFami | TF323577 |
Family and domain databases
Gene3Di | 1.10.555.10, 1 hit 1.25.40.530, 1 hit |
InterProi | View protein in InterPro IPR000857, MyTH4_dom IPR038185, MyTH4_dom_sf IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom IPR001202, WW_dom IPR036020, WW_dom_sf |
Pfami | View protein in Pfam PF00784, MyTH4, 1 hit PF00620, RhoGAP, 1 hit |
SMARTi | View protein in SMART SM00139, MyTH4, 1 hit SM00324, RhoGAP, 1 hit SM00456, WW, 2 hits |
SUPFAMi | SSF48350, SSF48350, 1 hit SSF51045, SSF51045, 1 hit |
PROSITEi | View protein in PROSITE PS51016, MYTH4, 1 hit PS50238, RHOGAP, 1 hit PS50020, WW_DOMAIN_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9C0H5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSQTQDYECR SHNVDLPESR IPGSNTRLEW VEIIEPRTRE RMYANLVTGE
60 70 80 90 100
CVWDPPAGVR IKRTSENQWW ELFDPNTSRF YYYNASTQRT VWHRPQGCDI
110 120 130 140 150
IPLAKLQTLK QNTESPRASA ESSPGRGSSV SREGSTSSSL EPEPDTEKAQ
160 170 180 190 200
ELPARAGRPA AFGTVKEDSG SSSPPGVFLE KDYEIYRDYS ADGQLLHYRT
210 220 230 240 250
SSLRWNSGAK ERMLIKVADR EPSFLAAQGN GYAPDGPPGV RSRRPSGSQH
260 270 280 290 300
SPSLQTFAPE ADGTIFFPER RPSPFLKRAE LPGSSSPLLA QPRKPSGDSQ
310 320 330 340 350
PSSPRYGYEP PLYEEPPVEY QAPIYDEPPM DVQFEAGGGY QAGSPQRSPG
360 370 380 390 400
RKPRPFLQPN KQGPPSPCQQ LVLTKQKCPE RFLSLEYSPA GKEYVRQLVY
410 420 430 440 450
VEQAGSSPKL RAGPRHKYAP NPGGGSYSLQ PSPCLLRDQR LGVKSGDYST
460 470 480 490 500
MEGPELRHSQ PPTPLPQAQE DAMSWSSQQD TLSSTGYSPG TRKRKSRKPS
510 520 530 540 550
LCQATSATPT EGPGDLLVEQ PLAEEQPPCG TSLAPVKRAE GEAEGARGAA
560 570 580 590 600
EPFLAQARLA WEAQQAHFHM KQRSSWDSQQ DGSGYESDGA LPLPMPGPVV
610 620 630 640 650
RAFSEDEALA QQENRHWRRG TFEKLGFPQI LLEKSVSVQT NLASPEPYLH
660 670 680 690 700
PSQSEDLAAC AQFESSRQSR SGVPSSSCVF PTFTLRKPSS ETDIENWASK
710 720 730 740 750
HFNKHTQGLF RRKVSIANML AWSSESIKKP MIVTSDRHVK KEACELFKLI
760 770 780 790 800
QMYMGDRRAK ADPLHVALEV ATKGWSVQGL RDELYIQLCR QTTENFRLES
810 820 830 840 850
LARGWELMAI CLAFFPPTPK FHSYLEGYIY RHMDPVNDTK GVAISTYAKY
860 870 880 890 900
CYHKLQKAAL TGAKKGLKKP NVEEIRHAKN AVFSPSMFGS ALQEVMGMQR
910 920 930 940 950
ERYPERQLPW VQTRLSEEVL ALNGDQTEGI FRVPGDIDEV NALKLQVDQW
960 970 980 990 1000
KVPTGLEDPH VPASLLKLWY RELEEPLIPH EFYEQCIAHY DSPEAAVAVV
1010 1020 1030 1040 1050
HALPRINRMV LCYLIRFLQV FVQPANVAVT KMDVSNLAMV MAPNCLRCQS
1060 1070 1080
DDPRVIFENT RKEMSFLRVL IQHLDTSFME GVL
Sequence cautioni
The sequence BAB21779 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAG64793 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040749 | 840 | K → KVTQHIKELLERNTKKKSKL RKKPKPYVEEPD in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB051475 mRNA Translation: BAB21779.1 Different initiation. AC084125 Genomic DNA No translation available. AK303851 mRNA Translation: BAG64793.1 Different initiation. |
CCDSi | CCDS34971.1 [Q9C0H5-2] CCDS78374.1 [Q9C0H5-1] |
PIRi | C59434 |
RefSeqi | NP_001295136.1, NM_001308207.1 [Q9C0H5-1] NP_001295137.1, NM_001308208.1 [Q9C0H5-1] NP_079527.1, NM_025251.2 [Q9C0H5-2] XP_011515610.1, XM_011517308.1 [Q9C0H5-2] XP_011515611.1, XM_011517309.1 [Q9C0H5-2] XP_016869359.1, XM_017013870.1 [Q9C0H5-2] XP_016869360.1, XM_017013871.1 |
Genome annotation databases
Ensembli | ENST00000276826; ENSP00000276826; ENSG00000147799 [Q9C0H5-1] ENST00000377307; ENSP00000366522; ENSG00000147799 [Q9C0H5-2] |
GeneIDi | 80728 |
KEGGi | hsa:80728 |
