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Protein

Exportin-4

Gene

XPO4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.2 Publications

GO - Molecular functioni

  • nuclear export signal receptor activity Source: GO_Central

GO - Biological processi

  • positive regulation of protein export from nucleus Source: BHF-UCL
  • protein export from nucleus Source: GO_Central

Keywordsi

Biological processProtein transport, Transport

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-4
Short name:
Exp4
Gene namesi
Name:XPO4
Synonyms:KIAA1721
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000132953.16
HGNCiHGNC:17796 XPO4
MIMi611449 gene
neXtProtiNX_Q9C0E2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64328
OpenTargetsiENSG00000132953
PharmGKBiPA134866468

Polymorphism and mutation databases

BioMutaiXPO4
DMDMi17368720

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002047111 – 1151Exportin-4Add BLAST1151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei464PhosphoserineCombined sources1
Modified residuei521PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9C0E2
MaxQBiQ9C0E2
PaxDbiQ9C0E2
PeptideAtlasiQ9C0E2
PRIDEiQ9C0E2
ProteomicsDBi80019

PTM databases

iPTMnetiQ9C0E2
PhosphoSitePlusiQ9C0E2

Expressioni

Gene expression databases

BgeeiENSG00000132953 Expressed in 172 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExiHS_XPO4
ExpressionAtlasiQ9C0E2 baseline and differential
GenevisibleiQ9C0E2 HS

Organism-specific databases

HPAiHPA053768

Interactioni

Subunit structurei

Found in a complex with XPO4, Ran and EIF5A. Found in a complex with XPO4, Ran and SMAD3. Interacts with SMAD3. Interacts with Ran and cargo proteins in a GTP-dependent manner.2 Publications

Protein-protein interaction databases

BioGridi122138, 59 interactors
IntActiQ9C0E2, 3 interactors
STRINGi9606.ENSP00000255305

Structurei

3D structure databases

ProteinModelPortaliQ9C0E2
SMRiQ9C0E2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

eggNOGiKOG4541 Eukaryota
ENOG410XNNN LUCA
GeneTreeiENSGT00730000111055
HOGENOMiHOG000154878
HOVERGENiHBG023214
InParanoidiQ9C0E2
OMAiESSQNVM
PhylomeDBiQ9C0E2
TreeFamiTF312991

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR014877 XPO1_C_dom
PfamiView protein in Pfam
PF08767 CRM1_C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9C0E2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMAAALGPPE VIAQLENAAK VLMAPPSMVN NEQRQHAEHI FLSFRKSKSP
60 70 80 90 100
FAVCKHILET SKVDYVLFQA ATAIMEAVVR EWILLEKGSI ESLRTFLLTY
110 120 130 140 150
VLQRPNLQKY VREQILLAVA VIVKRGSLDK SIDCKSIFHE VSQLISSGNP
160 170 180 190 200
TVQTLACSIL TALLSEFSSS SKTSNIGLSM EFHGNCKRVF QEEDLRQIFM
210 220 230 240 250
LTVEVLQEFS RRENLNAQMS SVFQRYLALA NQVLSWNFLP PNLGRHYIAM
260 270 280 290 300
FESSQNVLLK PTESWRETLL DSRVMELFFT VHRKIREDSD MAQDSLQCLA
310 320 330 340 350
QLASLHGPIF PDEGSQVDYL AHFIEGLLNT INGIEIEDSE AVGISSIISN
360 370 380 390 400
LITVFPRNVL TAIPSELFSS FVNCLTHLTC SFGRSAALEE VLDKDDMVYM
410 420 430 440 450
EAYDKLLESW LTLVQDDKHF HKGFFTQHAV QVFNSYIQCH LAAPDGTRNL
460 470 480 490 500
TANGVASREE EEISELQEDD RDQFSDQLAS VGMLGRIAAE HCIPLLTSLL
510 520 530 540 550
EERVTRLHGQ LQRHQQQLLA SPGSSTVDNK MLDDLYEDIH WLILVTGYLL
560 570 580 590 600
ADDTQGETPL IPPEIMEYSI KHSSEVDINT TLQILGSPGE KASSIPGYNR
610 620 630 640 650
TDSVIRLLSA ILRVSEVESR AIRADLTHLL SPQMGKDIVW FLKRWAKTYL
660 670 680 690 700
LVDEKLYDQI SLPFSTAFGA DTEGSQWIIG YLLQKVISNL SVWSSEQDLA
710 720 730 740 750
NDTVQLLVTL VERRERANLV IQCENWWNLA KQFASRSPPL NFLSSPVQRT
760 770 780 790 800
LMKALVLGGF AHMDTETKQQ YWTEVLQPLQ QRFLRVINQE NFQQMCQQEE
810 820 830 840 850
VKQEITATLE ALCGIAEATQ IDNVAILFNF LMDFLTNCIG LMEVYKNTPE
860 870 880 890 900
TVNLIIEVFV EVAHKQICYL GESKAMNLYE ACLTLLQVYS KNNLGRQRID
910 920 930 940 950
VTAEEEQYQD LLLIMELLTN LLSKEFIDFS DTDEVFRGHE PGQAANRSVS
960 970 980 990 1000
AADVVLYGVN LILPLMSQDL LKFPTLCNQY YKLITFICEI FPEKIPQLPE
1010 1020 1030 1040 1050
DLFKSLMYSL ELGMTSMSSE VCQLCLEALT PLAEQCAKAQ ETDSPLFLAT
1060 1070 1080 1090 1100
RHFLKLVFDM LVLQKHNTEM TTAAGEAFYT LVCLHQAEYS ELVETLLSSQ
1110 1120 1130 1140 1150
QDPVIYQRLA DAFNKLTASS TPPTLDRKQK MAFLKSLEEF MANVGGLLCV

