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Entry version 150 (11 Dec 2019)
Sequence version 3 (18 May 2010)
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Protein

Protein TANC1

Gene

TANC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a scaffold component in the postsynaptic density.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein TANC1
Alternative name(s):
Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TANC1
Synonyms:KIAA1728
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000115183.13

Human Gene Nomenclature Database

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HGNCi
HGNC:29364 TANC1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611397 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9C0D5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
85461

Open Targets

More...
OpenTargetsi
ENSG00000115183

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670838

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9C0D5 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TANC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452941

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003169591 – 1861Protein TANC1Add BLAST1861

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Modified residuei66PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei207PhosphoserineCombined sources1
Modified residuei270PhosphoserineCombined sources1
Modified residuei465PhosphoserineCombined sources1
Modified residuei1439PhosphoserineBy similarity1
Modified residuei1668PhosphoserineCombined sources1
Modified residuei1676PhosphoserineBy similarity1
Modified residuei1677PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated; by MINK1 and TNIK upon stimulation by RAP2A.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9C0D5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9C0D5

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9C0D5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9C0D5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9C0D5

PeptideAtlas

More...
PeptideAtlasi
Q9C0D5

PRoteomics IDEntifications database

More...
PRIDEi
Q9C0D5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80014 [Q9C0D5-1]
80015 [Q9C0D5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9C0D5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9C0D5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115183 Expressed in 206 organ(s), highest expression level in heart right ventricle

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9C0D5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036750

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts probably directly with DLG1, DLG4, HOMER1.

Interacts with DLGAP1, INA, CAMK2A, GRIN2B and GRIA1 (By similarity).

Interacts with TNIK.

Interacts with MINK1 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
124545, 18 interactors

Protein interaction database and analysis system

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IntActi
Q9C0D5, 13 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000263635

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9C0D5 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9C0D5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati896 – 928ANK 1Add BLAST33
Repeati934 – 963ANK 2Add BLAST30
Repeati967 – 996ANK 3Add BLAST30
Repeati1000 – 1029ANK 4Add BLAST30
Repeati1040 – 1069ANK 5Add BLAST30
Repeati1078 – 1107ANK 6Add BLAST30
Repeati1111 – 1140ANK 7Add BLAST30
Repeati1144 – 1173ANK 8Add BLAST30
Repeati1177 – 1206ANK 9Add BLAST30
Repeati1210 – 1239ANK 10Add BLAST30
Repeati1243 – 1272ANK 11Add BLAST30
Repeati1289 – 1322TPR 1Add BLAST34
Repeati1336 – 1369TPR 2Add BLAST34
Repeati1371 – 1403TPR 3Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi170 – 243Ser-richAdd BLAST74
Compositional biasi1659 – 1689Ser-richAdd BLAST31

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TANC family.Curated

Keywords - Domaini

ANK repeat, Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0504 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155655

