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Entry version 158 (22 Apr 2020)
Sequence version 2 (02 Nov 2001)
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Protein

Exportin-4

Gene

XPO4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exportin-4
Short name:
Exp4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:XPO4
Synonyms:KIAA1721
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17796 XPO4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611449 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9C0E2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64328

Open Targets

More...
OpenTargetsi
ENSG00000132953

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134866468

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9C0E2 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
XPO4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
17368720

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002047111 – 1151Exportin-4Add BLAST1151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei464PhosphoserineCombined sources1
Modified residuei521PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9C0E2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9C0E2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9C0E2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9C0E2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9C0E2

PeptideAtlas

More...
PeptideAtlasi
Q9C0E2

PRoteomics IDEntifications database

More...
PRIDEi
Q9C0E2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80019

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9C0E2

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q9C0E2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9C0E2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132953 Expressed in skeletal muscle tissue of rectus abdominis and 171 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9C0E2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9C0E2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000132953 Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a complex with XPO4, Ran and EIF5A.

Found in a complex with XPO4, Ran and SMAD3.

Interacts with SMAD3.

Interacts with Ran and cargo proteins in a GTP-dependent manner.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122138, 61 interactors

Protein interaction database and analysis system

More...
IntActi
Q9C0E2, 28 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000255305

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9C0E2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9C0E2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4541 Eukaryota
ENOG410XNNN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153139

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005818_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9C0E2

Identification of Orthologs from Complete Genome Data

More...
OMAi
MFEATQN

Database of Orthologous Groups

More...
OrthoDBi
106880at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9C0E2

TreeFam database of animal gene trees

More...
TreeFami
TF312991

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR014877 XPO1_C_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08767 CRM1_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9C0E2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMAAALGPPE VIAQLENAAK VLMAPPSMVN NEQRQHAEHI FLSFRKSKSP
60 70 80 90 100
FAVCKHILET SKVDYVLFQA ATAIMEAVVR EWILLEKGSI ESLRTFLLTY
110 120 130 140 150
VLQRPNLQKY VREQILLAVA VIVKRGSLDK SIDCKSIFHE VSQLISSGNP
160 170 180 190 200
TVQTLACSIL TALLSEFSSS SKTSNIGLSM EFHGNCKRVF QEEDLRQIFM
210 220 230 240 250
LTVEVLQEFS RRENLNAQMS SVFQRYLALA NQVLSWNFLP PNLGRHYIAM
260 270 280 290 300
FESSQNVLLK PTESWRETLL DSRVMELFFT VHRKIREDSD MAQDSLQCLA
310 320 330 340 350
QLASLHGPIF PDEGSQVDYL AHFIEGLLNT INGIEIEDSE AVGISSIISN
360 370 380 390 400
LITVFPRNVL TAIPSELFSS FVNCLTHLTC SFGRSAALEE VLDKDDMVYM
410 420 430 440 450
EAYDKLLESW LTLVQDDKHF HKGFFTQHAV QVFNSYIQCH LAAPDGTRNL
460 470 480 490 500
TANGVASREE EEISELQEDD RDQFSDQLAS VGMLGRIAAE HCIPLLTSLL
510 520 530 540 550
EERVTRLHGQ LQRHQQQLLA SPGSSTVDNK MLDDLYEDIH WLILVTGYLL
560 570 580 590 600
ADDTQGETPL IPPEIMEYSI KHSSEVDINT TLQILGSPGE KASSIPGYNR
610 620 630 640 650
TDSVIRLLSA ILRVSEVESR AIRADLTHLL SPQMGKDIVW FLKRWAKTYL
660 670 680 690 700
LVDEKLYDQI SLPFSTAFGA DTEGSQWIIG YLLQKVISNL SVWSSEQDLA
710 720 730 740 750
NDTVQLLVTL VERRERANLV IQCENWWNLA KQFASRSPPL NFLSSPVQRT
760 770 780 790 800
LMKALVLGGF AHMDTETKQQ YWTEVLQPLQ QRFLRVINQE NFQQMCQQEE
810 820 830 840 850
VKQEITATLE ALCGIAEATQ IDNVAILFNF LMDFLTNCIG LMEVYKNTPE
860 870 880 890 900
TVNLIIEVFV EVAHKQICYL GESKAMNLYE ACLTLLQVYS KNNLGRQRID
910 920 930 940 950
VTAEEEQYQD LLLIMELLTN LLSKEFIDFS DTDEVFRGHE PGQAANRSVS
960 970 980 990 1000
AADVVLYGVN LILPLMSQDL LKFPTLCNQY YKLITFICEI FPEKIPQLPE
1010 1020 1030 1040 1050
DLFKSLMYSL ELGMTSMSSE VCQLCLEALT PLAEQCAKAQ ETDSPLFLAT
1060 1070 1080 1090 1100
RHFLKLVFDM LVLQKHNTEM TTAAGEAFYT LVCLHQAEYS ELVETLLSSQ
1110 1120 1130 1140 1150
QDPVIYQRLA DAFNKLTASS TPPTLDRKQK MAFLKSLEEF MANVGGLLCV

