UniProtKB - Q9C0D3 (ZY11B_HUMAN)

BLAST

>sp|Q9C0D3|ZY11B_HUMAN Protein zyg-11 homolog B OS=Homo sapiens OX=9606 GN=ZYG11B PE=1 SV=2
MPEDQAGAAMEEASPYSLLDICLNFLTTHLEKFCSARQDGTLCLQEPGVFPQEVADRLLR
TMAFHGLLNDGTVGIFRGNQMRLKRACIRKAKISAVAFRKAFCHHKLVELDATGVNADIT
ITDIISGLGSNKWIQQNLQCLVLNSLTLSLEDPYERCFSRLSGLRALSITNVLFYNEDLA
EVASLPRLESLDISNTSITDITALLACKDRLKSLTMHHLKCLKMTTTQILDVVRELKHLN
HLDISDDKQFTSDIALRLLEQKDILPNLVSLDVSGRKHVTDKAVEAFIQQRPSMQFVGLL
ATDAGYSEFLTGEGHLKVSGEANETQIAEALKRYSERAFFVREALFHLFSLTHVMEKTKP
EILKLVVTGMRNHPMNLPVQLAASACVFNLTKQDLAAGMPVRLLADVTHLLLKAMEHFPN
HQQLQKNCLLSLCSDRILQDVPFNRFEAAKLVMQWLCNHEDQNMQRMAVAIISILAAKLS
TEQTAQLGTELFIVRQLLQIVKQKTNQNSVDTTLKFTLSALWNLTDESPTTCRHFIENQG
LELFMRVLESFPTESSIQQKVLGLLNNIAEVQELHSELMWKDFIDHISSLLHSVEVEVSY
FAAGIIAHLISRGEQAWTLSRSQRNSLLDDLHSAILKWPTPECEMVAYRSFNPFFPLLGC
FTTPGVQLWAVWAMQHVCSKNPSRYCSMLIEEGGLQHLYNIKDHEHTDPHVQQIAVAILD
SLEKHIVRHGRPPPCKKQPQARLN

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History
Entry version 122 (07 Nov 2018)
Sequence version 2 (02 Oct 2007)
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Protein

Protein zyg-11 homolog B

Gene

ZYG11B

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC.

GO - Molecular functionⁱ

ubiquitin-protein transferase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of ubiquitin-protein transferase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Ubl conjugation pathway

Biological process

Ubl conjugation pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein zyg-11 homolog B
Gene namesⁱ	Name:ZYG11B Synonyms:KIAA1730
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000162378.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25820 ZYG11B
neXtProtⁱ	NX_Q9C0D3

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	18	L → S: Abolishes interaction with TCEB1. 1 Publication		1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000162378
PharmGKBⁱ	PA142670468

Polymorphism and mutation databases

BioMutaⁱ	ZYG11B
DMDMⁱ	158706479

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000305087	1 – 744	Protein zyg-11 homolog BAdd BLAST		744

Proteomic databases

EPDⁱ	Q9C0D3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9C0D3
PaxDbⁱ	Q9C0D3
PeptideAtlas More...PeptideAtlasⁱ	Q9C0D3
PRIDEⁱ	Q9C0D3
ProteomicsDBⁱ	80011 80012 [Q9C0D3-2]

PTM databases

iPTMnetⁱ	Q9C0D3
PhosphoSitePlusⁱ	Q9C0D3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000162378 Expressed in 208 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_ZYG11B
ExpressionAtlasⁱ	Q9C0D3 baseline and differential
Genevisibleⁱ	Q9C0D3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA028156

HPAⁱ

HPA028156

Interactionⁱ

Subunit structureⁱ

Interacts with TCEB1/Elongin C. Part of an E3 ubiquitin ligase complex including ZYG11B, CUL2 and Elongin BC.1 Publication

Protein-protein interaction databases

BioGridⁱ	122820, 49 interactors
IntActⁱ	Q9C0D3, 5 interactors
Molecular INTeraction database More...MINTⁱ	Q9C0D3
STRINGⁱ	9606.ENSP00000294353

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9C0D3
SMRⁱ	Q9C0D3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	185 – 208	LRR 1Add BLAST	24
Repeatⁱ	216 – 236	LRR 2Add BLAST	21
Repeatⁱ	237 – 261	LRR 3Add BLAST	25

Sequence similaritiesⁱ

Belongs to the zyg-11 family.Curated

Keywords - Domainⁱ

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGⁱ	KOG3665 Eukaryota ENOG410XPSX LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063187
HOGENOMⁱ	HOG000004816
HOVERGENⁱ	HBG108780
InParanoidⁱ	Q9C0D3
KEGG Orthology (KO) More...KOⁱ	K10350
OMAⁱ	HVCSKNA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G031E
PhylomeDBⁱ	Q9C0D3
TreeFamⁱ	TF313007

