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UniProtKB - Q9C0H5 (RHG39_HUMAN)

Entry version 159 (17 Jun 2020)
Sequence version 2 (12 Feb 2003)
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Protein

Rho GTPase-activating protein 39

Gene

ARHGAP39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-194840 Rho GTPase cycle
R-HSA-428543 Inactivation of CDC42 and RAC1

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9C0H5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 39
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGAP39
Synonyms:KIAA1688
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000147799.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:29351 ARHGAP39

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615880 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9C0H5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000147799

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165585391

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9C0H5 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ARHGAP39

Domain mapping of disease mutations (DMDM)

More...DMDMi		28380079

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000760922 – 1083Rho GTPase-activating protein 39Add BLAST1082

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei169PhosphoserineCombined sources1
Modified residuei286PhosphoserineCombined sources1
Modified residuei384PhosphoserineBy similarity1
Modified residuei388PhosphoserineCombined sources1
Modified residuei406PhosphoserineCombined sources1
Modified residuei407PhosphoserineCombined sources1
Modified residuei604PhosphoserineCombined sources1
Modified residuei690PhosphoserineCombined sources1
Modified residuei715PhosphoserineBy similarity1
Modified residuei726PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9C0H5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9C0H5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9C0H5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9C0H5

PeptideAtlas

More...PeptideAtlasi		Q9C0H5

PRoteomics IDEntifications database

More...PRIDEi		Q9C0H5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		80042 [Q9C0H5-1]
80043 [Q9C0H5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9C0H5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9C0H5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000147799 Expressed in oviduct epithelium and 144 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9C0H5 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000147799 Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123278, 21 interactors

Protein interaction database and analysis system

More...IntActi		Q9C0H5, 30 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000366522

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9C0H5 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9C0H5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 58WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini63 – 97WW 2PROSITE-ProRule annotationAdd BLAST35
Domaini722 – 879MyTH4PROSITE-ProRule annotationAdd BLAST158
Domaini890 – 1078Rho-GAPPROSITE-ProRule annotationAdd BLAST189

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi234 – 367Pro-richAdd BLAST134

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IG4K Eukaryota
ENOG410XQ23 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003161

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005171_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9C0H5

KEGG Orthology (KO)

More...KOi		K20649

Identification of Orthologs from Complete Genome Data

More...OMAi		QDDAMSW

Database of Orthologous Groups

More...OrthoDBi		1123653at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9C0H5

TreeFam database of animal gene trees

More...TreeFami		TF323577

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.555.10, 1 hit
1.25.40.530, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR001202 WW_dom
IPR036020 WW_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00784 MyTH4, 1 hit
PF00620 RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00139 MyTH4, 1 hit
SM00324 RhoGAP, 1 hit
SM00456 WW, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48350 SSF48350, 1 hit
SSF51045 SSF51045, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51016 MYTH4, 1 hit
PS50238 RHOGAP, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9C0H5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQTQDYECR SHNVDLPESR IPGSNTRLEW VEIIEPRTRE RMYANLVTGE 
        60         70         80         90        100
CVWDPPAGVR IKRTSENQWW ELFDPNTSRF YYYNASTQRT VWHRPQGCDI 
       110        120        130        140        150
IPLAKLQTLK QNTESPRASA ESSPGRGSSV SREGSTSSSL EPEPDTEKAQ 
       160        170        180        190        200
ELPARAGRPA AFGTVKEDSG SSSPPGVFLE KDYEIYRDYS ADGQLLHYRT 
       210        220        230        240        250
SSLRWNSGAK ERMLIKVADR EPSFLAAQGN GYAPDGPPGV RSRRPSGSQH 
       260        270        280        290        300
SPSLQTFAPE ADGTIFFPER RPSPFLKRAE LPGSSSPLLA QPRKPSGDSQ 
       310        320        330        340        350
PSSPRYGYEP PLYEEPPVEY QAPIYDEPPM DVQFEAGGGY QAGSPQRSPG 
       360        370        380        390        400
RKPRPFLQPN KQGPPSPCQQ LVLTKQKCPE RFLSLEYSPA GKEYVRQLVY 
       410        420        430        440        450
VEQAGSSPKL RAGPRHKYAP NPGGGSYSLQ PSPCLLRDQR LGVKSGDYST 
       460        470        480        490        500
MEGPELRHSQ PPTPLPQAQE DAMSWSSQQD TLSSTGYSPG TRKRKSRKPS 
       510        520        530        540        550
LCQATSATPT EGPGDLLVEQ PLAEEQPPCG TSLAPVKRAE GEAEGARGAA 
       560        570        580        590        600
EPFLAQARLA WEAQQAHFHM KQRSSWDSQQ DGSGYESDGA LPLPMPGPVV 
       610        620        630        640        650
RAFSEDEALA QQENRHWRRG TFEKLGFPQI LLEKSVSVQT NLASPEPYLH 
       660        670        680        690        700
PSQSEDLAAC AQFESSRQSR SGVPSSSCVF PTFTLRKPSS ETDIENWASK 
       710        720        730        740        750
HFNKHTQGLF RRKVSIANML AWSSESIKKP MIVTSDRHVK KEACELFKLI 
       760        770        780        790        800
QMYMGDRRAK ADPLHVALEV ATKGWSVQGL RDELYIQLCR QTTENFRLES 
       810        820        830        840        850
LARGWELMAI CLAFFPPTPK FHSYLEGYIY RHMDPVNDTK GVAISTYAKY 
       860        870        880        890        900
CYHKLQKAAL TGAKKGLKKP NVEEIRHAKN AVFSPSMFGS ALQEVMGMQR 
       910        920        930        940        950
ERYPERQLPW VQTRLSEEVL ALNGDQTEGI FRVPGDIDEV NALKLQVDQW 
       960        970        980        990       1000
KVPTGLEDPH VPASLLKLWY RELEEPLIPH EFYEQCIAHY DSPEAAVAVV 
      1010       1020       1030       1040       1050
HALPRINRMV LCYLIRFLQV FVQPANVAVT KMDVSNLAMV MAPNCLRCQS 
      1060       1070       1080 
DDPRVIFENT RKEMSFLRVL IQHLDTSFME GVL
Length:1,083
Mass (Da):121,286
Last modified:February 12, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i782B213B1DCB4072
GO
Isoform 2 (identifier: Q9C0H5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     840-840: K → KVTQHIKELLERNTKKKSKLRKKPKPYVEEPD

