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Entry version 159 (23 Feb 2022)
Sequence version 2 (15 Jan 2008)
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Protein

Activating molecule in BECN1-regulated autophagy protein 1

Gene

AMBRA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex involved in cell cycle control and autophagy (PubMed:20921139, PubMed:23524951, PubMed:24587252, PubMed:33854232, PubMed:33854235, PubMed:33854239, PubMed:32333458).

The DCX(AMBRA1) complex specifically mediates the polyubiquitination of target proteins such as BECN1, CCND1, CCND2, CCND3, ELOC and ULK1 (PubMed:23524951, PubMed:33854232, PubMed:33854235, PubMed:33854239).

Acts as an upstream master regulator of the transition from G1 to S cell phase: AMBRA1 specifically recognizes and binds phosphorylated cyclin-D (CCND1, CCND2 and CCND3), leading to cyclin-D ubiquitination by the DCX(AMBRA1) complex and subsequent degradation (PubMed:33854232, PubMed:33854235, PubMed:33854239).

By controlling the transition from G1 to S phase and cyclin-D degradation, AMBRA1 acts as a tumor suppressor that promotes genomic integrity during DNA replication and counteracts developmental abnormalities and tumor growth (PubMed:33854232, PubMed:33854235, PubMed:33854239).

AMBRA1 also regulates the cell cycle by promoting MYC dephosphorylation and degradation independently of the DCX(AMBRA1) complex: acts via interaction with the catalytic subunit of protein phosphatase 2A (PPP2CA), which enhances interaction between PPP2CA and MYC, leading to MYC dephosphorylation and degradation (PubMed:25803737, PubMed:25438055).

Acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:25499913, PubMed:30166453).

Acts as a key regulator of autophagy by modulating the BECN1-PIK3C3 complex: controls protein turnover during neuronal development, and regulates normal cell survival and proliferation (PubMed:21358617).

In normal conditions, AMBRA1 is tethered to the cytoskeleton via interaction with dyneins DYNLL1 and DYNLL2 (PubMed:20921139).

Upon autophagy induction, AMBRA1 is released from the cytoskeletal docking site to induce autophagosome nucleation by mediating ubiquitination of proteins involved in autophagy (PubMed:20921139).

The DCX(AMBRA1) complex mediates 'Lys-63'-linked ubiquitination of BECN1, increasing the association between BECN1 and PIK3C3 to promote PIK3C3 activity (By similarity).

In collaboration with TRAF6, AMBRA1 mediates 'Lys-63'-linked ubiquitination of ULK1 following autophagy induction, promoting ULK1 stability and kinase activity (PubMed:23524951).

Also activates ULK1 via interaction with TRIM32: TRIM32 stimulates ULK1 through unanchored 'Lys-63'-linked polyubiquitin chains (PubMed:31123703).

Also acts as an activator of mitophagy via interaction with PRKN and LC3 proteins (MAP1LC3A, MAP1LC3B or MAP1LC3C); possibly by bringing damaged mitochondria onto autophagosomes (PubMed:21753002, PubMed:25215947).

Also activates mitophagy by acting as a cofactor for HUWE1; acts by promoting HUWE1-mediated ubiquitination of MFN2 (PubMed:30217973).

AMBRA1 is also involved in regulatory T-cells (Treg) differentiation by promoting FOXO3 dephosphorylation independently of the DCX(AMBRA1) complex: acts via interaction with PPP2CA, which enhances interaction between PPP2CA and FOXO3, leading to FOXO3 dephosphorylation and stabilization (PubMed:30513302).

May act as a regulator of intracellular trafficking, regulating the localization of active PTK2/FAK and SRC (By similarity).

Also involved in transcription regulation by acting as a scaffold for protein complexes at chromatin (By similarity).