UCSCi | uc064rpe.1, human [Q9C0H5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB051475 mRNA Translation: BAB21779.1 Different initiation. AC084125 Genomic DNA No translation available. AK303851 mRNA Translation: BAG64793.1 Different initiation. |
CCDSi | CCDS34971.1 [Q9C0H5-2] CCDS78374.1 [Q9C0H5-1] |
PIRi | C59434 |
RefSeqi | NP_001295136.1, NM_001308207.1 [Q9C0H5-1] NP_001295137.1, NM_001308208.1 [Q9C0H5-1] NP_079527.1, NM_025251.2 [Q9C0H5-2] XP_011515610.1, XM_011517308.1 [Q9C0H5-2] XP_011515611.1, XM_011517309.1 [Q9C0H5-2] XP_016869359.1, XM_017013870.1 [Q9C0H5-2] XP_016869360.1, XM_017013871.1 |
3D structure databases
SMRi | Q9C0H5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123278, 26 interactors |
IntActi | Q9C0H5, 30 interactors |
STRINGi | 9606.ENSP00000366522 |
PTM databases
iPTMneti | Q9C0H5 |
PhosphoSitePlusi | Q9C0H5 |
Genetic variation databases
BioMutai | ARHGAP39 |
DMDMi | 28380079 |
Proteomic databases
jPOSTi | Q9C0H5 |
MassIVEi | Q9C0H5 |
MaxQBi | Q9C0H5 |
PaxDbi | Q9C0H5 |
PeptideAtlasi | Q9C0H5 |
PRIDEi | Q9C0H5 |
ProteomicsDBi | 80042 [Q9C0H5-1] 80043 [Q9C0H5-2] |
Protocols and materials databases
Antibodypediai | 49512, 74 antibodies |
Genome annotation databases
Ensembli | ENST00000276826; ENSP00000276826; ENSG00000147799 [Q9C0H5-1] ENST00000377307; ENSP00000366522; ENSG00000147799 [Q9C0H5-2] |
GeneIDi | 80728 |
KEGGi | hsa:80728 |
UCSCi | uc064rpe.1, human [Q9C0H5-1] |
Organism-specific databases
CTDi | 80728 |
DisGeNETi | 80728 |
GeneCardsi | ARHGAP39 |
HGNCi | HGNC:29351, ARHGAP39 |
HPAi | ENSG00000147799, Tissue enhanced (testis) |
MIMi | 615880, gene |
neXtProti | NX_Q9C0H5 |
OpenTargetsi | ENSG00000147799 |
PharmGKBi | PA165585391 |
VEuPathDBi | HostDB:ENSG00000147799.11 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QR6X, Eukaryota |
GeneTreei | ENSGT00390000003161 |
HOGENOMi | CLU_005171_0_0_1 |
InParanoidi | Q9C0H5 |
OMAi | QDDAMSW |
OrthoDBi | 1123653at2759 |
PhylomeDBi | Q9C0H5 |
TreeFami | TF323577 |
Enzyme and pathway databases
PathwayCommonsi | Q9C0H5 |
Reactomei | R-HSA-194840, Rho GTPase cycle R-HSA-428543, Inactivation of CDC42 and RAC1 |
SignaLinki | Q9C0H5 |
SIGNORi | Q9C0H5 |
Miscellaneous databases
BioGRID-ORCSi | 80728, 5 hits in 861 CRISPR screens |
ChiTaRSi | ARHGAP39, human |
GenomeRNAii | 80728 |
Pharosi | Q9C0H5, Tbio |
PROi | PR:Q9C0H5 |
RNActi | Q9C0H5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000147799, Expressed in sural nerve and 162 other tissues |
Genevisiblei | Q9C0H5, HS |
Family and domain databases
Gene3Di | 1.10.555.10, 1 hit 1.25.40.530, 1 hit |
InterProi | View protein in InterPro IPR000857, MyTH4_dom IPR038185, MyTH4_dom_sf IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom IPR001202, WW_dom IPR036020, WW_dom_sf |
Pfami | View protein in Pfam PF00784, MyTH4, 1 hit PF00620, RhoGAP, 1 hit |
SMARTi | View protein in SMART SM00139, MyTH4, 1 hit SM00324, RhoGAP, 1 hit SM00456, WW, 2 hits |
SUPFAMi | SSF48350, SSF48350, 1 hit SSF51045, SSF51045, 1 hit |
PROSITEi | View protein in PROSITE PS51016, MYTH4, 1 hit PS50238, RHOGAP, 1 hit PS50020, WW_DOMAIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RHG39_HUMAN | |
Accessioni | Q9C0H5Primary (citable) accession number: Q9C0H5 Secondary accession number(s): B4E1I1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 12, 2003 |
Last sequence update: | February 12, 2003 | |
Last modified: | February 10, 2021 | |
This is version 162 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot