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UniProtKB - Q9C0B7 (TNG6_HUMAN)
Protein
Transport and Golgi organization protein 6 homolog
Gene
TANGO6
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- protein secretion Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q9C0B7 |
SignaLinki | Q9C0B7 |
Names & Taxonomyi
Protein namesi | Recommended name: Transport and Golgi organization protein 6 homologAlternative name(s): Transmembrane and coiled-coil domain-containing protein 7 |
Gene namesi | Name:TANGO6 Synonyms:KIAA1746, TMCO7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25749, TANGO6 |
neXtProti | NX_Q9C0B7 |
VEuPathDBi | HostDB:ENSG00000103047 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 468 – 488 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 79613 |
OpenTargetsi | ENSG00000103047 |
PharmGKBi | PA162405811 |
Miscellaneous databases
Pharosi | Q9C0B7, Tdark |
Genetic variation databases
BioMutai | TANGO6 |
DMDMi | 158706353 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000305059 | 1 – 1094 | Transport and Golgi organization protein 6 homologAdd BLAST | 1094 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 556 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9C0B7 |
jPOSTi | Q9C0B7 |
MassIVEi | Q9C0B7 |
MaxQBi | Q9C0B7 |
PaxDbi | Q9C0B7 |
PeptideAtlasi | Q9C0B7 |
PRIDEi | Q9C0B7 |
ProteomicsDBi | 79993 |
PTM databases
iPTMneti | Q9C0B7 |
PhosphoSitePlusi | Q9C0B7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000103047, Expressed in liver and 147 other tissues |
ExpressionAtlasi | Q9C0B7, baseline and differential |
Genevisiblei | Q9C0B7, HS |
Organism-specific databases
HPAi | ENSG00000103047, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 122747, 96 interactors |
IntActi | Q9C0B7, 6 interactors |
STRINGi | 9606.ENSP00000261778 |
Miscellaneous databases
RNActi | Q9C0B7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 873 – 909 | HEAT 1Add BLAST | 37 | |
Repeati | 952 – 988 | HEAT 2Add BLAST | 37 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 777 – 834 | DisorderedSequence analysisAdd BLAST | 58 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 777 – 796 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 797 – 834 | Polar residuesSequence analysisAdd BLAST | 38 |
Sequence similaritiesi
Belongs to the Tango6 family.Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4653, Eukaryota |
GeneTreei | ENSGT00390000010938 |
HOGENOMi | CLU_006971_1_0_1 |
InParanoidi | Q9C0B7 |
OMAi | TLVFTRH |
OrthoDBi | 917181at2759 |
PhylomeDBi | Q9C0B7 |
TreeFami | TF330876 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR019451, Rtp1_C1 IPR019414, Rtp1_C2 IPR039600, TANGO6/Rtp1 |
PANTHERi | PTHR20959, PTHR20959, 1 hit |
Pfami | View protein in Pfam PF10363, RTP1_C1, 1 hit PF10304, RTP1_C2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9C0B7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAARQAVGSG AQETCGLDRI LEALKLLLSP GGSGSSSLQV TKHDVLLATL
60 70 80 90 100
KSNLSALEDK FLKDPQWKNL KLLRDEIADK AEWPQNSVDV TWSFTSQTLL
110 120 130 140 150
LLLCLKETMI RLAANFNPGK PNPRTPEVAP ALSPDALSIS QQKTVQFVLQ
160 170 180 190 200
FVVTLGICPY LMPGVGVPLR YRTEFGAVVQ DVVCFDAAPD ATRRLYTSCK
210 220 230 240 250
ALLNVAQHTS LGSLIFCHHF GDIAAGLCQL GFCPTKRKLL TPAEEVLTEE
260 270 280 290 300
ERTLSRGALR DMLDQVYQPL AVRELLILQG GPPQSCTDVK TQMRCRAPAW
310 320 330 340 350
LRRLCGQLLS ERLMRPNGVQ AVVRGILEGA GAGAAGGSDA EVTAADWKKC
360 370 380 390 400
DLIAKILASC PQQSLSPENY YRDICPQVLD LFHFQDKLTA RQFQRVATTT
410 420 430 440 450
FITLSRERPH LAAKYLLQPV LAPLHRCLNT AELSESDMVP GTILVTEEEL
460 470 480 490 500
SRCIEDVFKV YVVGNEPLTV LMDSLLPVLG VLFLLYCFTK QSVSHIRSLC
510 520 530 540 550
QEILLWILGK LERKKAIASL KGFAGLDKAV PSLHSLCQFR VATQGGIMIT
560 570 580 590 600
IKEAISDEDE DEALYQKVSS EQGRVEHLGD LLSHCQECGL AGDFFIFCLK
610 620 630 640 650
ELTHVASENE TELKTEPFSS KSLLELEQHQ TLLVEGQERK LLVLQLMAVL
660 670 680 690 700
CERMSEQIFT NVTQVVDFVA ATLQRACASL AHQAESTVES QTLSMSMGLV
710 720 730 740 750
AVMLGGAVQL KSSDFAVLKQ LLPLLEKVSN TYPDPVIQEL AVDLRITIST
760 770 780 790 800
HGAFATEAVS MAAQSTLNRK DLEGKIEEQQ QTSHERPTDV AHSHLEQQQS
810 820 830 840 850
HETAPQTGLQ SNAPIIPQGV NEPSTTTSQK SGSVTTEQLQ EVLLSAYDPQ