By similarity17 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.5 Publications
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processAutophagy, Cell cycle, Differentiation, Neurogenesis, Transcription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9C0C7

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1632852, Macroautophagy

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9C0C7

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9C0C7

UniPathway: a resource for the exploration and annotation of metabolic pathways

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UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Activating molecule in BECN1-regulated autophagy protein 11 Publication
Alternative name(s):
DDB1- and CUL4-associated factor 31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AMBRA11 PublicationImported
Synonyms:DCAF31 Publication, KIAA17361 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:25990, AMBRA1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611359, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9C0C7

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000110497

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endoplasmic reticulum, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1 – 43Missing : Abolished interaction with DDB1. 1 PublicationAdd BLAST43
Mutagenesisi1 – 22Missing : Abolished interaction with DDB1. 1 PublicationAdd BLAST22
Mutagenesisi52S → A: Impaired phosphorylation by MTOR, leading to strong induction of autophagy. Does not affect interaction with DDB1. 1 Publication1
Mutagenesisi52S → E: Phospho-mimetic mutant; abolished ability to promote autophagy. Does not affect interaction with DDB1. 1 Publication1
Mutagenesisi275 – 277PQP → AQA: Abolished interaction with PPP2CA and MYC, leading to decreased MYC dephosphorylation; when associated with 1206-A--A-1208. Abolished interaction with PPP2CA and FOXO3, leading to decreased FOXO3 dephosphorylation; when associated with 1206-A--A-1208. 2 Publications3
Mutagenesisi482D → A: Abolished cleavage by caspases without affecting cleavage by calpains. 1 Publication1
Mutagenesisi620E → A: Abolished interaction with TRAF6. 1 Publication1
Mutagenesisi642E → A: Does not affect interaction with TRAF6. 1 Publication1
Mutagenesisi682E → A: Abolished interaction with TRAF6. 1 Publication1
Mutagenesisi918E → A: Does not affect interaction with TRAF6. 1 Publication1
Mutagenesisi1043S → A: Abolished phosphorylation by CHUK/IKKA, leading to impaired interaction with ATG8 family proteins and reduced mitophagic activity. 1 Publication1
Mutagenesisi1043S → D: Phospho-mimetic mutant; increased interaction with ATG8 family proteins and increased mitophagic activity. 1 Publication1
Mutagenesisi1049 – 1052WDQL → ADQA: Abolished interaction with LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). 1 Publication4
Mutagenesisi1105Q → A in TAT1 mutant; abolished interaction with DYNLL1 and DYNLL2, leading to constitutive induction of autophagy. 1 Publication1
Mutagenesisi1117Q → A in TAT2 mutant; abolished interaction with DYNLL1 and DYNLL2, leading to constitutive induction of autophagy. 1 Publication1
Mutagenesisi1134E → A: Does not affect interaction with TRAF6. 1 Publication1
Mutagenesisi1206 – 1208PQP → AQA: Abolished interaction with PPP2CA and MYC, leading to decreased MYC dephosphorylation; when associated with 275-A--A-277. Abolished interaction with PPP2CA and FOXO3, leading to decreased FOXO3 dephosphorylation; when associated with 275-A--A-277. 1 Publication3

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...
DisGeNETi
55626

Open Targets

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OpenTargetsi
ENSG00000110497

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162376307

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q9C0C7, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
AMBRA1

Domain mapping of disease mutations (DMDM)

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DMDMi
166215833

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003157031 – 1298Activating molecule in BECN1-regulated autophagy protein 1Add BLAST1298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki45Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei52Phosphoserine; by MTOR1 Publication1
Modified residuei328PhosphoserineCombined sources1
Modified residuei394PhosphoserineCombined sources1
Modified residuei443PhosphoserineCombined sources1
Modified residuei635PhosphoserineCombined sources1
Modified residuei639PhosphoserineCombined sources1
Modified residuei747Asymmetric dimethylarginineBy similarity1
Modified residuei1043Phosphoserine; by IKKA1 Publication1
Modified residuei1205PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-52 by MTOR inhibits its ability to regulate autophagy and mediate ubiquitination of ULK1 (PubMed:23524951). Phosphorylation by ULK1 in response to autophagy induction abolishes interaction with DYNLL1 and DYNLL2, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylation by MTOR inhibits interaction with PPP2CA and subsequent dephosphorylation of MYC (PubMed:25438055). Phosphorylation at Ser-1043 by CHUK/IKKA promotes its interaction with ATG8 family proteins GABARAP and MAP1LC3B and its mitophagic activity (PubMed:30217973).4 Publications
Ubiquitinated by RNF2 via 'Lys-48'-linkage in unstressed cells, leading to its degradation by the proteasome (PubMed:25499913). Induction of autophagy promotes stabilization via interaction with CUL4 (CUL4A or CUL4B) and DDB1 (PubMed:25499913). Upon prolonged starvation, ubiquitinated and degraded, terminating the autophagy response (PubMed:25499913).1 Publication
Undergoes proteolytic processing by caspase-6 (CASP6), caspase-7 (CASP7) and caspase-8 (CASP8) during apoptosis, resulting in the dismantling of the autophagic machinery and the accomplishment of the programmed cell death program (PubMed:22441670). Also cleaved by calpains during apoptosis, which mediate a complete proteolytic degradation (PubMed:22441670).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei482 – 483Cleavage; by caspase-6, caspase-7 and caspase-81 Publication2

