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Entry version 126 (16 Oct 2019)
Sequence version 3 (04 Dec 2007)
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Protein

Protein tweety homolog 3

Gene

TTYH3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable large-conductance Ca2+-activated chloride channel. May play a role in Ca2+ signal transduction.1 Publication

Miscellaneous

The current is completely inhibited by the addition of an anion permeability inhibitor. Addition of a Ca2+ ionophore induces an outward-rectified current in mock-transfected cells, but it introduced an overt linear current in TTYH3-transfected cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chloride channel activity Source: UniProtKB
  • intracellular calcium activated chloride channel activity Source: FlyBase
  • volume-sensitive chloride channel activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChloride channel, Ion channel
Biological processIon transport, Transport
LigandCalcium, Chloride

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2672351 Stimuli-sensing channels

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.48.1.4 the anion channel tweety (tweety) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein tweety homolog 3
Short name:
hTTY3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTYH3
Synonyms:KIAA1691
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:22222 TTYH3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608919 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9C0H2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 42ExtracellularSequence analysisAdd BLAST42
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei43 – 63Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini64 – 86CytoplasmicSequence analysisAdd BLAST23
Transmembranei87 – 107Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini108 – 211ExtracellularSequence analysisAdd BLAST104
Transmembranei212 – 232Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini233 – 236CytoplasmicSequence analysis4
Transmembranei237 – 257Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini258 – 386ExtracellularSequence analysisAdd BLAST129
Transmembranei387 – 407Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini408 – 523CytoplasmicSequence analysisAdd BLAST116

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi128T → A: Does not affect N-glycosylation state. 1 Publication1
Mutagenesisi146T → A: Does not affect N-glycosylation state. 1 Publication1
Mutagenesisi353T → A: Abolishes N-glycosylation. 1 Publication1
Mutagenesisi367R → Q: Induces a stronger permeability to cations. 1 Publication1
Mutagenesisi370H → D: Shows a different ion selectivity. 1 Publication1

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000136295

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134908427

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q9C0H2

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TTYH3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
162416242

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003122511 – 523Protein tweety homolog 3Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi144N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi351N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei496PhosphoserineBy similarity1
Modified residuei504PhosphoserineBy similarity1
Modified residuei522PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9C0H2

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9C0H2

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9C0H2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9C0H2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9C0H2

PeptideAtlas

More...
PeptideAtlasi
Q9C0H2

PRoteomics IDEntifications database

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PRIDEi
Q9C0H2

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
80038 [Q9C0H2-1]
80039 [Q9C0H2-2]
80040 [Q9C0H2-3]
80041 [Q9C0H2-4]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1671

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9C0H2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9C0H2

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9C0H2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in excitable tissues. Expressed in the brain, heart, skeletal muscle, colon, spleen, kidney and peripheral blood leukocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136295 Expressed in 166 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9C0H2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9C0H2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA053520

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123277, 41 interactors

Protein interaction database and analysis system

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IntActi
Q9C0H2, 23 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000258796

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tweety family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4433 Eukaryota
ENOG410ZNTN LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000183060

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000070449

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9C0H2

KEGG Orthology (KO)

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KOi
K22641

Identification of Orthologs from Complete Genome Data

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OMAi
QVNPFQQ

Database of Orthologous Groups

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OrthoDBi
725378at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9C0H2

TreeFam database of animal gene trees

More...
TreeFami
TF319025

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07912 Tweety_N, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006990 Tweety

The PANTHER Classification System

More...
PANTHERi
PTHR12424 PTHR12424, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04906 Tweety, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9C0H2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGVSYAAPW WVSLLHRLPH FDLSWEATSS QFRPEDTDYQ QALLLLGAAA
60 70 80 90 100
LACLALDLLF LLFYSFWLCC RRRKSEEHLD ADCCCTAWCV IIATLVCSAG
110 120 130 140 150
IAVGFYGNGE TSDGIHRATY SLRHANRTVA GVQDRVWDTA VGLNHTAEPS
160 170 180 190 200
LQTLERQLAG RPEPLRAVQR LQGLLETLLG YTAAIPFWRN TAVSLEVLAE
210 220 230 240 250
QVDLYDWYRW LGYLGLLLLD VIICLLVLVG LIRSSKGILV GVCLLGVLAL
260 270 280 290 300
VISWGALGLE LAVSVGSSDF CVDPDAYVTK MVEEYSVLSG DILQYYLACS
310 320 330 340 350
PRAANPFQQK LSGSHKALVE MQDVVAELLR TVPWEQPATK DPLLRVQEVL
360 370 380 390 400
NGTEVNLQHL TALVDCRSLH LDYVQALTGF CYDGVEGLIY LALFSFVTAL
410 420 430 440 450
MFSSIVCSVP HTWQQKRGPD EDGEEEAAPG PRQAHDSLYR VHMPSLYSCG
460 470 480 490 500
SSYGSETSIP AAAHTVSNAP VTEYMSQNAN FQNPRCENTP LIGRESPPPS
510 520
YTSSMRAKYL ATSQPRPDSS GSH
Length:523
Mass (Da):57,545
Last modified:December 4, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB398391787BA0301
GO
Isoform 2 (identifier: Q9C0H2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-241: Missing.

Note: No experimental confirmation available.
Show »
Length:491
Mass (Da):54,139
Checksum:i55B1B419CA483973
GO
Isoform 3 (identifier: Q9C0H2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-208: MAGVSYAAPW...AEQVDLYDWY → MPSGVPGCWP...VPWRTPRFAC

Note: No experimental confirmation available.
Show »
Length:352
Mass (Da):38,486
Checksum:i6424BEBAB65DE76D
GO
Isoform 4 (identifier: Q9C0H2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     501-523: YTSSMRAKYLATSQPRPDSSGSH → RYLAALDSGSHAGWQFKPMDSARTLW

Note: No experimental confirmation available.
Show »
Length:526
Mass (Da):57,982
Checksum:i37735FE203C594D9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C3T6H7C3T6_HUMAN
Protein tweety homolog
TTYH3
186Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MXJ9A8MXJ9_HUMAN
Protein tweety homolog
TTYH3
116Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB21782 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAL23958 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti169Q → K in BAB84984 (PubMed:12693554).Curated1
Sequence conflicti346V → F in BE263005 (PubMed:15489334).Curated1
Sequence conflicti520S → R in BAB84984 (PubMed:12693554).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0297691 – 208MAGVS…LYDWY → MPSGVPGCWPQLPLKGPWRP TPRPRVPVPWRTPRFAC in isoform 3. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_029770210 – 241Missing in isoform 2. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_042220501 – 523YTSSM…SSGSH → RYLAALDSGSHAGWQFKPMD SARTLW in isoform 4. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB162931 mRNA Translation: BAD20190.1
AB051478 mRNA Translation: BAB21782.2 Different initiation.
AK124608 mRNA Translation: BAC85898.1
AC006028 Genomic DNA No translation available.
AC073462 Genomic DNA No translation available.
CH236953 Genomic DNA Translation: EAL23958.1 Sequence problems.
CH471144 Genomic DNA Translation: EAW87266.1
BC131824 mRNA Translation: AAI31825.1
BC152447 mRNA Translation: AAI52448.1
BE263005 mRNA No translation available.
AK074158 mRNA Translation: BAB84984.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34588.1 [Q9C0H2-1]

NCBI Reference Sequences

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RefSeqi
NP_079526.1, NM_025250.2 [Q9C0H2-1]
XP_011513837.1, XM_011515535.2 [Q9C0H2-4]
XP_016868145.1, XM_017012656.1 [Q9C0H2-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000258796; ENSP00000258796; ENSG00000136295 [Q9C0H2-1]
ENST00000403167; ENSP00000385015; ENSG00000136295 [Q9C0H2-3]
ENST00000407643; ENSP00000385316; ENSG00000136295 [Q9C0H2-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
80727

