UniProtKB - Q9C0C4 (SEM4C_HUMAN)
Semaphorin-4C
SEMA4C
Functioni
Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity).
Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.
By similarity1 PublicationGO - Molecular functioni
- chemorepellent activity Source: GO_Central
- semaphorin receptor binding Source: GO_Central
GO - Biological processi
- axon guidance Source: GO_Central
- cell migration in hindbrain Source: UniProtKB
- cerebellum development Source: Ensembl
- muscle cell differentiation Source: UniProtKB
- negative chemotaxis Source: GO_Central
- negative regulation of axon extension involved in axon guidance Source: GO_Central
- neural crest cell migration Source: GO_Central
- neural tube closure Source: UniProtKB
- positive regulation of cell migration Source: GO_Central
- positive regulation of stress-activated MAPK cascade Source: UniProtKB
- semaphorin-plexin signaling pathway Source: UniProtKB
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q9C0C4 |
SignaLinki | Q9C0C4 |
Names & Taxonomyi
Protein namesi | Recommended name: Semaphorin-4C |
Gene namesi | Name:SEMA4C Synonyms:KIAA1739, SEMAI ORF Names:UNQ5855/PRO34487 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10731, SEMA4C |
MIMi | 604462, gene |
neXtProti | NX_Q9C0C4 |
VEuPathDBi | HostDB:ENSG00000168758 |
Subcellular locationi
Plasma membrane
- postsynaptic density membrane By similarity; Single-pass type I membrane protein By similarity
Other locations
- synaptic vesicle membrane By similarity; Single-pass type I membrane protein By similarity
Extracellular region or secreted
- extracellular space Source: UniProtKB
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- postsynaptic density membrane Source: UniProtKB-SubCell
Other locations
- postsynaptic density Source: UniProtKB
- synaptic vesicle membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 663 | ExtracellularSequence analysisAdd BLAST | 643 | |
Transmembranei | 664 – 684 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 685 – 833 | CytoplasmicSequence analysisAdd BLAST | 149 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 54910 |
OpenTargetsi | ENSG00000168758 |
PharmGKBi | PA35653 |
Miscellaneous databases
Pharosi | Q9C0C4, Tbio |
Genetic variation databases
BioMutai | SEMA4C |
DMDMi | 47606208 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000032325 | 21 – 833 | Semaphorin-4CAdd BLAST | 813 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 99 ↔ 110 | By similarity | ||
Glycosylationi | 106 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 121 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 128 ↔ 137 | By similarity | ||
Disulfide bondi | 261 ↔ 370 | By similarity | ||
Disulfide bondi | 285 ↔ 330 | By similarity | ||
Glycosylationi | 310 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 419 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 500 ↔ 517 | By similarity | ||
Disulfide bondi | 509 ↔ 526 | By similarity | ||
Glycosylationi | 522 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 564 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 742 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q9C0C4 |
jPOSTi | Q9C0C4 |
MassIVEi | Q9C0C4 |
MaxQBi | Q9C0C4 |
PaxDbi | Q9C0C4 |
PeptideAtlasi | Q9C0C4 |
PRIDEi | Q9C0C4 |
ProteomicsDBi | 79997 |
PTM databases
GlyConnecti | 1733, 3 N-Linked glycans (1 site) |
GlyGeni | Q9C0C4, 7 sites, 3 N-linked glycans (1 site) |
iPTMneti | Q9C0C4 |
PhosphoSitePlusi | Q9C0C4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000168758, Expressed in trigeminal ganglion and 247 other tissues |
ExpressionAtlasi | Q9C0C4, baseline and differential |
Genevisiblei | Q9C0C4, HS |
Organism-specific databases
HPAi | ENSG00000168758, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via the PDZ-binding motif) with GIPC (via the PDZ domain) (By similarity).
Interacts with NCDN (By similarity).
Interacts (via the PDZ-binding motif) with DLG4.
Interacts with PLXNB2 (By similarity).
