UniProtKB - Q9C093 (SPEF2_HUMAN)
Sperm flagellar protein 2
SPEF2
Functioni
Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis (PubMed:31278745, PubMed:31151990, PubMed:31048344).
Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation (By similarity).
By similarity3 PublicationsGO - Biological processi
- brain morphogenesis Source: UniProtKB
- epithelial cilium movement involved in extracellular fluid movement Source: UniProtKB
- respiratory system development Source: UniProtKB
- skeletal system morphogenesis Source: UniProtKB
- spermatogenesis Source: UniProtKB
- sperm axoneme assembly Source: UniProtKB
Keywordsi
Biological process | Differentiation, Spermatogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q9C093 |
SignaLinki | Q9C093 |
Names & Taxonomyi
Protein namesi | Recommended name: Sperm flagellar protein 2Alternative name(s): Protein KPL2 |
Gene namesi | Name:SPEF2 Synonyms:KIAA1770, KPL2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26293, SPEF2 |
MIMi | 610172, gene |
neXtProti | NX_Q9C093 |
VEuPathDBi | HostDB:ENSG00000152582 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- flagellum 3 Publications
Note: Shows dynamic localization in developing spermatozoa. Localizes to the manchette in step 10-12 elongating spermatids. Detected in the basal body and neck area of step 13-14 spermatids. Localizes to the midpiece of the sperm tail in step 15-16 spermatids. During the epididymal transport of spermatozoa, expression in the sperm tail reduces and becomes concentrated at the distal part of the midpiece. Detected in the Golgi apparatus of late spermatocytes and round spermatids. Detected in the cytoplasm of Sertoli cells.By similarity
Cytoskeleton
- manchette Source: UniProtKB
Extracellular region or secreted
- extracellular region Source: GOC
Golgi apparatus
- Golgi apparatus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- sperm flagellum Source: UniProtKB
- sperm midpiece Source: UniProtKB
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, Flagellum, Golgi apparatusPathology & Biotechi
Involvement in diseasei
Spermatogenic failure 43 (SPGF43)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_083842 | 304 – 1822 | Missing in SPGF43; loss of protein expression; changed sperm axoneme assembly. 1 PublicationAdd BLAST | 1519 | |
Natural variantiVAR_083843 | 1368 – 1822 | Missing in SPGF43; loss of protein expression; changed sperm axoneme assembly. 1 PublicationAdd BLAST | 455 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 79925 |
MalaCardsi | SPEF2 |
MIMi | 618751, phenotype |
OpenTargetsi | ENSG00000152582 |
Orphaneti | 276234, Non-syndromic male infertility due to sperm motility disorder 244, Primary ciliary dyskinesia |
PharmGKBi | PA162404451 |
Miscellaneous databases
Pharosi | Q9C093, Tdark |
Genetic variation databases
BioMutai | SPEF2 |
DMDMi | 156630941 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000299029 | 1 – 1822 | Sperm flagellar protein 2Add BLAST | 1822 |
Proteomic databases
EPDi | Q9C093 |
MassIVEi | Q9C093 |
PaxDbi | Q9C093 |
PeptideAtlasi | Q9C093 |
PRIDEi | Q9C093 |
ProteomicsDBi | 79968 [Q9C093-1] 79969 [Q9C093-2] 79970 [Q9C093-3] 79971 [Q9C093-4] |
PTM databases
CarbonylDBi | Q9C093 |
iPTMneti | Q9C093 |
PhosphoSitePlusi | Q9C093 |
Expressioni
Gene expression databases
Bgeei | ENSG00000152582, Expressed in right uterine tube and 147 other tissues |
ExpressionAtlasi | Q9C093, baseline and differential |
Genevisiblei | Q9C093, HS |
Organism-specific databases
HPAi | ENSG00000152582, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via C-terminus) with IFT20 (PubMed:19889948).
Interacts with DYNC1I2 (By similarity).
