Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase DCLK3

Gene

DCLK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei385ATPPROSITE-ProRule annotation1
Active sitei477Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi362 – 370ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: GO_Central
  • protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9C098

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase DCLK3 (EC:2.7.11.1)
Alternative name(s):
Doublecortin domain-containing protein 3C
Doublecortin-like and CAM kinase-like 3
Doublecortin-like kinase 3
Gene namesi
Name:DCLK3
Synonyms:DCAMKL3, DCDC3C, KIAA1765
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163673.6
HGNCiHGNC:19005 DCLK3
MIMi613167 gene
neXtProtiNX_Q9C098

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi85443
OpenTargetsiENSG00000163673
PharmGKBiPA162383403

Chemistry databases

ChEMBLiCHEMBL6123

Polymorphism and mutation databases

BioMutaiDCLK3
DMDMi115502142

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002522541 – 648Serine/threonine-protein kinase DCLK3Add BLAST648

Proteomic databases

MaxQBiQ9C098
PaxDbiQ9C098
PeptideAtlasiQ9C098
PRIDEiQ9C098
ProteomicsDBi79972

PTM databases

iPTMnetiQ9C098
PhosphoSitePlusiQ9C098

Expressioni

Gene expression databases

BgeeiENSG00000163673 Expressed in 75 organ(s), highest expression level in tibial nerve
CleanExiHS_DCLK3
ExpressionAtlasiQ9C098 baseline and differential
GenevisibleiQ9C098 HS

Organism-specific databases

HPAiHPA040685

Interactioni

Protein-protein interaction databases

BioGridi124530, 1 interactor
IntActiQ9C098, 8 interactors
STRINGi9606.ENSP00000394484

Chemistry databases

BindingDBiQ9C098

Structurei

3D structure databases

ProteinModelPortaliQ9C098
SMRiQ9C098
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini356 – 613Protein kinasePROSITE-ProRule annotationAdd BLAST258

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0615 Eukaryota
ENOG410YA63 LUCA
GeneTreeiENSGT00930000150819
HOGENOMiHOG000112176
HOVERGENiHBG101914
InParanoidiQ9C098
KOiK17530
OrthoDBiEOG091G02RF
PhylomeDBiQ9C098
TreeFamiTF318770

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9C098-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKEPLTLKS IQVAVEELYP NKARALTLAQ HSRAPSPRLR SRLFSKALKG
60 70 80 90 100
DHRCGETETP KSCSEVAGCK AAMRHQGKIP EELSLDDRAR TQKKWGRGKW
110 120 130 140 150
EPEPSSKPPR EATLEERHAR GEKHLGVEIE KTSGEIIRCE KCKRERELQQ
160 170 180 190 200
SLERERLSLG TSELDMGKGP MYDVEKLVRT RSCRRSPEAN PASGEEGWKG
210 220 230 240 250
DSHRSSPRNP TQELRRPSKS MDKKEDRGPE DQESHAQGAA KAKKDLVEVL
260 270 280 290 300
PVTEEGLREV KKDTRPMSRS KHGGWLLREH QAGFEKLRRT RGEEKEAEKE
310 320 330 340 350
KKPCMSGGRR MTLRDDQPAK LEKEPKTRPE ENKPERPSGR KPRPMGIIAA
360 370 380 390 400
NVEKHYETGR VIGDGNFAVV KECRHRETRQ AYAMKIIDKS RLKGKEDMVD
410 420 430 440 450
SEILIIQSLS HPNIVKLHEV YETDMEIYLI LEYVQGGDLF DAIIESVKFP
460 470 480 490 500
EPDAALMIMD LCKALVHMHD KSIVHRDLKP ENLLVQRNED KSTTLKLADF
510 520 530 540 550
GLAKHVVRPI FTVCGTPTYV APEILSEKGY GLEVDMWAAG VILYILLCGF
560 570 580 590 600
PPFRSPERDQ DELFNIIQLG HFEFLPPYWD NISDAAKDLV SRLLVVDPKK
610 620 630 640
RYTAHQVLQH PWIETAGKTN TVKRQKQVSP SSEGHFRSQH KRVVEQVS
Length:648
Mass (Da):73,814
Last modified:October 3, 2006 - v2
Checksum:i09E37E51920F2A21
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GTZ4A0A1B0GTZ4_HUMAN
Serine/threonine-protein kinase DCL...
DCLK3
817Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04044424R → Q1 PublicationCorresponds to variant dbSNP:rs56070233Ensembl.1
Natural variantiVAR_040445108P → L in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040446422E → K in a colorectal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs373605259Ensembl.1
Natural variantiVAR_040447472S → N in a lung large cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040448554R → C in a lung squamous cell carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs374711533Ensembl.1
Natural variantiVAR_040449570G → R in a renal clear cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040450596V → A in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040451633E → D1 PublicationCorresponds to variant dbSNP:rs35704209Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DA523113 mRNA No translation available.
AB051552 mRNA Translation: BAB21856.1
CCDSiCCDS43064.1
RefSeqiNP_208382.1, NM_033403.1
XP_011532469.1, XM_011534167.2
UniGeneiHs.631907

Genome annotation databases

EnsembliENST00000416516; ENSP00000394484; ENSG00000163673
GeneIDi85443
KEGGihsa:85443
UCSCiuc003cgi.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DA523113 mRNA No translation available.
AB051552 mRNA Translation: BAB21856.1
CCDSiCCDS43064.1
RefSeqiNP_208382.1, NM_033403.1
XP_011532469.1, XM_011534167.2
UniGeneiHs.631907

3D structure databases

ProteinModelPortaliQ9C098
SMRiQ9C098
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124530, 1 interactor
IntActiQ9C098, 8 interactors
STRINGi9606.ENSP00000394484

Chemistry databases

BindingDBiQ9C098
ChEMBLiCHEMBL6123

PTM databases

iPTMnetiQ9C098
PhosphoSitePlusiQ9C098

Polymorphism and mutation databases

BioMutaiDCLK3
DMDMi115502142

Proteomic databases

MaxQBiQ9C098
PaxDbiQ9C098
PeptideAtlasiQ9C098
PRIDEiQ9C098
ProteomicsDBi79972

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000416516; ENSP00000394484; ENSG00000163673
GeneIDi85443
KEGGihsa:85443
UCSCiuc003cgi.2 human

Organism-specific databases

CTDi85443
DisGeNETi85443
EuPathDBiHostDB:ENSG00000163673.6
GeneCardsiDCLK3
H-InvDBiHIX0003164
HGNCiHGNC:19005 DCLK3
HPAiHPA040685
MIMi613167 gene
neXtProtiNX_Q9C098
OpenTargetsiENSG00000163673
PharmGKBiPA162383403
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0615 Eukaryota
ENOG410YA63 LUCA
GeneTreeiENSGT00930000150819
HOGENOMiHOG000112176
HOVERGENiHBG101914
InParanoidiQ9C098
KOiK17530
OrthoDBiEOG091G02RF
PhylomeDBiQ9C098
TreeFamiTF318770

Enzyme and pathway databases

SignaLinkiQ9C098

Miscellaneous databases

GenomeRNAii85443
PROiPR:Q9C098
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163673 Expressed in 75 organ(s), highest expression level in tibial nerve
CleanExiHS_DCLK3
ExpressionAtlasiQ9C098 baseline and differential
GenevisibleiQ9C098 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDCLK3_HUMAN
AccessioniPrimary (citable) accession number: Q9C098
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 7, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again