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UniProtKB - Q9C0B2 (CFA74_HUMAN)

Entry version 113 (02 Dec 2020)
Sequence version 3 (04 Feb 2015)
Previous versions | rss
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Protein

Cilia- and flagella-associated protein 74

Gene

CFAP74

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

As part of the central apparatus of the cilium axoneme may play a role in cilium movement.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9C0B2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cilia- and flagella-associated protein 74Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CFAP74Imported
Synonyms:C1orf222Imported, KIAA1751Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000142609.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:29368, CFAP74

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9C0B2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		85452

Open Targets

More...OpenTargetsi		ENSG00000142609

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671598

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9C0B2, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CFAP74

Domain mapping of disease mutations (DMDM)

More...DMDMi		172046227

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003246641 – 1584Cilia- and flagella-associated protein 74CuratedAdd BLAST1584

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9C0B2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9C0B2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9C0B2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9C0B2

PeptideAtlas

More...PeptideAtlasi		Q9C0B2

PRoteomics IDEntifications database

More...PRIDEi		Q9C0B2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		45643
66171
79986 [Q9C0B2-1]
79987 [Q9C0B2-2]
79988 [Q9C0B2-3]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q9C0B2-2 [Q9C0B2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9C0B2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9C0B2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000142609, Expressed in right uterine tube and 124 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9C0B2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9C0B2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000142609, Tissue enhanced (brain, fallopian tube, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124537, 5 interactors

Protein interaction database and analysis system

More...IntActi		Q9C0B2, 6 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000417061

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9C0B2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9C0B2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili300 – 379Sequence analysisAdd BLAST80

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CFAP74 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QPUP, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00900000141054

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_243984_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9C0B2

