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Entry version 161 (13 Feb 2019)
Sequence version 4 (11 Jan 2011)
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Protein

182 kDa tankyrase-1-binding protein

Gene

TNKS1BP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ankyrin repeat binding Source: UniProtKB
  • cadherin binding Source: BHF-UCL
  • enzyme binding Source: UniProtKB
  • protein-containing complex binding Source: BHF-UCL

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-429947 Deadenylation of mRNA
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
182 kDa tankyrase-1-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNKS1BP1
Synonyms:KIAA1741, TAB182
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000149115.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19081 TNKS1BP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607104 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9C0C2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000149115

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38789

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TNKS1BP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373547

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000724371 – 1729182 kDa tankyrase-1-binding proteinAdd BLAST1729

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14PhosphoserineCombined sources1
Modified residuei131PhosphothreonineCombined sources1
Modified residuei178PhosphoserineCombined sources1
Modified residuei221PhosphoserineCombined sources1
Modified residuei228PhosphoserineCombined sources1
Modified residuei239PhosphothreonineCombined sources1
Modified residuei287PhosphoserineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei429PhosphoserineCombined sources1
Modified residuei435PhosphoserineCombined sources1
Modified residuei437PhosphoserineCombined sources1
Modified residuei494PhosphoserineCombined sources1
Modified residuei498PhosphoserineCombined sources1
Modified residuei501PhosphothreonineBy similarity1
Modified residuei601PhosphoserineCombined sources1
Modified residuei672PhosphoserineCombined sources1
Modified residuei691PhosphoserineCombined sources1
Modified residuei695PhosphoserineCombined sources1
Modified residuei712PhosphoserineCombined sources1
Modified residuei724PhosphoserineCombined sources1
Modified residuei744PhosphoserineCombined sources1
Modified residuei762PhosphoserineCombined sources1
Modified residuei806PhosphoserineCombined sources1
Modified residuei833PhosphothreonineCombined sources1
Modified residuei836PhosphoserineCombined sources1
Modified residuei851PhosphoserineCombined sources1
Modified residuei872PhosphoserineCombined sources1
Modified residuei877PhosphoserineCombined sources1
Modified residuei882PhosphoserineCombined sources1
Modified residuei893PhosphoserineCombined sources1
Modified residuei897PhosphotyrosineCombined sources1
Modified residuei899PhosphoserineCombined sources1
Modified residuei920PhosphoserineCombined sources1
Modified residuei936PhosphoserineCombined sources1
Modified residuei976PhosphoserineCombined sources1
Modified residuei979PhosphothreonineCombined sources1
Modified residuei983PhosphoserineCombined sources1
Modified residuei987PhosphoserineCombined sources1
Modified residuei1004PhosphoserineCombined sources1
Modified residuei1008PhosphoserineCombined sources1
Modified residuei1013PhosphoserineCombined sources1
Modified residuei1024PhosphoserineCombined sources1
Modified residuei1029PhosphoserineCombined sources1
Modified residuei1054PhosphoserineCombined sources1
Modified residuei1073PhosphoserineCombined sources1
Modified residuei1091PhosphoserineCombined sources1
Modified residuei1103PhosphoserineCombined sources1
Modified residuei1133PhosphoserineCombined sources1
Modified residuei1138PhosphoserineCombined sources1
Modified residuei1158PhosphoserineCombined sources1
Modified residuei1178PhosphoserineCombined sources1
Modified residuei1248PhosphoserineCombined sources1
Modified residuei1253PhosphoserineCombined sources1
Modified residuei1282PhosphothreonineCombined sources1
Modified residuei1297PhosphoserineCombined sources1
Modified residuei1328PhosphoserineCombined sources1
Modified residuei1331PhosphoserineCombined sources1
Modified residuei1383PhosphoserineCombined sources1
Modified residuei1385PhosphoserineCombined sources1
Modified residuei1435PhosphoserineCombined sources1
Modified residuei1439PhosphoserineCombined sources1
Modified residuei1450PhosphoserineCombined sources1
Modified residuei1452PhosphoserineCombined sources1
Modified residuei1473PhosphoserineCombined sources1
Modified residuei1476PhosphoserineCombined sources1
Modified residuei1503PhosphoserineCombined sources1
Modified residuei1506PhosphoserineCombined sources1
Modified residuei1518PhosphothreonineCombined sources1
Modified residuei1533PhosphoserineCombined sources1
Modified residuei1545PhosphoserineCombined sources1
Modified residuei1558PhosphoserineCombined sources1
Modified residuei1563PhosphothreonineCombined sources1
Modified residuei1620PhosphoserineCombined sources1
Modified residuei1621PhosphoserineCombined sources1
Modified residuei1631PhosphoserineCombined sources1
Modified residuei1644N6-methyllysineCombined sources1
Modified residuei1652PhosphoserineCombined sources1
Modified residuei1666PhosphoserineCombined sources1
Modified residuei1715PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

ADP-ribosylated by TNKS1 (in vitro).