860 870 880 890 900
IPTRAAALRT LSHWIEQREA KALEMQEKLL KIFLENLEHE DTFVYLSAIQ
910 920 930 940 950
GVALLSDVYP EKILPDLLAQ YDSSKDKHTP ETRMKVGEVL MRIVRALGDM
960 970 980 990 1000
VSKYREPLIH TFLRGVRDPD GAHRASSLAN LGELCQRLDF LLGSVVHEVT
1010 1020 1030 1040 1050
ACLIAVAKTD GEVQVRRAAI HVVVLLLRGL SQKATEVLSA VLKDLYHLLK
1060 1070 1080 1090
HVVCLEPDDV AKLHAQLALE ELDDIMKNFL FPPQKLEKKI MVLP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KT80 | J3KT80_HUMAN | Transport and Golgi organization pr... | TANGO6 | 37 | Annotation score: | ||
J3QL82 | J3QL82_HUMAN | Transport and Golgi organization pr... | TANGO6 | 27 | Annotation score: |
Sequence cautioni
The sequence BAB14224 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB21837 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB051533 mRNA Translation: BAB21837.1 Different initiation. AC009027 Genomic DNA No translation available. AC009082 Genomic DNA No translation available. AC009137 Genomic DNA No translation available. AK022750 mRNA Translation: BAB14224.1 Different initiation. |
CCDSi | CCDS45516.1 |
RefSeqi | NP_078838.1, NM_024562.1 |
Genome annotation databases
Ensembli | ENST00000261778.2; ENSP00000261778.1; ENSG00000103047.8 |
GeneIDi | 79613 |
KEGGi | hsa:79613 |
MANE-Selecti | ENST00000261778.2; ENSP00000261778.1; NM_024562.2; NP_078838.1 |
UCSCi | uc002ewi.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB051533 mRNA Translation: BAB21837.1 Different initiation. AC009027 Genomic DNA No translation available. AC009082 Genomic DNA No translation available. AC009137 Genomic DNA No translation available. AK022750 mRNA Translation: BAB14224.1 Different initiation. |
CCDSi | CCDS45516.1 |
RefSeqi | NP_078838.1, NM_024562.1 |
3D structure databases
AlphaFoldDBi | Q9C0B7 |
SMRi | Q9C0B7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122747, 96 interactors |
IntActi | Q9C0B7, 6 interactors |
STRINGi | 9606.ENSP00000261778 |
PTM databases
iPTMneti | Q9C0B7 |
PhosphoSitePlusi | Q9C0B7 |
Genetic variation databases
BioMutai | TANGO6 |
DMDMi | 158706353 |
Proteomic databases
EPDi | Q9C0B7 |
jPOSTi | Q9C0B7 |
MassIVEi | Q9C0B7 |
MaxQBi | Q9C0B7 |
PaxDbi | Q9C0B7 |
PeptideAtlasi | Q9C0B7 |
PRIDEi | Q9C0B7 |
ProteomicsDBi | 79993 |
Protocols and materials databases
Antibodypediai | 50648, 62 antibodies from 14 providers |
DNASUi | 79613 |
Genome annotation databases
Ensembli | ENST00000261778.2; ENSP00000261778.1; ENSG00000103047.8 |
GeneIDi | 79613 |
KEGGi | hsa:79613 |
MANE-Selecti | ENST00000261778.2; ENSP00000261778.1; NM_024562.2; NP_078838.1 |
UCSCi | uc002ewi.5, human |
Organism-specific databases
CTDi | 79613 |
DisGeNETi | 79613 |
GeneCardsi | TANGO6 |
HGNCi | HGNC:25749, TANGO6 |
HPAi | ENSG00000103047, Low tissue specificity |
neXtProti | NX_Q9C0B7 |
OpenTargetsi | ENSG00000103047 |
PharmGKBi | PA162405811 |
VEuPathDBi | HostDB:ENSG00000103047 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4653, Eukaryota |
GeneTreei | ENSGT00390000010938 |
HOGENOMi | CLU_006971_1_0_1 |
InParanoidi | Q9C0B7 |
OMAi | TLVFTRH |
OrthoDBi | 917181at2759 |
PhylomeDBi | Q9C0B7 |
TreeFami | TF330876 |
Enzyme and pathway databases
PathwayCommonsi | Q9C0B7 |
SignaLinki | Q9C0B7 |
Miscellaneous databases
BioGRID-ORCSi | 79613, 748 hits in 1078 CRISPR screens |
ChiTaRSi | TANGO6, human |
GenomeRNAii | 79613 |
Pharosi | Q9C0B7, Tdark |
PROi | PR:Q9C0B7 |
RNActi | Q9C0B7, protein |
Gene expression databases
Bgeei | ENSG00000103047, Expressed in liver and 147 other tissues |
ExpressionAtlasi | Q9C0B7, baseline and differential |
Genevisiblei | Q9C0B7, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR019451, Rtp1_C1 IPR019414, Rtp1_C2 IPR039600, TANGO6/Rtp1 |
PANTHERi | PTHR20959, PTHR20959, 1 hit |
Pfami | View protein in Pfam PF10363, RTP1_C1, 1 hit PF10304, RTP1_C2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TNG6_HUMAN | |
Accessioni | Q9C0B7Primary (citable) accession number: Q9C0B7 Secondary accession number(s): Q569F9, Q9H9K1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | October 2, 2007 | |
Last modified: | May 25, 2022 | |
This is version 136 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families