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UniProtKB - Q9C0G0 (ZN407_HUMAN)

Entry version 151 (10 Feb 2021)
Sequence version 2 (23 Oct 2007)
Previous versions | rss
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Protein

Zinc finger protein 407

Gene

ZNF407

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri186 – 208C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri215 – 238C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri244 – 268C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri528 – 551C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri557 – 581C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri615 – 639C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri705 – 728C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri850 – 873C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri879 – 903C2H2-type 9PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1017 – 1040C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1046 – 1070C2H2-type 11PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1444 – 1468C2H2-type 12PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1486 – 1509C2H2-type 13PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1537 – 1561C2H2-type 14; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1567 – 1589C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1595 – 1618C2H2-type 16PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1628 – 1650C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1656 – 1680C2H2-type 18PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1686 – 1708C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1714 – 1736C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1742 – 1767C2H2-type 21PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1773 – 1796C2H2-type 22PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9C0G0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 407
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF407
Synonyms:KIAA1703
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19904, ZNF407

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615894, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9C0G0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000215421.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55628

Open Targets

More...OpenTargetsi		ENSG00000215421

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134942906

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9C0G0, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF407

Domain mapping of disease mutations (DMDM)

More...DMDMi		160358927

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475681 – 2248Zinc finger protein 407Add BLAST2248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1262PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9C0G0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9C0G0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9C0G0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9C0G0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9C0G0

PeptideAtlas

More...PeptideAtlasi		Q9C0G0

PRoteomics IDEntifications database

More...PRIDEi		Q9C0G0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		80031 [Q9C0G0-1]
80032 [Q9C0G0-2]
80033 [Q9C0G0-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9C0G0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9C0G0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000215421, Expressed in secondary oocyte and 213 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9C0G0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9C0G0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000215421, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120767, 7 interactors

Protein interaction database and analysis system

More...IntActi		Q9C0G0, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000299687

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9C0G0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9C0G0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri186 – 208C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri215 – 238C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri244 – 268C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri528 – 551C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri557 – 581C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri615 – 639C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri705 – 728C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri850 – 873C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri879 – 903C2H2-type 9PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1017 – 1040C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1046 – 1070C2H2-type 11PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1444 – 1468C2H2-type 12PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1486 – 1509C2H2-type 13PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1537 – 1561C2H2-type 14; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1567 – 1589C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1595 – 1618C2H2-type 16PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1628 – 1650C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1656 – 1680C2H2-type 18PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1686 – 1708C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1714 – 1736C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1742 – 1767C2H2-type 21PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1773 – 1796C2H2-type 22PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156446

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002134_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9C0G0

