UniProtKB - Q9C0C4 (SEM4C_HUMAN)

BLAST

>sp|Q9C0C4|SEM4C_HUMAN Semaphorin-4C OS=Homo sapiens OX=9606 GN=SEMA4C PE=1 SV=2
MAPHWAVWLLAARLWGLGIGAEVWWNLVPRKTVSSGELATVVRRFSQTGIQDFLTLTLTE
PTGLLYVGAREALFAFSMEALELQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPY
NASHLYVCGTYAFQPKCTYVNMLTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSAT
LNNFLGTEPIILRNMGPHHSMKTEYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFR
ERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKARLACSAPNWQLYFNQLQAM
HTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTD
PVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNF
THLVADRVTGLDGATYTVLFIGTGDGWLLKAVSLGPWVHLIEELQLFDQEPMRSLVLSQS
KKLLFAGSRSQLVQLPVADCMKYRSCADCVLARDPYCAWSVNTSRCVAVGGHSGSLLIQH
VMTSDTSGICNLRGSKKVRPTPKNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQP
GSFLYDARLQALVVMAAQPRHAGAYHCFSEEQGARLAAEGYLVAVVAGPSVTLEARAPLE
NLGLVWLAVVALGAVCLVLLLLVLSLRRRLREELEKGAKATERTLVYPLELPKEPTSPPF
RPCPEPDEKLWDPVGYYYSDGSLKIVPGHARCQPGGGPPSPPPGIPGQPLPSPTRLHLGG
GRNSNANGYVRLQLGGEDRGGLGHPLPELADELRRKLQQRQPLPDSNPEESSV

Align
Format
Add to basket Added to basket
History
Entry version 152 (07 Nov 2018)
Sequence version 2 (24 May 2004)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Semaphorin-4C

Gene

SEMA4C

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.By similarity1 Publication

GO - Molecular functionⁱ

chemorepellent activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neuropilin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
semaphorin receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell migration in hindbrain Source: UniProtKB
cerebellum development Source: Ensembl
muscle cell differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 17498836
negative chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of axon extension involved in axon guidance
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neural crest cell migration
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neural tube closure Source: UniProtKB
positive regulation of cell migration
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of stress-activated MAPK cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 17498836
semaphorin-plexin signaling pathway Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Differentiation, Neurogenesis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Semaphorin-4C
Gene namesⁱ	Name:SEMA4C Synonyms:KIAA1739, SEMAI ORF Names:UNQ5855/PRO34487
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168758.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10731 SEMA4C
MIMⁱ	604462 gene
neXtProtⁱ	NX_Q9C0C4

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	21 – 663	ExtracellularSequence analysisAdd BLAST	643
Transmembraneⁱ	664 – 684	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	685 – 833	CytoplasmicSequence analysisAdd BLAST	149

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	54910
Open Targets More...OpenTargetsⁱ	ENSG00000168758
PharmGKBⁱ	PA35653

Polymorphism and mutation databases

BioMutaⁱ	SEMA4C
DMDMⁱ	47606208

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST		20
ChainⁱPRO_0000032325	21 – 833	Semaphorin-4CAdd BLAST		813

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	99 ↔ 110	By similarity
Glycosylationⁱ	106	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	121	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	128 ↔ 137	By similarity
Disulfide bondⁱ	261 ↔ 370	By similarity
Disulfide bondⁱ	285 ↔ 330	By similarity
Glycosylationⁱ	310	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	419	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	500 ↔ 517	By similarity
Disulfide bondⁱ	509 ↔ 526	By similarity
Glycosylationⁱ	522	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	564	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	742	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q9C0C4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9C0C4
PaxDbⁱ	Q9C0C4
PeptideAtlas More...PeptideAtlasⁱ	Q9C0C4
PRIDEⁱ	Q9C0C4
ProteomicsDBⁱ	79997