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9C0C7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9C0C7

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9C0C7

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9C0C7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9C0C7

PeptideAtlas

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PeptideAtlasi
Q9C0C7

PRoteomics IDEntifications database

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PRIDEi
Q9C0C7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
32296
79999 [Q9C0C7-1]
80000 [Q9C0C7-2]
80001 [Q9C0C7-3]
80002 [Q9C0C7-4]
80003 [Q9C0C7-5]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
Q9C0C7, 3 sites, 1 O-linked glycan (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9C0C7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9C0C7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Negatively regulated by microRNA 7-3HG (miR7-3HG), which targets the 3' untranslated (3'-UTR) region of AMBRA1 transcripts, leading to a decrease of AMBRA1 mRNA and protein levels, thereby inhibiting autophagy (PubMed:28059583). Strongly up-regulated during egulatory T-cells (Treg) differentiation (PubMed:30513302).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110497, Expressed in stomach and 242 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9C0C7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9C0C7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000110497, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the DCX(AMBRA1) E3 ubiquitin ligase complex, also named CRL4(AMBRA1), at least composed of CUL4 (CUL4A or CUL4B), DDB1, AMBRA1 and RBX1 (PubMed:25499913, PubMed:16949367, PubMed:30166453, PubMed:33854232, PubMed:33854239).

Interacts with BECN1 (PubMed:21358617, PubMed:25438055). Probably forms a complex with BECN1 and PIK3C3 (By similarity).

Interacts with BECN2 (PubMed:23954414).

Interacts with BCL2; leading to prevent interaction with BCN1 and autophagy, interaction is disrupted upon autophagy induction (PubMed:21358617).

Interacts with ULK1 (PubMed:25438055).

Interacts (via PxP motifs) with PPP2CA; enhancing interaction between PPP2CA and MYC or FOXO3 (PubMed:25438055, PubMed:30513302).

Forms a complex with PPP2CA and BECN1; AMBRA1 and BECN1 components of the complex regulate MYC stability via different pathways (PubMed:25803737).

Interacts (TQT motifs) with DYNLL1 and DYNLL2; tethering AMBRA1 and the BECN1-PIK3C3 complex in absence of autophagy (PubMed:20921139).

Interacts with TRAF6; interaction is required to mediate 'Lys-63'-linked ubiquitination of ULK1 (PubMed:23524951).

Interacts with TRIM32; promoting activation of ULK1 by TRIM32 via unanchored 'Lys-63'-linked polyubiquitin chains (PubMed:31123703).

Interacts with PRKN (By similarity).

Interacts (via LIR motif) with LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C) (PubMed:25215947, PubMed:30217973).

Interacts with HUWE1 (PubMed:30217973).

Interacts with PTK2/FAK (By similarity).

Interacts with SRC; required for SRC trafficking to autophagosomes (By similarity).