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9C0G0

TreeFam database of animal gene trees

More...TreeFami		TF350895

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 25 hits
SM00451, ZnF_U1, 7 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 5 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 8 hits
PS50157, ZINC_FINGER_C2H2_2, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9C0G0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMDSENKPEN DEDEKINKEA QDLTKLSSHN EDGGPVSDVI ASFPENSMGK 
        60         70         80         90        100
RGFSESSNSD SVVIGEDRNK HASKRRKLDE AEPLKSGKQG ICRLETSESS 
       110        120        130        140        150
VTEGGIALDE TGKETFLSDC TVGGTCLPNA LSPSCNFSTI DVVSLKTDTE 
       160        170        180        190        200
KTSAQEMVSL DLERESPFPP KEISVSCTIG NVDTVLKCSI CGHLFSSCSD 
       210        220        230        240        250
LEKHAESHMQ QPKEHTCCHC SHKAESSSAL HMHIKQAHGP QKVFSCDLCG 
       260        270        280        290        300
FQCSEENLLN AHYLGKTHLR RQNLAARGGF VQILTKQPFP KKSRTMATKN 
       310        320        330        340        350
VHSKPRTSKS IAKNSDSKGL RNVGSTFKDF RGSISKQSGS SSELLVEMMP 
       360        370        380        390        400
SRNTLSQEVE IVEEHVTSLG LAQNPENQSR KLDTLVTSEG LLEKLESTKN 
       410        420        430        440        450
TLQAAHGNSV TSRPRPERNI LVLGNSFRRR SSTFTLKGQA KKRFNLLGIK 
       460        470        480        490        500
RGTSETQRMY MKHLRTQMKT HDAESVLKHL EACSSVQRVC VTTSETQEAE 
       510        520        530        540        550
QGQGSARPPD SGLHSLTVKP ASGSQTLCAC TDCGQVATNR TDLEIHVKRC 
       560        570        580        590        600
HAREMKFYCR TCDFSSMSRR DLDEHLHSNQ HQQTASVLSC QCCSFISLDE 
       610        620        630        640        650
INLRDHMKEK HNMHFLCTPC NLFFLSEKDV EEHKATEKHI NSLVQPKTLQ 
       660        670        680        690        700
SSNSDLVLQT LPLSTLESEN AKESMDDSGK ASQEEPLKSR VSHGNEVRHS 
       710        720        730        740        750
SKPQFQCKKC FYKTRSSTVL TRHIKLRHGQ DYHFLCKACN LYSLSKEGME 
       760        770        780        790        800
KHIKRSKHLE NAKKNNIGLS FEECIERVCI GANDKKEEFD VSGNGRIEGH 
       810        820        830        840        850
IGVQLQEHSY LEKGMLASEE LSQSGGSTKD DELASTTTPK RGRPKGNISR 
       860        870        880        890        900
TCSHCGLLAS SITNLTVHIR RKHSHQYSYL CKVCKYYTVT KGDMERHCAT 
       910        920        930        940        950
KKHKGRVEIE ASGKHSSDII VGPEGGSLEA GKKNAGSAVT MSDEHANKPA 
       960        970        980        990       1000
ESPTSVLEKP DRGNSIEAEV ENVFHSLDGE VNSHLLDKKE QISSEPEDFA 
      1010       1020       1030       1040       1050
QPGDVYSQRD VTGTGENKCL HCEFSAHSSA SLELHVKRKH TKEFEFYCMA 
      1060       1070       1080       1090       1100
CDYYAVTRRE MTRHAATEKH KMKRQSYLNS ANVEAGSADM SKNIIMPEEE 
      1110       1120       1130       1140       1150
HQQNSEEFQI ISGQPSDTLK SRNAADCSIL NENTNLDMSK VLCAADSVEV 
      1160       1170       1180       1190       1200
ETEEESNFNE DHSFCETFQQ APVKDKVRKP EEMMSLTMSS NYGSPSRFQN 
      1210       1220       1230       1240       1250
ENSGSSALNC ETAKKNHEIS NDAGELRVHC EGEGGNAGDG GGVVPHRHLC 
      1260       1270       1280       1290       1300
PVTLDGERSA ESPVLVVTRI TREQGNLESG GQNRVARGHG LEDLKGVQED 
      1310       1320       1330       1340       1350
PVLGNKEILM NSQHETEFIL EEDGPASDST VESSDVYETI ISIDDKGQAM 
      1360       1370       1380       1390       1400
YSFGRFDSSI IRIKNPEDGE LIDQSEEGLI ATGVRISELP LKDCAQGVKK 
      1410       1420       1430       1440       1450
KKSEGSSIGE STRIRCDDCG FLADGLSGLN VHIAMKHPTK EKHFHCLLCG 
      1460       1470       1480       1490       1500
KSFYTESNLH QHLASAGHMR NEQASVEELP EGGATFKCVK CTEPFDSEQN 
      1510       1520       1530       1540       1550
LFLHIKGQHE ELLREVNKYI VEDTEQINRE REENQGNVCK YCGKMCRSSN 
      1560       1570       1580       1590       1600
SMAFLAHIRT HTGSKPFKCK ICHFATAQLG DARNHVKRHL GMREYKCHVC 
      1610       1620       1630       1640       1650
GVAFVMKKHL NTHLLGKHGV GTPKERKFTC HLCDRSFTEK WALNNHMKLH 
      1660       1670       1680       1690       1700
TGEKPFKCTW PTCHYSFLTA SAMKDHYRTH TGEKSFLCDL CGFAGGTRHA 
      1710       1720       1730       1740       1750
LTKHRRQHTG EKPFKCDECN FASTTQSHLT RHKRVHTGEK PYRCPWCDYR 
      1760       1770       1780       1790       1800
SNCAENIRKH ILHTGKHEGV KMYNCPKCDY GTNVPVEFRN HLKEQHPDIE 
      1810       1820       1830       1840       1850
NPDLAYLHAG IVSKSYECRL KGQGATFVET DSPFTAAALA EEPLVKEKPL 
      1860       1870       1880       1890       1900
RSSRRPAPPP EQVQQVIIFQ GYDGEFALDP SVEETAAATL QTLAMAGQVA 
      1910       1920       1930       1940       1950
RVVHITEDGQ VIATSQSGAH VGSVVPGPIL PEQLADGATQ VVVVGGSMEG 
      1960       1970       1980       1990       2000
HGMDESLSPG GAVIQQVTKQ EILNLSEAGV APPEASSALD ALLCAVTELG 
      2010       2020       2030       2040       2050
EVEGRAGLEE QGRPGAKDVL IQLPGQEVSH VAADPEAPEI QMFPQAQESP 
      2060       2070       2080       2090       2100
AAVEVLTQVV HPSAAMASQE RAQVAFKKMV QGVLQFAVCD TAAAGQLVKD 
      2110       2120       2130       2140       2150
GVTQVVVSEE GAVHMVAGEG AQIIMQEAQG EHMDLVESDG EISQIIVTEE 
      2160       2170       2180       2190       2200
LVQAMVQESS GGFSEGTTHY ILTELPPGVQ DEPGLYSHTV LETADSQELL 
      2210       2220       2230       2240 
QAGATLGTEA GAPSRAEQLA SVVIYTQEGS SAAAAIQSQR ESSELQEA
Length:2,248
Mass (Da):247,367
Last modified:October 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1AE958917F5F7B91
GO
Isoform 2 (identifier: Q9C0G0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1811-1815: IVSKS → KGQKL
     1816-2248: Missing.

