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UniProtKB - Q9C0G0 (ZN407_HUMAN)

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Protein

Zinc finger protein 407

Gene

ZNF407

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri186 – 208C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri215 – 238C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri244 – 268C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri528 – 551C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri557 – 581C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri615 – 639C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri705 – 728C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri850 – 873C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri879 – 903C2H2-type 9PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1017 – 1040C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1046 – 1070C2H2-type 11PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1444 – 1468C2H2-type 12PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1486 – 1509C2H2-type 13PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1537 – 1561C2H2-type 14; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1567 – 1589C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1595 – 1618C2H2-type 16PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1628 – 1650C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1656 – 1680C2H2-type 18PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1686 – 1708C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1714 – 1736C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1742 – 1767C2H2-type 21PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1773 – 1796C2H2-type 22PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 407
Gene namesi
Name:ZNF407
Synonyms:KIAA1703
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000215421.9
HGNCiHGNC:19904 ZNF407
MIMi615894 gene
neXtProtiNX_Q9C0G0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55628
OpenTargetsiENSG00000215421
PharmGKBiPA134942906

Polymorphism and mutation databases

BioMutaiZNF407
DMDMi160358927

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475681 – 2248Zinc finger protein 407Add BLAST2248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1262PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9C0G0
MaxQBiQ9C0G0
PaxDbiQ9C0G0
PeptideAtlasiQ9C0G0
PRIDEiQ9C0G0
ProteomicsDBi80031
80032 [Q9C0G0-2]
80033 [Q9C0G0-3]

PTM databases

iPTMnetiQ9C0G0
PhosphoSitePlusiQ9C0G0

Expressioni

Gene expression databases

BgeeiENSG00000215421
CleanExiHS_ZNF407
ExpressionAtlasiQ9C0G0 baseline and differential
GenevisibleiQ9C0G0 HS

Organism-specific databases

HPAiHPA028255
HPA041673

Interactioni

Protein-protein interaction databases

BioGridi120767, 5 interactors
IntActiQ9C0G0, 1 interactor
STRINGi9606.ENSP00000299687

Structurei

3D structure databases

ProteinModelPortaliQ9C0G0
SMRiQ9C0G0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri186 – 208C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri215 – 238C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri244 – 268C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri528 – 551C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri557 – 581C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri615 – 639C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri705 – 728C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri850 – 873C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri879 – 903C2H2-type 9PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1017 – 1040C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1046 – 1070C2H2-type 11PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1444 – 1468C2H2-type 12PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1486 – 1509C2H2-type 13PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1537 – 1561C2H2-type 14; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1567 – 1589C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1595 – 1618C2H2-type 16PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1628 – 1650C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1656 – 1680C2H2-type 18PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1686 – 1708C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1714 – 1736C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1742 – 1767C2H2-type 21PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1773 – 1796C2H2-type 22PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144144
HOGENOMiHOG000155792
HOVERGENiHBG108768
InParanoidiQ9C0G0
OrthoDBiEOG091G0058
PhylomeDBiQ9C0G0
TreeFamiTF350895

