Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Contactin-associated protein-like 4

Gene

CNTNAP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory interneuron synapses. Involved in the dopaminergic synaptic transmission by attenuating dopamine release through a presynaptic mechanism. Also participates in the GABAergic system (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Contactin-associated protein-like 4
Alternative name(s):
Cell recognition molecule Caspr4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CNTNAP4
Synonyms:CASPR4, KIAA1763
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000152910.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18747 CNTNAP4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610518 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9C0A0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 1241ExtracellularSequence analysisAdd BLAST1216
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1242 – 1262HelicalSequence analysisAdd BLAST21
Topological domaini1263 – 1308CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
85445

Open Targets

More...
OpenTargetsi
ENSG00000152910

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134874662

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CNTNAP4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
209572753

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001951026 – 1308Contactin-associated protein-like 4Add BLAST1283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi31 ↔ 177By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi332 ↔ 364By similarity
Glycosylationi359N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi515 ↔ 547By similarity
Glycosylationi538N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi553 ↔ 564By similarity
Disulfide bondi558 ↔ 573By similarity
Glycosylationi574N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi575 ↔ 585By similarity
Glycosylationi602N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi625N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi637N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi706N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi748N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi931 ↔ 958By similarity
Disulfide bondi962 ↔ 975By similarity
Disulfide bondi969 ↔ 984By similarity
Disulfide bondi986 ↔ 996By similarity
Glycosylationi1023N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1073N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1167 ↔ 1202By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9C0A0

PeptideAtlas

More...
PeptideAtlasi
Q9C0A0

PRoteomics IDEntifications database

More...
PRIDEi
Q9C0A0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79975

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9C0A0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9C0A0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000152910 Expressed in 96 organ(s), highest expression level in C1 segment of cervical spinal cord

CleanEx database of gene expression profiles

More...
CleanExi
HS_CNTNAP4

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9C0A0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9C0A0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031859
HPA057342

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TIAM1.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TIAM1Q130092EBI-16035743,EBI-1050007

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124532, 6 interactors

Database of interacting proteins

More...
DIPi
DIP-31652N

Protein interaction database and analysis system

More...
IntActi
Q9C0A0, 6 interactors

Molecular INTeraction database

More...
MINTi
Q9C0A0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000418741

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11308
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9C0A0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9C0A0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 177F5/8 type CPROSITE-ProRule annotationAdd BLAST147
Domaini212 – 364Laminin G-like 1PROSITE-ProRule annotationAdd BLAST153
Domaini398 – 547Laminin G-like 2PROSITE-ProRule annotationAdd BLAST150
Domaini549 – 586EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini587 – 792Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST206
Domaini793 – 957Laminin G-like 3PROSITE-ProRule annotationAdd BLAST165
Domaini958 – 997EGF-like 2PROSITE-ProRule annotationAdd BLAST40
Domaini1046 – 1202Laminin G-like 4PROSITE-ProRule annotationAdd BLAST157

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the neurexin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3516 Eukaryota
ENOG410XPHG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157674

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230964

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG057718

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9C0A0

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9C0A0

TreeFam database of animal gene trees

More...
TreeFami
TF321823

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00057 FA58C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028875 CASPR4
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR000421 FA58C
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR008979 Galactose-bd-like_sf
IPR001791 Laminin_G

