SET domain-containing protein 5

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• covalent chromatin modification Source: UniProtKB
• regulation of chromatin organization Source: UniProtKB
• regulation of histone acetylation Source: UniProtKB
• regulation of transcription, DNA-templated Source: UniProtKB-KW
• transcription, DNA-templated Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Diseaseⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MSIAIPLGVT TSDTSYSDMA AGSDPESVEA SPAVNEKSVY STHNYGTTQR 
        60         70         80         90        100
HGCRGLPYAT IIPRSDLNGL PSPVEERCGD SPNSEGETVP TWCPCGLSQD 
       110        120        130        140        150
GFLLNCDKCR GMSRGKVIRL HRRKQDNISG GDSSATESWD EELSPSTVLY 
       160        170        180        190        200
TATQHTPTSI TLTVRRTKPK KRKKSPEKGR AAPKTKKIKN SPSEAQNLDE 
       210        220        230        240        250
NTTEGWENRI RLWTDQYEEA FTNQYSADVQ NALEQHLHSS KEFVGKPTIL 
       260        270        280        290        300
DTINKTELAC NNTVIGSQMQ LQLGRVTRVQ KHRKILRAAR DLALDTLIIE 
       310        320        330        340        350
YRGKVMLRQQ FEVNGHFFKK PYPFVLFYSK FNGVEMCVDA RTFGNDARFI 
       360        370        380        390        400
RRSCTPNAEV RHMIADGMIH LCIYAVSAIT KDAEVTIAFD YEYSNCNYKV 
       410        420        430        440        450
DCACHKGNRN CPIQKRNPNA TELPLLPPPP SLPTIGAETR RRKARRKELE 
       460        470        480        490        500
MEQQNEASEE NNDQQSQEVP EKVTVSSDHE EVDNPEEKPE EEKEEVIDDQ 
       510        520        530        540        550
ENLAHSRRTR EDRKVEAIMH AFENLEKRKK RRDQPLEQSN SDVEITTTTS 
       560        570        580        590        600
ETPVGEETKT EAPESEVSNS VSNVTIPSTP QSVGVNTRRS SQAGDIAAEK 
       610        620        630        640        650
LVPKPPPAKP SRPRPKSRIS RYRTSSAQRL KRQKQANAQQ AELSQAALEE 
       660        670        680        690        700
GGSNSLVTPT EAGSLDSSGE NRPLTGSDPT VVSITGSHVN RAASKYPKTK 
       710        720        730        740        750
KYLVTEWLND KAEKQECPVE CPLRITTDPT VLATTLNMLP GLIHSPLICT 
       760        770        780        790        800
TPKHYIRFGS PFIPERRRRP LLPDGTFSSC KKRWIKQALE EGMTQTSSVP 
       810        820        830        840        850
QETRTQHLYQ SNENSSSSSI CKDNADLLSP LKKWKSRYLM EQNVTKLLRP 
       860        870        880        890        900
LSPVTPPPPN SGSKSPQLAT PGSSHPGEEE CRNGYSLMFS PVTSLTTASR 
       910        920        930        940        950
CNTPLQFELC HRKDLDLAKV GYLDSNTNSC ADRPSLLNSG HSDLAPHPSL 
       960        970        980        990       1000
GPTSETGFPS RSGDGHQTLV RNSDQAFRTE FNLMYAYSPL NAMPRADGLY 
      1010       1020       1030       1040       1050
RGSPLVGDRK PLHLDGGYCS PAEGFSSRYE HGLMKDLSRG SLSPGGERAC 
      1060       1070       1080       1090       1100
EGVPSAPQNP PQRKKVSLLE YRKRKQEAKE NSAGGGGDSA QSKSKSAGAG 
      1110       1120       1130       1140       1150
QGSSNSVSDT GAHGVQGSSA RTPSSPHKKF SPSHSSMSHL EAVSPSDSRG 
      1160       1170       1180       1190       1200
TSSSHCRPQE NISSRWMVPT SVERLREGGS IPKVLRSSVR VAQKGEPSPT 
      1210       1220       1230       1240       1250
WESNITEKDS DPADGEGPET LSSALSKGAT VYSPSRYSYQ LLQCDSPRTE 
      1260       1270       1280       1290       1300
