Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 117 (02 Jun 2021)
Sequence version 2 (10 Jun 2008)
Previous versions | rss
Add a publicationFeedback
Protein

Probable ribonuclease ZC3H12C

Gene

ZC3H12C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as RNase and regulate the levels of target RNA species.

Curated

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri410 – 435C3H1-typePROSITE-ProRule annotationAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
LigandMagnesium, Metal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9C0D7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable ribonuclease ZC3H12C (EC:3.1.-.-)
Alternative name(s):
MCP-induced protein 3
Zinc finger CCCH domain-containing protein 12C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZC3H12C
Synonyms:KIAA1726, MCPIP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29362, ZC3H12C

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615001, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9C0D7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000149289.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
85463

Open Targets

More...
OpenTargetsi
ENSG00000149289

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394739

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9C0D7, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZC3H12C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
190485746

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003378431 – 883Probable ribonuclease ZC3H12CAdd BLAST883

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei230PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9C0D7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9C0D7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9C0D7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9C0D7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9C0D7

PeptideAtlas

More...
PeptideAtlasi
Q9C0D7

PRoteomics IDEntifications database

More...
PRIDEi
Q9C0D7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
4923
80017 [Q9C0D7-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9C0D7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9C0D7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By cytokines (TNF-alpha and interleukin-1) in acute monocytic leukemia cell line THP-1 cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000149289, Expressed in gastrocnemius and 203 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9C0D7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9C0D7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000149289, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124547, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q9C0D7, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000278590

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9C0D7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9C0D7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini245 – 400RNase NYNSequence analysisAdd BLAST156

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni53 – 109DisorderedSequence analysisAdd BLAST57
Regioni139 – 158DisorderedSequence analysisAdd BLAST20
Regioni456 – 551DisorderedSequence analysisAdd BLAST96
Regioni680 – 738DisorderedSequence analysisAdd BLAST59
Regioni754 – 775DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi54 – 69Polar residuesSequence analysisAdd BLAST16
Compositional biasi71 – 85Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi456 – 480Polar residuesSequence analysisAdd BLAST25
Compositional biasi513 – 546Polar residuesSequence analysisAdd BLAST34
Compositional biasi687 – 701Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi754 – 769Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ZC3H12 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri410 – 435C3H1-typePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3777, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158397

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9C0D7

Identification of Orthologs from Complete Genome Data

More...
OMAi
HMHPHGR

Database of Orthologous Groups

More...
OrthoDBi
771251at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9C0D7

TreeFam database of animal gene trees

More...
TreeFami
TF315783

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040546, Rege-1_UBA-like
IPR040757, Regnase_1/ZC3H12_C
IPR021869, RNase_Zc3h12_NYN
IPR000571, Znf_CCCH

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18561, Regnase_1_C, 1 hit
PF11977, RNase_Zc3h12a, 1 hit
PF18039, UBA_6, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50103, ZF_C3H1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9C0D7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGGGSQEYG VLCIQEYRKN SKVESSTRNN FMGLKDHLGH DLGHLYVEST
60 70 80 90 100
DPQLSPAVPW STVENPSMDT VNVGKDEKEA SEENASSGDS EENTNSDHES
110 120 130 140 150
EQLGSISVEP GLITKTHRQL CRSPCLEPHI LKRNEILQDF KPEESQTTSK
160 170 180 190 200
EAKKPPDVVR EYQTKLEFAL KLGYSEEQVQ LVLNKLGTDA LINDILGELV
210 220 230 240 250
KLGNKSEADQ TVSTINTITR ETSSLESQRS ESPMQEIVTD DGENLRPIVI
260 270 280 290 300
DGSNVAMSHG NKEVFSCRGI KLAVDWFLER GHKDITVFVP AWRKEQSRPD
310 320 330 340 350
ALITDQEILR KLEKEKILVF TPSRRVQGRR VVCYDDRFIV KLAFESDGII
360 370 380 390 400
VSNDNYRDLA NEKPEWKKFI DERLLMYSFV NDKFMPPDDP LGRHGPSLDN
410 420 430 440 450
FLRKKPIVPE HKKQPCPYGK KCTYGHKCKY YHPERGSQPQ RSVADELRAM
460 470 480 490 500
SRNTAAKTAN EGGLVKSNSV PCSTKADSTS DVKRGAPKRQ SDPSIRTQVY
510 520 530 540 550
QDLEEKLPTK NKLETRSVPS LVSIPATSTA KPQSTTSLSN GLPSGVHFPP
560 570 580 590 600
QDQRPQGQYP SMMMATKNHG TPMPYEQYPK CDSPVDIGYY SMLNAYSNLS
610 620 630 640 650
LSGPRSPERR FSLDTDYRIS SVASDCSSEG SMSCGSSDSY VGYNDRSYVS
660 670 680 690 700
SPDPQLEENL KCQHMHPHSR LNPQPFLQNF HDPLTRGQSY SHEEPKFHHK
710 720 730 740 750
PPLPHLALHL PHSAVGARSS CPGDYPSPPS SAHSKAPHLG RSLVATRIDS
760 770 780 790 800
ISDSRLYDSS PSRQRKPYSR QEGLGSWERP GYGIDAYGYR QTYSLPDNST
810 820 830 840 850
QPCYEQFTFQ SLPEQQEPAW RIPYCGMPQD PPRYQDNREK IYINLCNIFP
860 870 880
PDLVRIVMKR NPHMTDAQQL AAAILVEKSQ LGY
Length:883
Mass (Da):99,340
Last modified:June 10, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBF369391C5A36854
GO
Isoform 2 (identifier: Q9C0D7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MPGGGSQ → MSLYFPAN