PTM databases

GlyConnectⁱ	1733
iPTMnetⁱ	Q9C0C4
PhosphoSitePlusⁱ	Q9C0C4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000168758 Expressed in 234 organ(s), highest expression level in trigeminal ganglion
CleanExⁱ	HS_SEMA4C
ExpressionAtlasⁱ	Q9C0C4 baseline and differential
Genevisibleⁱ	Q9C0C4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA011090

HPAⁱ

HPA011090

Interactionⁱ

Subunit structureⁱ

Interacts (via the PDZ-binding motif) with GIPC (via the PDZ domain) (By similarity). Interacts with NCDN (By similarity). Interacts (via the PDZ-binding motif) with DLG4. Interacts with PLXNB2 (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
KRT31	Q15323	5	EBI-10303490,EBI-948001
KRT40	Q6A162	3	EBI-10303490,EBI-10171697
NOTCH2NL	Q7Z3S9	5	EBI-10303490,EBI-945833
PNMA1	Q8ND90	5	EBI-10303490,EBI-302345
RCHY1	Q96PM5	3	EBI-10303490,EBI-947779

GO - Molecular functionⁱ

chemorepellent activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neuropilin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
semaphorin receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	120254, 91 interactors
IntActⁱ	Q9C0C4, 13 interactors
STRINGⁱ	9606.ENSP00000306844

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9C0C4
SMRⁱ	Q9C0C4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	30 – 497	SemaPROSITE-ProRule annotationAdd BLAST	468
Domainⁱ	499 – 551	PSIAdd BLAST	53
Domainⁱ	556 – 644	Ig-like C2-typeAdd BLAST	89

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	46 – 489	Dominant negative effect on myogenic differentiationBy similarityAdd BLAST		444

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	830 – 833	PDZ-binding		4

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	708 – 773	Pro-richAdd BLAST		66

Sequence similaritiesⁱ

Belongs to the semaphorin family.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3611 Eukaryota ENOG410XQZC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118854
HOGENOMⁱ	HOG000116087
HOVERGENⁱ	HBG061165
InParanoidⁱ	Q9C0C4
KEGG Orthology (KO) More...KOⁱ	K06521
OMAⁱ	CINNWHR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01W0
PhylomeDBⁱ	Q9C0C4
TreeFamⁱ	TF316102

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit 2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR002165 Plexin_repeat IPR016201 PSI IPR001627 Semap_dom IPR036352 Semap_dom_sf IPR027231 Semaphorin IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERⁱ	PTHR11036 PTHR11036, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01437 PSI, 1 hit PF01403 Sema, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 1 hit SM00423 PSI, 1 hit SM00630 Sema, 1 hit
SUPFAMⁱ	SSF101912 SSF101912, 1 hit SSF48726 SSF48726, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS51004 SEMA, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q9C0C4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAPHWAVWLL AARLWGLGIG AEVWWNLVPR KTVSSGELAT VVRRFSQTGI 
        60         70         80         90        100
QDFLTLTLTE PTGLLYVGAR EALFAFSMEA LELQGAISWE APVEKKTECI 
       110        120        130        140        150
QKGKNNQTEC FNFIRFLQPY NASHLYVCGT YAFQPKCTYV NMLTFTLEHG 
       160        170        180        190        200
EFEDGKGKCP YDPAKGHAGL LVDGELYSAT LNNFLGTEPI ILRNMGPHHS 
       210        220        230        240        250
MKTEYLAFWL NEPHFVGSAY VPESVGSFTG DDDKVYFFFR ERAVESDCYA 
       260        270        280        290        300
EQVVARVARV CKGDMGGART LQRKWTTFLK ARLACSAPNW QLYFNQLQAM 
       310        320        330        340        350
HTLQDTSWHN TTFFGVFQAQ WGDMYLSAIC EYQLEEIQRV FEGPYKEYHE 
       360        370        380        390        400
EAQKWDRYTD PVPSPRPGSC INNWHRRHGY TSSLELPDNI LNFVKKHPLM 
       410        420        430        440        450
EEQVGPRWSR PLLVKKGTNF THLVADRVTG LDGATYTVLF IGTGDGWLLK 
       460        470        480        490        500
AVSLGPWVHL IEELQLFDQE PMRSLVLSQS KKLLFAGSRS QLVQLPVADC 
       510        520        530        540        550
MKYRSCADCV LARDPYCAWS VNTSRCVAVG GHSGSLLIQH VMTSDTSGIC 
       560        570        580        590        600
NLRGSKKVRP TPKNITVVAG TDLVLPCHLS SNLAHARWTF GGRDLPAEQP 
       610        620        630        640        650
GSFLYDARLQ ALVVMAAQPR HAGAYHCFSE EQGARLAAEG YLVAVVAGPS 
       660        670        680        690        700
VTLEARAPLE NLGLVWLAVV ALGAVCLVLL LLVLSLRRRL REELEKGAKA 
       710        720        730        740        750
TERTLVYPLE LPKEPTSPPF RPCPEPDEKL WDPVGYYYSD GSLKIVPGHA 
       760        770        780        790        800
RCQPGGGPPS PPPGIPGQPL PSPTRLHLGG GRNSNANGYV RLQLGGEDRG 
       810        820        830 
GLGHPLPELA DELRRKLQQR QPLPDSNPEE SSV