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231045

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9C0D5

Identification of Orthologs from Complete Genome Data

More...
OMAi
DHFHLEE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9C0D5

TreeFam database of animal gene trees

More...
TreeFami
TF323159

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 10 hits
SM00028 TPR, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF48452 SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 6 hits
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9C0D5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLKAVLKKSR EGGKGGKKEA GSDFGPETSP VLHLDHSADS PVSSLPTAED
60 70 80 90 100
TYRVSLAKGV SMSLPSSPLL PRQSHLVQSR VNKKSPGPVR KPKYVESPRV
110 120 130 140 150
PGDAVIMPFR EVAKPTEPDE HEAKADNEPS CSPAAQELLT RLGFLLGEGI
160 170 180 190 200
PSATHITIED KNETMCTALS QGISPCSTLT SSTASPSTDS PCSTLNSCVS
210 220 230 240 250
KTAANKSPCE TISSPSSTLE SKDSGIIATI TSSSENDDRS GSSLEWNKDG
260 270 280 290 300
NLRLGVQKGV LHDRRADNCS PVAEEETTGS AESTLPKAES SAGDGPVPYS
310 320 330 340 350
QGSSSLIMPR PNSVAATSST KLEDLSYLDG QRNAPLRTSI RLPWHNTAGG
360 370 380 390 400
RAQEVKARFA PYKPQDILLK PLLFEVPSIT TDSVFVGRDW LFHQIEENLR
410 420 430 440 450
NTELAENRGA VVVGNVGFGK TAIISKLVAL SCHGSRMRQI ASNSPGSSPK
460 470 480 490 500
TSDPTQDLHF TPLLSPSSST SASSTAKTPL GSISAENQRP REDAVKYLAS
510 520 530 540 550
KVVAYHYCQA DNTYTCLVPE FVHSIAALLC RSHQLAAYRD LLIKEPQLQS
560 570 580 590 600
MLSLRSCVQD PVAAFKRGVL EPLTNLRNEQ KIPEEEYIIL IDGLNEAEFH
610 620 630 640 650
KPDYGDTLSS FITKIISKFP AWLKLIVTVR ANFQEIISAL PFVKLSLDDF
660 670 680 690 700
PDNKDIHSDL HAYVQHRVHS SQDILSNISL NGKADATLIG KVSSHLVLRS
710 720 730 740 750
LGSYLYLKLT LDLFQRGHLV IKSASYKVVP VSLSELYLLQ CNMKFMTQSA
760 770 780 790 800
FERALPILNV ALASLHPMTD EQIFQAINAG HIQGEQGWED FQQRMDALSC
810 820 830 840 850
FLIKRRDKTR MFCHPSFREW LVWRADGENT AFLCEPRNGH ALLAFMFSRQ
860 870 880 890 900
EGKLNRQQTM ELGHHILKAH IFKGLSKKTG ISSSHLQALW IGYSTEGLSA
910 920 930 940 950
ALASLRNLYT PNVKVSRLLI LGGANVNYRT EVLNNAPILC VQSHLGHEEV
960 970 980 990 1000
VTLLLEFGAC LDGTSENGMT ALCYAAAAGH MKLVCLLTKK GVRVDHLDKK
1010 1020 1030 1040 1050
GQCALVHSAL RGHGDILQYL LTCEWSPGPP QPGTLRKSHA LQQALTAAAS
1060 1070 1080 1090 1100
MGHSSVVQCL LGMEKEHEVE VNGTDTLWGE TALTAAAGRG KLEVCELLLG
1110 1120 1130 1140 1150
HGAAVSRTNR RGVPPLFCAA RQGHWQIVRL LLERGCDVNL SDKQGRTPLM
1160 1170 1180 1190 1200
VAACEGHLST VEFLLSKGAA LSSLDKEGLS ALSWACLKGH RAVVQYLVEE
1210 1220 1230 1240 1250
GAAIDQTDKN GRTPLDLAAF YGDAETVLYL VEKGAVIEHV DHSGMRPLDR
1260 1270 1280 1290 1300
AIGCRNTSVV VALLRKGAKL GNAAWAMATS KPDILIILLQ KLMEEGNVMY
1310 1320 1330 1340 1350
KKGKMKEAAQ RYQYALRKFP REGFGEDMRP FNELRVSLYL NLSRCRRKTN
1360 1370 1380 1390 1400
DFGMAEEFAS KALELKPKSY EAFYARARAK RNSRQFVAAL ADLQEAVKLC
1410 1420 1430 1440 1450
PTNQEVKRLL ARVEEECKQL QRSQQQKQQG PLPAPLNDSE NEEDTPTPGL
1460 1470 1480 1490 1500
SDHFHSEETE EEETSPQEES VSPTPRSQPS SSVPSSYIRN LQEGLQSKGR
1510 1520 1530 1540 1550
PVSPQSRAGI GKSLREPVAQ PGLLLQPSKQ AQIVKTSQHL GSGQSAVRNG
1560 1570 1580 1590 1600
SMKVQISSQN PPPSPMPGRI AATPAGSRTQ HLEGTGTFTT RAGCGHFGDR
1610 1620 1630 1640 1650
LGPSQNVRLQ CGENGPAHPL PSKTKTTERL LSHSSVAVDA APPNQGGLAT
1660 1670 1680 1690 1700
CSDVRHPASL TSSGSSGSPS SSIKMSSSTS SLTSSSSFSD GFKVQGPDTR
1710 1720 1730 1740 1750
IKDKVVTHVQ SGTAEHRPRN TPFMGIMDKT ARFQQQSNPP SRSWHCPAPE
1760 1770 1780 1790 1800
GLLTNTSSAA GLQSANTEKP SLMQVGGYNN QAKTCSVSTL SASVHNGAQV
1810 1820 1830 1840 1850
KELEESKCQI PVHSQENRIT KTVSHLYQES ISKQQPHISN EAHRSHLTAA
1860
KPKRSFIESN V
Length:1,861
Mass (Da):202,219
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE9BE1083E5FB9413
GO
Isoform 2 (identifier: Q9C0D5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-227: Missing.

