UniProtKB - Q9C0B5 (ZDHC5_HUMAN)
Protein
Palmitoyltransferase ZDHHC5
Gene
ZDHHC5
Organism
Homo sapiens (Human)
Status
Functioni
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:21820437). Palmitoylates the G-protein coupled receptor SSTR5 and for FLOT2 (PubMed:21820437).1 Publication
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 134 | S-palmitoyl cysteine intermediateBy similarity | 1 |
GO - Molecular functioni
- palmitoyltransferase activity Source: UniProtKB
- protein-cysteine S-palmitoyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- positive regulation of pattern recognition receptor signaling pathway Source: UniProtKB
- positive regulation of protein localization to phagocytic vesicle Source: Ensembl
- positive regulation of protein localization to plasma membrane Source: UniProtKB
- protein palmitoylation Source: UniProtKB
Keywordsi
Molecular function | Acyltransferase, Transferase |
Enzyme and pathway databases
PathwayCommonsi | Q9C0B5 |
SIGNORi | Q9C0B5 |
Names & Taxonomyi
Protein namesi | Recommended name: Palmitoyltransferase ZDHHC5 (EC:2.3.1.2251 Publication)Alternative name(s): Zinc finger DHHC domain-containing protein 5 Short name: DHHC-5 Zinc finger protein 375 |
Gene namesi | Name:ZDHHC5 Synonyms:KIAA1748, ZNF375 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18472, ZDHHC5 |
MIMi | 614586, gene |
neXtProti | NX_Q9C0B5 |
VEuPathDBi | HostDB:ENSG00000156599.10 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- dendrite Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
- membrane Source: UniProtKB
- phagocytic vesicle Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 13 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 14 – 34 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 35 – 38 | ExtracellularSequence analysis | 4 | |
Transmembranei | 39 – 59 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 60 – 148 | CytoplasmicSequence analysisAdd BLAST | 89 | |
Transmembranei | 149 – 169 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 170 – 191 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 192 – 212 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 213 – 715 | CytoplasmicSequence analysisAdd BLAST | 503 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 25921 |
OpenTargetsi | ENSG00000156599 |
PharmGKBi | PA38338 |
Miscellaneous databases
Pharosi | Q9C0B5, Tbio |
Genetic variation databases
BioMutai | ZDHHC5 |
DMDMi | 28202103 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212868 | 1 – 715 | Palmitoyltransferase ZDHHC5Add BLAST | 715 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 91 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 247 | PhosphoserineCombined sources | 1 | |
Modified residuei | 294 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 296 | PhosphoserineCombined sources | 1 | |
Modified residuei | 299 | PhosphoserineCombined sources | 1 | |
Modified residuei | 303 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 345 | PhosphoserineCombined sources | 1 | |
Modified residuei | 348 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 350 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 380 | PhosphoserineCombined sources | 1 | |
Modified residuei | 398 | PhosphoserineCombined sources | 1 | |
Modified residuei | 406 | PhosphoserineCombined sources | 1 | |
Modified residuei | 409 | PhosphoserineCombined sources | 1 | |
Modified residuei | 411 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 415 | PhosphoserineCombined sources | 1 | |
Modified residuei | 425 | PhosphoserineCombined sources | 1 | |
Modified residuei | 429 | PhosphoserineBy similarity | 1 | |
Modified residuei | 432 | PhosphoserineCombined sources | 1 | |
Modified residuei | 436 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 529 | PhosphoserineCombined sources | 1 | |