Show »
Length:884
Mass (Da):99,650
Checksum:i74012D3E93A318B1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PP00E9PP00_HUMAN
Probable ribonuclease ZC3H12C
ZC3H12C
852Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti69D → G in BAG58377 (PubMed:14702039).Curated1
Sequence conflicti574P → A in BAG58377 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0541271 – 7MPGGGSQ → MSLYFPAN in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK295437 mRNA Translation: BAG58377.1
AK299100 mRNA Translation: BAG61159.1
AP000901 Genomic DNA No translation available.
AP001889 Genomic DNA No translation available.
AB051513 mRNA Translation: BAB21817.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44727.1 [Q9C0D7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_203748.1, NM_033390.1 [Q9C0D7-1]
XP_016873966.1, XM_017018477.1 [Q9C0D7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000278590; ENSP00000278590; ENSG00000149289 [Q9C0D7-1]
ENST00000528673; ENSP00000431821; ENSG00000149289 [Q9C0D7-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
85463

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:85463

UCSC genome browser

More...
UCSCi
uc009yxw.3, human [Q9C0D7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295437 mRNA Translation: BAG58377.1
AK299100 mRNA Translation: BAG61159.1
AP000901 Genomic DNA No translation available.
AP001889 Genomic DNA No translation available.
AB051513 mRNA Translation: BAB21817.1
CCDSiCCDS44727.1 [Q9C0D7-1]
RefSeqiNP_203748.1, NM_033390.1 [Q9C0D7-1]
XP_016873966.1, XM_017018477.1 [Q9C0D7-2]

3D structure databases

SMRiQ9C0D7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124547, 4 interactors
IntActiQ9C0D7, 4 interactors
STRINGi9606.ENSP00000278590

PTM databases

iPTMnetiQ9C0D7
PhosphoSitePlusiQ9C0D7

Genetic variation databases

BioMutaiZC3H12C
DMDMi190485746

Proteomic databases

EPDiQ9C0D7
jPOSTiQ9C0D7
MassIVEiQ9C0D7
MaxQBiQ9C0D7
PaxDbiQ9C0D7
PeptideAtlasiQ9C0D7
PRIDEiQ9C0D7
ProteomicsDBi4923
80017 [Q9C0D7-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
45577, 56 antibodies

The DNASU plasmid repository

More...
DNASUi
85463

Genome annotation databases

EnsembliENST00000278590; ENSP00000278590; ENSG00000149289 [Q9C0D7-1]
ENST00000528673; ENSP00000431821; ENSG00000149289 [Q9C0D7-2]
GeneIDi85463
KEGGihsa:85463
UCSCiuc009yxw.3, human [Q9C0D7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
85463
DisGeNETi85463

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZC3H12C
HGNCiHGNC:29362, ZC3H12C
HPAiENSG00000149289, Low tissue specificity
MIMi615001, gene
neXtProtiNX_Q9C0D7
OpenTargetsiENSG00000149289
PharmGKBiPA128394739
VEuPathDBiHostDB:ENSG00000149289.10

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3777, Eukaryota
GeneTreeiENSGT00940000158397
InParanoidiQ9C0D7
OMAiHMHPHGR
OrthoDBi771251at2759
PhylomeDBiQ9C0D7
TreeFamiTF315783

Enzyme and pathway databases

PathwayCommonsiQ9C0D7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
85463, 6 hits in 988 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZC3H12C, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
85463
PharosiQ9C0D7, Tdark

Protein Ontology

More...
PROi
PR:Q9C0D7
RNActiQ9C0D7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000149289, Expressed in gastrocnemius and 203 other tissues
ExpressionAtlasiQ9C0D7, baseline and differential
GenevisibleiQ9C0D7, HS

Family and domain databases

InterProiView protein in InterPro
IPR040546, Rege-1_UBA-like
IPR040757, Regnase_1/ZC3H12_C
IPR021869, RNase_Zc3h12_NYN
IPR000571, Znf_CCCH
PfamiView protein in Pfam
PF18561, Regnase_1_C, 1 hit
PF11977, RNase_Zc3h12a, 1 hit
PF18039, UBA_6, 1 hit
PROSITEiView protein in PROSITE
PS50103, ZF_C3H1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZC12C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C0D7
Secondary accession number(s): B4DI65, B4DR47
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: June 2, 2021
This is version 117 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again