UniProtKB - Q9C0C9 (UBE2O_HUMAN)

BLAST

>sp|Q9C0C9|UBE2O_HUMAN (E3-independent) E2 ubiquitin-conjugating enzyme OS=Homo sapiens OX=9606 GN=UBE2O PE=1 SV=3
MADPAAPTPAAPAPAQAPAPAPEAVPAPAAAPVPAPAPASDSASGPSSDSGPEAGSQRLL
FSHDLVSGRYRGSVHFGLVRLIHGEDSDSEGEEEGRGSSGCSEAGGAGHEEGRASPLRRG
YVRVQWYPEGVKQHVKETKLKLEDRSVVPRDVVRHMRSTDSQCGTVIDVNIDCAVKLIGT
NCIIYPVNSKDLQHIWPFMYGDYIAYDCWLGKVYDLKNQIILKLSNGARCSMNTEDGAKL
YDVCPHVSDSGLFFDDSYGFYPGQVLIGPAKIFSSVQWLSGVKPVLSTKSKFRVVVEEVQ
VVELKVTWITKSFCPGGTDSVSPPPSVITQENLGRVKRLGCFDHAQRQLGERCLYVFPAK
VEPAKIAWECPEKNCAQGEGSMAKKVKRLLKKQVVRIMSCSPDTQCSRDHSMEDPDKKGE
SKTKSEAESASPEETPDGSASPVEMQDEGAEEPHEAGEQLPPFLLKEGRDDRLHSAEQDA
DDEAADDTDDTSSVTSSASSTTSSQSGSGTSRKKSIPLSIKNLKRKHKRKKNKITRDFKP
GDRVAVEVVTTMTSADVMWQDGSVECNIRSNDLFPVHHLDNNEFCPGDFVVDKRVQSCPD
PAVYGVVQSGDHIGRTCMVKWFKLRPSGDDVELIGEEEDVSVYDIADHPDFRFRTTDIVI
RIGNTEDGAPHKEDEPSVGQVARVDVSSKVEVVWADNSKTIILPQHLYNIESEIEESDYD
SVEGSTSGASSDEWEDDSDSWETDNGLVEDEHPKIEEPPIPPLEQPVAPEDKGVVISEEA
ATAAVQGAVAMAAPMAGLMEKAGKDGPPKSFRELKEAIKILESLKNMTVEQLLTGSPTSP
TVEPEKPTREKKFLDDIKKLQENLKKTLDNVAIVEEEKMEAVPDVERKEDKPEGQSPVKA
EWPSETPVLCQQCGGKPGVTFTSAKGEVFSVLEFAPSNHSFKKIEFQPPEAKKFFSTVRK
EMALLATSLPEGIMVKTFEDRMDLFSALIKGPTRTPYEDGLYLFDIQLPNIYPAVPPHFC
YLSQCSGRLNPNLYDNGKVCVSLLGTWIGKGTERWTSKSSLLQVLISIQGLILVNEPYYN
EAGFDSDRGLQEGYENSRCYNEMALIRVVQSMTQLVRRPPEVFEQEIRQHFSTGGWRLVN
RIESWLETHALLEKAQALPNGVPKASSSPEPPAVAELSDSGQQEPEDGGPAPGEASQGSD
SEGGAQGLASASRDHTDQTSETAPDASVPPSVKPKKRRKSYRSFLPEKSGYPDIGFPLFP
LSKGFIKSIRGVLTQFRAALLEAGMPECTEDK

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History
Entry version 147 (07 Nov 2018)
Sequence version 3 (14 Oct 2008)
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Protein

(E3-independent) E2 ubiquitin-conjugating enzyme

Gene

UBE2O

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853).4 Publications

Catalytic activityⁱ

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N₆-monoubiquitinyl-[acceptor protein]-L-lysine.PROSITE-ProRule annotation2 Publications

Activity regulationⁱ

inhibited by phenylarsine oxide (PAO).1 Publication

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	1040	Glycyl thioester intermediate		1

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22681889
ubiquitin conjugating enzyme activity
Source: MGI
Inferred from direct assayⁱ
- 23455153
ubiquitin protein ligase activity
Source: MGI
Inferred from direct assayⁱ
- 23455153
ubiquitin-protein transferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 23455153

