Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9C0B5 (ZDHC5_HUMAN)

Protein

Palmitoyltransferase ZDHHC5

Gene

ZDHHC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity).By similarity1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei134S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC5 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 5
Short name:
DHHC-5
Zinc finger protein 375
Gene namesi
Name:ZDHHC5
Synonyms:KIAA1748, ZNF375
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000156599.10
HGNCiHGNC:18472 ZDHHC5
MIMi614586 gene
neXtProtiNX_Q9C0B5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 38ExtracellularSequence analysis4
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 148CytoplasmicSequence analysisAdd BLAST89
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 191ExtracellularSequence analysisAdd BLAST22
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 715CytoplasmicSequence analysisAdd BLAST503

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi25921
OpenTargetsiENSG00000156599
PharmGKBiPA38338

Polymorphism and mutation databases

BioMutaiZDHHC5
DMDMi28202103

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128681 – 715Palmitoyltransferase ZDHHC5Add BLAST715

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91PhosphotyrosineBy similarity1
Modified residuei247PhosphoserineCombined sources1
Modified residuei294PhosphothreonineBy similarity1
Modified residuei296PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1
Modified residuei303PhosphothreonineBy similarity1
Modified residuei345PhosphoserineCombined sources1
Modified residuei348PhosphothreonineCombined sources1
Modified residuei350PhosphothreonineBy similarity1
Modified residuei380PhosphoserineCombined sources1
Modified residuei398PhosphoserineCombined sources1
Modified residuei406PhosphoserineCombined sources1
Modified residuei409PhosphoserineCombined sources1
Modified residuei411PhosphothreonineCombined sources1
Modified residuei415PhosphoserineCombined sources1
Modified residuei425PhosphoserineCombined sources1
Modified residuei429PhosphoserineBy similarity1
Modified residuei432PhosphoserineCombined sources1
Modified residuei436PhosphothreonineCombined sources1
Modified residuei529PhosphoserineCombined sources1
Modified residuei554PhosphoserineCombined sources1
Modified residuei617Omega-N-methylarginineCombined sources1
Modified residuei621PhosphoserineCombined sources1
Modified residuei659PhosphothreonineCombined sources1
Modified residuei684PhosphoserineCombined sources1
Modified residuei694PhosphoserineCombined sources1
Modified residuei697Omega-N-methylarginineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ9C0B5
MaxQBiQ9C0B5
PaxDbiQ9C0B5
PeptideAtlasiQ9C0B5
PRIDEiQ9C0B5
ProteomicsDBi79989
79990 [Q9C0B5-2]

PTM databases

iPTMnetiQ9C0B5
PhosphoSitePlusiQ9C0B5
SwissPalmiQ9C0B5

Expressioni

Gene expression databases

BgeeiENSG00000156599 Expressed in 204 organ(s), highest expression level in esophagus squamous epithelium
CleanExiHS_ZDHHC5
ExpressionAtlasiQ9C0B5 baseline and differential
GenevisibleiQ9C0B5 HS

Organism-specific databases

HPAiHPA014670

Interactioni

Protein-protein interaction databases

BioGridi117422, 25 interactors
IntActiQ9C0B5, 17 interactors
STRINGi9606.ENSP00000287169

Structurei

3D structure databases

ProteinModelPortaliQ9C0B5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 154DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00550000074293
HOGENOMiHOG000234346
HOVERGENiHBG057186
InParanoidiQ9C0B5
KOiK20030
OMAiYSSQKAQ
OrthoDBiEOG091G02XW
PhylomeDBiQ9C0B5
TreeFamiTF354263