SQSLLQQSSS PFRGHPTQSP GYSYRTTALR PGNPPSHGSS ESSLSSTSYS 
      1310       1320       1330       1340       1350
SPAHPVSTDS LAPFTGTPGY FSSQPHSGNS TGSNLPRRSC PSSAASPTLQ 
      1360       1370       1380       1390       1400
GPSDSPTSDS VSQSSTGTLS STSFPQNSRS SLPSDLRTIS LPSAGQSAVY 
      1410       1420       1430       1440 
QASRVSAVSN SQHYPHRGSG GVHQYRLQPL QGSGVKTQTG LS         

        10         20         30         40         50
MSRGKVIRLH RRKQDNISGG DSSATESWDE ELSPSTVLYT ATQHTPTSIT 
        60         70         80         90        100
LTVRRTKPKK RKKSPEKGRA APKTKKIKNS PSEAQNLDEN TTEGWENRIR 
       110        120        130        140        150
LWTDQYEEAF TNQYSADVQN ALEQHLHSSK EFVGKPTILD TINKTELACN 
       160        170        180        190        200
NTVIGSQMQL QLGRVTRVQK HRKILRAARD LALDTLIIEY RGKVMLRQQF 
       210        220        230        240        250
EVNGHFFKKP YPFVLFYSKF NGVEMCVDAR TFGNDARFIR RSCTPNAEVR 
       260        270        280        290        300
HMIADGMIHL CIYAVSAITK DAEVTIAFDY EYSNCNYKVD CACHKGNRNC 
       310        320        330        340        350
PIQKRNPNAT ELPLLPPPPS LPTIGAETRR RKARRKELEM EQQNEASEEN 
       360        370        380        390        400
NDQQSQEVPE KVTVSSDHEE VDNPEEKPEE EKEEVIDDQE NLAHSRRTRE 
       410        420        430        440        450
DRKVEAIMHA FENLEKRKKR RDQPLEQSNS DVEITTTTSE TPVGEETKTE 
       460        470        480        490        500
APESEVSNSV SNVTIPSTPQ SVGVNTRRSS QAGDIAAEKL VPKPPPAKPS 
       510        520        530        540        550
RPRPKSRISR YRTSSAQRLK RQKQANAQQA ELSQAALEEG GSNSLVTPTE 
       560        570        580        590        600
AGSLDSSGEN RPLTGSDPTV VSITGSHVNR AASKYPKTKK YLVTEWLNDK 
       610        620        630        640        650
AEKQECPVEC PLRITTDPTV LATTLNMLPG LIHSPLICTT PKHYIRFGSP 
       660        670        680        690        700
FIPERRRRPL LPDGTFSSCK KRWIKQALEE GMTQTSSVPQ ETRTQHLYQS 
       710        720        730        740        750
NENSSSSSIC KDNADLLSPL KKWKSRYLME QNVTKLLRPL SPVTPPPPNS 
       760        770        780        790        800
GSKSPQLATP GSSHPGEEEC RNGYSLMFSP VTSLTTASRC NTPLQFELCH 
       810        820        830        840        850
RKDLDLAKVG YLDSNTNSCA DRPSLLNSGH SDLAPHPSLG PTSETGFPSR 
       860        870        880        890        900
SGDGHQTLVR NSDQAFRTEF NLMYAYSPLN AMPRADGLYR GSPLVGDRKP 
       910        920        930        940        950
LHLDGGYCSP AEGFSSRYEH GLMKDLSRGS LSPGGERACE GVPSAPQNPP 
       960        970        980        990       1000
QRKKVSLLEY RKRKQEAKEN SAGGGGDSAQ SKSKSAGAGQ GSSNSVSDTG 
      1010       1020       1030       1040       1050
AHGVQGSSAR TPSSPHKKFS PSHSSMSHLE AVSPSDSRGT SSSHCRPQEN 
      1060       1070       1080       1090       1100
ISSRWMVPTS VERLREGGSI PKVLRSSVRV AQKGEPSPTW ESNITEKDSD 
      1110       1120       1130       1140       1150
PADGEGPETL SSALSKGATV YSPSRYSYQL LQCDSPRTES QSLLQQSSSP 
      1160       1170       1180       1190       1200
FRGHPTQSPG YSYRTTALRP GNPPSHGSSE SSLSSTSYSS PAHPVSTDSL 
      1210       1220       1230       1240       1250
APFTGTPGYF SSQPHSGNST GSNLPRRSCP SSAASPTLQG PSDSPTSDSV 
      1260       1270       1280       1290       1300
SQSSTGTLSS TSFPQNSRSS LPSDLRTISL PSAGQSAVYQ ASRVSAVSNS 