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of BMP signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 23455153
protein K63-linked ubiquitination
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23452853
protein monoubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 23455153
retrograde transport, endosome to Golgi
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23452853

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Transport, Ubl conjugation pathway
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS10987-MONOMER
Reactomeⁱ	R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkⁱ	Q9C0C9
SIGNORⁱ	Q9C0C9
UniPathwayⁱ	UPA00143

Protein family/group databases

MoonDBⁱ	Q9C0C9 Predicted

MoonDBⁱ

Q9C0C9 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: (E3-independent) E2 ubiquitin-conjugating enzyme (EC:2.3.2.242 Publications) Alternative name(s): E2/E3 hybrid ubiquitin-protein ligase UBE2O Ubiquitin carrier protein O Ubiquitin-conjugating enzyme E2 O Ubiquitin-conjugating enzyme E2 of 230 kDa Short name: Ubiquitin-conjugating enzyme E2-230K Ubiquitin-protein ligase O
Gene namesⁱ	Name:UBE2O Synonyms:KIAA1734
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000175931.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29554 UBE2O
MIMⁱ	617649 gene
neXtProtⁱ	NX_Q9C0C9

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	1040	C → S: Loss of function. 2 Publications		1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000175931
PharmGKBⁱ	PA142670651

Polymorphism and mutation databases

BioMutaⁱ	UBE2O
DMDMⁱ	209572710

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000280637	1 – 1292	(E3-independent) E2 ubiquitin-conjugating enzymeAdd BLAST		1292

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	50	PhosphoserineCombined sources	1
Modified residueⁱ	87	PhosphoserineCombined sources	1
Modified residueⁱ	89	PhosphoserineCombined sources	1
Modified residueⁱ	399	PhosphoserineCombined sources	1
Modified residueⁱ	401	PhosphoserineCombined sources	1
Modified residueⁱ	441	PhosphoserineCombined sources	1
Modified residueⁱ	488	PhosphothreonineCombined sources	1
Modified residueⁱ	491	PhosphothreonineCombined sources	1
Modified residueⁱ	515	PhosphoserineCombined sources	1
Modified residueⁱ	836	PhosphoserineCombined sources	1
Modified residueⁱ	838	PhosphothreonineBy similarity	1
Modified residueⁱ	839	PhosphoserineBy similarity	1
Modified residueⁱ	896	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated. Phosphorylation affects subcellular location.1 Publication

Ubiquitinated: autoubiquitinates, possibly affecting its subcellular location.1 Publication

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9C0C9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9C0C9
PaxDbⁱ	Q9C0C9
PeptideAtlas More...PeptideAtlasⁱ	Q9C0C9
PRIDEⁱ	Q9C0C9
ProteomicsDBⁱ	80004

PTM databases

iPTMnetⁱ	Q9C0C9
PhosphoSitePlusⁱ	Q9C0C9

Expressionⁱ

Tissue specificityⁱ

Predominantly expressed in skeletal muscle and heart.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000175931 Expressed in 185 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_UBE2O
ExpressionAtlasⁱ	Q9C0C9 baseline and differential
Genevisibleⁱ	Q9C0C9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA023605

HPAⁱ

HPA023605

Interactionⁱ

Subunit structureⁱ

Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
APPL1	Q9UKG1	5	EBI-2339946,EBI-741243
SFMBT2	Q5VUG0	4	EBI-2339946,EBI-12025260
Smad6	O35182	4	EBI-2339946,EBI-4321242	From Mus musculus.
Smad7	O35253	2	EBI-2339946,EBI-5274835	From Mus musculus.