Family and domain databases

InterProiView protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 25 hits
SM00451 ZnF_U1, 7 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C0G0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMDSENKPEN DEDEKINKEA QDLTKLSSHN EDGGPVSDVI ASFPENSMGK 
        60         70         80         90        100
RGFSESSNSD SVVIGEDRNK HASKRRKLDE AEPLKSGKQG ICRLETSESS 
       110        120        130        140        150
VTEGGIALDE TGKETFLSDC TVGGTCLPNA LSPSCNFSTI DVVSLKTDTE 
       160        170        180        190        200
KTSAQEMVSL DLERESPFPP KEISVSCTIG NVDTVLKCSI CGHLFSSCSD 
       210        220        230        240        250
LEKHAESHMQ QPKEHTCCHC SHKAESSSAL HMHIKQAHGP QKVFSCDLCG 
       260        270        280        290        300
FQCSEENLLN AHYLGKTHLR RQNLAARGGF VQILTKQPFP KKSRTMATKN 
       310        320        330        340        350
VHSKPRTSKS IAKNSDSKGL RNVGSTFKDF RGSISKQSGS SSELLVEMMP 
       360        370        380        390        400
SRNTLSQEVE IVEEHVTSLG LAQNPENQSR KLDTLVTSEG LLEKLESTKN 
       410        420        430        440        450
TLQAAHGNSV TSRPRPERNI LVLGNSFRRR SSTFTLKGQA KKRFNLLGIK 
       460        470        480        490        500
RGTSETQRMY MKHLRTQMKT HDAESVLKHL EACSSVQRVC VTTSETQEAE 
       510        520        530        540        550
QGQGSARPPD SGLHSLTVKP ASGSQTLCAC TDCGQVATNR TDLEIHVKRC 
       560        570        580        590        600
HAREMKFYCR TCDFSSMSRR DLDEHLHSNQ HQQTASVLSC QCCSFISLDE 
       610        620        630        640        650
INLRDHMKEK HNMHFLCTPC NLFFLSEKDV EEHKATEKHI NSLVQPKTLQ 
       660        670        680        690        700
SSNSDLVLQT LPLSTLESEN AKESMDDSGK ASQEEPLKSR VSHGNEVRHS 
       710        720        730        740        750
SKPQFQCKKC FYKTRSSTVL TRHIKLRHGQ DYHFLCKACN LYSLSKEGME 
       760        770        780        790        800
KHIKRSKHLE NAKKNNIGLS FEECIERVCI GANDKKEEFD VSGNGRIEGH 
       810        820        830        840        850
IGVQLQEHSY LEKGMLASEE LSQSGGSTKD DELASTTTPK RGRPKGNISR 
       860        870        880        890        900
TCSHCGLLAS SITNLTVHIR RKHSHQYSYL CKVCKYYTVT KGDMERHCAT 
       910        920        930        940        950
KKHKGRVEIE ASGKHSSDII VGPEGGSLEA GKKNAGSAVT MSDEHANKPA 
       960        970        980        990       1000
ESPTSVLEKP DRGNSIEAEV ENVFHSLDGE VNSHLLDKKE QISSEPEDFA 
      1010       1020       1030       1040       1050
QPGDVYSQRD VTGTGENKCL HCEFSAHSSA SLELHVKRKH TKEFEFYCMA 
      1060       1070       1080       1090       1100
CDYYAVTRRE MTRHAATEKH KMKRQSYLNS ANVEAGSADM SKNIIMPEEE 
      1110       1120       1130       1140       1150
HQQNSEEFQI ISGQPSDTLK SRNAADCSIL NENTNLDMSK VLCAADSVEV 
      1160       1170       1180       1190       1200
ETEEESNFNE DHSFCETFQQ APVKDKVRKP EEMMSLTMSS NYGSPSRFQN 
      1210       1220       1230       1240       1250
ENSGSSALNC ETAKKNHEIS NDAGELRVHC EGEGGNAGDG GGVVPHRHLC 
      1260       1270       1280       1290       1300
PVTLDGERSA ESPVLVVTRI TREQGNLESG GQNRVARGHG LEDLKGVQED 
      1310       1320       1330       1340       1350
PVLGNKEILM NSQHETEFIL EEDGPASDST VESSDVYETI ISIDDKGQAM 
      1360       1370       1380       1390       1400
YSFGRFDSSI IRIKNPEDGE LIDQSEEGLI ATGVRISELP LKDCAQGVKK 
      1410       1420       1430       1440       1450
KKSEGSSIGE STRIRCDDCG FLADGLSGLN VHIAMKHPTK EKHFHCLLCG 
      1460       1470       1480       1490       1500
KSFYTESNLH QHLASAGHMR NEQASVEELP EGGATFKCVK CTEPFDSEQN 
      1510       1520       1530       1540       1550
LFLHIKGQHE ELLREVNKYI VEDTEQINRE REENQGNVCK YCGKMCRSSN 
      1560       1570       1580       1590       1600
SMAFLAHIRT HTGSKPFKCK ICHFATAQLG DARNHVKRHL GMREYKCHVC 
      1610       1620       1630       1640       1650
GVAFVMKKHL NTHLLGKHGV GTPKERKFTC HLCDRSFTEK WALNNHMKLH 
      1660       1670       1680       1690       1700
TGEKPFKCTW PTCHYSFLTA SAMKDHYRTH TGEKSFLCDL CGFAGGTRHA 
      1710       1720       1730       1740       1750
LTKHRRQHTG EKPFKCDECN FASTTQSHLT RHKRVHTGEK PYRCPWCDYR 
      1760       1770       1780       1790       1800
SNCAENIRKH ILHTGKHEGV KMYNCPKCDY GTNVPVEFRN HLKEQHPDIE 
      1810       1820       1830       1840       1850
NPDLAYLHAG IVSKSYECRL KGQGATFVET DSPFTAAALA EEPLVKEKPL 
      1860       1870       1880       1890       1900
RSSRRPAPPP EQVQQVIIFQ GYDGEFALDP SVEETAAATL QTLAMAGQVA 
      1910       1920       1930       1940       1950
RVVHITEDGQ VIATSQSGAH VGSVVPGPIL PEQLADGATQ VVVVGGSMEG 
      1960       1970       1980       1990       2000
HGMDESLSPG GAVIQQVTKQ EILNLSEAGV APPEASSALD ALLCAVTELG 
      2010       2020       2030       2040       2050
EVEGRAGLEE QGRPGAKDVL IQLPGQEVSH VAADPEAPEI QMFPQAQESP 
      2060       2070       2080       2090       2100
AAVEVLTQVV HPSAAMASQE RAQVAFKKMV QGVLQFAVCD TAAAGQLVKD 
      2110       2120       2130       2140       2150
GVTQVVVSEE GAVHMVAGEG AQIIMQEAQG EHMDLVESDG EISQIIVTEE 
      2160       2170       2180       2190       2200
LVQAMVQESS GGFSEGTTHY ILTELPPGVQ DEPGLYSHTV LETADSQELL 
      2210       2220       2230       2240 
QAGATLGTEA GAPSRAEQLA SVVIYTQEGS SAAAAIQSQR ESSELQEA
Length:2,248
Mass (Da):247,367
Last modified:October 23, 2007 - v2
Checksum:i1AE958917F5F7B91
GO
Isoform 2 (identifier: Q9C0G0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1811-1815: IVSKS → KGQKL
     1816-2248: Missing.