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit 3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR001611 Leu-rich_rpt IPR032675 LRR_dom_sf
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
PROSITEⁱ	View protein in PROSITE PS51450 LRR, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9C0D3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPEDQAGAAM EEASPYSLLD ICLNFLTTHL EKFCSARQDG TLCLQEPGVF 
        60         70         80         90        100
PQEVADRLLR TMAFHGLLND GTVGIFRGNQ MRLKRACIRK AKISAVAFRK 
       110        120        130        140        150
AFCHHKLVEL DATGVNADIT ITDIISGLGS NKWIQQNLQC LVLNSLTLSL 
       160        170        180        190        200
EDPYERCFSR LSGLRALSIT NVLFYNEDLA EVASLPRLES LDISNTSITD 
       210        220        230        240        250
ITALLACKDR LKSLTMHHLK CLKMTTTQIL DVVRELKHLN HLDISDDKQF 
       260        270        280        290        300
TSDIALRLLE QKDILPNLVS LDVSGRKHVT DKAVEAFIQQ RPSMQFVGLL 
       310        320        330        340        350
ATDAGYSEFL TGEGHLKVSG EANETQIAEA LKRYSERAFF VREALFHLFS 
       360        370        380        390        400
LTHVMEKTKP EILKLVVTGM RNHPMNLPVQ LAASACVFNL TKQDLAAGMP 
       410        420        430        440        450
VRLLADVTHL LLKAMEHFPN HQQLQKNCLL SLCSDRILQD VPFNRFEAAK 
       460        470        480        490        500
LVMQWLCNHE DQNMQRMAVA IISILAAKLS TEQTAQLGTE LFIVRQLLQI 
       510        520        530        540        550
VKQKTNQNSV DTTLKFTLSA LWNLTDESPT TCRHFIENQG LELFMRVLES 
       560        570        580        590        600
FPTESSIQQK VLGLLNNIAE VQELHSELMW KDFIDHISSL LHSVEVEVSY 
       610        620        630        640        650
FAAGIIAHLI SRGEQAWTLS RSQRNSLLDD LHSAILKWPT PECEMVAYRS 
       660        670        680        690        700
FNPFFPLLGC FTTPGVQLWA VWAMQHVCSK NPSRYCSMLI EEGGLQHLYN 
       710        720        730        740 
IKDHEHTDPH VQQIAVAILD SLEKHIVRHG RPPPCKKQPQ ARLN

Length:744

Mass (Da):83,921

Last modified:October 2, 2007 - v2

Checksum:ⁱ0D8C19251CA67573

Isoform 2 (identifier: Q9C0D3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-578: Missing.

« Hide

        10         20         30         40         50
MWKDFIDHIS SLLHSVEVEV SYFAAGIIAH LISRGEQAWT LSRSQRNSLL 
        60         70         80         90        100
DDLHSAILKW PTPECEMVAY RSFNPFFPLL GCFTTPGVQL WAVWAMQHVC 
       110        120        130        140        150
SKNPSRYCSM LIEEGGLQHL YNIKDHEHTD PHVQQIAVAI LDSLEKHIVR 
       160 
HGRPPPCKKQ PQARLN

Note: No experimental confirmation available.

Show »

Length:166

Mass (Da):19,006

Checksum:ⁱ0225A6D407596545

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A8DPD7	A8DPD7_HUMAN		Protein zyg-11 homolog B Protein zyg-11 homolog B (ZYG11B)	ZYG11B	566	Annotation score:

Sequence cautionⁱ

The sequence BAB21821 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	672	W → C in BAB14596 (PubMed:14702039).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_028224	1 – 578	Missing in isoform 2. 1 PublicationAdd BLAST		578

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB051517 mRNA Translation: BAB21821.1 Different initiation. AK023518 mRNA Translation: BAB14596.1 BC029832 mRNA Translation: AAH29832.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30717.1 [Q9C0D3-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_078922.1, NM_024646.2 [Q9C0D3-1]
UniGeneⁱ	Hs.476280