      1310       1320       1330 
QHYPHRGSGG VHQYRLQPLQ GSGVKTQTGL S                     

        10         20         30         40         50
MSRGKVIRLH RRKQDNISGG DSSATESWDE ELSPSTVLYT ATQHTPTSIT 
        60         70         80         90        100
LTVRRTKPKK RKKSPEKGRA APKTKKIKAF REGSRKSLRM KNSPSEAQNL 
       110        120        130        140        150
DENTTEGWEN RIRLWTDQYE EAFTNQYSAD VQNALEQHLH SSKEFVGKPT 
       160        170        180        190        200
ILDTINKTEL ACNNTVIGSQ MQLQLGRVTR VQKHRKILRA ARDLALDTLI 
       210        220        230        240        250
IEYRGKVMLR QQFEVNGHFF KKPYPFVLFY SKFNGVEMCV DARTFGNDAR 
       260        270        280        290        300
FIRRSCTPNA EVRHMIADGM IHLCIYAVSA ITKDAEVTIA FDYEYSNCNY 
       310        320        330        340        350
KVDCACHKGN RNCPIQKRNP NATELPLLPP PPSLPTIGAE TRRRKARRKE 
       360        370        380        390        400
LEMEQQNEAS EENNDQQSQE VPEKVTVSSD HEEVDNPEEK PEEEKEEVID 
       410        420        430        440        450
DQENLAHSRR TREDRKVEAI MHAFENLEKR KKRRDQPLEQ SNSDVEITTT 
       460        470        480        490        500
TSETPVGEET KTEAPESEVS NSVSNVTIPS TPQSVGVNTR RSSQAGDIAA 
       510        520        530        540        550
EKLVPKPPPA KPSRPRPKSR ISRYRTSSAQ RLKRQKQANA QQAELSQAAL 
       560        570        580        590        600
EEGGSNSLVT PTEAGSLDSS GENRPLTGSD PTVVSITGSH VNRAASKYPK 
       610        620        630        640        650
TKKYLVTEWL NDKAEKQECP VECPLRITTD PTVLATTLNM LPGLIHSPLI 
       660        670        680        690        700
CTTPKHYIRF GSPFIPERRR RPLLPDGTFS SCKKRWIKQA LEEGMTQTSS 
       710        720        730        740        750
VPQETRTQHL YQSNENSSSS SICKDNADLL SPLKKWKSRY LMEQNVTKLL 
       760        770        780        790        800
RPLSPVTPPP PNSGSKSPQL ATPGSSHPGE EECRNGYSLM FSPVTSLTTA 
       810        820        830        840        850
SRCNTPLQFE LCHRKDLDLA KVGYLDSNTN SCADRPSLLN SGHSDLAPHP 
       860        870        880        890        900
SLGPTSETGF PSRSGDGHQT LVRNSDQAFR TEFNLMYAYS PLNAMPRADG 
       910        920        930        940        950
LYRGSPLVGD RKPLHLDGGY CSPAEGFSSR YEHGLMKDLS RGSLSPGGER 
       960        970        980        990       1000
ACEGVPSAPQ NPPQRKKVSL LEYRKRKQEA KENSAGGGGD SAQSKSKSAG 
      1010       1020       1030       1040       1050
AGQGSSNSVS DTGAHGVQGS SARTPSSPHK KFSPSHSSMS HLEAVSPSDS 
      1060       1070       1080       1090       1100
RGTSSSHCRP QENISSRWMV PTSVERLREG GSIPKVLRSS VRVAQKGEPS 
      1110       1120       1130       1140       1150
PTWESNITEK DSDPADGEGP ETLSSALSKG ATVYSPSRYS YQLLQCDSPR 
      1160       1170       1180       1190       1200
TESQSLLQQS SSPFRGHPTQ SPGYSYRTTA LRPGNPPSHG SSESSLSSTS 
      1210       1220       1230       1240       1250
YSSPAHPVST DSLAPFTGTP GYFSSQPHSG NSTGSNLPRR SCPSSAASPT 
      1260       1270       1280       1290       1300
LQGPSDSPTS DSVSQSSTGT LSSTSFPQNS RSSLPSDLRT ISLPSAGQSA 
      1310       1320       1330       1340 
VYQASRVSAV SNSQHYPHRG SGGVHQYRLQ PLQGSGVKTQ TGLS       

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 3
   Human chromosome 3: entries, gene names and cross-references to MIM
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot