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Protein

Zinc finger CCHC domain-containing protein 2

Gene

ZCCHC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1131 – 1148CCHC-typePROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCHC domain-containing protein 2
Gene namesi
Name:ZCCHC2Imported
Synonyms:C18orf49Imported, KIAA1744
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000141664.9
HGNCiHGNC:22916 ZCCHC2
neXtProtiNX_Q9C0B9

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi54877
OpenTargetsiENSG00000141664
PharmGKBiPA134861180

Polymorphism and mutation databases

BioMutaiZCCHC2
DMDMi182676458

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001509491 – 1178Zinc finger CCHC domain-containing protein 2Add BLAST1178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei236PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9C0B9
MaxQBiQ9C0B9
PaxDbiQ9C0B9
PeptideAtlasiQ9C0B9
PRIDEiQ9C0B9
ProteomicsDBi79994

PTM databases

iPTMnetiQ9C0B9
PhosphoSitePlusiQ9C0B9

Expressioni

Gene expression databases

BgeeiENSG00000141664 Expressed in 217 organ(s), highest expression level in secondary oocyte
CleanExiHS_ZCCHC2
ExpressionAtlasiQ9C0B9 baseline and differential
GenevisibleiQ9C0B9 HS

Organism-specific databases

HPAiHPA040943

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000269499

Structurei

3D structure databases

ProteinModelPortaliQ9C0B9
SMRiQ9C0B9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 70Pro-richAdd BLAST64

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1131 – 1148CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IZZC Eukaryota
ENOG4111U3M LUCA
GeneTreeiENSGT00520000055637
HOGENOMiHOG000155766
HOVERGENiHBG108762
InParanoidiQ9C0B9
KOiK22700
OMAiSMEASQQ
OrthoDBiEOG091G01BF
PhylomeDBiQ9C0B9
TreeFamiTF335574

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR036871 PX_dom_sf
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00098 zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 1 hit
SUPFAMiSSF57756 SSF57756, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9C0B9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRMKLPLKP THPAEPPPEA EEPEADARPG AKAPSRRRRD CRPPPPPPPP
60 70 80 90 100
AGPSRGPLPP PPPPRGLGPP VAGGAAAGAG MPGGGGGPSA ALREQERVYE
110 120 130 140 150
WFGLVLGSAQ RLEFMCGLLD LCNPLELRFL GSCLEDLARK DYHYLRDSEA
160 170 180 190 200
KANGLSDPGP LADFREPAVR SRLIVYLALL GSENREAAGR LHRLLPQVDS
210 220 230 240 250
VLKSLRAARG EGSRGGAEDE RGEDGDGEQD AEKDGSGPEG GIVEPRVGGG
260 270 280 290 300
LGSRAQEELL LLFTMASLHP AFSFHQRVTL REHLERLRAA LRGGPEDAEV
310 320 330 340 350
EVEPCKFAGP RAQNNSAHGD YMQNNESSLI EQAPIPQDGL TVAPHRAQRE
360 370 380 390 400
AVHIEKIMLK GVQRKRADKY WEYTFKVNWS DLSVTTVTKT HQELQEFLLK
410 420 430 440 450
LPKELSSETF DKTILRALNQ GSLKREERRH PDLEPILRQL FSSSSQAFLQ
460 470 480 490 500
SQKVHSFFQS ISSDSLHSIN NLQSSLKTSK ILEHLKEDSS EASSQEEDVL
510 520 530 540 550
QHAIIHKKHT GKSPIVNNIG TSCSPLDGLT MQYSEQNGIV DWRKQSCTTI
560 570 580 590 600
QHPEHCVTSA DQHSAEKRSL SSINKKKGKP QTEKEKIKKT DNRLNSRING
610 620 630 640 650
IRLSTPQHAH GGTVKDVNLD IGSGHDTCGE TSSESYSSPS SPRHDGRESF
660 670 680 690 700
ESEEEKDRDT DSNSEDSGNP STTRFTGYGS VNQTVTVKPP VQIASLGNEN
710 720 730 740 750
GNLLEDPLNS PKYQHISFMP TLHCVMHNGA QKSEVVVPAP KPADGKTIGM
760 770 780 790 800
LVPSPVAISA IRESANSTPV GILGPTACTG ESEKHLELLA SPLPIPSTFL
810 820 830 840 850
PHSSTPALHL TVQRLKLPPP QGSSESCTVN IPQQPPGSLS IASPNTAFIP
860 870 880 890 900
IHNPGSFPGS PVATTDPITK SASQVVGLNQ MVPQIEGNTG TVPQPTNVKV
910 920 930 940 950
VLPAAGLSAA QPPASYPLPG SPLAAGVLPS QNSSVLSTAA TSPQPASAGI
960 970 980 990 1000
SQAQATVPPA VPTHTPGPAP SPSPALTHST AQSDSTSYIS AVGNTNANGT
1010 1020 1030 1040 1050
VVPPQQMGSG PCGSCGRRCS CGTNGNLQLN SYYYPNPMPG PMYRVPSFFT
1060 1070 1080 1090 1100
LPSICNGSYL NQAHQSNGNQ LPFFLPQTPY ANGLVHDPVM GSQANYGMQQ
1110 1120 1130 1140 1150
MAGFGRFYPV YPAPNVVANT SGSGPKKNGN VSCYNCGVSG HYAQDCKQSS
1160 1170
MEANQQGTYR LRYAPPLPPS NDTLDSAD
Length:1,178
Mass (Da):125,936
Last modified:April 8, 2008 - v6
Checksum:iB93600F7D6B9A484
GO
Isoform 2 (identifier: Q9C0B9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-321: Missing.