Keywords - PTMi

ADP-ribosylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9C0C2

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9C0C2

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9C0C2

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9C0C2

PeptideAtlas

More...
PeptideAtlasi
Q9C0C2

PRoteomics IDEntifications database

More...
PRIDEi
Q9C0C2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79995
79996 [Q9C0C2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9C0C2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9C0C2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in testis, ovary, lung, skeletal muscle, heart, prostate and pancreas, and at very low levels in brain and peripheral blood leukocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000149115 Expressed in 185 organ(s), highest expression level in left lobe of thyroid gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9C0C2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9C0C2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037929
HPA037930

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to the ANK repeat domain of TNKS1 and TNKS2.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124540, 60 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9C0C2

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q9C0C2

Protein interaction database and analysis system

More...
IntActi
Q9C0C2, 28 interactors

Molecular INTeraction database

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MINTi
Q9C0C2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000350990

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9C0C2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9C0C2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni210 – 1572AcidicAdd BLAST1363
Regioni1450 – 1542Tankyrase-bindingAdd BLAST93

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1629 – 1635Nuclear localization signalSequence analysis7
Motifi1723 – 1729Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2 – 103Arg/Glu/Lys/Pro-rich (charged)Add BLAST102
Compositional biasi127 – 767Pro-richAdd BLAST641
Compositional biasi1010 – 1340Gly-richAdd BLAST331
Compositional biasi1572 – 1729Arg/Glu/Lys-rich (charged)Add BLAST158

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IK8U Eukaryota
ENOG410ZTHW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154184

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000001569

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG080593

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9C0C2

Identification of Orthologs from Complete Genome Data

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OMAi
FEWTFPT

Database of Orthologous Groups

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OrthoDBi
1565323at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9C0C2

TreeFam database of animal gene trees

More...
TreeFami
TF336029

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032764 Tankyrase-bd_C
IPR040006 TNKS1BP1-like

