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Entry version 147 (17 Jun 2020)
Sequence version 6 (08 Apr 2008)
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Protein

Zinc finger CCHC domain-containing protein 2

Gene

ZCCHC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1131 – 1148CCHC-typePROSITE-ProRule annotationAdd BLAST18

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger CCHC domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZCCHC2Imported
Synonyms:C18orf49Imported, KIAA1744
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000141664.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22916 ZCCHC2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9C0B9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54877

Open Targets

More...
OpenTargetsi
ENSG00000141664

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134861180

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9C0B9 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZCCHC2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
182676458

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001509491 – 1178Zinc finger CCHC domain-containing protein 2Add BLAST1178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei236PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9C0B9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9C0B9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9C0B9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9C0B9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9C0B9

PeptideAtlas

More...
PeptideAtlasi
Q9C0B9

PRoteomics IDEntifications database

More...
PRIDEi
Q9C0B9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79994 [Q9C0B9-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9C0B9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9C0B9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000141664 Expressed in secondary oocyte and 216 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9C0B9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9C0B9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000141664 Tissue enriched (salivary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120225, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q9C0B9, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000269499

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9C0B9 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9C0B9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi7 – 70Pro-richAdd BLAST64

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1131 – 1148CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IZZC Eukaryota
ENOG4111U3M LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00520000055637

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012453_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9C0B9

KEGG Orthology (KO)

More...
KOi
K22700

Identification of Orthologs from Complete Genome Data

More...
OMAi
TCGCHNN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9C0B9

TreeFam database of animal gene trees

More...
TreeFami
TF335574

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036871 PX_dom_sf
IPR042793 ZCCHC2
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf

The PANTHER Classification System

More...
PANTHERi
PTHR46939 PTHR46939, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00098 zf-CCHC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00343 ZnF_C2HC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57756 SSF57756, 1 hit
SSF64268 SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50158 ZF_CCHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9C0B9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRMKLPLKP THPAEPPPEA EEPEADARPG AKAPSRRRRD CRPPPPPPPP
60 70 80 90 100
AGPSRGPLPP PPPPRGLGPP VAGGAAAGAG MPGGGGGPSA ALREQERVYE
110 120 130 140 150
WFGLVLGSAQ RLEFMCGLLD LCNPLELRFL GSCLEDLARK DYHYLRDSEA
160 170 180 190 200
KANGLSDPGP LADFREPAVR SRLIVYLALL GSENREAAGR LHRLLPQVDS
210 220 230 240 250
VLKSLRAARG EGSRGGAEDE RGEDGDGEQD AEKDGSGPEG GIVEPRVGGG
260 270 280 290 300
LGSRAQEELL LLFTMASLHP AFSFHQRVTL REHLERLRAA LRGGPEDAEV
310 320 330 340 350
EVEPCKFAGP RAQNNSAHGD YMQNNESSLI EQAPIPQDGL TVAPHRAQRE
360 370 380 390 400
AVHIEKIMLK GVQRKRADKY WEYTFKVNWS DLSVTTVTKT HQELQEFLLK
410 420 430 440 450
LPKELSSETF DKTILRALNQ GSLKREERRH PDLEPILRQL FSSSSQAFLQ
460 470 480 490 500
SQKVHSFFQS ISSDSLHSIN NLQSSLKTSK ILEHLKEDSS EASSQEEDVL
510 520 530 540 550
QHAIIHKKHT GKSPIVNNIG TSCSPLDGLT MQYSEQNGIV DWRKQSCTTI
560 570 580 590 600
QHPEHCVTSA DQHSAEKRSL SSINKKKGKP QTEKEKIKKT DNRLNSRING
610 620 630 640 650
IRLSTPQHAH GGTVKDVNLD IGSGHDTCGE TSSESYSSPS SPRHDGRESF
660 670 680 690 700
ESEEEKDRDT DSNSEDSGNP STTRFTGYGS VNQTVTVKPP VQIASLGNEN
710 720 730 740 750
GNLLEDPLNS PKYQHISFMP TLHCVMHNGA QKSEVVVPAP KPADGKTIGM
760 770 780 790 800
LVPSPVAISA IRESANSTPV GILGPTACTG ESEKHLELLA SPLPIPSTFL
810 820 830 840 850
PHSSTPALHL TVQRLKLPPP QGSSESCTVN IPQQPPGSLS IASPNTAFIP
860 870 880 890 900
IHNPGSFPGS PVATTDPITK SASQVVGLNQ MVPQIEGNTG TVPQPTNVKV
910 920 930 940 950
VLPAAGLSAA QPPASYPLPG SPLAAGVLPS QNSSVLSTAA TSPQPASAGI
960 970 980 990 1000
SQAQATVPPA VPTHTPGPAP SPSPALTHST AQSDSTSYIS AVGNTNANGT
1010 1020 1030 1040 1050
VVPPQQMGSG PCGSCGRRCS CGTNGNLQLN SYYYPNPMPG PMYRVPSFFT
1060 1070 1080 1090 1100
LPSICNGSYL NQAHQSNGNQ LPFFLPQTPY ANGLVHDPVM GSQANYGMQQ
1110 1120 1130 1140 1150
MAGFGRFYPV YPAPNVVANT SGSGPKKNGN VSCYNCGVSG HYAQDCKQSS
1160 1170
MEANQQGTYR LRYAPPLPPS NDTLDSAD
Length:1,178
Mass (Da):125,936
Last modified:April 8, 2008 - v6
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB93600F7D6B9A484
GO
Isoform 2 (identifier: Q9C0B9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-321: Missing.

