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Protein

Protein zyg-11 homolog B

Gene

ZYG11B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC.

GO - Molecular functioni

  • ubiquitin-protein transferase activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein zyg-11 homolog B
Gene namesi
Name:ZYG11B
Synonyms:KIAA1730
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162378.12
HGNCiHGNC:25820 ZYG11B
neXtProtiNX_Q9C0D3

Subcellular locationi

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi18L → S: Abolishes interaction with TCEB1. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000162378
PharmGKBiPA142670468

Polymorphism and mutation databases

BioMutaiZYG11B
DMDMi158706479

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003050871 – 744Protein zyg-11 homolog BAdd BLAST744

Proteomic databases

EPDiQ9C0D3
MaxQBiQ9C0D3
PaxDbiQ9C0D3
PeptideAtlasiQ9C0D3
PRIDEiQ9C0D3
ProteomicsDBi80011
80012 [Q9C0D3-2]

PTM databases

iPTMnetiQ9C0D3
PhosphoSitePlusiQ9C0D3

Expressioni

Gene expression databases

BgeeiENSG00000162378 Expressed in 208 organ(s), highest expression level in quadriceps femoris
CleanExiHS_ZYG11B
ExpressionAtlasiQ9C0D3 baseline and differential
GenevisibleiQ9C0D3 HS

Organism-specific databases

HPAiHPA028156

Interactioni

Subunit structurei

Interacts with TCEB1/Elongin C. Part of an E3 ubiquitin ligase complex including ZYG11B, CUL2 and Elongin BC.1 Publication

Protein-protein interaction databases

BioGridi122820, 49 interactors
IntActiQ9C0D3, 5 interactors
MINTiQ9C0D3
STRINGi9606.ENSP00000294353

Structurei

3D structure databases

ProteinModelPortaliQ9C0D3
SMRiQ9C0D3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati185 – 208LRR 1Add BLAST24
Repeati216 – 236LRR 2Add BLAST21
Repeati237 – 261LRR 3Add BLAST25

Sequence similaritiesi

Belongs to the zyg-11 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG3665 Eukaryota
ENOG410XPSX LUCA
GeneTreeiENSGT00530000063187
HOGENOMiHOG000004816
HOVERGENiHBG108780
InParanoidiQ9C0D3
KOiK10350
OMAiHVCSKNA
OrthoDBiEOG091G031E
PhylomeDBiQ9C0D3
TreeFamiTF313007

Family and domain databases

Gene3Di1.25.10.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9C0D3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPEDQAGAAM EEASPYSLLD ICLNFLTTHL EKFCSARQDG TLCLQEPGVF
60 70 80 90 100
PQEVADRLLR TMAFHGLLND GTVGIFRGNQ MRLKRACIRK AKISAVAFRK
110 120 130 140 150
AFCHHKLVEL DATGVNADIT ITDIISGLGS NKWIQQNLQC LVLNSLTLSL
160 170 180 190 200
EDPYERCFSR LSGLRALSIT NVLFYNEDLA EVASLPRLES LDISNTSITD
210 220 230 240 250
ITALLACKDR LKSLTMHHLK CLKMTTTQIL DVVRELKHLN HLDISDDKQF
260 270 280 290 300
TSDIALRLLE QKDILPNLVS LDVSGRKHVT DKAVEAFIQQ RPSMQFVGLL
310 320 330 340 350
ATDAGYSEFL TGEGHLKVSG EANETQIAEA LKRYSERAFF VREALFHLFS
360 370 380 390 400
LTHVMEKTKP EILKLVVTGM RNHPMNLPVQ LAASACVFNL TKQDLAAGMP
410 420 430 440 450
VRLLADVTHL LLKAMEHFPN HQQLQKNCLL SLCSDRILQD VPFNRFEAAK
460 470 480 490 500
LVMQWLCNHE DQNMQRMAVA IISILAAKLS TEQTAQLGTE LFIVRQLLQI
510 520 530 540 550
VKQKTNQNSV DTTLKFTLSA LWNLTDESPT TCRHFIENQG LELFMRVLES
560 570 580 590 600
FPTESSIQQK VLGLLNNIAE VQELHSELMW KDFIDHISSL LHSVEVEVSY
610 620 630 640 650
FAAGIIAHLI SRGEQAWTLS RSQRNSLLDD LHSAILKWPT PECEMVAYRS
660 670 680 690 700
FNPFFPLLGC FTTPGVQLWA VWAMQHVCSK NPSRYCSMLI EEGGLQHLYN
710 720 730 740
IKDHEHTDPH VQQIAVAILD SLEKHIVRHG RPPPCKKQPQ ARLN
Length:744
Mass (Da):83,921
Last modified:October 2, 2007 - v2
Checksum:i0D8C19251CA67573
GO
Isoform 2 (identifier: Q9C0D3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-578: Missing.