K
Length:1,151
Mass (Da):130,139
Last modified:November 2, 2001 - v2
Checksum:i38E7EEFC938B07C5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z2X4F2Z2X4_HUMAN
Exportin-4
XPO4
1,151Annotation score:

Sequence cautioni

The sequence BAB14409 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti511L → S in BAB14409 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048958149N → S. Corresponds to variant dbSNP:rs17320607Ensembl.1
Natural variantiVAR_048959451T → A. Corresponds to variant dbSNP:rs9552285Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051508 mRNA Translation: BAB21812.1
AL512652 Genomic DNA No translation available.
AL356285 Genomic DNA No translation available.
AK023108 mRNA Translation: BAB14409.1 Different initiation.
AL831819 mRNA Translation: CAD38533.2
CCDSiCCDS41872.1
RefSeqiNP_071904.4, NM_022459.4
UniGeneiHs.507452

Genome annotation databases

EnsembliENST00000255305; ENSP00000255305; ENSG00000132953
GeneIDi64328
KEGGihsa:64328
UCSCiuc001unq.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051508 mRNA Translation: BAB21812.1
AL512652 Genomic DNA No translation available.
AL356285 Genomic DNA No translation available.
AK023108 mRNA Translation: BAB14409.1 Different initiation.
AL831819 mRNA Translation: CAD38533.2
CCDSiCCDS41872.1
RefSeqiNP_071904.4, NM_022459.4
UniGeneiHs.507452

3D structure databases

ProteinModelPortaliQ9C0E2
SMRiQ9C0E2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122138, 59 interactors
IntActiQ9C0E2, 3 interactors
STRINGi9606.ENSP00000255305

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiQ9C0E2
PhosphoSitePlusiQ9C0E2

Polymorphism and mutation databases

BioMutaiXPO4
DMDMi17368720

Proteomic databases

EPDiQ9C0E2
MaxQBiQ9C0E2
PaxDbiQ9C0E2
PeptideAtlasiQ9C0E2
PRIDEiQ9C0E2
ProteomicsDBi80019

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255305; ENSP00000255305; ENSG00000132953
GeneIDi64328
KEGGihsa:64328
UCSCiuc001unq.5 human

Organism-specific databases

CTDi64328
DisGeNETi64328
EuPathDBiHostDB:ENSG00000132953.16
GeneCardsiXPO4
H-InvDBiHIX0011162
HGNCiHGNC:17796 XPO4
HPAiHPA053768
MIMi611449 gene
neXtProtiNX_Q9C0E2
OpenTargetsiENSG00000132953
PharmGKBiPA134866468
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4541 Eukaryota
ENOG410XNNN LUCA
GeneTreeiENSGT00730000111055
HOGENOMiHOG000154878
HOVERGENiHBG023214
InParanoidiQ9C0E2
OMAiESSQNVM
PhylomeDBiQ9C0E2
TreeFamiTF312991

Miscellaneous databases

GeneWikiiXPO4
GenomeRNAii64328
PROiPR:Q9C0E2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132953 Expressed in 172 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExiHS_XPO4
ExpressionAtlasiQ9C0E2 baseline and differential
GenevisibleiQ9C0E2 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR014877 XPO1_C_dom
PfamiView protein in Pfam
PF08767 CRM1_C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiXPO4_HUMAN
AccessioniPrimary (citable) accession number: Q9C0E2
Secondary accession number(s): Q5VUZ5, Q8N3V6, Q9H934
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 2, 2001
Last modified: November 7, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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