Show »
Length:857
Mass (Da):91,738
Checksum:i95C7A36B05B0B2F1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ESN2K7ESN2_HUMAN
Zinc finger CCHC domain-containing ...
ZCCHC2
1,098Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERQ9K7ERQ9_HUMAN
Zinc finger CCHC domain-containing ...
ZCCHC2
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXC7A0A087WXC7_HUMAN
Zinc finger CCHC domain-containing ...
ZCCHC2
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKB8K7EKB8_HUMAN
Zinc finger CCHC domain-containing ...
ZCCHC2
378Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91057 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti508K → R in CAD38618 (PubMed:17974005).Curated1
Sequence conflicti802H → Y in CAD38618 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060121941T → A. Corresponds to variant dbSNP:rs35643152Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0559951 – 321Missing in isoform 2. 1 PublicationAdd BLAST321

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC064801 Genomic DNA No translation available.
BC137435 mRNA Translation: AAI37436.1
AL832323 mRNA Translation: CAD38618.1
AB051531 mRNA Translation: BAB21835.1
AK000288 mRNA Translation: BAA91057.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45880.1 [Q9C0B9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_060212.4, NM_017742.5 [Q9C0B9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000269499; ENSP00000269499; ENSG00000141664 [Q9C0B9-1]
ENST00000586834; ENSP00000464791; ENSG00000141664 [Q9C0B9-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54877

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54877

UCSC genome browser

More...
UCSCi
uc002lip.5 human [Q9C0B9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC064801 Genomic DNA No translation available.
BC137435 mRNA Translation: AAI37436.1
AL832323 mRNA Translation: CAD38618.1
AB051531 mRNA Translation: BAB21835.1
AK000288 mRNA Translation: BAA91057.1 Different initiation.
CCDSiCCDS45880.1 [Q9C0B9-1]
RefSeqiNP_060212.4, NM_017742.5 [Q9C0B9-1]

3D structure databases

SMRiQ9C0B9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120225, 2 interactors
IntActiQ9C0B9, 1 interactor
STRINGi9606.ENSP00000269499

PTM databases

iPTMnetiQ9C0B9
PhosphoSitePlusiQ9C0B9

Polymorphism and mutation databases

BioMutaiZCCHC2
DMDMi182676458

Proteomic databases

EPDiQ9C0B9
jPOSTiQ9C0B9
MassIVEiQ9C0B9
MaxQBiQ9C0B9
PaxDbiQ9C0B9
PeptideAtlasiQ9C0B9
PRIDEiQ9C0B9
ProteomicsDBi79994 [Q9C0B9-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23063 20 antibodies

Genome annotation databases

EnsembliENST00000269499; ENSP00000269499; ENSG00000141664 [Q9C0B9-1]
ENST00000586834; ENSP00000464791; ENSG00000141664 [Q9C0B9-2]
GeneIDi54877
KEGGihsa:54877
UCSCiuc002lip.5 human [Q9C0B9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54877
DisGeNETi54877
EuPathDBiHostDB:ENSG00000141664.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZCCHC2
HGNCiHGNC:22916 ZCCHC2
HPAiENSG00000141664 Tissue enriched (salivary)
neXtProtiNX_Q9C0B9
OpenTargetsiENSG00000141664
PharmGKBiPA134861180

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IZZC Eukaryota
ENOG4111U3M LUCA
GeneTreeiENSGT00520000055637
HOGENOMiCLU_012453_0_0_1
InParanoidiQ9C0B9
KOiK22700
OMAiTCGCHNN
PhylomeDBiQ9C0B9
TreeFamiTF335574

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
54877 2 hits in 790 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZCCHC2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ZCCHC2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54877
PharosiQ9C0B9 Tdark

Protein Ontology

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PROi
PR:Q9C0B9
RNActiQ9C0B9 protein

Gene expression databases

BgeeiENSG00000141664 Expressed in secondary oocyte and 216 other tissues
ExpressionAtlasiQ9C0B9 baseline and differential
GenevisibleiQ9C0B9 HS

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR036871 PX_dom_sf
IPR042793 ZCCHC2
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PANTHERiPTHR46939 PTHR46939, 1 hit
PfamiView protein in Pfam
PF00098 zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 1 hit
SUPFAMiSSF57756 SSF57756, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZCHC2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C0B9
Secondary accession number(s): B2RPG6, Q8N3S1, Q9NXF6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: April 8, 2008
Last modified: June 17, 2020
This is version 147 of the entry and version 6 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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