Show »
Length:1,815
Mass (Da):202,418
Checksum:i4C5D56BA3F87F5FD
GO
Isoform 3 (identifier: Q9C0G0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1625-1660: ERKFTCHLCDRSFTEKWALNNHMKLHTGEKPFKCTW → ERVKVAYRKIGTLPGIQNNRNASSASEAQSLCEHFS
     1661-2248: Missing.

Show »
Length:1,660
Mass (Da):184,081
Checksum:i8A585EBEA30D9E8D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WV78A0A087WV78_HUMAN
Zinc finger protein 407
ZNF407
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYH1A0A087WYH1_HUMAN
Zinc finger protein 407
ZNF407
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91077 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91080 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti988K → E in BAA91077 (PubMed:14702039).Curated1
Sequence conflicti1297V → D in BAA91077 (PubMed:14702039).Curated1
Sequence conflicti1353F → S in BAA91077 (PubMed:14702039).Curated1
Sequence conflicti1415R → C in BAA91077 (PubMed:14702039).Curated1
Sequence conflicti1520I → V in BAA91077 (PubMed:14702039).Curated1
Sequence conflicti1584N → D in BAA91080 (PubMed:14702039).Curated1
Sequence conflicti2181D → G in AK023901 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05282069N → S. Corresponds to variant dbSNP:rs3794942EnsemblClinVar.1
Natural variantiVAR_052821512G → R. Corresponds to variant dbSNP:rs7227263EnsemblClinVar.1
Natural variantiVAR_036694972N → T. Corresponds to variant dbSNP:rs948615EnsemblClinVar.1
Natural variantiVAR_0619451259S → L. Corresponds to variant dbSNP:rs34048449EnsemblClinVar.1
Natural variantiVAR_0528221913A → T. Corresponds to variant dbSNP:rs17056248EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0288431625 – 1660ERKFT…FKCTW → ERVKVAYRKIGTLPGIQNNR NASSASEAQSLCEHFS in isoform 3. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_0288441661 – 2248Missing in isoform 3. 1 PublicationAdd BLAST588
Alternative sequenceiVSP_0288451811 – 1815IVSKS → KGQKL in isoform 2. 1 Publication5
Alternative sequenceiVSP_0288461816 – 2248Missing in isoform 2. 1 PublicationAdd BLAST433

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC138660 Genomic DNA No translation available.
AC091589 Genomic DNA No translation available.
AC023380 Genomic DNA No translation available.
AC100783 Genomic DNA No translation available.
AC015819 Genomic DNA No translation available.
AK000314 mRNA Translation: BAA91077.1 Different initiation.
AK000317 mRNA Translation: BAA91080.1 Different initiation.
AK023901 mRNA No translation available.
AK056288 mRNA Translation: BAB71139.1
AB051490 mRNA Translation: BAB21794.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45885.1 [Q9C0G0-1]
CCDS54191.1 [Q9C0G0-3]
CCDS58634.1 [Q9C0G0-2]

