UniProtKB - Q9C0D3 (ZY11B_HUMAN)
Protein
Protein zyg-11 homolog B
Gene
ZYG11B
Organism
Homo sapiens (Human)
Status
Functioni
Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZER1 to target substrates bearing N-terminal glycine degrons for proteasomal degradation (PubMed:33093214). Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation (PubMed:31273098).2 Publications
GO - Biological processi
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
- protein quality control for misfolded or incompletely synthesized proteins Source: UniProtKB
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | Q9C0D3 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein zyg-11 homolog BCurated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25820, ZYG11B |
MIMi | 618673, gene |
neXtProti | NX_Q9C0D3 |
VEuPathDBi | HostDB:ENSG00000162378.12 |
Subcellular locationi
Other locations
- Cul2-RING ubiquitin ligase complex Source: UniProtKB
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 18 | L → S: Abolishes interaction with ELOC. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 79699 |
OpenTargetsi | ENSG00000162378 |
PharmGKBi | PA142670468 |
Miscellaneous databases
Pharosi | Q9C0D3, Tdark |
Genetic variation databases
BioMutai | ZYG11B |
DMDMi | 158706479 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000305087 | 1 – 744 | Protein zyg-11 homolog BAdd BLAST | 744 |
Proteomic databases
EPDi | Q9C0D3 |
jPOSTi | Q9C0D3 |
MassIVEi | Q9C0D3 |
MaxQBi | Q9C0D3 |
PaxDbi | Q9C0D3 |
PeptideAtlasi | Q9C0D3 |
PRIDEi | Q9C0D3 |
ProteomicsDBi | 80011 [Q9C0D3-1] 80012 [Q9C0D3-2] |
PTM databases
iPTMneti | Q9C0D3 |
PhosphoSitePlusi | Q9C0D3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000162378, Expressed in quadriceps femoris and 221 other tissues |
ExpressionAtlasi | Q9C0D3, baseline and differential |
Genevisiblei | Q9C0D3, HS |
Organism-specific databases
HPAi | ENSG00000162378, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
Interacts with ELOC/Elongin C.
Part of an E3 ubiquitin ligase complex including ZYG11B, CUL2 and Elongin BC.
1 PublicationBinary interactionsi
Hide detailsQ9C0D3
With | #Exp. | IntAct |
---|---|---|
CUL2 [Q13617] | 4 | EBI-1811414,EBI-456179 |
GBF1 - isoform 3 [Q92538-3] | 3 | EBI-1811414,EBI-17724521 |
OPTN [Q96CV9] | 3 | EBI-1811414,EBI-748974 |
Protein-protein interaction databases
BioGRIDi | 122820, 55 interactors |
IntActi | Q9C0D3, 42 interactors |
MINTi | Q9C0D3 |
STRINGi | 9606.ENSP00000294353 |
Miscellaneous databases
RNActi | Q9C0D3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 185 – 208 | LRR 1Add BLAST | 24 | |
Repeati | 216 – 236 | LRR 2Add BLAST | 21 | |
Repeati | 237 – 261 | LRR 3Add BLAST | 25 |
Sequence similaritiesi
Belongs to the zyg-11 family.Curated
Keywords - Domaini
Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | KOG3665, Eukaryota |
GeneTreei | ENSGT00530000063187 |
HOGENOMi | CLU_011533_1_0_1 |
InParanoidi | Q9C0D3 |
OMAi | HSAILNW |
PhylomeDBi | Q9C0D3 |
TreeFami | TF313007 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR040367, ZYG11B |
PANTHERi | PTHR12904:SF21, PTHR12904:SF21, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9C0D3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPEDQAGAAM EEASPYSLLD ICLNFLTTHL EKFCSARQDG TLCLQEPGVF
60 70 80 90 100
PQEVADRLLR TMAFHGLLND GTVGIFRGNQ MRLKRACIRK AKISAVAFRK
110 120 130 140 150
AFCHHKLVEL DATGVNADIT ITDIISGLGS NKWIQQNLQC LVLNSLTLSL
160 170 180 190 200
EDPYERCFSR LSGLRALSIT NVLFYNEDLA EVASLPRLES LDISNTSITD
210 220 230 240 250
ITALLACKDR LKSLTMHHLK CLKMTTTQIL DVVRELKHLN HLDISDDKQF
260 270 280 290 300
TSDIALRLLE QKDILPNLVS LDVSGRKHVT DKAVEAFIQQ RPSMQFVGLL
310 320 330 340 350
ATDAGYSEFL TGEGHLKVSG EANETQIAEA LKRYSERAFF VREALFHLFS
360 370 380 390 400
LTHVMEKTKP EILKLVVTGM RNHPMNLPVQ LAASACVFNL TKQDLAAGMP
410 420 430 440 450