By similarity15 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
120765, 233 interactors

Database of interacting proteins

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DIPi
DIP-53597N

Protein interaction database and analysis system

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IntActi
Q9C0C7, 53 interactors

Molecular INTeraction database

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MINTi
Q9C0C7

STRING: functional protein association networks

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STRINGi
9606.ENSP00000431926

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q9C0C7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9C0C7

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati51 – 90WD 1Add BLAST40
Repeati93 – 133WD 2Add BLAST41
Repeati135 – 175WD 3Add BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 22Interaction with DDB11 PublicationAdd BLAST22
Regioni254 – 284DisorderedSequence analysisAdd BLAST31
Regioni343 – 413DisorderedSequence analysisAdd BLAST71
Regioni458 – 494DisorderedSequence analysisAdd BLAST37
Regioni538 – 561DisorderedSequence analysisAdd BLAST24
Regioni590 – 690DisorderedSequence analysisAdd BLAST101
Regioni747 – 796DisorderedSequence analysisAdd BLAST50
Regioni1060 – 1079DisorderedSequence analysisAdd BLAST20
Regioni1112 – 1143DisorderedSequence analysisAdd BLAST32
Regioni1190 – 1214DisorderedSequence analysisAdd BLAST25
Regioni1227 – 1298DisorderedSequence analysisAdd BLAST72

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi275 – 281PxP motif 12 Publications7
Motifi1043 – 1052LIR1 Publication10
Motifi1104 – 1106TQT motif 11 Publication3
Motifi1116 – 1118TQT motif 21 Publication3
Motifi1206 – 1212PxP motif 22 Publications7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi266 – 280Pro residuesSequence analysisAdd BLAST15
Compositional biasi343 – 389Polar residuesSequence analysisAdd BLAST47
Compositional biasi480 – 494Polar residuesSequence analysisAdd BLAST15
Compositional biasi590 – 648Polar residuesSequence analysisAdd BLAST59
Compositional biasi656 – 677Polar residuesSequence analysisAdd BLAST22
Compositional biasi747 – 769Polar residuesSequence analysisAdd BLAST23
Compositional biasi1242 – 1260Pro residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PxP motifs mediate interaction with the catalytic subunit of protein phosphatase 2A (PPP2CA).2 Publications
The TQT motifs mediate interaction with the dynein light chain proteins DYNLL1 and DYNLL2, tethering AMBRA1 to the cytoskeleton in absence of autophagy.1 Publication
The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family proteins GABARAP and MAP1LC3B.2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat AMBRA1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0266, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016223

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008882_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9C0C7

Identification of Orthologs from Complete Genome Data

More...
OMAi
PPAECCQ

Database of Orthologous Groups

More...
OrthoDBi
488527at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9C0C7