NCBI Reference Sequences

More...RefSeqi		NP_001139661.1, NM_001146189.1 [Q9C0G0-2]
NP_001139662.1, NM_001146190.1 [Q9C0G0-3]
NP_060227.2, NM_017757.2 [Q9C0G0-1]
XP_005266783.1, XM_005266726.4
XP_011524370.1, XM_011526068.2
XP_011524372.1, XM_011526070.1 [Q9C0G0-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000299687; ENSP00000299687; ENSG00000215421 [Q9C0G0-1]
ENST00000309902; ENSP00000310359; ENSG00000215421 [Q9C0G0-3]
ENST00000577538; ENSP00000463270; ENSG00000215421 [Q9C0G0-2]
ENST00000582337; ENSP00000462348; ENSG00000215421 [Q9C0G0-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55628

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55628

UCSC genome browser

More...UCSCi		uc002llw.3, human [Q9C0G0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138660 Genomic DNA No translation available.
AC091589 Genomic DNA No translation available.
AC023380 Genomic DNA No translation available.
AC100783 Genomic DNA No translation available.
AC015819 Genomic DNA No translation available.
AK000314 mRNA Translation: BAA91077.1 Different initiation.
AK000317 mRNA Translation: BAA91080.1 Different initiation.
AK023901 mRNA No translation available.
AK056288 mRNA Translation: BAB71139.1
AB051490 mRNA Translation: BAB21794.1
CCDSiCCDS45885.1 [Q9C0G0-1]
CCDS54191.1 [Q9C0G0-3]
CCDS58634.1 [Q9C0G0-2]
RefSeqiNP_001139661.1, NM_001146189.1 [Q9C0G0-2]
NP_001139662.1, NM_001146190.1 [Q9C0G0-3]
NP_060227.2, NM_017757.2 [Q9C0G0-1]
XP_005266783.1, XM_005266726.4
XP_011524370.1, XM_011526068.2
XP_011524372.1, XM_011526070.1 [Q9C0G0-3]

3D structure databases

SMRiQ9C0G0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120767, 7 interactors
IntActiQ9C0G0, 3 interactors
STRINGi9606.ENSP00000299687

PTM databases

iPTMnetiQ9C0G0
PhosphoSitePlusiQ9C0G0

Genetic variation databases

BioMutaiZNF407
DMDMi160358927

Proteomic databases

EPDiQ9C0G0
jPOSTiQ9C0G0
MassIVEiQ9C0G0
MaxQBiQ9C0G0
PaxDbiQ9C0G0
PeptideAtlasiQ9C0G0
PRIDEiQ9C0G0
ProteomicsDBi80031 [Q9C0G0-1]
80032 [Q9C0G0-2]
80033 [Q9C0G0-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23353, 47 antibodies

Genome annotation databases

EnsembliENST00000299687; ENSP00000299687; ENSG00000215421 [Q9C0G0-1]
ENST00000309902; ENSP00000310359; ENSG00000215421 [Q9C0G0-3]
ENST00000577538; ENSP00000463270; ENSG00000215421 [Q9C0G0-2]
ENST00000582337; ENSP00000462348; ENSG00000215421 [Q9C0G0-3]
GeneIDi55628
KEGGihsa:55628
UCSCiuc002llw.3, human [Q9C0G0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55628
DisGeNETi55628

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF407
HGNCiHGNC:19904, ZNF407
HPAiENSG00000215421, Low tissue specificity
MIMi615894, gene
neXtProtiNX_Q9C0G0
OpenTargetsiENSG00000215421
PharmGKBiPA134942906
VEuPathDBiHostDB:ENSG00000215421.9

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000156446
HOGENOMiCLU_002134_0_0_1
InParanoidiQ9C0G0
OrthoDBi1318335at2759
PhylomeDBiQ9C0G0
TreeFamiTF350895

Enzyme and pathway databases

PathwayCommonsiQ9C0G0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55628, 610 hits in 897 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF407, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55628
PharosiQ9C0G0, Tdark

Protein Ontology

More...PROi		PR:Q9C0G0
RNActiQ9C0G0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000215421, Expressed in secondary oocyte and 213 other tissues
ExpressionAtlasiQ9C0G0, baseline and differential
GenevisibleiQ9C0G0, HS

Family and domain databases

InterProiView protein in InterPro
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 25 hits
SM00451, ZnF_U1, 7 hits
SUPFAMiSSF57667, SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 8 hits
PS50157, ZINC_FINGER_C2H2_2, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN407_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C0G0
Secondary accession number(s): B5MD54
, Q96MY0, Q9H8A1, Q9NXD4, Q9NXD7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: October 23, 2007
Last modified: February 10, 2021
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  4. Human entries with genetic variants
    List of human entries with genetic variants
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