Protein-protein interaction databases

BioGridⁱ	121973, 96 interactors
IntActⁱ	Q9C0C9, 41 interactors
Molecular INTeraction database More...MINTⁱ	Q9C0C9
STRINGⁱ	9606.ENSP00000323687

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9C0C9
SMRⁱ	Q9C0C9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	812 – 882	Sequence analysisAdd BLAST		71

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	512 – 536	Nuclear localization signal1 PublicationAdd BLAST		25

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	2 – 43	Ala-richAdd BLAST		42

Sequence similaritiesⁱ

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG0895 Eukaryota ENOG410XQ7W LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110680
HOVERGENⁱ	HBG080116
InParanoidⁱ	Q9C0C9
KEGG Orthology (KO) More...KOⁱ	K10581
OMAⁱ	KAEWPSE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04SX
PhylomeDBⁱ	Q9C0C9
TreeFamⁱ	TF325556

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00195 UBCc, 1 hit
Gene3Dⁱ	3.10.110.10, 1 hit
InterProⁱ	View protein in InterPro IPR000608 UBQ-conjugat_E2 IPR016135 UBQ-conjugating_enzyme/RWD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00179 UQ_con, 1 hit
SUPFAMⁱ	SSF54495 SSF54495, 1 hit
PROSITEⁱ	View protein in PROSITE PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q9C0C9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MADPAAPTPA APAPAQAPAP APEAVPAPAA APVPAPAPAS DSASGPSSDS 
        60         70         80         90        100
GPEAGSQRLL FSHDLVSGRY RGSVHFGLVR LIHGEDSDSE GEEEGRGSSG 
       110        120        130        140        150
CSEAGGAGHE EGRASPLRRG YVRVQWYPEG VKQHVKETKL KLEDRSVVPR 
       160        170        180        190        200
DVVRHMRSTD SQCGTVIDVN IDCAVKLIGT NCIIYPVNSK DLQHIWPFMY 
       210        220        230        240        250
GDYIAYDCWL GKVYDLKNQI ILKLSNGARC SMNTEDGAKL YDVCPHVSDS 
       260        270        280        290        300
GLFFDDSYGF YPGQVLIGPA KIFSSVQWLS GVKPVLSTKS KFRVVVEEVQ 
       310        320        330        340        350
VVELKVTWIT KSFCPGGTDS VSPPPSVITQ ENLGRVKRLG CFDHAQRQLG 
       360        370        380        390        400
ERCLYVFPAK VEPAKIAWEC PEKNCAQGEG SMAKKVKRLL KKQVVRIMSC 
       410        420        430        440        450
SPDTQCSRDH SMEDPDKKGE SKTKSEAESA SPEETPDGSA SPVEMQDEGA 
       460        470        480        490        500
EEPHEAGEQL PPFLLKEGRD DRLHSAEQDA DDEAADDTDD TSSVTSSASS 
       510        520        530        540        550
TTSSQSGSGT SRKKSIPLSI KNLKRKHKRK KNKITRDFKP GDRVAVEVVT 
       560        570        580        590        600
TMTSADVMWQ DGSVECNIRS NDLFPVHHLD NNEFCPGDFV VDKRVQSCPD 
       610        620        630        640        650
PAVYGVVQSG DHIGRTCMVK WFKLRPSGDD VELIGEEEDV SVYDIADHPD 
       660        670        680        690        700
FRFRTTDIVI RIGNTEDGAP HKEDEPSVGQ VARVDVSSKV EVVWADNSKT 
       710        720        730        740        750
IILPQHLYNI ESEIEESDYD SVEGSTSGAS SDEWEDDSDS WETDNGLVED 
       760        770        780        790        800
EHPKIEEPPI PPLEQPVAPE DKGVVISEEA ATAAVQGAVA MAAPMAGLME 
       810        820        830        840        850
KAGKDGPPKS FRELKEAIKI LESLKNMTVE QLLTGSPTSP TVEPEKPTRE 
       860        870        880        890        900
KKFLDDIKKL QENLKKTLDN VAIVEEEKME AVPDVERKED KPEGQSPVKA 
       910        920        930        940        950
EWPSETPVLC QQCGGKPGVT FTSAKGEVFS VLEFAPSNHS FKKIEFQPPE 
       960        970        980        990       1000
AKKFFSTVRK EMALLATSLP EGIMVKTFED RMDLFSALIK GPTRTPYEDG 
      1010       1020       1030       1040       1050
LYLFDIQLPN IYPAVPPHFC YLSQCSGRLN PNLYDNGKVC VSLLGTWIGK 
      1060       1070       1080       1090       1100
GTERWTSKSS LLQVLISIQG LILVNEPYYN EAGFDSDRGL QEGYENSRCY 
      1110       1120       1130       1140       1150
NEMALIRVVQ SMTQLVRRPP EVFEQEIRQH FSTGGWRLVN RIESWLETHA 
      1160       1170       1180       1190       1200
LLEKAQALPN GVPKASSSPE PPAVAELSDS GQQEPEDGGP APGEASQGSD 
      1210       1220       1230       1240       1250
SEGGAQGLAS ASRDHTDQTS ETAPDASVPP SVKPKKRRKS YRSFLPEKSG 
      1260       1270       1280       1290 
YPDIGFPLFP LSKGFIKSIR GVLTQFRAAL LEAGMPECTE DK