Identification of Orthologs from Complete Genome Data

More...OMAi		CPTVAPS

Database of Orthologous Groups

More...OrthoDBi		1032303at2759

TreeFam database of animal gene trees

More...TreeFami		TF343713

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013783, Ig-like_fold

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9C0B2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDDGSLLPE DELLADALLL EDERDELEDP EFDIKCLLQE AEDDVDPGHS 
        60         70         80         90        100
SSVKELDTDA DKLKKKTAED RTQAFHLRQN LSALDKMHEE QELFTEKMRG 
       110        120        130        140        150
ELRACRQRRD LIDKQQEAVA AEIATEEEAG NMAAVGRLQA VSRRLFAELE 
       160        170        180        190        200
NERDLQSRTE AVLKESENTM WHIEIQEGRL EAFRTADREE VEATGRRLQV 
       210        220        230        240        250
RAAEQLCREQ EALGKVERNR LLRIRKSLNT QKELGLRHQK LLEDARKNHK 
       260        270        280        290        300
VAVRFLKASL GRIREQEKKE EMECHEYMRR RMDAVVALKG SISANRDTLR 
       310        320        330        340        350
KFQAWDRAKA ELAEQRVQAE KKAILAQGRD AFRHLVHQRR RQELEAQKRA 
       360        370        380        390        400
FEEEQKLRKQ EIISRILKEE AEEEKRKKQH PPTSARHRLT LRDKTWNYIS 
       410        420        430        440        450
DFCKKTTVPT NTYTLDYEAA AGPGPSRLLE VVSSELIQGD PGASSEEETL 
       460        470        480        490        500
AEPEISGLWN EDYKPYQVPK EDVDRKPVGG TKMDKDILER TVERLRSRVV 
       510        520        530        540        550
HKQVVWGREF QGRPFNSKPE LLHFQDFDIG KVYKKKITLV NTTYTINYCK 
       560        570        580        590        600
LVGVEEHLRD FIHVDFDPPG PLSAGMSCEV LVTFKPMINK DLEGNISFLA 
       610        620        630        640        650
QTGEFSVPLK CSTKKCSLSL DKELIDFGSY VVGETTSRTI TLTNVGGLGT 
       660        670        680        690        700
TFKFLPASEP CEMDDSQSAL KLSSLLTYED KSLYDKAATS FSEQQLEGTE 
       710        720        730        740        750
SSQADMQSRK ELEKLDKEQE EEQPAEPERL TTVIPPSEEQ TEITLGEVTE 
       760        770        780        790        800
GEIGPFSSIK VPIVFTPVVP GDVQARFKVT FKNPQCPTLH FRVVGVAIDV 
       810        820        830        840        850
PVWVPKPSVD LKICMYDRLY QDSVLVHTRS KAALRLKFEV CKELRAHLEL 
       860        870        880        890        900
LPKTGYIQAQ SSYSVQLKFL PRHSLPEDAG RYFDKETRVL EAPMTIWVAD 
       910        920        930        940        950
QNKPVGFTVH AIVTTSDLEL SPSEVDFGYC TIYEAIRTEI SLHNHSLLPQ 
       960        970        980        990       1000
EFGFVRLPKF VDVQPNDGFG TILPLETLQF CVIFQPTKAE EHRFQLTCKS 
      1010       1020       1030       1040       1050
EINRCFKLSC RAVGVHPPLE LSHYQIKFAA TALYDTSVAT VYVINSHLSM 
      1060       1070       1080       1090       1100
SSPTHSKPRI GSEDASPMGP TSFEFLLPPD SPITISPSVG TVWPGKRCLV 
      1110       1120       1130       1140       1150
QVAFRPVLPE KLIRQEALPL LNKEMETKSF RKNMAPQRKD LHGLSFSVLR 
      1160       1170       1180       1190       1200
AQNRDKLFKV SVPHVLEMRK RELRPSSDEY QAARATLLRA FQAKFDTFVV 
      1210       1220       1230       1240       1250
PCVVASGDIK DRKGSEPLSF SPHNTLYLEL WCPTVAPSVV VTSHKGKTIF 
      1260       1270       1280       1290       1300
NFGDVAVGHR SIKKISIQNV SPEDLALDFS LLNPNGPFVL LNHSSLLRAG 
      1310       1320       1330       1340       1350
GTQVLVLSFS PHESILAQET LDIITKRGTL TLTLMGTGVA SMITCSIEGS 
      1360       1370       1380       1390       1400
VLNMGYVIAG ESVSSGFKLQ NNSLLPIKFS MHLDSLSSTR GRGQQQLPQF 
      1410       1420       1430       1440       1450
LSSPSQRTEV VGTQNLNGQS VFSVAPVKGV MDPGKTQDFT VTFSPDHESL 
      1460       1470       1480       1490       1500
YFSDKLQVVL FEKKISHQIL LKGAACQHMM FVEGGDPLDV PVESLTAIPV 
      1510       1520       1530       1540       1550
FDPRHREEAE ELRPILVTLD YIQFDTDTPA PPATRELQVG CIRTTQPSPK 
      1560       1570       1580 
KPDHPLMVSA LLQLRGDVKE TYKVIFVAQV LTGP
Length:1,584
Mass (Da):178,589
Last modified:February 4, 2015 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B11F64C8AFE2C28
GO
Isoform 2 (identifier: Q9C0B2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     726-851: EPERLTTVIP...KELRAHLELL → VLFLEWTKMY...SVLLLSVFAW
     852-1584: Missing.

Show »
Length:851
Mass (Da):96,947
Checksum:i04EC8D7AEB456C0E
GO
Isoform 3 (identifier: Q9C0B2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     168-1584: Missing.

Show »
Length:167
Mass (Da):19,055
Checksum:i0C6DBD7AB5E96A01
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YEX1A0A2R8YEX1_HUMAN
Cilia- and flagella-associated prot...
CFAP74
1,046Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T2D8Q5T2D8_HUMAN
Cilia- and flagella-associated prot...
CFAP74
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI14927 differs from that shown. Probable cloning artifact.Curated
The sequence BAB21842 differs from that shown. Probable cloning artifact.Curated
The sequence CAH10703 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18L → F in BAC86954 (PubMed:14702039).Curated1
Sequence conflicti207C → R in AAI39755 (PubMed:15489334).Curated1
Sequence conflicti335L → F in AAI39755 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03987350S → I. Corresponds to variant dbSNP:rs13303083Ensembl.1
Natural variantiVAR_039874363I → V. Corresponds to variant dbSNP:rs16824588Ensembl.1
Natural variantiVAR_039875628G → C. Corresponds to variant dbSNP:rs3820011Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_032345168 – 1584Missing in isoform 3. 1 PublicationAdd BLAST1417
Alternative sequenceiVSP_057369726 – 851EPERL…HLELL → VLFLEWTKMYIHVDANRRLE GTSSIGPAGPARAEPHRAGK RLCGAPWRGRAAGGFCLALQ LWLLLDAHQRGEVPRNGRAL PSPCLLPCSPPPSGIACVSS LLLLIVFPHTHRDPETSVLL LSVFAW in isoform 2. 1 PublicationAdd BLAST126
Alternative sequenceiVSP_057370852 – 1584Missing in isoform 2. 1 PublicationAdd BLAST733