By similarityBinary interactionsi
Q9C0C4
GO - Molecular functioni
- chemorepellent activity Source: GO_Central
- semaphorin receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 120254, 171 interactors |
IntActi | Q9C0C4, 27 interactors |
MINTi | Q9C0C4 |
STRINGi | 9606.ENSP00000306844 |
Miscellaneous databases
RNActi | Q9C0C4, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q9C0C4 |
SMRi | Q9C0C4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 497 | SemaPROSITE-ProRule annotationAdd BLAST | 468 | |
Domaini | 499 – 551 | PSIAdd BLAST | 53 | |
Domaini | 556 – 644 | Ig-like C2-typeAdd BLAST | 89 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 46 – 489 | Dominant negative effect on myogenic differentiationBy similarityAdd BLAST | 444 | |
Regioni | 748 – 807 | DisorderedSequence analysisAdd BLAST | 60 | |
Regioni | 814 – 833 | DisorderedSequence analysisAdd BLAST | 20 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 830 – 833 | PDZ-binding | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 754 – 770 | Pro residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3611, Eukaryota |
GeneTreei | ENSGT00940000159885 |
HOGENOMi | CLU_009051_4_2_1 |
InParanoidi | Q9C0C4 |
OMAi | CSAPNWQ |
OrthoDBi | 176445at2759 |
PhylomeDBi | Q9C0C4 |
TreeFami | TF316102 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR002165, Plexin_repeat IPR016201, PSI IPR001627, Semap_dom IPR036352, Semap_dom_sf IPR027231, Semaphorin IPR015943, WD40/YVTN_repeat-like_dom_sf |
PANTHERi | PTHR11036, PTHR11036, 1 hit |
Pfami | View protein in Pfam PF01437, PSI, 1 hit PF01403, Sema, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00423, PSI, 1 hit SM00630, Sema, 1 hit |
SUPFAMi | SSF101912, SSF101912, 1 hit SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS51004, SEMA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAPHWAVWLL AARLWGLGIG AEVWWNLVPR KTVSSGELAT VVRRFSQTGI
60 70 80 90 100
QDFLTLTLTE PTGLLYVGAR EALFAFSMEA LELQGAISWE APVEKKTECI
110 120 130 140 150
QKGKNNQTEC FNFIRFLQPY NASHLYVCGT YAFQPKCTYV NMLTFTLEHG
160 170 180 190 200
EFEDGKGKCP YDPAKGHAGL LVDGELYSAT LNNFLGTEPI ILRNMGPHHS
210 220 230 240 250
MKTEYLAFWL NEPHFVGSAY VPESVGSFTG DDDKVYFFFR ERAVESDCYA
260 270 280 290 300
EQVVARVARV CKGDMGGART LQRKWTTFLK ARLACSAPNW QLYFNQLQAM
310 320 330 340 350
HTLQDTSWHN TTFFGVFQAQ WGDMYLSAIC EYQLEEIQRV FEGPYKEYHE
360 370 380 390 400
EAQKWDRYTD PVPSPRPGSC INNWHRRHGY TSSLELPDNI LNFVKKHPLM
410 420 430 440 450
EEQVGPRWSR PLLVKKGTNF THLVADRVTG LDGATYTVLF IGTGDGWLLK
460 470 480 490 500
AVSLGPWVHL IEELQLFDQE PMRSLVLSQS KKLLFAGSRS QLVQLPVADC
510 520 530 540 550
MKYRSCADCV LARDPYCAWS VNTSRCVAVG GHSGSLLIQH VMTSDTSGIC
560 570 580 590 600
NLRGSKKVRP TPKNITVVAG TDLVLPCHLS SNLAHARWTF GGRDLPAEQP
610 620 630 640 650
GSFLYDARLQ ALVVMAAQPR HAGAYHCFSE EQGARLAAEG YLVAVVAGPS
660 670 680 690 700
VTLEARAPLE NLGLVWLAVV ALGAVCLVLL LLVLSLRRRL REELEKGAKA
710 720 730 740 750
TERTLVYPLE LPKEPTSPPF RPCPEPDEKL WDPVGYYYSD GSLKIVPGHA
760 770 780 790 800
RCQPGGGPPS PPPGIPGQPL PSPTRLHLGG GRNSNANGYV RLQLGGEDRG
810 820 830
GLGHPLPELA DELRRKLQQR QPLPDSNPEE SSV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J4M7 | C9J4M7_HUMAN | Semaphorin-4C | SEMA4C | 139 | Annotation score: | ||
C9JV89 | C9JV89_HUMAN | Semaphorin-4C | SEMA4C | 201 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 602 | S → T in AAQ89201 (PubMed:12975309).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358842 mRNA Translation: AAQ89201.1 BC017476 mRNA Translation: AAH17476.2 BC109103 mRNA Translation: AAI09104.1 BC109104 mRNA Translation: AAI09105.1 AB051526 mRNA Translation: BAB21830.1 |
CCDSi | CCDS2029.1 |
RefSeqi | NP_060259.4, NM_017789.4 XP_011509680.1, XM_011511378.2 XP_011509681.1, XM_011511379.2 XP_011509682.1, XM_011511380.1 XP_011509683.1, XM_011511381.1 XP_011509684.1, XM_011511382.2 XP_011509685.1, XM_011511383.1 |