Note: No experimental confirmation available.
Show »
Length:166
Mass (Da):19,006
Checksum:i0225A6D407596545
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8DPD7A8DPD7_HUMAN
Protein zyg-11 homolog B
ZYG11B
566Annotation score:

Sequence cautioni

The sequence BAB21821 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti672W → C in BAB14596 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0282241 – 578Missing in isoform 2. 1 PublicationAdd BLAST578

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051517 mRNA Translation: BAB21821.1 Different initiation.
AK023518 mRNA Translation: BAB14596.1
BC029832 mRNA Translation: AAH29832.2
CCDSiCCDS30717.1 [Q9C0D3-1]
RefSeqiNP_078922.1, NM_024646.2 [Q9C0D3-1]
UniGeneiHs.476280

Genome annotation databases

EnsembliENST00000294353; ENSP00000294353; ENSG00000162378 [Q9C0D3-1]
GeneIDi79699
KEGGihsa:79699
UCSCiuc001cuj.4 human [Q9C0D3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051517 mRNA Translation: BAB21821.1 Different initiation.
AK023518 mRNA Translation: BAB14596.1
BC029832 mRNA Translation: AAH29832.2
CCDSiCCDS30717.1 [Q9C0D3-1]
RefSeqiNP_078922.1, NM_024646.2 [Q9C0D3-1]
UniGeneiHs.476280

3D structure databases

ProteinModelPortaliQ9C0D3
SMRiQ9C0D3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122820, 49 interactors
IntActiQ9C0D3, 5 interactors
MINTiQ9C0D3
STRINGi9606.ENSP00000294353

PTM databases

iPTMnetiQ9C0D3
PhosphoSitePlusiQ9C0D3

Polymorphism and mutation databases

BioMutaiZYG11B
DMDMi158706479

Proteomic databases

EPDiQ9C0D3
MaxQBiQ9C0D3
PaxDbiQ9C0D3
PeptideAtlasiQ9C0D3
PRIDEiQ9C0D3
ProteomicsDBi80011
80012 [Q9C0D3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294353; ENSP00000294353; ENSG00000162378 [Q9C0D3-1]
GeneIDi79699
KEGGihsa:79699
UCSCiuc001cuj.4 human [Q9C0D3-1]

Organism-specific databases

CTDi79699
EuPathDBiHostDB:ENSG00000162378.12
GeneCardsiZYG11B
HGNCiHGNC:25820 ZYG11B
HPAiHPA028156
neXtProtiNX_Q9C0D3
OpenTargetsiENSG00000162378
PharmGKBiPA142670468
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3665 Eukaryota
ENOG410XPSX LUCA
GeneTreeiENSGT00530000063187
HOGENOMiHOG000004816
HOVERGENiHBG108780
InParanoidiQ9C0D3
KOiK10350
OMAiHVCSKNA
OrthoDBiEOG091G031E
PhylomeDBiQ9C0D3
TreeFamiTF313007

Miscellaneous databases

ChiTaRSiZYG11B human
GenomeRNAii79699
PROiPR:Q9C0D3

Gene expression databases

BgeeiENSG00000162378 Expressed in 208 organ(s), highest expression level in quadriceps femoris
CleanExiHS_ZYG11B
ExpressionAtlasiQ9C0D3 baseline and differential
GenevisibleiQ9C0D3 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZY11B_HUMAN
AccessioniPrimary (citable) accession number: Q9C0D3
Secondary accession number(s): Q8N2X3, Q9H8L8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 7, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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