Note: No experimental confirmation available.
Show »
Length:1,815
Mass (Da):202,418
Checksum:i4C5D56BA3F87F5FD
GO
Isoform 3 (identifier: Q9C0G0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1625-1660: ERKFTCHLCDRSFTEKWALNNHMKLHTGEKPFKCTW → ERVKVAYRKIGTLPGIQNNRNASSASEAQSLCEHFS
     1661-2248: Missing.

Note: No experimental confirmation available.
Show »
Length:1,660
Mass (Da):184,081
Checksum:i8A585EBEA30D9E8D
GO

Sequence cautioni

The sequence BAA91077 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91080 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti988K → E in BAA91077 (PubMed:14702039).Curated1
Sequence conflicti1297V → D in BAA91077 (PubMed:14702039).Curated1
Sequence conflicti1353F → S in BAA91077 (PubMed:14702039).Curated1
Sequence conflicti1415R → C in BAA91077 (PubMed:14702039).Curated1
Sequence conflicti1520I → V in BAA91077 (PubMed:14702039).Curated1
Sequence conflicti1584N → D in BAA91080 (PubMed:14702039).Curated1
Sequence conflicti2181D → G in AK023901 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05282069N → S. Corresponds to variant dbSNP:rs3794942EnsemblClinVar.1
Natural variantiVAR_052821512G → R. Corresponds to variant dbSNP:rs7227263EnsemblClinVar.1
Natural variantiVAR_036694972N → T. Corresponds to variant dbSNP:rs948615EnsemblClinVar.1
Natural variantiVAR_0619451259S → L. Corresponds to variant dbSNP:rs34048449Ensembl.1
Natural variantiVAR_0528221913A → T. Corresponds to variant dbSNP:rs17056248EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0288431625 – 1660ERKFT…FKCTW → ERVKVAYRKIGTLPGIQNNR NASSASEAQSLCEHFS in isoform 3. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_0288441661 – 2248Missing in isoform 3. 1 PublicationAdd BLAST588
Alternative sequenceiVSP_0288451811 – 1815IVSKS → KGQKL in isoform 2. 1 Publication5
Alternative sequenceiVSP_0288461816 – 2248Missing in isoform 2. 1 PublicationAdd BLAST433

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138660 Genomic DNA No translation available.
AC091589 Genomic DNA No translation available.
AC023380 Genomic DNA No translation available.
AC100783 Genomic DNA No translation available.
AC015819 Genomic DNA No translation available.
AK000314 mRNA Translation: BAA91077.1 Different initiation.
AK000317 mRNA Translation: BAA91080.1 Different initiation.
AK023901 mRNA No translation available.
AK056288 mRNA Translation: BAB71139.1
AB051490 mRNA Translation: BAB21794.1
CCDSiCCDS45885.1 [Q9C0G0-1]
CCDS54191.1 [Q9C0G0-3]
CCDS58634.1 [Q9C0G0-2]
RefSeqiNP_001139661.1, NM_001146189.1 [Q9C0G0-2]
NP_001139662.1, NM_001146190.1 [Q9C0G0-3]
NP_060227.2, NM_017757.2 [Q9C0G0-1]
XP_005266783.1, XM_005266726.4 [Q9C0G0-1]
XP_011524370.1, XM_011526068.2 [Q9C0G0-1]
XP_011524372.1, XM_011526070.1 [Q9C0G0-3]
UniGeneiHs.536490

Genome annotation databases

EnsembliENST00000299687; ENSP00000299687; ENSG00000215421 [Q9C0G0-1]
ENST00000309902; ENSP00000310359; ENSG00000215421 [Q9C0G0-3]
ENST00000577538; ENSP00000463270; ENSG00000215421 [Q9C0G0-2]
ENST00000582337; ENSP00000462348; ENSG00000215421 [Q9C0G0-3]
GeneIDi55628
KEGGihsa:55628
UCSCiuc002llw.3 human [Q9C0G0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN407_HUMAN
AccessioniPrimary (citable) accession number: Q9C0G0
Secondary accession number(s): B5MD54
, Q96MY0, Q9H8A1, Q9NXD4, Q9NXD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: October 23, 2007
Last modified: June 20, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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