K
Length:1,151
Mass (Da):130,139
Last modified:November 2, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i38E7EEFC938B07C5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z2X4F2Z2X4_HUMAN
Exportin-4
XPO4
1,151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14409 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti511L → S in BAB14409 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048958149N → S. Corresponds to variant dbSNP:rs17320607Ensembl.1
Natural variantiVAR_048959451T → A. Corresponds to variant dbSNP:rs9552285Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB051508 mRNA Translation: BAB21812.1
AL512652 Genomic DNA No translation available.
AL356285 Genomic DNA No translation available.
AK023108 mRNA Translation: BAB14409.1 Different initiation.
AL831819 mRNA Translation: CAD38533.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41872.1

NCBI Reference Sequences

More...
RefSeqi
NP_071904.4, NM_022459.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000255305; ENSP00000255305; ENSG00000132953

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
64328

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64328

UCSC genome browser

More...
UCSCi
uc001unq.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051508 mRNA Translation: BAB21812.1
AL512652 Genomic DNA No translation available.
AL356285 Genomic DNA No translation available.
AK023108 mRNA Translation: BAB14409.1 Different initiation.
AL831819 mRNA Translation: CAD38533.2
CCDSiCCDS41872.1
RefSeqiNP_071904.4, NM_022459.4

3D structure databases

SMRiQ9C0E2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122138, 61 interactors
IntActiQ9C0E2, 28 interactors
STRINGi9606.ENSP00000255305

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiQ9C0E2
MetOSiteiQ9C0E2
PhosphoSitePlusiQ9C0E2

Polymorphism and mutation databases

BioMutaiXPO4
DMDMi17368720

Proteomic databases

EPDiQ9C0E2
jPOSTiQ9C0E2
MassIVEiQ9C0E2
MaxQBiQ9C0E2
PaxDbiQ9C0E2
PeptideAtlasiQ9C0E2
PRIDEiQ9C0E2
ProteomicsDBi80019

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q9C0E2

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
41969 48 antibodies

Genome annotation databases

EnsembliENST00000255305; ENSP00000255305; ENSG00000132953
GeneIDi64328
KEGGihsa:64328
UCSCiuc001unq.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64328
DisGeNETi64328

GeneCards: human genes, protein and diseases

More...
GeneCardsi
XPO4
HGNCiHGNC:17796 XPO4
HPAiENSG00000132953 Tissue enhanced (skeletal)
MIMi611449 gene
neXtProtiNX_Q9C0E2
OpenTargetsiENSG00000132953
PharmGKBiPA134866468

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4541 Eukaryota
ENOG410XNNN LUCA
GeneTreeiENSGT00940000153139
HOGENOMiCLU_005818_0_0_1
InParanoidiQ9C0E2
OMAiMFEATQN
OrthoDBi106880at2759
PhylomeDBiQ9C0E2
TreeFamiTF312991

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
XPO4 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
XPO4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
64328
PharosiQ9C0E2 Tbio

Protein Ontology

More...
PROi
PR:Q9C0E2
RNActiQ9C0E2 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000132953 Expressed in skeletal muscle tissue of rectus abdominis and 171 other tissues
ExpressionAtlasiQ9C0E2 baseline and differential
GenevisibleiQ9C0E2 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR014877 XPO1_C_dom
PfamiView protein in Pfam
PF08767 CRM1_C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXPO4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C0E2
Secondary accession number(s): Q5VUZ5, Q8N3V6, Q9H934
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 2, 2001
Last modified: April 22, 2020
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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