Modified residuei | 554 | PhosphoserineCombined sources | 1 | |
Modified residuei | 617 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 621 | PhosphoserineCombined sources | 1 | |
Modified residuei | 659 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 684 | PhosphoserineCombined sources | 1 | |
Modified residuei | 694 | PhosphoserineCombined sources | 1 | |
Modified residuei | 697 | Omega-N-methylarginineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, Methylation, Palmitate, PhosphoproteinProteomic databases
EPDi | Q9C0B5 |
jPOSTi | Q9C0B5 |
MassIVEi | Q9C0B5 |
MaxQBi | Q9C0B5 |
PaxDbi | Q9C0B5 |
PeptideAtlasi | Q9C0B5 |
PRIDEi | Q9C0B5 |
ProteomicsDBi | 79989 [Q9C0B5-1] 79990 [Q9C0B5-2] |
PTM databases
iPTMneti | Q9C0B5 |
PhosphoSitePlusi | Q9C0B5 |
SwissPalmi | Q9C0B5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000156599, Expressed in esophagus squamous epithelium and 218 other tissues |
ExpressionAtlasi | Q9C0B5, baseline and differential |
Genevisiblei | Q9C0B5, HS |
Organism-specific databases
HPAi | ENSG00000156599, Low tissue specificity |
Interactioni
Binary interactionsi
Q9C0B5
With | #Exp. | IntAct |
---|---|---|
GOLGA7B [Q2TAP0] | 3 | EBI-2799626,EBI-13310443 |
Protein-protein interaction databases
BioGRIDi | 117422, 39 interactors |
IntActi | Q9C0B5, 499 interactors |
STRINGi | 9606.ENSP00000287169 |
Miscellaneous databases
RNActi | Q9C0B5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 104 – 154 | DHHCPROSITE-ProRule annotationAdd BLAST | 51 |
Domaini
The DHHC domain is required for palmitoyltransferase activity.By similarity
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1311, Eukaryota |
GeneTreei | ENSGT00940000156001 |
HOGENOMi | CLU_013779_0_0_1 |
InParanoidi | Q9C0B5 |
OMAi | TLANFCM |
PhylomeDBi | Q9C0B5 |
TreeFami | TF354263 |
Family and domain databases
InterProi | View protein in InterPro IPR001594, Palmitoyltrfase_DHHC |
Pfami | View protein in Pfam PF01529, DHHC, 1 hit |
PROSITEi | View protein in PROSITE PS50216, DHHC, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9C0B5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPAESGKRFK PSKYVPVSAA AIFLVGATTL FFAFTCPGLS LYVSPAVPIY
60 70 80 90 100
NAIMFLFVLA NFSMATFMDP GIFPRAEEDE DKEDDFRAPL YKTVEIKGIQ
110 120 130 140 150
VRMKWCATCR FYRPPRCSHC SVCDNCVEEF DHHCPWVNNC IGRRNYRYFF
160 170 180 190 200
LFLLSLTAHI MGVFGFGLLY VLYHIEELSG VRTAVTMAVM CVAGLFFIPV
210 220 230 240 250
AGLTGFHVVL VARGRTTNEQ VTGKFRGGVN PFTNGCCNNV SRVLCSSPAP
260 270 280 290 300
RYLGRPKKEK TIVIRPPFLR PEVSDGQITV KIMDNGIQGE LRRTKSKGSL
310 320 330 340 350
EITESQSADA EPPPPPKPDL SRYTGLRTHL GLATNEDSSL LAKDSPPTPT
360 370 380 390 400
MYKYRPGYSS SSTSAAMPHS SSAKLSRGDS LKEPTSIAES SRHPSYRSEP
410 420 430 440 450
SLEPESFRSP TFGKSFHFDP LSSGSRSSSL KSAQGTGFEL GQLQSIRSEG
460 470 480 490 500
TTSTSYKSLA NQTRNGSLSY DSLLTPSDSP DFESVQAGPE PDPPLGYTSP
510 520 530 540 550
FLSARLAQQR EAERHPRLVP TGPTHREPSP VRYDNLSRHI VASLQEREKL
560 570 580 590 600
LRQSPPLPGR EEEPGLGDSG IQSTPGSGHA PRTSSSSDDS KRSPLGKTPL
610 620 630 640 650
GRPAVPRFGK PDGLRGRGVG SPEPGPTAPY LGRSMSYSSQ KAQPGVSETE
660 670 680 690 700
EVALQPLLTP KDEVQLKTTY SKSNGQPKSL GSASPGPGQP PLSSPTRGGV
710
KKVSGVGGTT YEISV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PJ97 | E9PJ97_HUMAN | Palmitoyltransferase | ZDHHC5 | 103 | Annotation score: | ||
E9PMA5 | E9PMA5_HUMAN | Palmitoyltransferase | ZDHHC5 | 138 | Annotation score: | ||
H0YEF4 | H0YEF4_HUMAN | Palmitoyltransferase ZDHHC5 | ZDHHC5 | 300 | Annotation score: |
Sequence cautioni