The PANTHER Classification System

More...
PANTHERi
PTHR43925:SF2 PTHR43925:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00754 F5_F8_type_C, 1 hit
PF02210 Laminin_G_2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 2 hits
SM00231 FA58C, 1 hit
SM00282 LamG, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785 SSF49785, 1 hit
SSF49899 SSF49899, 4 hits
SSF56496 SSF56496, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50026 EGF_3, 2 hits
PS01285 FA58C_1, 1 hit
PS01286 FA58C_2, 1 hit
PS50022 FA58C_3, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
PS50025 LAM_G_DOMAIN, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9C0A0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSVTGAVLK TLLLLSTQNW NRVEAGNSYD CDDPLVSALP QASFSSSSEL
60 70 80 90 100
SSSHGPGFAR LNRRDGAGGW SPLVSNKYQW LQIDLGERME VTAVATQGGY
110 120 130 140 150
GSSNWVTSYL LMFSDSGWNW KQYRQEDSIW GFSGNANADS VVYYRLQPSI
160 170 180 190 200
KARFLRFIPL EWNPKGRIGM RIEVFGCAYR SEVVDLDGKS SLLYRFDQKS
210 220 230 240 250
LSPIKDIISL KFKTMQSDGI LLHREGPNGD HITLQLRRAR LFLLINSGEA
260 270 280 290 300
KLPSTSTLVN LTLGSLLDDQ HWHSVLIQRL GKQVNFTVDE HRHHFHARGE
310 320 330 340 350
FNLMNLDYEI SFGGIPAPGK SVSFPHRNFH GCLENLYYNG VDIIDLAKQQ
360 370 380 390 400
KPQIIAMGNV SFSCSQPQSM PVTFLSSRSY LALPDFSGEE EVSATFQFRT
410 420 430 440 450
WNKAGLLLFS ELQLISGGIL LFLSDGKLKS NLYQPGKLPS DITAGVELND
460 470 480 490 500
GQWHSVSLSA KKNHLSVAVD GQMASAAPLL GPEQIYSGGT YYFGGCPDKS
510 520 530 540 550
FGSKCKSPLG GFQGCMRLIS ISGKVVDLIS VQQGSLGNFS DLQIDSCGIS
560 570 580 590 600
DRCLPNYCEH GGECSQSWST FHCNCTNTGY RGATCHNSIY EQSCEAYKHR
610 620 630 640 650
GNTSGFYYID SDGSGPLEPF LLYCNMTETA WTIIQHNGSD LTRVRNTNPE
660 670 680 690 700
NPYAGFFEYV ASMEQLQATI NRAEHCEQEF TYYCKKSRLV NKQDGTPLSW
710 720 730 740 750
WVGRTNETQT YWGGSSPDLQ KCTCGLEGNC IDSQYYCNCD ADRNEWTNDT
760 770 780 790 800
GLLAYKEHLP VTKIVITDTG RLHSEAAYKL GPLLCQGDRS FWNSASFDTE
810 820 830 840 850
ASYLHFPTFH GELSADVSFF FKTTASSGVF LENLGIADFI RIELRSPTVV
860 870 880 890 900
TFSFDVGNGP FEISVQSPTH FNDNQWHHVR VERNMKEASL QVDQLTPKTQ
910 920 930 940 950
PAPADGHVLL QLNSQLFVGG TATRQRGFLG CIRSLQLNGM TLDLEERAQV
960 970 980 990 1000
TPEVQPGCRG HCSSYGKLCR NGGKCRERPI GFFCDCTFSA YTGPFCSNEI
1010 1020 1030 1040 1050
SAYFGSGSSV IYNFQENYLL SKNSSSHAAS FHGDMKLSRE MIKFSFRTTR
1060 1070 1080 1090 1100
TPSLLLFVSS FYKEYLSVII AKNGSLQIRY KLNKYQEPDV VNFDFKNMAD
1110 1120 1130 1140 1150
GQLHHIMINR EEGVVFIEID DNRRRQVHLS SGTEFSAVKS LVLGRILEHS
1160 1170 1180 1190 1200
DVDQDTALAG AQGFTGCLSA VQLSHVAPLK AALHPSHPDP VTVTGHVTES
1210 1220 1230 1240 1250
SCMAQPGTDA TSRERTHSFA DHSGTIDDRE PLANAIKSDS AVIGGLIAVV
1260 1270 1280 1290 1300
IFILLCITAI AVRIYQQKRL YKRSEAKRSE NVDSAEAVLK SELNIQNAVN

ENQKEYFF
Length:1,308
Mass (Da):145,274
Last modified:October 14, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC135FD64184E82B1
GO
Isoform 2 (identifier: Q9C0A0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MGSVTGAVLKTLLLLSTQNWNRVEAGNS → MWN
     310-357: Missing.

Show »
Length:1,235
Mass (Da):137,495
Checksum:i97955649BF1D90D1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WTA1A0A087WTA1_HUMAN
Contactin-associated protein-like 4
CNTNAP4
1,260Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PDN6E9PDN6_HUMAN
Contactin-associated protein-like 4
CNTNAP4
1,311Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H107F5H107_HUMAN
Contactin-associated protein-like 4
CNTNAP4
1,260Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MR20A0A0A0MR20_HUMAN
Contactin-associated protein-like 4
CNTNAP4
1,308Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB21854 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti244L → R in BAC55271 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061371276L → V. Corresponds to variant dbSNP:rs34251012Ensembl.1
Natural variantiVAR_050268513Q → H. Corresponds to variant dbSNP:rs6564343Ensembl.1
Natural variantiVAR_061372786Q → R2 PublicationsCorresponds to variant dbSNP:rs12933808Ensembl.1
Natural variantiVAR_0502691155D → E2 PublicationsCorresponds to variant dbSNP:rs7202925Ensembl.1
Natural variantiVAR_0502701300N → S. Corresponds to variant dbSNP:rs34198820Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0444641 – 28MGSVT…EAGNS → MWN in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_044465310 – 357Missing in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB100093 mRNA Translation: BAC55271.1
AB051550 mRNA Translation: BAB21854.2 Different initiation.
AC010528 Genomic DNA No translation available.
AC106741 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10924.2 [Q9C0A0-2]
CCDS73915.1 [Q9C0A0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_207837.2, NM_033401.4 [Q9C0A0-1]
NP_620481.2, NM_138994.4 [Q9C0A0-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.461389