By similarity1 PublicationProtein-protein interaction databases
BioGRIDi | 123002, 8 interactors |
CORUMi | Q9C093 |
IntActi | Q9C093, 9 interactors |
STRINGi | 9606.ENSP00000348314 |
Miscellaneous databases
RNActi | Q9C093, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 105 | Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST | 105 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 896 – 1004 | DisorderedSequence analysisAdd BLAST | 109 | |
Regioni | 1278 – 1327 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 1324 – 1676 | Interaction with IFT201 PublicationAdd BLAST | 353 | |
Regioni | 1664 – 1718 | DisorderedSequence analysisAdd BLAST | 55 | |
Regioni | 1803 – 1822 | DisorderedSequence analysisAdd BLAST | 20 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 227 – 260 | Sequence analysisAdd BLAST | 34 | |
Coiled coili | 321 – 396 | Sequence analysisAdd BLAST | 76 | |
Coiled coili | 732 – 758 | Sequence analysisAdd BLAST | 27 | |
Coiled coili | 871 – 909 | Sequence analysisAdd BLAST | 39 | |
Coiled coili | 1686 – 1712 | Sequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 953 – 972 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1278 – 1319 | Basic and acidic residuesSequence analysisAdd BLAST | 42 | |
Compositional biasi | 1684 – 1715 | Basic and acidic residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 1805 – 1822 | Basic and acidic residuesSequence analysisAdd BLAST | 18 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QR7Y, Eukaryota |
GeneTreei | ENSGT00390000008160 |
HOGENOMi | CLU_015066_0_0_1 |
InParanoidi | Q9C093 |
OMAi | LWDICDN |
OrthoDBi | 81320at2759 |
PhylomeDBi | Q9C093 |
TreeFami | TF329522 |
Family and domain databases
Gene3Di | 1.10.418.10, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR001715, CH-domain IPR010441, CH_2 IPR036872, CH_dom_sf IPR011992, EF-hand-dom_pair IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF06294, CH_2, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50021, CH, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSEILCQWLN KELKVSRTVS PKSFAKAFSS GYLLGEVLHK FELQDDFSEF
60 70 80 90 100
LDSRVSSAKL NNFSRLEPTL NLLGVQFDQN VAHGIITEKP GVATKLLYQL
110 120 130 140 150
YIALQKKKKS GLTGVEMQTM QRLTNLRLQN MKSDTFQERL RHMIPRQTDF
160 170 180 190 200
NLMRITYRFQ EKYKHVKEDL AHLHFEKLER FQKLKEEQRC FDIEKQYLNR
210 220 230 240 250
RRQNEIMAKI QAAIIQIPKP ASNRTLKALE AQKMMKKKKE AEDVADEIKK
260 270 280 290 300
FEALIKKDLQ AKESASKTSL DTAGQTTTDL LNTYSDDEYI KKIQKRLEED
310 320 330 340 350
AFAREQREKR RRKLLMDQLI AHEAQEEAYR EEQLINRLMR QSQQERRIAV
360 370 380 390 400
QLMHVRHEKE VLWQNRIFRE KQHEERRLKD FQDALDREAA LAKQAKIDFE
410 420 430 440 450
EQFLKEKRFH DQIAVERAQA RYEKHYSVCA EILDQIVDLS TKVADYRMLT
460 470 480 490 500
NNLIPYKLMH DWKELFFNAK PIYEQASVKT LPANPSREQL TELEKRDLLD
510 520 530 540 550
TNDYEEYKNM VGEWALPEEM VDNLPPSNNC ILGHILHRLA EKSLPPRAES
560 570 580 590 600
TTPELPSFAV KGCLLGKTLS GKTTILRSLQ KDFPIQILSI DTLVQEAIQA
610 620 630 640 650
FHDNEKVSEV LPIQKNDEED ALPVLQEEIK ESQDPQHVFS AGPVSDEVLP
660 670 680 690 700
ETEGETMLSA NADKTPKAEE VKSSDSFLKL TTRAQLGAKS EQLLKKGKSI