Genome annotation databases

Ensemblⁱ	ENST00000294353; ENSP00000294353; ENSG00000162378 [Q9C0D3-1]
GeneIDⁱ	79699
KEGGⁱ	hsa:79699
UCSC genome browser More...UCSCⁱ	uc001cuj.4 human [Q9C0D3-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q9C0D3	Protein zyg-11 homolog B		MACMU		744	UniRef100_Q9C0D3
ZYG11B isoform 1		PANTR		744
ZYG11B isoform 2		PONAB		744
Uncharacterized protein		PAPAN		744
Uncharacterized protein		CHLSB		744
+3
Q9C0D3-2	Uncharacterized protein		MACFA		390	UniRef100_Q9GMX0
Uncharacterized protein		AOTNA		761
FLJ13456 (Fragment)		MACMU		122
UPI0002AD52F1		NOMLE		529
UPI0005F46661		MANLE		683
+1

Protein	Similar proteins		Species	Score	Length	Source
Q9C0D3	Protein zyg-11 homolog B		MOUSE		744	UniRef90_Q9C0D3
Protein zyg-11 homolog B		MACMU		744
ZYG11B isoform 1		PANTR		744
ZYG11B isoform 2		PONAB		744
Uncharacterized protein		PAPAN		744
+282

Protein	Similar proteins		Species	Score	Length	Source
Q9C0D3	Protein zyg-11 homolog B		MOUSE		744	UniRef50_Q9C0D3
Protein zyg-11 homolog A		HUMAN		759
Protein zyg-11 homolog B		MACMU		744
ZYG11B isoform 1		PANTR		744
ZYG11B isoform 2		PONAB		744
+437

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB051517 mRNA Translation: BAB21821.1 Different initiation. AK023518 mRNA Translation: BAB14596.1 BC029832 mRNA Translation: AAH29832.2
CCDSⁱ	CCDS30717.1 [Q9C0D3-1]
RefSeqⁱ	NP_078922.1, NM_024646.2 [Q9C0D3-1]
UniGeneⁱ	Hs.476280

3D structure databases

ProteinModelPortalⁱ	Q9C0D3
SMRⁱ	Q9C0D3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122820, 49 interactors
IntActⁱ	Q9C0D3, 5 interactors
MINTⁱ	Q9C0D3
STRINGⁱ	9606.ENSP00000294353

PTM databases

iPTMnetⁱ	Q9C0D3
PhosphoSitePlusⁱ	Q9C0D3

Polymorphism and mutation databases

BioMutaⁱ	ZYG11B
DMDMⁱ	158706479

Proteomic databases

EPDⁱ	Q9C0D3
MaxQBⁱ	Q9C0D3
PaxDbⁱ	Q9C0D3
PeptideAtlasⁱ	Q9C0D3
PRIDEⁱ	Q9C0D3
ProteomicsDBⁱ	80011 80012 [Q9C0D3-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000294353; ENSP00000294353; ENSG00000162378 [Q9C0D3-1]
GeneIDⁱ	79699
KEGGⁱ	hsa:79699
UCSCⁱ	uc001cuj.4 human [Q9C0D3-1]

Organism-specific databases

CTDⁱ	79699
EuPathDBⁱ	HostDB:ENSG00000162378.12
GeneCardsⁱ	ZYG11B
HGNCⁱ	HGNC:25820 ZYG11B
HPAⁱ	HPA028156
neXtProtⁱ	NX_Q9C0D3
OpenTargetsⁱ	ENSG00000162378
PharmGKBⁱ	PA142670468
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3665 Eukaryota ENOG410XPSX LUCA
GeneTreeⁱ	ENSGT00530000063187
HOGENOMⁱ	HOG000004816
HOVERGENⁱ	HBG108780
InParanoidⁱ	Q9C0D3
KOⁱ	K10350
OMAⁱ	HVCSKNA
OrthoDBⁱ	EOG091G031E
PhylomeDBⁱ	Q9C0D3
TreeFamⁱ	TF313007

Miscellaneous databases

ChiTaRSⁱ	ZYG11B human
GenomeRNAiⁱ	79699
Protein Ontology More...PROⁱ	PR:Q9C0D3

Gene expression databases

Bgeeⁱ	ENSG00000162378 Expressed in 208 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_ZYG11B
ExpressionAtlasⁱ	Q9C0D3 baseline and differential
Genevisibleⁱ	Q9C0D3 HS

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit 3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR001611 Leu-rich_rpt IPR032675 LRR_dom_sf
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
PROSITEⁱ	View protein in PROSITE PS51450 LRR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZY11B_HUMAN
Accessionⁱ	Q9C0D3Primary (citable) accession number: Q9C0D3 Secondary accession number(s): Q8N2X3, Q9H8L8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
	Last sequence update:	October 2, 2007
	Last modified:	November 7, 2018
	This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9C0D3 (ZY11B_HUMAN)

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Protein zyg-11 homolog B

ZYG11B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