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000478060; ENSP00000418741; ENSG00000152910 [Q9C0A0-2]
ENST00000611870; ENSP00000479811; ENSG00000152910 [Q9C0A0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
85445

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:85445

UCSC genome browser

More...
UCSCi
uc010chb.2 human [Q9C0A0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100093 mRNA Translation: BAC55271.1
AB051550 mRNA Translation: BAB21854.2 Different initiation.
AC010528 Genomic DNA No translation available.
AC106741 Genomic DNA No translation available.
CCDSiCCDS10924.2 [Q9C0A0-2]
CCDS73915.1 [Q9C0A0-1]
RefSeqiNP_207837.2, NM_033401.4 [Q9C0A0-1]
NP_620481.2, NM_138994.4 [Q9C0A0-2]
UniGeneiHs.461389

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NXQX-ray2.10D/E/F1301-1308[»]
ProteinModelPortaliQ9C0A0
SMRiQ9C0A0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124532, 6 interactors
DIPiDIP-31652N
IntActiQ9C0A0, 6 interactors
MINTiQ9C0A0
STRINGi9606.ENSP00000418741

PTM databases

iPTMnetiQ9C0A0
PhosphoSitePlusiQ9C0A0

Polymorphism and mutation databases

BioMutaiCNTNAP4
DMDMi209572753

Proteomic databases

PaxDbiQ9C0A0
PeptideAtlasiQ9C0A0
PRIDEiQ9C0A0
ProteomicsDBi79975

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
85445
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000478060; ENSP00000418741; ENSG00000152910 [Q9C0A0-2]
ENST00000611870; ENSP00000479811; ENSG00000152910 [Q9C0A0-1]
GeneIDi85445
KEGGihsa:85445
UCSCiuc010chb.2 human [Q9C0A0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
85445
DisGeNETi85445
EuPathDBiHostDB:ENSG00000152910.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CNTNAP4
HGNCiHGNC:18747 CNTNAP4
HPAiHPA031859
HPA057342
MIMi610518 gene
neXtProtiNX_Q9C0A0
OpenTargetsiENSG00000152910
PharmGKBiPA134874662

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3516 Eukaryota
ENOG410XPHG LUCA
GeneTreeiENSGT00940000157674
HOGENOMiHOG000230964
HOVERGENiHBG057718
InParanoidiQ9C0A0
PhylomeDBiQ9C0A0
TreeFamiTF321823

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CNTNAP4 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CNTNAP4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
85445

Protein Ontology

More...
PROi
PR:Q9C0A0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000152910 Expressed in 96 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_CNTNAP4
ExpressionAtlasiQ9C0A0 baseline and differential
GenevisibleiQ9C0A0 HS

Family and domain databases

CDDicd00057 FA58C, 1 hit
Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR028875 CASPR4
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR000421 FA58C
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR008979 Galactose-bd-like_sf
IPR001791 Laminin_G
PANTHERiPTHR43925:SF2 PTHR43925:SF2, 1 hit
PfamiView protein in Pfam
PF00754 F5_F8_type_C, 1 hit
PF02210 Laminin_G_2, 4 hits
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00231 FA58C, 1 hit
SM00282 LamG, 4 hits
SUPFAMiSSF49785 SSF49785, 1 hit
SSF49899 SSF49899, 4 hits
SSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS50026 EGF_3, 2 hits
PS01285 FA58C_1, 1 hit
PS01286 FA58C_2, 1 hit
PS50022 FA58C_3, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
PS50025 LAM_G_DOMAIN, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNTP4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C0A0
Secondary accession number(s): E9PFZ6, Q86YZ7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 14, 2008
Last modified: December 5, 2018
This is version 161 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again