Note: No experimental confirmation available.
Show »
Length:857
Mass (Da):91,738
Checksum:i95C7A36B05B0B2F1
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ESN2K7ESN2_HUMAN
Zinc finger CCHC domain-containing ...
ZCCHC2
1,098Annotation score:
K7ERQ9K7ERQ9_HUMAN
Zinc finger CCHC domain-containing ...
ZCCHC2
106Annotation score:
A0A087WXC7A0A087WXC7_HUMAN
Zinc finger CCHC domain-containing ...
ZCCHC2
195Annotation score:
K7EKB8K7EKB8_HUMAN
Zinc finger CCHC domain-containing ...
ZCCHC2
378Annotation score:

Sequence cautioni

The sequence BAA91057 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti508K → R in CAD38618 (PubMed:17974005).Curated1
Sequence conflicti802H → Y in CAD38618 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060121941T → A. Corresponds to variant dbSNP:rs35643152Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559951 – 321Missing in isoform 2. 1 PublicationAdd BLAST321

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC064801 Genomic DNA No translation available.
BC137435 mRNA Translation: AAI37436.1
AL832323 mRNA Translation: CAD38618.1
AB051531 mRNA Translation: BAB21835.1
AK000288 mRNA Translation: BAA91057.1 Different initiation.
CCDSiCCDS45880.1 [Q9C0B9-1]
RefSeqiNP_060212.4, NM_017742.5 [Q9C0B9-1]
UniGeneiHs.114191
Hs.714637
Hs.733355

Genome annotation databases

EnsembliENST00000269499; ENSP00000269499; ENSG00000141664 [Q9C0B9-1]
ENST00000586834; ENSP00000464791; ENSG00000141664 [Q9C0B9-2]
GeneIDi54877
KEGGihsa:54877
UCSCiuc002lip.5 human [Q9C0B9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC064801 Genomic DNA No translation available.
BC137435 mRNA Translation: AAI37436.1
AL832323 mRNA Translation: CAD38618.1
AB051531 mRNA Translation: BAB21835.1
AK000288 mRNA Translation: BAA91057.1 Different initiation.
CCDSiCCDS45880.1 [Q9C0B9-1]
RefSeqiNP_060212.4, NM_017742.5 [Q9C0B9-1]
UniGeneiHs.114191
Hs.714637
Hs.733355

3D structure databases

ProteinModelPortaliQ9C0B9
SMRiQ9C0B9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000269499

PTM databases

iPTMnetiQ9C0B9
PhosphoSitePlusiQ9C0B9

Polymorphism and mutation databases

BioMutaiZCCHC2
DMDMi182676458

Proteomic databases

EPDiQ9C0B9
MaxQBiQ9C0B9
PaxDbiQ9C0B9
PeptideAtlasiQ9C0B9
PRIDEiQ9C0B9
ProteomicsDBi79994

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269499; ENSP00000269499; ENSG00000141664 [Q9C0B9-1]
ENST00000586834; ENSP00000464791; ENSG00000141664 [Q9C0B9-2]
GeneIDi54877
KEGGihsa:54877
UCSCiuc002lip.5 human [Q9C0B9-1]

Organism-specific databases

CTDi54877
DisGeNETi54877
EuPathDBiHostDB:ENSG00000141664.9
GeneCardsiZCCHC2
H-InvDBiHIX0014493
HGNCiHGNC:22916 ZCCHC2
HPAiHPA040943
neXtProtiNX_Q9C0B9
OpenTargetsiENSG00000141664
PharmGKBiPA134861180
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZZC Eukaryota
ENOG4111U3M LUCA
GeneTreeiENSGT00520000055637
HOGENOMiHOG000155766
HOVERGENiHBG108762
InParanoidiQ9C0B9
KOiK22700
OMAiSMEASQQ
OrthoDBiEOG091G01BF
PhylomeDBiQ9C0B9
TreeFamiTF335574

Miscellaneous databases

ChiTaRSiZCCHC2 human
GeneWikiiZCCHC2
GenomeRNAii54877
PROiPR:Q9C0B9

Gene expression databases

BgeeiENSG00000141664 Expressed in 217 organ(s), highest expression level in secondary oocyte
CleanExiHS_ZCCHC2
ExpressionAtlasiQ9C0B9 baseline and differential
GenevisibleiQ9C0B9 HS

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR036871 PX_dom_sf
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00098 zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 1 hit
SUPFAMiSSF57756 SSF57756, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZCHC2_HUMAN
AccessioniPrimary (citable) accession number: Q9C0B9
Secondary accession number(s): B2RPG6, Q8N3S1, Q9NXF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: April 8, 2008
Last modified: November 7, 2018
This is version 135 of the entry and version 6 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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