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9C0B5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPAESGKRFK PSKYVPVSAA AIFLVGATTL FFAFTCPGLS LYVSPAVPIY 
        60         70         80         90        100
NAIMFLFVLA NFSMATFMDP GIFPRAEEDE DKEDDFRAPL YKTVEIKGIQ 
       110        120        130        140        150
VRMKWCATCR FYRPPRCSHC SVCDNCVEEF DHHCPWVNNC IGRRNYRYFF 
       160        170        180        190        200
LFLLSLTAHI MGVFGFGLLY VLYHIEELSG VRTAVTMAVM CVAGLFFIPV 
       210        220        230        240        250
AGLTGFHVVL VARGRTTNEQ VTGKFRGGVN PFTNGCCNNV SRVLCSSPAP 
       260        270        280        290        300
RYLGRPKKEK TIVIRPPFLR PEVSDGQITV KIMDNGIQGE LRRTKSKGSL 
       310        320        330        340        350
EITESQSADA EPPPPPKPDL SRYTGLRTHL GLATNEDSSL LAKDSPPTPT 
       360        370        380        390        400
MYKYRPGYSS SSTSAAMPHS SSAKLSRGDS LKEPTSIAES SRHPSYRSEP 
       410        420        430        440        450
SLEPESFRSP TFGKSFHFDP LSSGSRSSSL KSAQGTGFEL GQLQSIRSEG 
       460        470        480        490        500
TTSTSYKSLA NQTRNGSLSY DSLLTPSDSP DFESVQAGPE PDPPLGYTSP 
       510        520        530        540        550
FLSARLAQQR EAERHPRLVP TGPTHREPSP VRYDNLSRHI VASLQEREKL 
       560        570        580        590        600
LRQSPPLPGR EEEPGLGDSG IQSTPGSGHA PRTSSSSDDS KRSPLGKTPL 
       610        620        630        640        650
GRPAVPRFGK PDGLRGRGVG SPEPGPTAPY LGRSMSYSSQ KAQPGVSETE 
       660        670        680        690        700
EVALQPLLTP KDEVQLKTTY SKSNGQPKSL GSASPGPGQP PLSSPTRGGV 
       710 
KKVSGVGGTT YEISV
Length:715
Mass (Da):77,545
Last modified:February 1, 2003 - v2
Checksum:i9E4FB0C9AC8EFE28
GO
Isoform 2 (identifier: Q9C0B5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Note: No experimental confirmation available.
Show »
Length:662
Mass (Da):71,952
Checksum:i9BC8E828B718A32E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PMA5E9PMA5_HUMAN
Palmitoyltransferase
ZDHHC5
138Annotation score:
E9PJ97E9PJ97_HUMAN
Palmitoyltransferase
ZDHHC5
103Annotation score:
H0YEF4H0YEF4_HUMAN
Palmitoyltransferase ZDHHC5
ZDHHC5
300Annotation score:

Sequence cautioni

The sequence BAB21839 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAD18778 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti508 – 509QQ → TR in CAB56033 (PubMed:17974005).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0069351 – 53Missing in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051535 mRNA Translation: BAB21839.1 Different initiation.
AY894889 mRNA Translation: AAX73368.1
AK023130 mRNA Translation: BAB14420.1
AK172807 mRNA Translation: BAD18778.1 Different initiation.
CH471076 Genomic DNA Translation: EAW73771.1
BC026967 mRNA Translation: AAH26967.1
AL117662 mRNA Translation: CAB56033.1
CCDSiCCDS7965.1 [Q9C0B5-1]
PIRiT17343
RefSeqiNP_056272.2, NM_015457.2 [Q9C0B5-1]
XP_011543201.1, XM_011544899.1 [Q9C0B5-1]
XP_011543202.1, XM_011544900.1 [Q9C0B5-1]
XP_011543203.1, XM_011544901.1 [Q9C0B5-1]
UniGeneiHs.27239

Genome annotation databases

EnsembliENST00000287169; ENSP00000287169; ENSG00000156599 [Q9C0B5-1]
ENST00000527985; ENSP00000432202; ENSG00000156599 [Q9C0B5-2]
GeneIDi25921
KEGGihsa:25921
UCSCiuc001nkx.2 human [Q9C0B5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZDHC5_HUMAN
AccessioniPrimary (citable) accession number: Q9C0B5
Secondary accession number(s): Q2TGF0
, Q6ZMF0, Q8TAK8, Q9H923, Q9UFI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: February 1, 2003
Last modified: September 12, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again