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UniProtKB - Q9C0C4 (SEM4C_HUMAN)

Entry version 172 (25 May 2022)
Sequence version 2 (24 May 2004)
Previous versions | rss
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Protein

Semaphorin-4C

Gene

SEMA4C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity).

Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9C0C4

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9C0C4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Semaphorin-4C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEMA4C
Synonyms:KIAA1739, SEMAI
ORF Names:UNQ5855/PRO34487
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10731, SEMA4C

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604462, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9C0C4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000168758

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 663ExtracellularSequence analysisAdd BLAST643
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei664 – 684HelicalSequence analysisAdd BLAST21
Topological domaini685 – 833CytoplasmicSequence analysisAdd BLAST149

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		54910

Open Targets

More...OpenTargetsi		ENSG00000168758

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35653

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9C0C4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SEMA4C

Domain mapping of disease mutations (DMDM)

More...DMDMi		47606208

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003232521 – 833Semaphorin-4CAdd BLAST813

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi99 ↔ 110By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi128 ↔ 137By similarity
Disulfide bondi261 ↔ 370By similarity
Disulfide bondi285 ↔ 330By similarity
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi419N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi500 ↔ 517By similarity
Disulfide bondi509 ↔ 526By similarity
Glycosylationi522N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi564N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei742PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9C0C4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9C0C4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9C0C4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9C0C4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9C0C4

PeptideAtlas

More...PeptideAtlasi		Q9C0C4

PRoteomics IDEntifications database

More...PRIDEi		Q9C0C4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		79997

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1733, 3 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9C0C4, 7 sites, 3 N-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9C0C4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9C0C4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000168758, Expressed in trigeminal ganglion and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9C0C4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9C0C4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000168758, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via the PDZ-binding motif) with GIPC (via the PDZ domain) (By similarity).

Interacts with NCDN (By similarity).

Interacts (via the PDZ-binding motif) with DLG4.

Interacts with PLXNB2 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120254, 171 interactors

Protein interaction database and analysis system

More...IntActi		Q9C0C4, 27 interactors

Molecular INTeraction database

More...MINTi		Q9C0C4

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000306844

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9C0C4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1833
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9C0C4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9C0C4

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 497SemaPROSITE-ProRule annotationAdd BLAST468
Domaini499 – 551PSIAdd BLAST53
Domaini556 – 644Ig-like C2-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni46 – 489Dominant negative effect on myogenic differentiationBy similarityAdd BLAST444
Regioni748 – 807DisorderedSequence analysisAdd BLAST60
Regioni814 – 833DisorderedSequence analysisAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi830 – 833PDZ-binding4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi754 – 770Pro residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3611, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159885

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009051_4_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9C0C4

Identification of Orthologs from Complete Genome Data

More...OMAi		CSAPNWQ

Database of Orthologous Groups

More...OrthoDBi		176445at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9C0C4

TreeFam database of animal gene trees

More...TreeFami		TF316102

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 1 hit
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR002165, Plexin_repeat
IPR016201, PSI
IPR001627, Semap_dom
IPR036352, Semap_dom_sf
IPR027231, Semaphorin
IPR015943, WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR11036, PTHR11036, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01437, PSI, 1 hit
PF01403, Sema, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 1 hit
SM00423, PSI, 1 hit
SM00630, Sema, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101912, SSF101912, 1 hit
SSF48726, SSF48726, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS51004, SEMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9C0C4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPHWAVWLL AARLWGLGIG AEVWWNLVPR KTVSSGELAT VVRRFSQTGI 
        60         70         80         90        100
QDFLTLTLTE PTGLLYVGAR EALFAFSMEA LELQGAISWE APVEKKTECI 
       110        120        130        140        150
QKGKNNQTEC FNFIRFLQPY NASHLYVCGT YAFQPKCTYV NMLTFTLEHG 
       160        170        180        190        200
EFEDGKGKCP YDPAKGHAGL LVDGELYSAT LNNFLGTEPI ILRNMGPHHS 
       210        220        230        240        250
MKTEYLAFWL NEPHFVGSAY VPESVGSFTG DDDKVYFFFR ERAVESDCYA 
       260        270        280        290        300
EQVVARVARV CKGDMGGART LQRKWTTFLK ARLACSAPNW QLYFNQLQAM 
       310        320        330        340        350
HTLQDTSWHN TTFFGVFQAQ WGDMYLSAIC EYQLEEIQRV FEGPYKEYHE 
       360        370        380        390        400
EAQKWDRYTD PVPSPRPGSC INNWHRRHGY TSSLELPDNI LNFVKKHPLM 
       410        420        430        440        450
EEQVGPRWSR PLLVKKGTNF THLVADRVTG LDGATYTVLF IGTGDGWLLK 
       460        470        480        490        500
AVSLGPWVHL IEELQLFDQE PMRSLVLSQS KKLLFAGSRS QLVQLPVADC 
       510        520        530        540        550
MKYRSCADCV LARDPYCAWS VNTSRCVAVG GHSGSLLIQH VMTSDTSGIC 
       560        570        580        590        600
NLRGSKKVRP TPKNITVVAG TDLVLPCHLS SNLAHARWTF GGRDLPAEQP 
       610        620        630        640        650
GSFLYDARLQ ALVVMAAQPR HAGAYHCFSE EQGARLAAEG YLVAVVAGPS 
       660        670        680        690        700
VTLEARAPLE NLGLVWLAVV ALGAVCLVLL LLVLSLRRRL REELEKGAKA 
       710        720        730        740        750
TERTLVYPLE LPKEPTSPPF RPCPEPDEKL WDPVGYYYSD GSLKIVPGHA 
       760        770        780        790        800
RCQPGGGPPS PPPGIPGQPL PSPTRLHLGG GRNSNANGYV RLQLGGEDRG 
       810        820        830 
GLGHPLPELA DELRRKLQQR QPLPDSNPEE SSV
Length:833
Mass (Da):92,623
Last modified:May 24, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i075FDC0A392F0CE3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J4M7C9J4M7_HUMAN
Semaphorin-4C
SEMA4C
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JV89C9JV89_HUMAN
Semaphorin-4C
SEMA4C
201Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti602S → T in AAQ89201 (PubMed:12975309).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY358842 mRNA Translation: AAQ89201.1
BC017476 mRNA Translation: AAH17476.2
BC109103 mRNA Translation: AAI09104.1
BC109104 mRNA Translation: AAI09105.1
AB051526 mRNA Translation: BAB21830.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2029.1

