UniProtKB - Q9C0B7 (TNG6_HUMAN)

BLAST

>sp|Q9C0B7|TNG6_HUMAN Transport and Golgi organization protein 6 homolog OS=Homo sapiens OX=9606 GN=TANGO6 PE=1 SV=2
MAARQAVGSGAQETCGLDRILEALKLLLSPGGSGSSSLQVTKHDVLLATLKSNLSALEDK
FLKDPQWKNLKLLRDEIADKAEWPQNSVDVTWSFTSQTLLLLLCLKETMIRLAANFNPGK
PNPRTPEVAPALSPDALSISQQKTVQFVLQFVVTLGICPYLMPGVGVPLRYRTEFGAVVQ
DVVCFDAAPDATRRLYTSCKALLNVAQHTSLGSLIFCHHFGDIAAGLCQLGFCPTKRKLL
TPAEEVLTEEERTLSRGALRDMLDQVYQPLAVRELLILQGGPPQSCTDVKTQMRCRAPAW
LRRLCGQLLSERLMRPNGVQAVVRGILEGAGAGAAGGSDAEVTAADWKKCDLIAKILASC
PQQSLSPENYYRDICPQVLDLFHFQDKLTARQFQRVATTTFITLSRERPHLAAKYLLQPV
LAPLHRCLNTAELSESDMVPGTILVTEEELSRCIEDVFKVYVVGNEPLTVLMDSLLPVLG
VLFLLYCFTKQSVSHIRSLCQEILLWILGKLERKKAIASLKGFAGLDKAVPSLHSLCQFR
VATQGGIMITIKEAISDEDEDEALYQKVSSEQGRVEHLGDLLSHCQECGLAGDFFIFCLK
ELTHVASENETELKTEPFSSKSLLELEQHQTLLVEGQERKLLVLQLMAVLCERMSEQIFT
NVTQVVDFVAATLQRACASLAHQAESTVESQTLSMSMGLVAVMLGGAVQLKSSDFAVLKQ
LLPLLEKVSNTYPDPVIQELAVDLRITISTHGAFATEAVSMAAQSTLNRKDLEGKIEEQQ
QTSHERPTDVAHSHLEQQQSHETAPQTGLQSNAPIIPQGVNEPSTTTSQKSGSVTTEQLQ
EVLLSAYDPQIPTRAAALRTLSHWIEQREAKALEMQEKLLKIFLENLEHEDTFVYLSAIQ
GVALLSDVYPEKILPDLLAQYDSSKDKHTPETRMKVGEVLMRIVRALGDMVSKYREPLIH
TFLRGVRDPDGAHRASSLANLGELCQRLDFLLGSVVHEVTACLIAVAKTDGEVQVRRAAI
HVVVLLLRGLSQKATEVLSAVLKDLYHLLKHVVCLEPDDVAKLHAQLALEELDDIMKNFL
FPPQKLEKKIMVLP

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History
Entry version 116 (07 Nov 2018)
Sequence version 2 (02 Oct 2007)
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Protein

Transport and Golgi organization protein 6 homolog

Gene

TANGO6

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transport and Golgi organization protein 6 homolog Alternative name(s): Transmembrane and coiled-coil domain-containing protein 7
Gene namesⁱ	Name:TANGO6 Synonyms:KIAA1746, TMCO7
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000103047.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25749 TANGO6
neXtProtⁱ	NX_Q9C0B7

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	468 – 488	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000103047
PharmGKBⁱ	PA162405811

Polymorphism and mutation databases

BioMutaⁱ	TANGO6
DMDMⁱ	158706353

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000305059	1 – 1094	Transport and Golgi organization protein 6 homologAdd BLAST		1094

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	556	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9C0B7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9C0B7
PaxDbⁱ	Q9C0B7
PeptideAtlas More...PeptideAtlasⁱ	Q9C0B7
PRIDEⁱ	Q9C0B7
ProteomicsDBⁱ	79993

PTM databases

iPTMnetⁱ	Q9C0B7
PhosphoSitePlusⁱ	Q9C0B7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000103047 Expressed in 125 organ(s), highest expression level in liver
CleanExⁱ	HS_TMCO7
ExpressionAtlasⁱ	Q9C0B7 baseline and differential
Genevisibleⁱ	Q9C0B7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA041312

HPAⁱ

HPA041312

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	122747, 12 interactors
IntActⁱ	Q9C0B7, 4 interactors
STRINGⁱ	9606.ENSP00000261778

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9C0B7
SMRⁱ	Q9C0B7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Repeatⁱ	873 – 909	HEAT 1Add BLAST		37
Repeatⁱ	952 – 988	HEAT 2Add BLAST		37

Sequence similaritiesⁱ

Belongs to the Tango6 family.Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4653 Eukaryota ENOG410XS2I LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010938
HOGENOMⁱ	HOG000154637
HOVERGENⁱ	HBG057050
InParanoidⁱ	Q9C0B7
OMAⁱ	FTLFCFT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02MW
PhylomeDBⁱ	Q9C0B7
TreeFamⁱ	TF330876

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR019451 Rtp1_C1 IPR019414 Rtp1_C2 IPR039600 TANGO6/Rtp1
PANTHERⁱ	PTHR20959 PTHR20959, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10363 RTP1_C1, 1 hit PF10304 RTP1_C2, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q9C0B7-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MAARQAVGSG AQETCGLDRI LEALKLLLSP GGSGSSSLQV TKHDVLLATL 
        60         70         80         90        100
KSNLSALEDK FLKDPQWKNL KLLRDEIADK AEWPQNSVDV TWSFTSQTLL 
       110        120        130        140        150
LLLCLKETMI RLAANFNPGK PNPRTPEVAP ALSPDALSIS QQKTVQFVLQ 
       160        170        180        190        200
FVVTLGICPY LMPGVGVPLR YRTEFGAVVQ DVVCFDAAPD ATRRLYTSCK 
       210        220        230        240        250
ALLNVAQHTS LGSLIFCHHF GDIAAGLCQL GFCPTKRKLL TPAEEVLTEE 
       260        270        280        290        300
ERTLSRGALR DMLDQVYQPL AVRELLILQG GPPQSCTDVK TQMRCRAPAW 
       310        320        330        340        350
LRRLCGQLLS ERLMRPNGVQ AVVRGILEGA GAGAAGGSDA EVTAADWKKC 
       360        370        380        390        400
DLIAKILASC PQQSLSPENY YRDICPQVLD LFHFQDKLTA RQFQRVATTT 
       410        420        430        440        450
FITLSRERPH LAAKYLLQPV LAPLHRCLNT AELSESDMVP GTILVTEEEL 
       460        470        480        490        500
SRCIEDVFKV YVVGNEPLTV LMDSLLPVLG VLFLLYCFTK QSVSHIRSLC 
       510        520        530        540        550
QEILLWILGK LERKKAIASL KGFAGLDKAV PSLHSLCQFR VATQGGIMIT 
       560        570        580        590        600
IKEAISDEDE DEALYQKVSS EQGRVEHLGD LLSHCQECGL AGDFFIFCLK 
       610        620        630        640        650
ELTHVASENE TELKTEPFSS KSLLELEQHQ TLLVEGQERK LLVLQLMAVL 
       660        670        680        690        700
CERMSEQIFT NVTQVVDFVA ATLQRACASL AHQAESTVES QTLSMSMGLV 
       710        720        730        740        750
AVMLGGAVQL KSSDFAVLKQ LLPLLEKVSN TYPDPVIQEL AVDLRITIST 
       760        770        780        790        800
HGAFATEAVS MAAQSTLNRK DLEGKIEEQQ QTSHERPTDV AHSHLEQQQS 
       810        820        830        840        850
HETAPQTGLQ SNAPIIPQGV NEPSTTTSQK SGSVTTEQLQ EVLLSAYDPQ 
       860        870        880        890        900
IPTRAAALRT LSHWIEQREA KALEMQEKLL KIFLENLEHE DTFVYLSAIQ 
       910        920        930        940        950
GVALLSDVYP EKILPDLLAQ YDSSKDKHTP ETRMKVGEVL MRIVRALGDM 
       960        970        980        990       1000
VSKYREPLIH TFLRGVRDPD GAHRASSLAN LGELCQRLDF LLGSVVHEVT 
      1010       1020       1030       1040       1050
ACLIAVAKTD GEVQVRRAAI HVVVLLLRGL SQKATEVLSA VLKDLYHLLK 
      1060       1070       1080       1090 
HVVCLEPDDV AKLHAQLALE ELDDIMKNFL FPPQKLEKKI MVLP

Length:1,094

Mass (Da):120,748

Last modified:October 2, 2007 - v2

Checksum:ⁱ48E9BBD05E6902CE

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3KT80	J3KT80_HUMAN	Transport and Golgi organization pr... Transport and Golgi organization protein 6 homolog	TANGO6	37	Annotation score:
J3QL82	J3QL82_HUMAN	Transport and Golgi organization pr... Transport and Golgi organization protein 6 homolog	TANGO6	27	Annotation score:

Sequence cautionⁱ

The sequence BAB14224 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence BAB21837 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB051533 mRNA Translation: BAB21837.1 Different initiation. AC009027 Genomic DNA No translation available. AC009082 Genomic DNA No translation available. AC009137 Genomic DNA No translation available. AK022750 mRNA Translation: BAB14224.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS45516.1
NCBI Reference Sequences More...RefSeqⁱ	NP_078838.1, NM_024562.1
UniGeneⁱ	Hs.13526