TreeFam database of animal gene trees

More...
TreeFami
TF328981

Family and domain databases

Database of protein disorder

More...
DisProti
DP01328

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR036322, WD40_repeat_dom_sf

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9C0C7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVVPEKNAV RILWGRERGA RAMGAQRLLQ ELVEDKTRWM KWEGKRVELP
60 70 80 90 100
DSPRSTFLLA FSPDRTLLAS THVNHNIYIT EVKTGKCVHS LIGHRRTPWC
110 120 130 140 150
VTFHPTISGL IASGCLDGEV RIWDLHGGSE SWFTDSNNAI ASLAFHPTAQ
160 170 180 190 200
LLLIATANEI HFWDWSRREP FAVVKTASEM ERVRLVRFDP LGHYLLTAIV
210 220 230 240 250
NPSNQQGDDE PEIPIDGTEL SHYRQRALLQ SQPVRRTPLL HNFLHMLSSR
260 270 280 290 300
SSGIQVGEQS TVQDSATPSP PPPPPQPSTE RPRTSAYIRL RQRVSYPTAE
310 320 330 340 350
CCQHLGILCL CSRCSGTRVP SLLPHQDSVP PASARATTPS FSFVQTEPFH
360 370 380 390 400
PPEQASSTQQ DQGLLNRPSA FSTVQSSTAG NTLRNLSLGP TRRSLGGPLS
410 420 430 440 450
SHPSRYHREI APGLTGSEWT RTVLSLNSRS EAESMPPPRT SASSVSLLSV
460 470 480 490 500
LRQQEGGSQA SVYTSATEGR GFPASGLATE SDGGNGSSQN NSGSIRHELQ
510 520 530 540 550
CDLRRFFLEY DRLQELDQSL SGEAPQTQQA QEMLNNNIES ERPGPSHQPT
560 570 580 590 600
PHSSENNSNL SRGHLNRCRA CHNLLTFNND TLRWERTTPN YSSGEASSSW
610 620 630 640 650
QVPSSFESVP SSGSQLPPLE RTEGQTPSSS RLELSSSASP QEERTVGVAF
660 670 680 690 700
NQETGHWERI YTQSSRSGTV SQEALHQDMP EESSEEDSLR RRLLESSLIS
710 720 730 740 750
LSRYDGAGSR EHPIYPDPAR LSPAAYYAQR MIQYLSRRDS IRQRSMRYQQ
760 770 780 790 800
NRLRSSTSSS SSDNQGPSVE GTDLEFEDFE DNGDRSRHRA PRNARMSAPS
810 820 830 840 850
LGRFVPRRFL LPEYLPYAGI FHERGQPGLA THSSVNRVLA GAVIGDGQSA
860 870 880 890 900
VASNIANTTY RLQWWDFTKF DLPEISNASV NVLVQNCKIY NDASCDISAD
910 920 930 940 950
GQLLAAFIPS SQRGFPDEGI LAVYSLAPHN LGEMLYTKRF GPNAISVSLS
960 970 980 990 1000
PMGRYVMVGL ASRRILLHPS TEHMVAQVFR LQQAHGGETS MRRVFNVLYP
1010 1020 1030 1040 1050
MPADQRRHVS INSARWLPEP GLGLAYGTNK GDLVICRPEA LNSGVEYYWD
1060 1070 1080 1090 1100
QLNETVFTVH SNSRSSERPG TSRATWRTDR DMGLMNAIGL QPRNPATSVT
1110 1120 1130 1140 1150
SQGTQTLALQ LQNAETQTER EVPEPGTAAS GPGEGEGSEY GASGEDALSR
1160 1170 1180 1190 1200
IQRLMAEGGM TAVVQREQST TMASMGGFGN NIIVSHRIHR SSQTGTEPGA
1210 1220 1230 1240 1250
AHTSSPQPST SRGLLPEAGQ LAERGLSPRT ASWDQPGTPG REPTQPTLPS
1260 1270 1280 1290
SSPVPIPVSL PSAEGPTLHC ELTNNNHLLD GGSSRGDAAG PRGEPRNR
Length:1,298
Mass (Da):142,507
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i44FE9CDFFFE6811E
GO
Isoform 2 (identifier: Q9C0C7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     721-780: Missing.

Show »
Length:1,238
Mass (Da):135,528
Checksum:iEE24A481D1388999
GO
Isoform 3 (identifier: Q9C0C7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     691-719: Missing.

Show »
Length:1,269
Mass (Da):139,269
Checksum:iC9902123C4EE6199
GO
Isoform 4 (identifier: Q9C0C7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-344: Missing.

Show »
Length:1,208
Mass (Da):132,837
Checksum:i3BA3D281C30318F1
GO
Isoform 5 (identifier: Q9C0C7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-344: Missing.
     691-691: R → RRSLALSPRL...ITGVSHRAWP

Show »
Length:1,301
Mass (Da):142,585
Checksum:i0EF81F37DFCA142D
GO
Isoform 6 (identifier: Q9C0C7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-344: Missing.
     691-719: Missing.
     864-880: WWDFTKFDLPEISNASV → GGGTSLSLTSLKSVMLP
     881-1298: Missing.