Show »
Length:1,114
Mass (Da):125,029
Checksum:iA232D306723FEAB6
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB21779 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAG64793 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040749840K → KVTQHIKELLERNTKKKSKL RKKPKPYVEEPD in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB051475 mRNA Translation: BAB21779.1 Different initiation.
AC084125 Genomic DNA No translation available.
AK303851 mRNA Translation: BAG64793.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34971.1 [Q9C0H5-2]
CCDS78374.1 [Q9C0H5-1]

Protein sequence database of the Protein Information Resource

More...PIRi		C59434

NCBI Reference Sequences

More...RefSeqi		NP_001295136.1, NM_001308207.1 [Q9C0H5-1]
NP_001295137.1, NM_001308208.1 [Q9C0H5-1]
NP_079527.1, NM_025251.2 [Q9C0H5-2]
XP_011515610.1, XM_011517308.1 [Q9C0H5-2]
XP_011515611.1, XM_011517309.1 [Q9C0H5-2]
XP_016869359.1, XM_017013870.1 [Q9C0H5-2]
XP_016869360.1, XM_017013871.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000276826; ENSP00000276826; ENSG00000147799 [Q9C0H5-1]
ENST00000377307; ENSP00000366522; ENSG00000147799 [Q9C0H5-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		80728

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:80728

UCSC genome browser

More...UCSCi		uc064rpe.1 human [Q9C0H5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051475 mRNA Translation: BAB21779.1 Different initiation.
AC084125 Genomic DNA No translation available.
AK303851 mRNA Translation: BAG64793.1 Different initiation.
CCDSiCCDS34971.1 [Q9C0H5-2]
CCDS78374.1 [Q9C0H5-1]
PIRiC59434
RefSeqiNP_001295136.1, NM_001308207.1 [Q9C0H5-1]
NP_001295137.1, NM_001308208.1 [Q9C0H5-1]
NP_079527.1, NM_025251.2 [Q9C0H5-2]
XP_011515610.1, XM_011517308.1 [Q9C0H5-2]
XP_011515611.1, XM_011517309.1 [Q9C0H5-2]
XP_016869359.1, XM_017013870.1 [Q9C0H5-2]
XP_016869360.1, XM_017013871.1

3D structure databases

SMRiQ9C0H5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123278, 21 interactors
IntActiQ9C0H5, 30 interactors
STRINGi9606.ENSP00000366522

PTM databases

iPTMnetiQ9C0H5
PhosphoSitePlusiQ9C0H5

Polymorphism and mutation databases

BioMutaiARHGAP39
DMDMi28380079

Proteomic databases

jPOSTiQ9C0H5
MassIVEiQ9C0H5
MaxQBiQ9C0H5
PaxDbiQ9C0H5
PeptideAtlasiQ9C0H5
PRIDEiQ9C0H5
ProteomicsDBi80042 [Q9C0H5-1]
80043 [Q9C0H5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		49512 74 antibodies

Genome annotation databases

EnsembliENST00000276826; ENSP00000276826; ENSG00000147799 [Q9C0H5-1]
ENST00000377307; ENSP00000366522; ENSG00000147799 [Q9C0H5-2]
GeneIDi80728
KEGGihsa:80728
UCSCiuc064rpe.1 human [Q9C0H5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		80728
EuPathDBiHostDB:ENSG00000147799.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		ARHGAP39
HGNCiHGNC:29351 ARHGAP39
HPAiENSG00000147799 Tissue enhanced (testis)
MIMi615880 gene
neXtProtiNX_Q9C0H5
OpenTargetsiENSG00000147799
PharmGKBiPA165585391

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IG4K Eukaryota
ENOG410XQ23 LUCA
GeneTreeiENSGT00390000003161
HOGENOMiCLU_005171_0_0_1
InParanoidiQ9C0H5
KOiK20649
OMAiQDDAMSW
OrthoDBi1123653at2759
PhylomeDBiQ9C0H5
TreeFamiTF323577

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle
R-HSA-428543 Inactivation of CDC42 and RAC1
SignaLinkiQ9C0H5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		80728 2 hits in 789 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ARHGAP39 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		80728
PharosiQ9C0H5 Tbio

Protein Ontology

More...PROi		PR:Q9C0H5
RNActiQ9C0H5 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000147799 Expressed in oviduct epithelium and 144 other tissues
GenevisibleiQ9C0H5 HS

Family and domain databases

Gene3Di1.10.555.10, 1 hit
1.25.40.530, 1 hit
InterProiView protein in InterPro
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00784 MyTH4, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00139 MyTH4, 1 hit
SM00324 RhoGAP, 1 hit
SM00456 WW, 2 hits
SUPFAMiSSF48350 SSF48350, 1 hit
SSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS51016 MYTH4, 1 hit
PS50238 RHOGAP, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG39_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C0H5
Secondary accession number(s): B4E1I1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: February 12, 2003
Last modified: June 17, 2020
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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