The PANTHER Classification System

More...
PANTHERi
PTHR22042 PTHR22042, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15327 Tankyrase_bdg_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01319 Tankyrase_bdg_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9C0C2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVSTLRESS AMASPLPREM EEELVPTGSE PGDTRAKPPV KPKPRALPAK
60 70 80 90 100
PALPAKPSLL VPVGPRPPRG PLAELPSARK MNMLAGPQPY GGSKRPLPFA
110 120 130 140 150
PRPAVEASTG GEATQETGKE EAGKEEPPPL TPPARCAAPG GVRKAPAPFR
160 170 180 190 200
PASERFAATT VEEILAKMEQ PRKEVLASPD RLWGSRLTFN HDGSSRYGPR
210 220 230 240 250
TYGTTTAPRD EDGSTLFRGW SQEGPVKSPA ECREEHSKTP EERSLPSDLA
260 270 280 290 300
FNGDLAKAAS SELPADISKP WIPSSPAPSS ENGGPASPGL PAEASGSGPG
310 320 330 340 350
SPHLHPPDKS SPCHSQLLEA QTPEASQASP CPAVTPSAPS AALPDEGSRH
360 370 380 390 400
TPSPGLPAEG APEAPRPSSP PPEVLEPHSL DQPPATSPRP LIEVGELLDL
410 420 430 440 450
TRTFPSGGEE EAKGDAHLRP TSLVQRRFSE GVLQSPSQDQ EKLGGSLAAL
460 470 480 490 500
PQGQGSQLAL DRPFGAESNW SLSQSFEWTF PTRPSGLGVW RLDSPPPSPI
510 520 530 540 550
TEASEAAEAA EAGNLAVSSR EEGVSQQGQG AGSAPSGSGS SWVQGDDPSM
560 570 580 590 600
SLTQKGDGES QPQFPAVPLE PLPTTEGTPG LPLQQAEERY ESQEPLAGQE
610 620 630 640 650
SPLPLATREA ALPILEPVLG QEQPAAPDQP CVLFADAPEP GQALPVEEEA
660 670 680 690 700
VTLARAETTQ ARTEAQDLCR ASPEPPGPES SSRWLDDLLA SPPPSGGGAR
710 720 730 740 750
RGAGAELKDT QSPSTCSEGL LGWSQKDLQS EFGITGDPQP SSFSPSSWCQ
760 770 780 790 800
GASQDYGLGG ASPRGDPGLG ERDWTSKYGQ GAGEGSTREW ASRCGIGQEE
810 820 830 840 850
MEASSSQDQS KVSAPGVLTA QDRVVGKPAQ LGTQRSQEAD VQDWEFRKRD
860 870 880 890 900
SQGTYSSRDA ELQDQEFGKR DSLGTYSSRD VSLGDWEFGK RDSLGAYASQ
910 920 930 940 950
DANEQGQDLG KRDHHGRYSS QDADEQDWEF QKRDVSLGTY GSRAAEPQEQ
960 970 980 990 1000
EFGKSAWIRD YSSGGSSRTL DAQDRSFGTR PLSSGFSPEE AQQQDEEFEK
1010 1020 1030 1040 1050
KIPSVEDSLG EGSRDAGRPG ERGSGGLFSP STAHVPDGAL GQRDQSSWQN
1060 1070 1080 1090 1100
SDASQEVGGH QERQQAGAQG PGSADLEDGE MGKRGWVGEF SLSVGPQREA
1110 1120 1130 1140 1150
AFSPGQQDWS RDFCIEASER SYQFGIIGND RVSGAGFSPS SKMEGGHFVP
1160 1170 1180 1190 1200
PGKTTAGSVD WTDQLGLRNL EVSSCVGSGG SSEARESAVG QMGWSGGLSL
1210 1220 1230 1240 1250
RDMNLTGCLE SGGSEEPGGI GVGEKDWTSD VNVKSKDLAE VGEGGGHSQA
1260 1270 1280 1290 1300
RESGVGQTDW SGVEAGEFLK SRERGVGQAD WTPDLGLRNM APGAVCSPGE
1310 1320 1330 1340 1350
SKELGVGQMD WGNNLGLRDL EVTCDPDSGG SQGLRGCGVG QMDWTQDLAP
1360 1370 1380 1390 1400
QNVELFGAPS EAREHGVGGV SQCPEPGLRH NGSLSPGLEA RDPLEARELG
1410 1420 1430 1440 1450
VGETSGPETQ GEDYSSSSLE PHPADPGMET GEALSFGASP GRCPARPPPS
1460 1470 1480 1490 1500
GSQGLLEEML AASSSKAVAR RESAASGLGG LLEEEGAGAG AAQEEVLEPG
1510 1520 1530 1540 1550
RDSPPSWRPQ PDGEASQTED VDGTWGSSAA RWSDQGPAQT SRRPSQGPPA
1560 1570 1580 1590 1600
RSPSQDFSFI EDTEILDSAM YRSRANLGRK RGHRAPVIRP GGTLGLSEAA
1610 1620 1630 1640 1650
DSDAHLFQDS TEPRASRVPS SDEEVVEEPQ SRRTRMSLGT KGLKVNLFPG
1660 1670 1680 1690 1700
LSPSALKAKL RPRNRSAEEG ELAESKSSQK ESAVQRSKSC KVPGLGKPLT
1710 1720
LPPKPEKSSG SEGSSPNWLQ ALKLKKKKV
Length:1,729
Mass (Da):181,796
Last modified:January 11, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i561FA5C27C923036
GO
Isoform 2 (identifier: Q9C0C2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-549: Missing.
     1275-1327: GVGQADWTPD...RDLEVTCDPD → LGRHIYALCI...SSSSLPWVFF
     1328-1729: Missing.

Note: No experimental confirmation available.
Show »
Length:778
Mass (Da):82,677
Checksum:iA08CC80D7372B25D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PKK0E9PKK0_HUMAN
182 kDa tankyrase-1-binding protein
TNKS1BP1
243Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKE7E9PKE7_HUMAN
182 kDa tankyrase-1-binding protein
TNKS1BP1
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y5C4A0A2R8Y5C4_HUMAN
182 kDa tankyrase-1-binding protein
TNKS1BP1
283Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB21832 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB84939 differs from that shown. Reason: Frameshift at positions 1070, 1098 and 1466.Curated
The sequence BAB84939 differs from that shown. Reason: Frameshift at positions 1071, 1097 and 1467.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti84L → P in AAM15531 (PubMed:11854288).Curated1
Sequence conflicti388P → S in AAM15531 (PubMed:11854288).Curated1
Sequence conflicti554Q → H in BAB84939 (PubMed:15489334).Curated1
Sequence conflicti604P → S in AAM15531 (PubMed:11854288).Curated1
Sequence conflicti1450S → F in AAM15531 (PubMed:11854288).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028141322T → S1 PublicationCorresponds to variant dbSNP:rs4939134Ensembl.1
Natural variantiVAR_032615714S → N. Corresponds to variant dbSNP:rs34203865Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0260001 – 549Missing in isoform 2. 1 PublicationAdd BLAST549
Alternative sequenceiVSP_0260011275 – 1327GVGQA…TCDPD → LGRHIYALCITLRTPPTPSL PWISSLVVEGFVPSSPPSLS LSASSSSLPWVFF in isoform 2. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_0260021328 – 1729Missing in isoform 2. 1 PublicationAdd BLAST402