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK127388 mRNA Translation: BAC86954.1
AL391845 Genomic DNA No translation available.
AL109917 Genomic DNA No translation available.
BC114926 mRNA Translation: AAI14927.1 Sequence problems.
BC139754 mRNA Translation: AAI39755.1
AB051538 mRNA Translation: BAB21842.1 Sequence problems.
AL137547 mRNA Translation: CAH10703.1 Sequence problems.

NCBI Reference Sequences

More...RefSeqi		NP_001291289.1, NM_001304360.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000493964; ENSP00000417061; ENSG00000142609 [Q9C0B2-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		85452

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:85452

UCSC genome browser

More...UCSCi		uc057bjv.1, human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127388 mRNA Translation: BAC86954.1
AL391845 Genomic DNA No translation available.
AL109917 Genomic DNA No translation available.
BC114926 mRNA Translation: AAI14927.1 Sequence problems.
BC139754 mRNA Translation: AAI39755.1
AB051538 mRNA Translation: BAB21842.1 Sequence problems.
AL137547 mRNA Translation: CAH10703.1 Sequence problems.
RefSeqiNP_001291289.1, NM_001304360.1

3D structure databases

SMRiQ9C0B2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124537, 5 interactors
IntActiQ9C0B2, 6 interactors
STRINGi9606.ENSP00000417061

PTM databases

iPTMnetiQ9C0B2
PhosphoSitePlusiQ9C0B2

Polymorphism and mutation databases

BioMutaiCFAP74
DMDMi172046227

Proteomic databases

EPDiQ9C0B2
jPOSTiQ9C0B2
MassIVEiQ9C0B2
PaxDbiQ9C0B2
PeptideAtlasiQ9C0B2
PRIDEiQ9C0B2
ProteomicsDBi45643
66171
79986 [Q9C0B2-1]
79987 [Q9C0B2-2]
79988 [Q9C0B2-3]
TopDownProteomicsiQ9C0B2-2 [Q9C0B2-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26630, 34 antibodies

Genome annotation databases

EnsembliENST00000493964; ENSP00000417061; ENSG00000142609 [Q9C0B2-1]
GeneIDi85452
KEGGihsa:85452
UCSCiuc057bjv.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		85452
DisGeNETi85452
EuPathDBiHostDB:ENSG00000142609.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		CFAP74
HGNCiHGNC:29368, CFAP74
HPAiENSG00000142609, Tissue enhanced (brain, fallopian tube, testis)
neXtProtiNX_Q9C0B2
OpenTargetsiENSG00000142609
PharmGKBiPA142671598

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QPUP, Eukaryota
GeneTreeiENSGT00900000141054
HOGENOMiCLU_243984_0_0_1
InParanoidiQ9C0B2
OMAiCPTVAPS
OrthoDBi1032303at2759
TreeFamiTF343713

Enzyme and pathway databases

PathwayCommonsiQ9C0B2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		85452, 2 hits in 68 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CFAP74, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		85452
PharosiQ9C0B2, Tdark

Protein Ontology

More...PROi		PR:Q9C0B2
RNActiQ9C0B2, protein

Gene expression databases

BgeeiENSG00000142609, Expressed in right uterine tube and 124 other tissues
ExpressionAtlasiQ9C0B2, baseline and differential
GenevisibleiQ9C0B2, HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR013783, Ig-like_fold

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCFA74_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C0B2
Secondary accession number(s): A4VCI2
, H7C4E1, Q5T2D9, Q5T2E0, Q69YW0, Q6ZSJ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 4, 2015
Last modified: December 2, 2020
This is version 113 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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