710 720 730 740 750
PDVLLVDIIV NAINEIPVNQ DCILDGFPMT LNQAQLLEEA LTGCNRNLTE
760 770 780 790 800
VERKKAQKST LAIDPATSKE IPLPSPAFDF VILLDVSDTS SMSRMNDIIA
810 820 830 840 850
EELSYKTAHE DISQRVAAEN QDKDGDQNLR DQIQHRIIGF LDNWPLLEQW
860 870 880 890 900
FSEPENILIK INAEIDKESL CEKVKEILTT EIAKKKNKVE KKLEEKEAEK
910 920 930 940 950
KAAASLAELP LPTPPPAPPP EPEKEKEIHQ SHVASKTPTA KGKPQSEAPH
960 970 980 990 1000
GKQESLQEGK GKKGETALKR KGSPKGKSSG GKVPVKKSPA DSTDTSPVAI
1010 1020 1030 1040 1050
VPQPPKPGSE EWVYVNEPVP EEMPLFLVPY WELIENSYIN TIKTVLRHLR
1060 1070 1080 1090 1100
EDQHTVLAYL YEIRTSFQEF LKRPDHKQDF VAQWQADFNS LPDDLWDDEE
1110 1120 1130 1140 1150
TKAELHQRVN DLRDRLWDIC DARKEEAEQE RLDIINESWL QDTLGMTMNH
1160 1170 1180 1190 1200
FFSLMQAELN RFQDTKRLLQ DYYWGMESKI PVEDNKRFTR IPLVQLDSKD
1210 1220 1230 1240 1250
NSESQLRIPL VPRISISLET VTPKPKTKSV LKGKMDNSLE NVESNFEADE
1260 1270 1280 1290 1300
KLVMDTWQQA SLAVSHMVAA EIHQRLMEEE KENQPADPKE KSPQMGANKK
1310 1320 1330 1340 1350
VKKEPPKKKQ EDKKPKGKSP PMAEATPVIV TTEEIAEIKR KNELRVKIKE
1360 1370 1380 1390 1400
EHLAALQFEE IATQFRLELI KTKALALLED LVTKVVDVYK LMEKWLGERY
1410 1420 1430 1440 1450
LNEMASTEKL TDVARYHIET STKIQNELYL SQEDFFINGN IKVFPDPPPS
1460 1470 1480 1490 1500
IRPPPVEKEE DGTLTIEQLD SLRDQFLDMA PKGIIGNKAF TDILIDLVTL
1510 1520 1530 1540 1550
NLGTNNFPSN WMHLTQPELQ ELTSLLTVNS EFVDWRKFLL VTSMPWPIPL
1560 1570 1580 1590 1600
EEELLETLQK FKAVDKEQLG TITFEQYMQA GLWFTGDEDI KIPENPLEPL
1610 1620 1630 1640 1650
PFNRQEHLIE FFFRLFADYE KDPPQLDYTQ MLLYFACHPD TVEGVYRALS
1660 1670 1680 1690 1700
VAVGTHVFQQ VKASIPSAEK TSSTDAGPAE EFPEPEENAA REERKLKDDT
1710 1720 1730 1740 1750
EKREQKDEEI PENANNEKMS METLLKVFKG GSEAQDSNRF ASHLKIENIY
1760 1770 1780 1790 1800
AEGFIKTFQD LGAKNLEPIE VAVLLKHPFI QDLISNYSDY KFPDIKIILQ
1810 1820
RSEHVQGSDG ERSPSRHTEE KK
The sequence of this isoform differs from the canonical sequence as follows:
1-1483: MSEILCQWLN...DQFLDMAPKG → MPSQIGDRKW...HMHAKIKAES
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6REZ4 | D6REZ4_HUMAN | Sperm flagellar protein 2 | SPEF2 | 943 | Annotation score: | ||
A0A1B0GWD8 | A0A1B0GWD8_HUMAN | Sperm flagellar protein 2 | SPEF2 | 2,169 | Annotation score: | ||
D6RGZ5 | D6RGZ5_HUMAN | Sperm flagellar protein 2 | SPEF2 | 240 | Annotation score: | ||
H0YAC0 | H0YAC0_HUMAN | Sperm flagellar protein 2 | SPEF2 | 151 | Annotation score: | ||
H0Y989 | H0Y989_HUMAN | Sperm flagellar protein 2 | SPEF2 | 115 | Annotation score: | ||
H0Y8H6 | H0Y8H6_HUMAN | Sperm flagellar protein 2 | SPEF2 | 115 | Annotation score: | ||
A0A1B0GWC1 | A0A1B0GWC1_HUMAN | Sperm flagellar protein 2 | SPEF2 | 174 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1698 | D → G in BAB15563 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034766 | 71 | N → H1 PublicationCorresponds to variant dbSNP:rs6897513EnsemblClinVar. | 1 | |
Natural variantiVAR_034767 | 74 | G → S. Corresponds to variant dbSNP:rs34307272Ensembl. | 1 | |
Natural variantiVAR_083842 | 304 – 1822 | Missing in SPGF43; loss of protein expression; changed sperm axoneme assembly. 1 PublicationAdd BLAST | 1519 | |
Natural variantiVAR_034768 | 366 | R → K. Corresponds to variant dbSNP:rs16902381Ensembl. | 1 | |
Natural variantiVAR_034769 | 447 | R → Q. Corresponds to variant dbSNP:rs34852821Ensembl. | 1 | |
Natural variantiVAR_034770 | 500 | D → N1 PublicationCorresponds to variant dbSNP:rs34708521EnsemblClinVar. | 1 | |
Natural variantiVAR_034771 | 616 | N → K. Corresponds to variant dbSNP:rs7710284EnsemblClinVar. | 1 | |
Natural variantiVAR_034772 | 655 | E → G. Corresponds to variant dbSNP:rs12332369EnsemblClinVar. | 1 | |
Natural variantiVAR_051376 | 904 | A → V1 PublicationCorresponds to variant dbSNP:rs13170082EnsemblClinVar. | 1 | |
Natural variantiVAR_051377 | 934 | A → P1 PublicationCorresponds to variant dbSNP:rs13170390EnsemblClinVar. | 1 | |
Natural variantiVAR_083843 | 1368 – 1822 | Missing in SPGF43; loss of protein expression; changed sperm axoneme assembly. 1 PublicationAdd BLAST | 455 | |
Natural variantiVAR_034773 | 1482 | K → N. Corresponds to variant dbSNP:rs2277044Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027521 | 1 – 1483 | MSEIL…MAPKG → MPSQIGDRKWLHGLQAALQN FLKGYPAIVRQLHSAGRGKS DTSQKKPKELLESLLQADIV KFAHFLLDVMNVLSILSCVN KNRNSSIADIFATLESMLEM LQMYQTRLGPKERMVDSATH FHGNCLRGKENISAVRNIVL THLIKRLQGCFRDASQNVVR ATVIGSFKLWPTKINQEFGE KEVSILTAHYEPVLEAANVK LSEVDTEWSMLKLEIYARFQ NIRKLTWDFVNSIYLHKYPN ILTLVDLVLTLPASSAEAEH GFSQMKWTKSHMHAKIKAES in isoform 4. 1 PublicationAdd BLAST | 1483 | |
Alternative sequenceiVSP_027522 | 509 – 514 | NMVGEW → VPTDMK in isoform 3. 2 Publications | 6 | |
Alternative sequenceiVSP_027523 | 515 – 1822 | Missing in isoform 3. 2 PublicationsAdd BLAST | 1308 | |
Alternative sequenceiVSP_027524 | 655 – 659 | Missing in isoform 2. 1 Publication | 5 | |
Alternative sequenceiVSP_027525 | 1794 – 1822 | DIKII…TEEKK → VHIIYVVEMIVCAKGWAPLP SGKQCARWRN in isoform 2. 1 PublicationAdd BLAST | 29 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK026817 mRNA Translation: BAB15563.1 AK027230 mRNA Translation: BAB15700.1 Different initiation. AK058124 mRNA Translation: BAB71674.1 BC110984 mRNA Translation: AAI10985.1 AB051557 mRNA Translation: BAB21861.1 |
CCDSi | CCDS3910.1 [Q9C093-3] CCDS43309.1 [Q9C093-1] |
RefSeqi | NP_079143.3, NM_024867.3 [Q9C093-1] NP_653323.1, NM_144722.3 [Q9C093-3] XP_005248434.1, XM_005248377.3 [Q9C093-2] |
Genome annotation databases
Ensembli | ENST00000282469.10; ENSP00000282469.6; ENSG00000152582.14 [Q9C093-3] ENST00000356031.8; ENSP00000348314.3; ENSG00000152582.14 ENST00000440995.6; ENSP00000412125.2; ENSG00000152582.14 [Q9C093-2] |
GeneIDi | 79925 |
KEGGi | hsa:79925 |
MANE-Selecti | ENST00000356031.8; ENSP00000348314.3; NM_024867.4; NP_079143.3 |
UCSCi | uc003jjn.2, human [Q9C093-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK026817 mRNA Translation: BAB15563.1 AK027230 mRNA Translation: BAB15700.1 Different initiation. AK058124 mRNA Translation: BAB71674.1 BC110984 mRNA Translation: AAI10985.1 AB051557 mRNA Translation: BAB21861.1 |
CCDSi | CCDS3910.1 [Q9C093-3] CCDS43309.1 [Q9C093-1] |
RefSeqi | NP_079143.3, NM_024867.3 [Q9C093-1] NP_653323.1, NM_144722.3 [Q9C093-3] XP_005248434.1, XM_005248377.3 [Q9C093-2] |
3D structure databases
AlphaFoldDBi | Q9C093 |
SMRi | Q9C093 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123002, 8 interactors |
CORUMi | Q9C093 |
IntActi | Q9C093, 9 interactors |
STRINGi | 9606.ENSP00000348314 |
PTM databases
CarbonylDBi | Q9C093 |
iPTMneti | Q9C093 |
PhosphoSitePlusi | Q9C093 |
Genetic variation databases
BioMutai | SPEF2 |
DMDMi | 156630941 |
Proteomic databases
EPDi | Q9C093 |
MassIVEi | Q9C093 |
PaxDbi | Q9C093 |
PeptideAtlasi | Q9C093 |
PRIDEi | Q9C093 |
ProteomicsDBi | 79968 [Q9C093-1] 79969 [Q9C093-2] 79970 [Q9C093-3] 79971 [Q9C093-4] |
Protocols and materials databases
Antibodypediai | 22874, 50 antibodies from 12 providers |
DNASUi | 79925 |
Genome annotation databases
Ensembli | ENST00000282469.10; ENSP00000282469.6; ENSG00000152582.14 [Q9C093-3] ENST00000356031.8; ENSP00000348314.3; ENSG00000152582.14 ENST00000440995.6; ENSP00000412125.2; ENSG00000152582.14 [Q9C093-2] |
GeneIDi | 79925 |
KEGGi | hsa:79925 |
MANE-Selecti | ENST00000356031.8; ENSP00000348314.3; NM_024867.4; NP_079143.3 |
UCSCi | uc003jjn.2, human [Q9C093-1] |
Organism-specific databases
CTDi | 79925 |
DisGeNETi | 79925 |
GeneCardsi | SPEF2 |
HGNCi | HGNC:26293, SPEF2 |
HPAi | ENSG00000152582, Low tissue specificity |
MalaCardsi | SPEF2 |
MIMi | 610172, gene 618751, phenotype |
neXtProti | NX_Q9C093 |
OpenTargetsi | ENSG00000152582 |
Orphaneti | 276234, Non-syndromic male infertility due to sperm motility disorder 244, Primary ciliary dyskinesia |
PharmGKBi | PA162404451 |
VEuPathDBi | HostDB:ENSG00000152582 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QR7Y, Eukaryota |
GeneTreei | ENSGT00390000008160 |
HOGENOMi | CLU_015066_0_0_1 |
InParanoidi | Q9C093 |
OMAi | LWDICDN |
OrthoDBi | 81320at2759 |
PhylomeDBi | Q9C093 |
TreeFami | TF329522 |
Enzyme and pathway databases
PathwayCommonsi | Q9C093 |
SignaLinki | Q9C093 |
Miscellaneous databases
BioGRID-ORCSi | 79925, 18 hits in 1062 CRISPR screens |
ChiTaRSi | SPEF2, human |
GeneWikii | SPEF2 |
GenomeRNAii | 79925 |
Pharosi | Q9C093, Tdark |
PROi | PR:Q9C093 |
RNActi | Q9C093, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000152582, Expressed in right uterine tube and 147 other tissues |
ExpressionAtlasi | Q9C093, baseline and differential |
Genevisiblei | Q9C093, HS |
Family and domain databases
Gene3Di | 1.10.418.10, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR001715, CH-domain IPR010441, CH_2 IPR036872, CH_dom_sf IPR011992, EF-hand-dom_pair IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF06294, CH_2, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50021, CH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SPEF2_HUMAN | |
Accessioni | Q9C093Primary (citable) accession number: Q9C093 Secondary accession number(s): Q2TAC9 Q9H5Q7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 21, 2007 |
Last sequence update: | August 21, 2007 | |
Last modified: | May 25, 2022 | |
This is version 137 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot