UniProtKB - Q9C0H2 (TTYH3_HUMAN)
Protein
Protein tweety homolog 3
Gene
TTYH3
Organism
Homo sapiens (Human)
Status
Functioni
Probable large-conductance Ca2+-activated chloride channel. May play a role in Ca2+ signal transduction.1 Publication
Miscellaneous
The current is completely inhibited by the addition of an anion permeability inhibitor. Addition of a Ca2+ ionophore induces an outward-rectified current in mock-transfected cells, but it introduced an overt linear current in TTYH3-transfected cells.
GO - Molecular functioni
- chloride channel activity Source: UniProtKB
- intracellular calcium activated chloride channel activity Source: FlyBase
- volume-sensitive chloride channel activity Source: GO_Central
GO - Biological processi
- chloride transport Source: FlyBase
- ion transmembrane transport Source: Reactome
Keywordsi
Molecular function | Chloride channel, Ion channel |
Biological process | Ion transport, Transport |
Ligand | Calcium, Chloride |
Enzyme and pathway databases
PathwayCommonsi | Q9C0H2 |
Reactomei | R-HSA-2672351, Stimuli-sensing channels |
Protein family/group databases
TCDBi | 1.A.48.1.4, the anion channel tweety (tweety) family |
Names & Taxonomyi
Protein namesi | Recommended name: Protein tweety homolog 3Short name: hTTY3 |
Gene namesi | Name:TTYH3 Synonyms:KIAA1691 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000136295.14 |
HGNCi | HGNC:22222, TTYH3 |
MIMi | 608919, gene |
neXtProti | NX_Q9C0H2 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- chloride channel complex Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 42 | ExtracellularSequence analysisAdd BLAST | 42 | |
Transmembranei | 43 – 63 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 64 – 86 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 87 – 107 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 108 – 211 | ExtracellularSequence analysisAdd BLAST | 104 | |
Transmembranei | 212 – 232 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 233 – 236 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 237 – 257 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 258 – 386 | ExtracellularSequence analysisAdd BLAST | 129 | |
Transmembranei | 387 – 407 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 408 – 523 | CytoplasmicSequence analysisAdd BLAST | 116 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 128 | T → A: Does not affect N-glycosylation state. 1 Publication | 1 | |
Mutagenesisi | 146 | T → A: Does not affect N-glycosylation state. 1 Publication | 1 | |
Mutagenesisi | 353 | T → A: Abolishes N-glycosylation. 1 Publication | 1 | |
Mutagenesisi | 367 | R → Q: Induces a stronger permeability to cations. 1 Publication | 1 | |
Mutagenesisi | 370 | H → D: Shows a different ion selectivity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 80727 |
OpenTargetsi | ENSG00000136295 |
PharmGKBi | PA134908427 |
Miscellaneous databases
Pharosi | Q9C0H2, Tbio |
Polymorphism and mutation databases
BioMutai | TTYH3 |
DMDMi | 162416242 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000312251 | 1 – 523 | Protein tweety homolog 3Add BLAST | 523 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 126 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 144 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 351 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 496 | PhosphoserineBy similarity | 1 | |
Modified residuei | 504 | PhosphoserineBy similarity | 1 | |
Modified residuei | 522 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
N-glycosylated.2 Publications
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q9C0H2 |
jPOSTi | Q9C0H2 |
MassIVEi | Q9C0H2 |
MaxQBi | Q9C0H2 |
PaxDbi | Q9C0H2 |
PeptideAtlasi | Q9C0H2 |
PRIDEi | Q9C0H2 |
ProteomicsDBi | 80038 [Q9C0H2-1] 80039 [Q9C0H2-2] 80040 [Q9C0H2-3] 80041 [Q9C0H2-4] |
PTM databases
GlyConnecti | 1671, 2 N-Linked glycans (1 site) |
GlyGeni | Q9C0H2, 3 sites |
iPTMneti | Q9C0H2 |
PhosphoSitePlusi | Q9C0H2 |
SwissPalmi | Q9C0H2 |
Expressioni
Tissue specificityi
Expressed in excitable tissues. Expressed in the brain, heart, skeletal muscle, colon, spleen, kidney and peripheral blood leukocytes.1 Publication
Gene expression databases
Bgeei | ENSG00000136295, Expressed in ventricular zone and 181 other tissues |
ExpressionAtlasi | Q9C0H2, baseline and differential |
Genevisiblei | Q9C0H2, HS |
Organism-specific databases
HPAi | ENSG00000136295, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 123277, 44 interactors |
IntActi | Q9C0H2, 24 interactors |
STRINGi | 9606.ENSP00000258796 |
Miscellaneous databases
RNActi | Q9C0H2, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the tweety family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4433, Eukaryota |
GeneTreei | ENSGT00950000183060 |
HOGENOMi | CLU_023758_0_1_1 |
InParanoidi | Q9C0H2 |
OMAi | DTYITRV |
OrthoDBi | 725378at2759 |
PhylomeDBi | Q9C0H2 |
TreeFami | TF319025 |
Family and domain databases
CDDi | cd07912, Tweety_N, 1 hit |
InterProi | View protein in InterPro IPR006990, Tweety |
PANTHERi | PTHR12424, PTHR12424, 1 hit |
Pfami | View protein in Pfam PF04906, Tweety, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9C0H2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGVSYAAPW WVSLLHRLPH FDLSWEATSS QFRPEDTDYQ QALLLLGAAA
60 70 80 90 100
LACLALDLLF LLFYSFWLCC RRRKSEEHLD ADCCCTAWCV IIATLVCSAG
110 120 130 140 150
IAVGFYGNGE TSDGIHRATY SLRHANRTVA GVQDRVWDTA VGLNHTAEPS
160 170 180 190 200
LQTLERQLAG RPEPLRAVQR LQGLLETLLG YTAAIPFWRN TAVSLEVLAE
210 220 230 240 250
QVDLYDWYRW LGYLGLLLLD VIICLLVLVG LIRSSKGILV GVCLLGVLAL
260 270 280 290 300
VISWGALGLE LAVSVGSSDF CVDPDAYVTK MVEEYSVLSG DILQYYLACS
310 320 330 340 350
PRAANPFQQK LSGSHKALVE MQDVVAELLR TVPWEQPATK DPLLRVQEVL
360 370 380 390 400
NGTEVNLQHL TALVDCRSLH LDYVQALTGF CYDGVEGLIY LALFSFVTAL
410 420 430 440 450
MFSSIVCSVP HTWQQKRGPD EDGEEEAAPG PRQAHDSLYR VHMPSLYSCG
460 470 480 490 500
SSYGSETSIP AAAHTVSNAP VTEYMSQNAN FQNPRCENTP LIGRESPPPS
510 520
YTSSMRAKYL ATSQPRPDSS GSH
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C3T6 | H7C3T6_HUMAN | Protein tweety homolog | TTYH3 | 186 | Annotation score: | ||
A8MXJ9 | A8MXJ9_HUMAN | Protein tweety homolog | TTYH3 | 116 | Annotation score: |
Sequence cautioni
The sequence BAB21782 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAL23958 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 169 | Q → K in BAB84984 (PubMed:12693554).Curated | 1 | |
Sequence conflicti | 346 | V → F in BE263005 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 520 | S → R in BAB84984 (PubMed:12693554).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_029769 | 1 – 208 | MAGVS…LYDWY → MPSGVPGCWPQLPLKGPWRP TPRPRVPVPWRTPRFAC in isoform 3. 1 PublicationAdd BLAST | 208 | |
Alternative sequenceiVSP_029770 | 210 – 241 | Missing in isoform 2. 1 PublicationAdd BLAST | 32 | |
Alternative sequenceiVSP_042220 | 501 – 523 | YTSSM…SSGSH → RYLAALDSGSHAGWQFKPMD SARTLW in isoform 4. 1 PublicationAdd BLAST | 23 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB162931 mRNA Translation: BAD20190.1 AB051478 mRNA Translation: BAB21782.2 Different initiation. AK124608 mRNA Translation: BAC85898.1 AC006028 Genomic DNA No translation available. AC073462 Genomic DNA No translation available. CH236953 Genomic DNA Translation: EAL23958.1 Sequence problems. CH471144 Genomic DNA Translation: EAW87266.1 BC131824 mRNA Translation: AAI31825.1 BC152447 mRNA Translation: AAI52448.1 BE263005 mRNA No translation available. AK074158 mRNA Translation: BAB84984.1 |
CCDSi | CCDS34588.1 [Q9C0H2-1] |
RefSeqi | NP_079526.1, NM_025250.2 [Q9C0H2-1] XP_011513837.1, XM_011515535.2 [Q9C0H2-4] XP_016868145.1, XM_017012656.1 [Q9C0H2-2] |
Genome annotation databases
Ensembli | ENST00000258796; ENSP00000258796; ENSG00000136295 [Q9C0H2-1] ENST00000403167; ENSP00000385015; ENSG00000136295 [Q9C0H2-3] ENST00000407643; ENSP00000385316; ENSG00000136295 [Q9C0H2-2] |
GeneIDi | 80727 |
KEGGi | hsa:80727 |
UCSCi | uc003smp.4, human [Q9C0H2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB162931 mRNA Translation: BAD20190.1 AB051478 mRNA Translation: BAB21782.2 Different initiation. AK124608 mRNA Translation: BAC85898.1 AC006028 Genomic DNA No translation available. AC073462 Genomic DNA No translation available. CH236953 Genomic DNA Translation: EAL23958.1 Sequence problems. CH471144 Genomic DNA Translation: EAW87266.1 BC131824 mRNA Translation: AAI31825.1 BC152447 mRNA Translation: AAI52448.1 BE263005 mRNA No translation available. AK074158 mRNA Translation: BAB84984.1 |
CCDSi | CCDS34588.1 [Q9C0H2-1] |
RefSeqi | NP_079526.1, NM_025250.2 [Q9C0H2-1] XP_011513837.1, XM_011515535.2 [Q9C0H2-4] XP_016868145.1, XM_017012656.1 [Q9C0H2-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123277, 44 interactors |
IntActi | Q9C0H2, 24 interactors |
STRINGi | 9606.ENSP00000258796 |
Protein family/group databases
TCDBi | 1.A.48.1.4, the anion channel tweety (tweety) family |
PTM databases
GlyConnecti | 1671, 2 N-Linked glycans (1 site) |
GlyGeni | Q9C0H2, 3 sites |
iPTMneti | Q9C0H2 |
PhosphoSitePlusi | Q9C0H2 |
SwissPalmi | Q9C0H2 |
Polymorphism and mutation databases
BioMutai | TTYH3 |
DMDMi | 162416242 |
Proteomic databases
EPDi | Q9C0H2 |
jPOSTi | Q9C0H2 |
MassIVEi | Q9C0H2 |
MaxQBi | Q9C0H2 |
PaxDbi | Q9C0H2 |
PeptideAtlasi | Q9C0H2 |
PRIDEi | Q9C0H2 |
ProteomicsDBi | 80038 [Q9C0H2-1] 80039 [Q9C0H2-2] 80040 [Q9C0H2-3] 80041 [Q9C0H2-4] |
Protocols and materials databases
Antibodypediai | 43641, 24 antibodies |
Genome annotation databases
Ensembli | ENST00000258796; ENSP00000258796; ENSG00000136295 [Q9C0H2-1] ENST00000403167; ENSP00000385015; ENSG00000136295 [Q9C0H2-3] ENST00000407643; ENSP00000385316; ENSG00000136295 [Q9C0H2-2] |
GeneIDi | 80727 |
KEGGi | hsa:80727 |
UCSCi | uc003smp.4, human [Q9C0H2-1] |
Organism-specific databases
CTDi | 80727 |
DisGeNETi | 80727 |
EuPathDBi | HostDB:ENSG00000136295.14 |
GeneCardsi | TTYH3 |
HGNCi | HGNC:22222, TTYH3 |
HPAi | ENSG00000136295, Low tissue specificity |
MIMi | 608919, gene |
neXtProti | NX_Q9C0H2 |
OpenTargetsi | ENSG00000136295 |
PharmGKBi | PA134908427 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4433, Eukaryota |
GeneTreei | ENSGT00950000183060 |
HOGENOMi | CLU_023758_0_1_1 |
InParanoidi | Q9C0H2 |
OMAi | DTYITRV |
OrthoDBi | 725378at2759 |
PhylomeDBi | Q9C0H2 |
TreeFami | TF319025 |
Enzyme and pathway databases
PathwayCommonsi | Q9C0H2 |
Reactomei | R-HSA-2672351, Stimuli-sensing channels |
Miscellaneous databases
BioGRID-ORCSi | 80727, 3 hits in 842 CRISPR screens |
ChiTaRSi | TTYH3, human |
GenomeRNAii | 80727 |
Pharosi | Q9C0H2, Tbio |
PROi | PR:Q9C0H2 |
RNActi | Q9C0H2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000136295, Expressed in ventricular zone and 181 other tissues |
ExpressionAtlasi | Q9C0H2, baseline and differential |
Genevisiblei | Q9C0H2, HS |
Family and domain databases
CDDi | cd07912, Tweety_N, 1 hit |
InterProi | View protein in InterPro IPR006990, Tweety |
PANTHERi | PTHR12424, PTHR12424, 1 hit |
Pfami | View protein in Pfam PF04906, Tweety, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TTYH3_HUMAN | |
Accessioni | Q9C0H2Primary (citable) accession number: Q9C0H2 Secondary accession number(s): A4D201 Q8TEG6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 4, 2007 |
Last sequence update: | December 4, 2007 | |
Last modified: | December 2, 2020 | |
This is version 133 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families