Length:833

Mass (Da):92,623

Last modified:May 24, 2004 - v2

Checksum:ⁱ075FDC0A392F0CE3

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JV89	C9JV89_HUMAN	Semaphorin-4C Semaphorin-4C	SEMA4C	201	Annotation score:
C9J4M7	C9J4M7_HUMAN	Semaphorin-4C Semaphorin-4C	SEMA4C	139	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	602	S → T in AAQ89201 (PubMed:12975309).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358842 mRNA Translation: AAQ89201.1 BC017476 mRNA Translation: AAH17476.2 BC109103 mRNA Translation: AAI09104.1 BC109104 mRNA Translation: AAI09105.1 AB051526 mRNA Translation: BAB21830.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2029.1
NCBI Reference Sequences More...RefSeqⁱ	NP_060259.4, NM_017789.4 XP_011509680.1, XM_011511378.2 XP_011509681.1, XM_011511379.2 XP_011509682.1, XM_011511380.1 XP_011509683.1, XM_011511381.1 XP_011509684.1, XM_011511382.2 XP_011509685.1, XM_011511383.1
UniGeneⁱ	Hs.516220

Genome annotation databases

Ensemblⁱ	ENST00000305476; ENSP00000306844; ENSG00000168758
GeneIDⁱ	54910
KEGGⁱ	hsa:54910
UCSC genome browser More...UCSCⁱ	uc002sxh.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9C0C4	SEMA4C protein (Fragment)		HUMAN		543	UniRef100_Q9C0C4
SEMA4C isoform 1 (Fragment)		PANTR		139
Semaphorin-4C (Fragment)		HUMAN		139
Semaphorin-4C (Fragment)		HUMAN		201
Uncharacterized protein SEMA4C		HUMAN		510
+3

Protein	Similar proteins		Species	Score	Length	Source
Q9C0C4	SEMA4C protein (Fragment)		HUMAN		543	UniRef90_Q9C0C4
SEMA4C isoform 1 (Fragment)		PANTR		139
Semaphorin 4C		FELCA		1000
Uncharacterized protein		MACMU		875
Semaphorin 4C		MUSPF		867
+113

Protein	Similar proteins		Species	Score	Length	Source
Q9C0C4	Semaphorin-4C		MOUSE		834	UniRef50_Q64151
Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (Semaphorin) 4C (Predicted)		RAT		834
Uncharacterized protein		MONDO		832
Semaphorin 4C		PIG		833
semaphorin-4C isoform X1		DELLE		945
+200