Show »
Length:761
Mass (Da):84,428
Checksum:i4512BD3DCDD64FE1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A075B6T1A0A075B6T1_HUMAN
Activating molecule in BECN1-regula...
AMBRA1
1,179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YE34H0YE34_HUMAN
Activating molecule in BECN1-regula...
AMBRA1
256Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PL55E9PL55_HUMAN
Activating molecule in BECN1-regula...
AMBRA1
24Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AL834190 differs from that shown. Reason: Frameshift.Curated
The sequence BAA91067 differs from that shown. Reason: Frameshift.Curated
The sequence BAB14457 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB21827 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti165W → R in BAA91067 (PubMed:14702039).Curated1
Sequence conflicti793N → K in AL834190 (PubMed:17974005).Curated1
Sequence conflicti869K → E in BAB14457 (PubMed:14702039).Curated1
Sequence conflicti983Q → L in BAB14457 (PubMed:14702039).Curated1
Sequence conflicti1105Q → E in AAH45609 (PubMed:15489334).Curated1
Sequence conflicti1268L → V in AAH45609 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08505180T → M Found in a child with spina bifida; unknown pathological significance; reduced induction of autophagy. 1 Publication1
Natural variantiVAR_085052364L → F Found in a fetus with encephalocele; unknown pathological significance; reduced induction of autophagy. 1 Publication1
Natural variantiVAR_085053833S → F Found in a child with spina bifida; unknown pathological significance; reduced induction of autophagy. 1 Publication1
Natural variantiVAR_085054974M → V Found in a fetus with encephalocele and spina bifida; unknown pathological significance; reduced induction of autophagy. 1 Publication1
Natural variantiVAR_0850551043S → F Found in a fetus with anencephaly and spina bifida; unknown pathological significance; does not impair induction of autophagy. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030654255 – 344Missing in isoform 4, isoform 5 and isoform 6. 3 PublicationsAdd BLAST90
Alternative sequenceiVSP_030655691 – 719Missing in isoform 3 and isoform 6. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_030656691R → RRSLALSPRLEYSGAILAHC KLRLPGSCHSPASASQVAGT TGAHHHARLIFAFLVEMEFH HVSQAGLELLTSGDLPTSAS QSAGITGVSHRAWP in isoform 5. 1 Publication1
Alternative sequenceiVSP_030657721 – 780Missing in isoform 2. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_045989864 – 880WWDFT…SNASV → GGGTSLSLTSLKSVMLP in isoform 6. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_045990881 – 1298Missing in isoform 6. 1 PublicationAdd BLAST418

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ870924 mRNA Translation: ABI74670.1
AB051523 mRNA Translation: BAB21827.1 Different initiation.
AK000301 mRNA Translation: BAA91067.1 Frameshift.
AK023197 mRNA Translation: BAB14457.1 Different initiation.
AL834190 mRNA No translation available.
AC024293 Genomic DNA No translation available.
AC115097 Genomic DNA No translation available.
AC116021 Genomic DNA No translation available.
AC127035 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW67996.1
CH471064 Genomic DNA Translation: EAW67999.1
CH471064 Genomic DNA Translation: EAW68001.1
BC045609 mRNA Translation: AAH45609.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31475.1 [Q9C0C7-4]
CCDS73281.1 [Q9C0C7-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001254711.1, NM_001267782.1 [Q9C0C7-5]
NP_001254712.1, NM_001267783.1
NP_001287660.1, NM_001300731.1 [Q9C0C7-2]
NP_060219.2, NM_017749.3 [Q9C0C7-4]
XP_005253066.1, XM_005253009.3 [Q9C0C7-1]
XP_005253068.1, XM_005253011.3 [Q9C0C7-3]
XP_005253071.1, XM_005253014.3
XP_006718322.1, XM_006718259.2 [Q9C0C7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000314845; ENSP00000318313; ENSG00000110497 [Q9C0C7-4]
ENST00000458649; ENSP00000415327; ENSG00000110497
ENST00000528950; ENSP00000433945; ENSG00000110497 [Q9C0C7-3]
ENST00000534300; ENSP00000431926; ENSG00000110497 [Q9C0C7-2]
ENST00000683756; ENSP00000508322; ENSG00000110497

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55626

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55626

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...
MANE-Selecti
ENST00000683756.1; ENSP00000508322.1; NM_001387011.1; NP_001373940.1