Genome annotation databases

Ensemblⁱ	ENST00000261778; ENSP00000261778; ENSG00000103047
GeneIDⁱ	79613
KEGGⁱ	hsa:79613
UCSC genome browser More...UCSCⁱ	uc002ewi.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9C0B7	cDNA FLJ38014 fis, clone CTONG2012607		HUMAN		933	UniRef100_Q9C0B7

Protein	Similar proteins		Species	Score	Length	Source
Q9C0B7	cDNA FLJ38014 fis, clone CTONG2012607		HUMAN		933	UniRef90_Q9C0B7
Uncharacterized protein		CHLSB		1097
TANGO6 isoform 1		PANTR		1095
Uncharacterized protein		MACMU		1095
TANGO6 isoform 2		PONAB		1095
+23

Protein	Similar proteins		Species	Score	Length	Source
Q9C0B7	Transport and Golgi organization protein 6 homolog		MOUSE		1079	UniRef50_Q8C3S2
Transport and golgi organization 6 homolog		RAT		1084
Uncharacterized protein		Cebus capucinus imitator		1041
Uncharacterized protein		SARHA		1095
Uncharacterized protein		LEPOC		1060
+219

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB051533 mRNA Translation: BAB21837.1 Different initiation. AC009027 Genomic DNA No translation available. AC009082 Genomic DNA No translation available. AC009137 Genomic DNA No translation available. AK022750 mRNA Translation: BAB14224.1 Different initiation.
CCDSⁱ	CCDS45516.1
RefSeqⁱ	NP_078838.1, NM_024562.1
UniGeneⁱ	Hs.13526

3D structure databases

ProteinModelPortalⁱ	Q9C0B7
SMRⁱ	Q9C0B7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122747, 12 interactors
IntActⁱ	Q9C0B7, 4 interactors
STRINGⁱ	9606.ENSP00000261778

PTM databases

iPTMnetⁱ	Q9C0B7
PhosphoSitePlusⁱ	Q9C0B7

Polymorphism and mutation databases

BioMutaⁱ	TANGO6
DMDMⁱ	158706353

Proteomic databases

EPDⁱ	Q9C0B7
MaxQBⁱ	Q9C0B7
PaxDbⁱ	Q9C0B7
PeptideAtlasⁱ	Q9C0B7
PRIDEⁱ	Q9C0B7
ProteomicsDBⁱ	79993

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000261778; ENSP00000261778; ENSG00000103047
GeneIDⁱ	79613
KEGGⁱ	hsa:79613
UCSCⁱ	uc002ewi.5 human

Organism-specific databases

CTDⁱ	79613
EuPathDBⁱ	HostDB:ENSG00000103047.7
GeneCardsⁱ	TANGO6
H-InvDBⁱ	HIX0013178
HGNCⁱ	HGNC:25749 TANGO6
HPAⁱ	HPA041312
neXtProtⁱ	NX_Q9C0B7
OpenTargetsⁱ	ENSG00000103047
PharmGKBⁱ	PA162405811
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4653 Eukaryota ENOG410XS2I LUCA
GeneTreeⁱ	ENSGT00390000010938
HOGENOMⁱ	HOG000154637
HOVERGENⁱ	HBG057050
InParanoidⁱ	Q9C0B7
OMAⁱ	FTLFCFT
OrthoDBⁱ	EOG091G02MW
PhylomeDBⁱ	Q9C0B7
TreeFamⁱ	TF330876

Miscellaneous databases

ChiTaRSⁱ	TANGO6 human
GenomeRNAiⁱ	79613
Protein Ontology More...PROⁱ	PR:Q9C0B7

Gene expression databases

Bgeeⁱ	ENSG00000103047 Expressed in 125 organ(s), highest expression level in liver
CleanExⁱ	HS_TMCO7
ExpressionAtlasⁱ	Q9C0B7 baseline and differential
Genevisibleⁱ	Q9C0B7 HS

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR019451 Rtp1_C1 IPR019414 Rtp1_C2 IPR039600 TANGO6/Rtp1
PANTHERⁱ	PTHR20959 PTHR20959, 1 hit
Pfamⁱ	View protein in Pfam PF10363 RTP1_C1, 1 hit PF10304 RTP1_C2, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TNG6_HUMAN
Accessionⁱ	Q9C0B7Primary (citable) accession number: Q9C0B7 Secondary accession number(s): Q569F9, Q9H9K1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
	Last sequence update:	October 2, 2007
	Last modified:	November 7, 2018
	This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9C0B7 (TNG6_HUMAN)

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Transport and Golgi organization protein 6 homolog

TANGO6

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