NCBI Reference Sequences

More...RefSeqi		NP_060259.4, NM_017789.4
XP_011509680.1, XM_011511378.2
XP_011509681.1, XM_011511379.2
XP_011509682.1, XM_011511380.1
XP_011509683.1, XM_011511381.1
XP_011509684.1, XM_011511382.2
XP_011509685.1, XM_011511383.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000305476.10; ENSP00000306844.5; ENSG00000168758.11

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54910

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54910

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000305476.10; ENSP00000306844.5; NM_017789.5; NP_060259.4

UCSC genome browser

More...UCSCi		uc002sxh.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358842 mRNA Translation: AAQ89201.1
BC017476 mRNA Translation: AAH17476.2
BC109103 mRNA Translation: AAI09104.1
BC109104 mRNA Translation: AAI09105.1
AB051526 mRNA Translation: BAB21830.1
CCDSiCCDS2029.1
RefSeqiNP_060259.4, NM_017789.4
XP_011509680.1, XM_011511378.2
XP_011509681.1, XM_011511379.2
XP_011509682.1, XM_011511380.1
XP_011509683.1, XM_011511381.1
XP_011509684.1, XM_011511382.2
XP_011509685.1, XM_011511383.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6N5ZX-ray2.45A/B731-755[»]
AlphaFoldDBiQ9C0C4
SMRiQ9C0C4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120254, 171 interactors
IntActiQ9C0C4, 27 interactors
MINTiQ9C0C4
STRINGi9606.ENSP00000306844

PTM databases

GlyConnecti1733, 3 N-Linked glycans (1 site)
GlyGeniQ9C0C4, 7 sites, 3 N-linked glycans (1 site)
iPTMnetiQ9C0C4
PhosphoSitePlusiQ9C0C4

Genetic variation databases

BioMutaiSEMA4C
DMDMi47606208

Proteomic databases

EPDiQ9C0C4
jPOSTiQ9C0C4
MassIVEiQ9C0C4
MaxQBiQ9C0C4
PaxDbiQ9C0C4
PeptideAtlasiQ9C0C4
PRIDEiQ9C0C4
ProteomicsDBi79997

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2594, 186 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		54910

Genome annotation databases

EnsembliENST00000305476.10; ENSP00000306844.5; ENSG00000168758.11
GeneIDi54910
KEGGihsa:54910
MANE-SelectiENST00000305476.10; ENSP00000306844.5; NM_017789.5; NP_060259.4
UCSCiuc002sxh.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54910
DisGeNETi54910

GeneCards: human genes, protein and diseases

More...GeneCardsi		SEMA4C
HGNCiHGNC:10731, SEMA4C
HPAiENSG00000168758, Low tissue specificity
MIMi604462, gene
neXtProtiNX_Q9C0C4
OpenTargetsiENSG00000168758
PharmGKBiPA35653
VEuPathDBiHostDB:ENSG00000168758

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3611, Eukaryota
GeneTreeiENSGT00940000159885
HOGENOMiCLU_009051_4_2_1
InParanoidiQ9C0C4
OMAiCSAPNWQ
OrthoDBi176445at2759
PhylomeDBiQ9C0C4
TreeFamiTF316102

Enzyme and pathway databases

PathwayCommonsiQ9C0C4
SignaLinkiQ9C0C4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54910, 12 hits in 1078 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SEMA4C

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54910
PharosiQ9C0C4, Tbio

Protein Ontology

More...PROi		PR:Q9C0C4
RNActiQ9C0C4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000168758, Expressed in trigeminal ganglion and 247 other tissues
ExpressionAtlasiQ9C0C4, baseline and differential
GenevisibleiQ9C0C4, HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR002165, Plexin_repeat
IPR016201, PSI
IPR001627, Semap_dom
IPR036352, Semap_dom_sf
IPR027231, Semaphorin
IPR015943, WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036, PTHR11036, 1 hit
PfamiView protein in Pfam
PF01437, PSI, 1 hit
PF01403, Sema, 1 hit
SMARTiView protein in SMART
SM00409, IG, 1 hit
SM00423, PSI, 1 hit
SM00630, Sema, 1 hit
SUPFAMiSSF101912, SSF101912, 1 hit
SSF48726, SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS51004, SEMA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEM4C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C0C4
Secondary accession number(s): Q32MJ3, Q7Z5X0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: May 25, 2022
This is version 172 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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