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:80727

UCSC genome browser

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UCSCi
uc003smp.4 human [Q9C0H2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB162931 mRNA Translation: BAD20190.1
AB051478 mRNA Translation: BAB21782.2 Different initiation.
AK124608 mRNA Translation: BAC85898.1
AC006028 Genomic DNA No translation available.
AC073462 Genomic DNA No translation available.
CH236953 Genomic DNA Translation: EAL23958.1 Sequence problems.
CH471144 Genomic DNA Translation: EAW87266.1
BC131824 mRNA Translation: AAI31825.1
BC152447 mRNA Translation: AAI52448.1
BE263005 mRNA No translation available.
AK074158 mRNA Translation: BAB84984.1
CCDSiCCDS34588.1 [Q9C0H2-1]
RefSeqiNP_079526.1, NM_025250.2 [Q9C0H2-1]
XP_011513837.1, XM_011515535.2 [Q9C0H2-4]
XP_016868145.1, XM_017012656.1 [Q9C0H2-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi123277, 41 interactors
IntActiQ9C0H2, 23 interactors
STRINGi9606.ENSP00000258796

Protein family/group databases

TCDBi1.A.48.1.4 the anion channel tweety (tweety) family

PTM databases

GlyConnecti1671
iPTMnetiQ9C0H2
PhosphoSitePlusiQ9C0H2
SwissPalmiQ9C0H2

Polymorphism and mutation databases

BioMutaiTTYH3
DMDMi162416242

Proteomic databases

EPDiQ9C0H2
jPOSTiQ9C0H2
MassIVEiQ9C0H2
MaxQBiQ9C0H2
PaxDbiQ9C0H2
PeptideAtlasiQ9C0H2
PRIDEiQ9C0H2
ProteomicsDBi80038 [Q9C0H2-1]
80039 [Q9C0H2-2]
80040 [Q9C0H2-3]
80041 [Q9C0H2-4]

Genome annotation databases

EnsembliENST00000258796; ENSP00000258796; ENSG00000136295 [Q9C0H2-1]
ENST00000403167; ENSP00000385015; ENSG00000136295 [Q9C0H2-3]
ENST00000407643; ENSP00000385316; ENSG00000136295 [Q9C0H2-2]
GeneIDi80727
KEGGihsa:80727
UCSCiuc003smp.4 human [Q9C0H2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
80727

GeneCards: human genes, protein and diseases

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GeneCardsi
TTYH3
HGNCiHGNC:22222 TTYH3
HPAiHPA053520
MIMi608919 gene
neXtProtiNX_Q9C0H2
OpenTargetsiENSG00000136295
PharmGKBiPA134908427

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4433 Eukaryota
ENOG410ZNTN LUCA
GeneTreeiENSGT00950000183060
HOGENOMiHOG000070449
InParanoidiQ9C0H2
KOiK22641
OMAiQVNPFQQ
OrthoDBi725378at2759
PhylomeDBiQ9C0H2
TreeFamiTF319025

Enzyme and pathway databases

ReactomeiR-HSA-2672351 Stimuli-sensing channels

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TTYH3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
80727
PharosiQ9C0H2

Protein Ontology

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PROi
PR:Q9C0H2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000136295 Expressed in 166 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ9C0H2 baseline and differential
GenevisibleiQ9C0H2 HS

Family and domain databases

CDDicd07912 Tweety_N, 1 hit
InterProiView protein in InterPro
IPR006990 Tweety
PANTHERiPTHR12424 PTHR12424, 1 hit
PfamiView protein in Pfam
PF04906 Tweety, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTYH3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C0H2
Secondary accession number(s): A4D201
, B7WP98, Q6L749, Q6ZVG3, Q8TEG6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: October 16, 2019
This is version 126 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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