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF441771 mRNA Translation: AAM15531.1
AB051528 mRNA Translation: BAB21832.2 Different initiation.
AK124903 mRNA Translation: BAC85989.1
AP000781 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW73731.1
BC023622 mRNA Translation: AAH23622.1
BC150333 mRNA Translation: AAI50334.1
AK074113 mRNA Translation: BAB84939.1 Frameshift.

The Consensus CDS (CCDS) project

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CCDSi
CCDS7951.1 [Q9C0C2-1]

NCBI Reference Sequences

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RefSeqi
NP_203754.2, NM_033396.2 [Q9C0C2-1]
XP_006718788.1, XM_006718725.3 [Q9C0C2-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.530730

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000358252; ENSP00000350990; ENSG00000149115 [Q9C0C2-1]
ENST00000532437; ENSP00000437271; ENSG00000149115 [Q9C0C2-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
85456

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:85456

UCSC genome browser

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UCSCi
uc001njr.4 human [Q9C0C2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF441771 mRNA Translation: AAM15531.1
AB051528 mRNA Translation: BAB21832.2 Different initiation.
AK124903 mRNA Translation: BAC85989.1
AP000781 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW73731.1
BC023622 mRNA Translation: AAH23622.1
BC150333 mRNA Translation: AAI50334.1
AK074113 mRNA Translation: BAB84939.1 Frameshift.
CCDSiCCDS7951.1 [Q9C0C2-1]
RefSeqiNP_203754.2, NM_033396.2 [Q9C0C2-1]
XP_006718788.1, XM_006718725.3 [Q9C0C2-1]
UniGeneiHs.530730

3D structure databases

ProteinModelPortaliQ9C0C2
SMRiQ9C0C2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124540, 60 interactors
CORUMiQ9C0C2
ELMiQ9C0C2
IntActiQ9C0C2, 28 interactors
MINTiQ9C0C2
STRINGi9606.ENSP00000350990

PTM databases

iPTMnetiQ9C0C2
PhosphoSitePlusiQ9C0C2

Polymorphism and mutation databases

BioMutaiTNKS1BP1
DMDMi317373547

Proteomic databases

EPDiQ9C0C2
jPOSTiQ9C0C2
MaxQBiQ9C0C2
PaxDbiQ9C0C2
PeptideAtlasiQ9C0C2
PRIDEiQ9C0C2
ProteomicsDBi79995
79996 [Q9C0C2-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358252; ENSP00000350990; ENSG00000149115 [Q9C0C2-1]
ENST00000532437; ENSP00000437271; ENSG00000149115 [Q9C0C2-1]
GeneIDi85456
KEGGihsa:85456
UCSCiuc001njr.4 human [Q9C0C2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
85456
EuPathDBiHostDB:ENSG00000149115.13

GeneCards: human genes, protein and diseases

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GeneCardsi
TNKS1BP1
HGNCiHGNC:19081 TNKS1BP1
HPAiHPA037929
HPA037930
MIMi607104 gene
neXtProtiNX_Q9C0C2
OpenTargetsiENSG00000149115
PharmGKBiPA38789

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IK8U Eukaryota
ENOG410ZTHW LUCA
GeneTreeiENSGT00940000154184
HOGENOMiHOG000001569
HOVERGENiHBG080593
InParanoidiQ9C0C2
OMAiFEWTFPT
OrthoDBi1565323at2759
PhylomeDBiQ9C0C2
TreeFamiTF336029

Enzyme and pathway databases

ReactomeiR-HSA-429947 Deadenylation of mRNA
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TNKS1BP1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TNKS1BP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
85456

Protein Ontology

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PROi
PR:Q9C0C2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000149115 Expressed in 185 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasiQ9C0C2 baseline and differential
GenevisibleiQ9C0C2 HS

Family and domain databases

InterProiView protein in InterPro
IPR032764 Tankyrase-bd_C
IPR040006 TNKS1BP1-like
PANTHERiPTHR22042 PTHR22042, 1 hit
PfamiView protein in Pfam
PF15327 Tankyrase_bdg_C, 1 hit
SMARTiView protein in SMART
SM01319 Tankyrase_bdg_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTB182_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C0C2
Secondary accession number(s): A7E2F8, Q6PJ35, Q6ZV74
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: January 11, 2011
Last modified: February 13, 2019
This is version 161 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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