Genome annotation databases
Ensembli | ENST00000305476.10; ENSP00000306844.5; ENSG00000168758.11 |
GeneIDi | 54910 |
KEGGi | hsa:54910 |
MANE-Selecti | ENST00000305476.10; ENSP00000306844.5; NM_017789.5; NP_060259.4 |
UCSCi | uc002sxh.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358842 mRNA Translation: AAQ89201.1 BC017476 mRNA Translation: AAH17476.2 BC109103 mRNA Translation: AAI09104.1 BC109104 mRNA Translation: AAI09105.1 AB051526 mRNA Translation: BAB21830.1 |
CCDSi | CCDS2029.1 |
RefSeqi | NP_060259.4, NM_017789.4 XP_011509680.1, XM_011511378.2 XP_011509681.1, XM_011511379.2 XP_011509682.1, XM_011511380.1 XP_011509683.1, XM_011511381.1 XP_011509684.1, XM_011511382.2 XP_011509685.1, XM_011511383.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6N5Z | X-ray | 2.45 | A/B | 731-755 | [»] | |
AlphaFoldDBi | Q9C0C4 | |||||
SMRi | Q9C0C4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120254, 171 interactors |
IntActi | Q9C0C4, 27 interactors |
MINTi | Q9C0C4 |
STRINGi | 9606.ENSP00000306844 |
PTM databases
GlyConnecti | 1733, 3 N-Linked glycans (1 site) |
GlyGeni | Q9C0C4, 7 sites, 3 N-linked glycans (1 site) |
iPTMneti | Q9C0C4 |
PhosphoSitePlusi | Q9C0C4 |
Genetic variation databases
BioMutai | SEMA4C |
DMDMi | 47606208 |
Proteomic databases
EPDi | Q9C0C4 |
jPOSTi | Q9C0C4 |
MassIVEi | Q9C0C4 |
MaxQBi | Q9C0C4 |
PaxDbi | Q9C0C4 |
PeptideAtlasi | Q9C0C4 |
PRIDEi | Q9C0C4 |
ProteomicsDBi | 79997 |
Protocols and materials databases
Antibodypediai | 2594, 186 antibodies from 30 providers |
DNASUi | 54910 |
Genome annotation databases
Ensembli | ENST00000305476.10; ENSP00000306844.5; ENSG00000168758.11 |
GeneIDi | 54910 |
KEGGi | hsa:54910 |
MANE-Selecti | ENST00000305476.10; ENSP00000306844.5; NM_017789.5; NP_060259.4 |
UCSCi | uc002sxh.5, human |
Organism-specific databases
CTDi | 54910 |
DisGeNETi | 54910 |
GeneCardsi | SEMA4C |
HGNCi | HGNC:10731, SEMA4C |
HPAi | ENSG00000168758, Low tissue specificity |
MIMi | 604462, gene |
neXtProti | NX_Q9C0C4 |
OpenTargetsi | ENSG00000168758 |
PharmGKBi | PA35653 |
VEuPathDBi | HostDB:ENSG00000168758 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3611, Eukaryota |
GeneTreei | ENSGT00940000159885 |
HOGENOMi | CLU_009051_4_2_1 |
InParanoidi | Q9C0C4 |
OMAi | CSAPNWQ |
OrthoDBi | 176445at2759 |
PhylomeDBi | Q9C0C4 |
TreeFami | TF316102 |
Enzyme and pathway databases
PathwayCommonsi | Q9C0C4 |
SignaLinki | Q9C0C4 |
Miscellaneous databases
BioGRID-ORCSi | 54910, 12 hits in 1078 CRISPR screens |
GeneWikii | SEMA4C |
GenomeRNAii | 54910 |
Pharosi | Q9C0C4, Tbio |
PROi | PR:Q9C0C4 |
RNActi | Q9C0C4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168758, Expressed in trigeminal ganglion and 247 other tissues |
ExpressionAtlasi | Q9C0C4, baseline and differential |
Genevisiblei | Q9C0C4, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR002165, Plexin_repeat IPR016201, PSI IPR001627, Semap_dom IPR036352, Semap_dom_sf IPR027231, Semaphorin IPR015943, WD40/YVTN_repeat-like_dom_sf |
PANTHERi | PTHR11036, PTHR11036, 1 hit |
Pfami | View protein in Pfam PF01437, PSI, 1 hit PF01403, Sema, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00423, PSI, 1 hit SM00630, Sema, 1 hit |
SUPFAMi | SSF101912, SSF101912, 1 hit SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS51004, SEMA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SEM4C_HUMAN | |
Accessioni | Q9C0C4Primary (citable) accession number: Q9C0C4 Secondary accession number(s): Q32MJ3, Q7Z5X0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2004 |
Last sequence update: | May 24, 2004 | |
Last modified: | May 25, 2022 | |
This is version 172 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families