Length:1,292

Mass (Da):141,293

Last modified:October 14, 2008 - v3

Checksum:ⁱC9DF6395A32E9AB0

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7ES11	K7ES11_HUMAN	(E3-independent) E2 ubiquitin-conju... (E3-independent) E2 ubiquitin-conjugating enzyme	UBE2O	807	Annotation score:
K7EQ12	K7EQ12_HUMAN	(E3-independent) E2 ubiquitin-conju... (E3-independent) E2 ubiquitin-conjugating enzyme	UBE2O	189	Annotation score:

Sequence cautionⁱ

The sequence AAH22237 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAH25977 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAH36820 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAH51868 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAB14320 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAB14948 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAB15313 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAB21825 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	50	S → F in BAB21825 (PubMed:11214970).Curated	1
Sequence conflictⁱ	675	E → EQ in BAB15313 (PubMed:14702039).Curated	1
Sequence conflictⁱ	1047	W → C in AAH22237 (PubMed:15489334).Curated	1
Sequence conflictⁱ	1143	E → D in AAH25977 (PubMed:15489334).Curated	1
Sequence conflictⁱ	1150	A → T in BAB14320 (PubMed:14702039).Curated	1
Sequence conflictⁱ	1261	L → P in BAB14320 (PubMed:14702039).Curated	1
Sequence conflictⁱ	1290	E → G in BAB14948 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_031184	1207	G → S4 PublicationsCorresponds to variant dbSNP:rs3803739Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB051521 mRNA Translation: BAB21825.1 Different initiation. AC090699 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89396.1 BC004525 mRNA Translation: AAH04525.2 BC022237 mRNA Translation: AAH22237.1 Different initiation. BC025977 mRNA Translation: AAH25977.1 Different initiation. BC036820 mRNA Translation: AAH36820.1 Different initiation. BC051868 mRNA Translation: AAH51868.2 Different initiation. AL832432 mRNA Translation: CAH10644.1 AK022940 mRNA Translation: BAB14320.1 Different initiation. AK024657 mRNA Translation: BAB14948.1 Different initiation. AK025999 mRNA Translation: BAB15313.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32742.1
NCBI Reference Sequences More...RefSeqⁱ	NP_071349.3, NM_022066.3
UniGeneⁱ	Hs.16130

Genome annotation databases

Ensemblⁱ	ENST00000319380; ENSP00000323687; ENSG00000175931
GeneIDⁱ	63893
KEGGⁱ	hsa:63893
UCSC genome browser More...UCSCⁱ	uc002jrm.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9C0C9	Ubiquitin-conjugating enzyme E2 O		CALJA		1301	UniRef90_Q9C0C9
Uncharacterized protein		AOTNA		1295
Ubiquitin-conjugating enzyme E2 O		MACMU		1293
Uncharacterized protein		CERAT		1293
Uncharacterized protein		PAPAN		1293
+33

Protein	Similar proteins		Species	Score	Length	Source
Q9C0C9	(E3-independent) E2 ubiquitin-conjugating enzyme UBE2O		MOUSE		1288	UniRef50_Q9C0C9
Ubiquitin-conjugating enzyme E2 O		CALJA		1301
Uncharacterized protein		AOTNA		1295
Uncharacterized protein		CHLSB		1293
Ubiquitin-conjugating enzyme E2 O		MACMU		1293
+373