VRLLADVTHL LLKAMEHFPN HQQLQKNCLL SLCSDRILQD VPFNRFEAAK
460 470 480 490 500
LVMQWLCNHE DQNMQRMAVA IISILAAKLS TEQTAQLGTE LFIVRQLLQI
510 520 530 540 550
VKQKTNQNSV DTTLKFTLSA LWNLTDESPT TCRHFIENQG LELFMRVLES
560 570 580 590 600
FPTESSIQQK VLGLLNNIAE VQELHSELMW KDFIDHISSL LHSVEVEVSY
610 620 630 640 650
FAAGIIAHLI SRGEQAWTLS RSQRNSLLDD LHSAILKWPT PECEMVAYRS
660 670 680 690 700
FNPFFPLLGC FTTPGVQLWA VWAMQHVCSK NPSRYCSMLI EEGGLQHLYN
710 720 730 740
IKDHEHTDPH VQQIAVAILD SLEKHIVRHG RPPPCKKQPQ ARLN
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA8DPD7 | A8DPD7_HUMAN | Protein zyg-11 homolog B | ZYG11B | 566 | Annotation score: |
Sequence cautioni
The sequence BAB21821 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 672 | W → C in BAB14596 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028224 | 1 – 578 | Missing in isoform 2. 1 PublicationAdd BLAST | 578 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB051517 mRNA Translation: BAB21821.1 Different initiation. AK023518 mRNA Translation: BAB14596.1 BC029832 mRNA Translation: AAH29832.2 |
CCDSi | CCDS30717.1 [Q9C0D3-1] |
RefSeqi | NP_078922.1, NM_024646.2 [Q9C0D3-1] |
Genome annotation databases
Ensembli | ENST00000294353; ENSP00000294353; ENSG00000162378 [Q9C0D3-1] |
GeneIDi | 79699 |
KEGGi | hsa:79699 |
UCSCi | uc001cuj.4, human [Q9C0D3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB051517 mRNA Translation: BAB21821.1 Different initiation. AK023518 mRNA Translation: BAB14596.1 BC029832 mRNA Translation: AAH29832.2 |
CCDSi | CCDS30717.1 [Q9C0D3-1] |
RefSeqi | NP_078922.1, NM_024646.2 [Q9C0D3-1] |
3D structure databases
SMRi | Q9C0D3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122820, 55 interactors |
IntActi | Q9C0D3, 42 interactors |
MINTi | Q9C0D3 |
STRINGi | 9606.ENSP00000294353 |
PTM databases
iPTMneti | Q9C0D3 |
PhosphoSitePlusi | Q9C0D3 |
Genetic variation databases
BioMutai | ZYG11B |
DMDMi | 158706479 |
Proteomic databases
EPDi | Q9C0D3 |
jPOSTi | Q9C0D3 |
MassIVEi | Q9C0D3 |
MaxQBi | Q9C0D3 |
PaxDbi | Q9C0D3 |
PeptideAtlasi | Q9C0D3 |
PRIDEi | Q9C0D3 |
ProteomicsDBi | 80011 [Q9C0D3-1] 80012 [Q9C0D3-2] |
Protocols and materials databases
Antibodypediai | 33029, 54 antibodies |
Genome annotation databases
Ensembli | ENST00000294353; ENSP00000294353; ENSG00000162378 [Q9C0D3-1] |
GeneIDi | 79699 |
KEGGi | hsa:79699 |
UCSCi | uc001cuj.4, human [Q9C0D3-1] |
Organism-specific databases
CTDi | 79699 |
DisGeNETi | 79699 |
GeneCardsi | ZYG11B |
HGNCi | HGNC:25820, ZYG11B |
HPAi | ENSG00000162378, Tissue enhanced (skeletal) |
MIMi | 618673, gene |
neXtProti | NX_Q9C0D3 |
OpenTargetsi | ENSG00000162378 |
PharmGKBi | PA142670468 |
VEuPathDBi | HostDB:ENSG00000162378.12 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3665, Eukaryota |
GeneTreei | ENSGT00530000063187 |
HOGENOMi | CLU_011533_1_0_1 |
InParanoidi | Q9C0D3 |
OMAi | HSAILNW |
PhylomeDBi | Q9C0D3 |
TreeFami | TF313007 |
Enzyme and pathway databases
PathwayCommonsi | Q9C0D3 |
Miscellaneous databases
BioGRID-ORCSi | 79699, 12 hits in 872 CRISPR screens |
ChiTaRSi | ZYG11B, human |
GenomeRNAii | 79699 |
Pharosi | Q9C0D3, Tdark |
PROi | PR:Q9C0D3 |
RNActi | Q9C0D3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162378, Expressed in quadriceps femoris and 221 other tissues |
ExpressionAtlasi | Q9C0D3, baseline and differential |
Genevisiblei | Q9C0D3, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR040367, ZYG11B |
PANTHERi | PTHR12904:SF21, PTHR12904:SF21, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZY11B_HUMAN | |
Accessioni | Q9C0D3Primary (citable) accession number: Q9C0D3 Secondary accession number(s): Q8N2X3, Q9H8L8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | October 2, 2007 | |
Last modified: | February 10, 2021 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families