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358842 mRNA Translation: AAQ89201.1 BC017476 mRNA Translation: AAH17476.2 BC109103 mRNA Translation: AAI09104.1 BC109104 mRNA Translation: AAI09105.1 AB051526 mRNA Translation: BAB21830.1
CCDSⁱ	CCDS2029.1
RefSeqⁱ	NP_060259.4, NM_017789.4 XP_011509680.1, XM_011511378.2 XP_011509681.1, XM_011511379.2 XP_011509682.1, XM_011511380.1 XP_011509683.1, XM_011511381.1 XP_011509684.1, XM_011511382.2 XP_011509685.1, XM_011511383.1
UniGeneⁱ	Hs.516220

3D structure databases

ProteinModelPortalⁱ	Q9C0C4
SMRⁱ	Q9C0C4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120254, 91 interactors
IntActⁱ	Q9C0C4, 13 interactors
STRINGⁱ	9606.ENSP00000306844

PTM databases

GlyConnectⁱ	1733
iPTMnetⁱ	Q9C0C4
PhosphoSitePlusⁱ	Q9C0C4

Polymorphism and mutation databases

BioMutaⁱ	SEMA4C
DMDMⁱ	47606208

Proteomic databases

EPDⁱ	Q9C0C4
MaxQBⁱ	Q9C0C4
PaxDbⁱ	Q9C0C4
PeptideAtlasⁱ	Q9C0C4
PRIDEⁱ	Q9C0C4
ProteomicsDBⁱ	79997

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000305476; ENSP00000306844; ENSG00000168758
GeneIDⁱ	54910
KEGGⁱ	hsa:54910
UCSCⁱ	uc002sxh.5 human

Organism-specific databases

CTDⁱ	54910
DisGeNETⁱ	54910
EuPathDBⁱ	HostDB:ENSG00000168758.10
GeneCardsⁱ	SEMA4C
HGNCⁱ	HGNC:10731 SEMA4C
HPAⁱ	HPA011090
MIMⁱ	604462 gene
neXtProtⁱ	NX_Q9C0C4
OpenTargetsⁱ	ENSG00000168758
PharmGKBⁱ	PA35653
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3611 Eukaryota ENOG410XQZC LUCA
GeneTreeⁱ	ENSGT00760000118854
HOGENOMⁱ	HOG000116087
HOVERGENⁱ	HBG061165
InParanoidⁱ	Q9C0C4
KOⁱ	K06521
OMAⁱ	CINNWHR
OrthoDBⁱ	EOG091G01W0
PhylomeDBⁱ	Q9C0C4
TreeFamⁱ	TF316102

Miscellaneous databases

GeneWikiⁱ	SEMA4C
GenomeRNAiⁱ	54910
Protein Ontology More...PROⁱ	PR:Q9C0C4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000168758 Expressed in 234 organ(s), highest expression level in trigeminal ganglion
CleanExⁱ	HS_SEMA4C
ExpressionAtlasⁱ	Q9C0C4 baseline and differential
Genevisibleⁱ	Q9C0C4 HS

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit 2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR002165 Plexin_repeat IPR016201 PSI IPR001627 Semap_dom IPR036352 Semap_dom_sf IPR027231 Semaphorin IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERⁱ	PTHR11036 PTHR11036, 1 hit
Pfamⁱ	View protein in Pfam PF01437 PSI, 1 hit PF01403 Sema, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 1 hit SM00423 PSI, 1 hit SM00630 Sema, 1 hit
SUPFAMⁱ	SSF101912 SSF101912, 1 hit SSF48726 SSF48726, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS51004 SEMA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SEM4C_HUMAN
Accessionⁱ	Q9C0C4Primary (citable) accession number: Q9C0C4 Secondary accession number(s): Q32MJ3, Q7Z5X0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
	Last sequence update:	May 24, 2004
	Last modified:	November 7, 2018
	This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9C0C4 (SEM4C_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Semaphorin-4C

SEMA4C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