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB051521 mRNA Translation: BAB21825.1 Different initiation. AC090699 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89396.1 BC004525 mRNA Translation: AAH04525.2 BC022237 mRNA Translation: AAH22237.1 Different initiation. BC025977 mRNA Translation: AAH25977.1 Different initiation. BC036820 mRNA Translation: AAH36820.1 Different initiation. BC051868 mRNA Translation: AAH51868.2 Different initiation. AL832432 mRNA Translation: CAH10644.1 AK022940 mRNA Translation: BAB14320.1 Different initiation. AK024657 mRNA Translation: BAB14948.1 Different initiation. AK025999 mRNA Translation: BAB15313.1 Different initiation.
CCDSⁱ	CCDS32742.1
RefSeqⁱ	NP_071349.3, NM_022066.3
UniGeneⁱ	Hs.16130

3D structure databases

ProteinModelPortalⁱ	Q9C0C9
SMRⁱ	Q9C0C9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121973, 96 interactors
IntActⁱ	Q9C0C9, 41 interactors
MINTⁱ	Q9C0C9
STRINGⁱ	9606.ENSP00000323687

Protein family/group databases

MoonDBⁱ	Q9C0C9 Predicted

MoonDBⁱ

Q9C0C9 Predicted

PTM databases

iPTMnetⁱ	Q9C0C9
PhosphoSitePlusⁱ	Q9C0C9

Polymorphism and mutation databases

BioMutaⁱ	UBE2O
DMDMⁱ	209572710

Proteomic databases

EPDⁱ	Q9C0C9
MaxQBⁱ	Q9C0C9
PaxDbⁱ	Q9C0C9
PeptideAtlasⁱ	Q9C0C9
PRIDEⁱ	Q9C0C9
ProteomicsDBⁱ	80004

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000319380; ENSP00000323687; ENSG00000175931
GeneIDⁱ	63893
KEGGⁱ	hsa:63893
UCSCⁱ	uc002jrm.5 human

Organism-specific databases

CTDⁱ	63893
EuPathDBⁱ	HostDB:ENSG00000175931.12
GeneCardsⁱ	UBE2O
H-InvDBⁱ	HIX0020035
HGNCⁱ	HGNC:29554 UBE2O
HPAⁱ	HPA023605
MIMⁱ	617649 gene
neXtProtⁱ	NX_Q9C0C9
OpenTargetsⁱ	ENSG00000175931
PharmGKBⁱ	PA142670651
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0895 Eukaryota ENOG410XQ7W LUCA
GeneTreeⁱ	ENSGT00730000110680
HOVERGENⁱ	HBG080116
InParanoidⁱ	Q9C0C9
KOⁱ	K10581
OMAⁱ	KAEWPSE
OrthoDBⁱ	EOG091G04SX
PhylomeDBⁱ	Q9C0C9
TreeFamⁱ	TF325556

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
BioCycⁱ	MetaCyc:HS10987-MONOMER
Reactomeⁱ	R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkⁱ	Q9C0C9
SIGNORⁱ	Q9C0C9

Miscellaneous databases

ChiTaRSⁱ	UBE2O human
GeneWikiⁱ	UBE2O
GenomeRNAiⁱ	63893
Protein Ontology More...PROⁱ	PR:Q9C0C9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000175931 Expressed in 185 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_UBE2O
ExpressionAtlasⁱ	Q9C0C9 baseline and differential
Genevisibleⁱ	Q9C0C9 HS

Family and domain databases

CDDⁱ	cd00195 UBCc, 1 hit
Gene3Dⁱ	3.10.110.10, 1 hit
InterProⁱ	View protein in InterPro IPR000608 UBQ-conjugat_E2 IPR016135 UBQ-conjugating_enzyme/RWD
Pfamⁱ	View protein in Pfam PF00179 UQ_con, 1 hit
SUPFAMⁱ	SSF54495 SSF54495, 1 hit
PROSITEⁱ	View protein in PROSITE PS50127 UBIQUITIN_CONJUGAT_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	UBE2O_HUMAN
Accessionⁱ	Q9C0C9Primary (citable) accession number: Q9C0C9 Secondary accession number(s): A6NDU5 Q9H9B2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
	Last sequence update:	October 14, 2008
	Last modified:	November 7, 2018
	This is version 147 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

UniProtKB

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9C0C9 (UBE2O_HUMAN)

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(E3-independent) E2 ubiquitin-conjugating enzyme

UBE2O

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