UCSC genome browser

More...
UCSCi
uc001ncu.3, human [Q9C0C7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ870924 mRNA Translation: ABI74670.1
AB051523 mRNA Translation: BAB21827.1 Different initiation.
AK000301 mRNA Translation: BAA91067.1 Frameshift.
AK023197 mRNA Translation: BAB14457.1 Different initiation.
AL834190 mRNA No translation available.
AC024293 Genomic DNA No translation available.
AC115097 Genomic DNA No translation available.
AC116021 Genomic DNA No translation available.
AC127035 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW67996.1
CH471064 Genomic DNA Translation: EAW67999.1
CH471064 Genomic DNA Translation: EAW68001.1
BC045609 mRNA Translation: AAH45609.1
CCDSiCCDS31475.1 [Q9C0C7-4]
CCDS73281.1 [Q9C0C7-2]
RefSeqiNP_001254711.1, NM_001267782.1 [Q9C0C7-5]
NP_001254712.1, NM_001267783.1
NP_001287660.1, NM_001300731.1 [Q9C0C7-2]
NP_060219.2, NM_017749.3 [Q9C0C7-4]
XP_005253066.1, XM_005253009.3 [Q9C0C7-1]
XP_005253068.1, XM_005253011.3 [Q9C0C7-3]
XP_005253071.1, XM_005253014.3
XP_006718322.1, XM_006718259.2 [Q9C0C7-1]

3D structure databases

SMRiQ9C0C7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120765, 233 interactors
DIPiDIP-53597N
IntActiQ9C0C7, 53 interactors
MINTiQ9C0C7
STRINGi9606.ENSP00000431926

PTM databases

GlyGeniQ9C0C7, 3 sites, 1 O-linked glycan (3 sites)
iPTMnetiQ9C0C7
PhosphoSitePlusiQ9C0C7

Genetic variation databases

BioMutaiAMBRA1
DMDMi166215833

Proteomic databases

EPDiQ9C0C7
jPOSTiQ9C0C7
MassIVEiQ9C0C7
MaxQBiQ9C0C7
PaxDbiQ9C0C7
PeptideAtlasiQ9C0C7
PRIDEiQ9C0C7
ProteomicsDBi32296
79999 [Q9C0C7-1]
80000 [Q9C0C7-2]
80001 [Q9C0C7-3]
80002 [Q9C0C7-4]
80003 [Q9C0C7-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
26331, 431 antibodies from 36 providers

The DNASU plasmid repository

More...
DNASUi
55626

Genome annotation databases

EnsembliENST00000314845; ENSP00000318313; ENSG00000110497 [Q9C0C7-4]
ENST00000458649; ENSP00000415327; ENSG00000110497
ENST00000528950; ENSP00000433945; ENSG00000110497 [Q9C0C7-3]
ENST00000534300; ENSP00000431926; ENSG00000110497 [Q9C0C7-2]
ENST00000683756; ENSP00000508322; ENSG00000110497
GeneIDi55626
KEGGihsa:55626
MANE-SelectiENST00000683756.1; ENSP00000508322.1; NM_001387011.1; NP_001373940.1
UCSCiuc001ncu.3, human [Q9C0C7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55626
DisGeNETi55626

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AMBRA1
HGNCiHGNC:25990, AMBRA1
HPAiENSG00000110497, Low tissue specificity
MIMi611359, gene
neXtProtiNX_Q9C0C7
OpenTargetsiENSG00000110497
PharmGKBiPA162376307
VEuPathDBiHostDB:ENSG00000110497

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0266, Eukaryota
GeneTreeiENSGT00390000016223
HOGENOMiCLU_008882_0_0_1
InParanoidiQ9C0C7
OMAiPPAECCQ
OrthoDBi488527at2759
PhylomeDBiQ9C0C7
TreeFamiTF328981

Enzyme and pathway databases

UniPathwayiUPA00143
PathwayCommonsiQ9C0C7
ReactomeiR-HSA-1632852, Macroautophagy
SignaLinkiQ9C0C7
SIGNORiQ9C0C7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
55626, 108 hits in 1104 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
AMBRA1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55626
PharosiQ9C0C7, Tbio

Protein Ontology

More...
PROi
PR:Q9C0C7
RNActiQ9C0C7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000110497, Expressed in stomach and 242 other tissues
ExpressionAtlasiQ9C0C7, baseline and differential
GenevisibleiQ9C0C7, HS

Family and domain databases

DisProtiDP01328
Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR036322, WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320, WD40, 3 hits
SUPFAMiSSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAMRA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C0C7
Secondary accession number(s): A6XN33
, D3DQP8, G3V193, Q86XD6, Q9H8Z0, Q9NXE7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: February 23, 2022
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families
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