The sequence BAB21839 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAD18778 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 508 – 509 | QQ → TR in CAB56033 (PubMed:17974005).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006935 | 1 – 53 | Missing in isoform 2. 1 PublicationAdd BLAST | 53 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB051535 mRNA Translation: BAB21839.1 Different initiation. AY894889 mRNA Translation: AAX73368.1 AK023130 mRNA Translation: BAB14420.1 AK172807 mRNA Translation: BAD18778.1 Different initiation. CH471076 Genomic DNA Translation: EAW73771.1 BC026967 mRNA Translation: AAH26967.1 AL117662 mRNA Translation: CAB56033.1 |
CCDSi | CCDS7965.1 [Q9C0B5-1] |
PIRi | T17343 |
RefSeqi | NP_056272.2, NM_015457.2 [Q9C0B5-1] XP_011543201.1, XM_011544899.1 [Q9C0B5-1] XP_011543202.1, XM_011544900.1 [Q9C0B5-1] XP_011543203.1, XM_011544901.1 [Q9C0B5-1] |
Genome annotation databases
Ensembli | ENST00000287169; ENSP00000287169; ENSG00000156599 [Q9C0B5-1] ENST00000527985; ENSP00000432202; ENSG00000156599 [Q9C0B5-2] |
GeneIDi | 25921 |
KEGGi | hsa:25921 |
UCSCi | uc001nkx.2, human [Q9C0B5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB051535 mRNA Translation: BAB21839.1 Different initiation. AY894889 mRNA Translation: AAX73368.1 AK023130 mRNA Translation: BAB14420.1 AK172807 mRNA Translation: BAD18778.1 Different initiation. CH471076 Genomic DNA Translation: EAW73771.1 BC026967 mRNA Translation: AAH26967.1 AL117662 mRNA Translation: CAB56033.1 |
CCDSi | CCDS7965.1 [Q9C0B5-1] |
PIRi | T17343 |
RefSeqi | NP_056272.2, NM_015457.2 [Q9C0B5-1] XP_011543201.1, XM_011544899.1 [Q9C0B5-1] XP_011543202.1, XM_011544900.1 [Q9C0B5-1] XP_011543203.1, XM_011544901.1 [Q9C0B5-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 117422, 39 interactors |
IntActi | Q9C0B5, 499 interactors |
STRINGi | 9606.ENSP00000287169 |
PTM databases
iPTMneti | Q9C0B5 |
PhosphoSitePlusi | Q9C0B5 |
SwissPalmi | Q9C0B5 |
Genetic variation databases
BioMutai | ZDHHC5 |
DMDMi | 28202103 |
Proteomic databases
EPDi | Q9C0B5 |
jPOSTi | Q9C0B5 |
MassIVEi | Q9C0B5 |
MaxQBi | Q9C0B5 |
PaxDbi | Q9C0B5 |
PeptideAtlasi | Q9C0B5 |
PRIDEi | Q9C0B5 |
ProteomicsDBi | 79989 [Q9C0B5-1] 79990 [Q9C0B5-2] |
Protocols and materials databases
Antibodypediai | 3027, 90 antibodies |
DNASUi | 25921 |
Genome annotation databases
Ensembli | ENST00000287169; ENSP00000287169; ENSG00000156599 [Q9C0B5-1] ENST00000527985; ENSP00000432202; ENSG00000156599 [Q9C0B5-2] |
GeneIDi | 25921 |
KEGGi | hsa:25921 |
UCSCi | uc001nkx.2, human [Q9C0B5-1] |
Organism-specific databases
CTDi | 25921 |
DisGeNETi | 25921 |
GeneCardsi | ZDHHC5 |
HGNCi | HGNC:18472, ZDHHC5 |
HPAi | ENSG00000156599, Low tissue specificity |
MIMi | 614586, gene |
neXtProti | NX_Q9C0B5 |
OpenTargetsi | ENSG00000156599 |
PharmGKBi | PA38338 |
VEuPathDBi | HostDB:ENSG00000156599.10 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1311, Eukaryota |
GeneTreei | ENSGT00940000156001 |
HOGENOMi | CLU_013779_0_0_1 |
InParanoidi | Q9C0B5 |
OMAi | TLANFCM |
PhylomeDBi | Q9C0B5 |
TreeFami | TF354263 |
Enzyme and pathway databases
PathwayCommonsi | Q9C0B5 |
SIGNORi | Q9C0B5 |
Miscellaneous databases
BioGRID-ORCSi | 25921, 14 hits in 1013 CRISPR screens |
ChiTaRSi | ZDHHC5, human |
GenomeRNAii | 25921 |
Pharosi | Q9C0B5, Tbio |
PROi | PR:Q9C0B5 |
RNActi | Q9C0B5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000156599, Expressed in esophagus squamous epithelium and 218 other tissues |
ExpressionAtlasi | Q9C0B5, baseline and differential |
Genevisiblei | Q9C0B5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001594, Palmitoyltrfase_DHHC |
Pfami | View protein in Pfam PF01529, DHHC, 1 hit |
PROSITEi | View protein in PROSITE PS50216, DHHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZDHC5_HUMAN | |
Accessioni | Q9C0B5Primary (citable) accession number: Q9C0B5 Secondary accession number(s): Q2TGF0 Q9UFI7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2003 |
Last sequence update: | February 1, 2003 | |
Last modified: | April 7, 2021 | |
This is version 165 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families