Note: Incomplete sequence.Curated
Show »
Length:1,755
Mass (Da):191,427
Checksum:iB00C28AF4CA6E30D
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH37329 differs from that shown. The cDNA sequence appears to be not correctly spliced at its 3'-end.Curated
The sequence AAH37329 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06102230P → S. Corresponds to variant dbSNP:rs34588551Ensembl.1
Natural variantiVAR_038435251N → S2 PublicationsCorresponds to variant dbSNP:rs12466551Ensembl.1
Natural variantiVAR_0384361511G → S. Corresponds to variant dbSNP:rs13421084Ensembl.1
Natural variantiVAR_0384371573T → A1 PublicationCorresponds to variant dbSNP:rs4664277Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030828122 – 227Missing in isoform 2. 1 PublicationAdd BLAST106

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC009307 Genomic DNA No translation available.
AC010093 Genomic DNA No translation available.
BC037329 mRNA Translation: AAH37329.1 Sequence problems.
AB051515 mRNA Translation: BAB21819.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42766.1 [Q9C0D5-1]

NCBI Reference Sequences

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RefSeqi
NP_001139381.1, NM_001145909.1
NP_203752.2, NM_033394.2 [Q9C0D5-1]
XP_006712873.1, XM_006712810.3 [Q9C0D5-1]
XP_011510360.1, XM_011512058.2 [Q9C0D5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263635; ENSP00000263635; ENSG00000115183 [Q9C0D5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
85461

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:85461

UCSC genome browser

More...
UCSCi
uc002uag.4 human [Q9C0D5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009307 Genomic DNA No translation available.
AC010093 Genomic DNA No translation available.
BC037329 mRNA Translation: AAH37329.1 Sequence problems.
AB051515 mRNA Translation: BAB21819.1
CCDSiCCDS42766.1 [Q9C0D5-1]
RefSeqiNP_001139381.1, NM_001145909.1
NP_203752.2, NM_033394.2 [Q9C0D5-1]
XP_006712873.1, XM_006712810.3 [Q9C0D5-1]
XP_011510360.1, XM_011512058.2 [Q9C0D5-2]

3D structure databases

SMRiQ9C0D5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124545, 18 interactors
IntActiQ9C0D5, 13 interactors
STRINGi9606.ENSP00000263635

PTM databases

iPTMnetiQ9C0D5
PhosphoSitePlusiQ9C0D5

Polymorphism and mutation databases

BioMutaiTANC1
DMDMi296452941

Proteomic databases

EPDiQ9C0D5
jPOSTiQ9C0D5
MassIVEiQ9C0D5
MaxQBiQ9C0D5
PaxDbiQ9C0D5
PeptideAtlasiQ9C0D5
PRIDEiQ9C0D5
ProteomicsDBi80014 [Q9C0D5-1]
80015 [Q9C0D5-2]

Genome annotation databases

EnsembliENST00000263635; ENSP00000263635; ENSG00000115183 [Q9C0D5-1]
GeneIDi85461
KEGGihsa:85461
UCSCiuc002uag.4 human [Q9C0D5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
85461
DisGeNETi85461
EuPathDBiHostDB:ENSG00000115183.13

GeneCards: human genes, protein and diseases

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GeneCardsi
TANC1
HGNCiHGNC:29364 TANC1
HPAiHPA036750
MIMi611397 gene
neXtProtiNX_Q9C0D5
OpenTargetsiENSG00000115183
PharmGKBiPA142670838

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000155655
HOGENOMiHOG000231045
InParanoidiQ9C0D5
OMAiDHFHLEE
PhylomeDBiQ9C0D5
TreeFamiTF323159

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TANC1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
85461
PharosiQ9C0D5 Tdark

Protein Ontology

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PROi
PR:Q9C0D5
RNActiQ9C0D5 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000115183 Expressed in 206 organ(s), highest expression level in heart right ventricle
GenevisibleiQ9C0D5 HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 3 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 10 hits
SM00028 TPR, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
SSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 6 hits
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTANC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C0D5
Secondary accession number(s): C9JD88, Q49AI8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 18, 2010
Last modified: December 11, 2019
This is version 150 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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