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Protein

Keratin, type I cytoskeletal 23

Gene

KRT23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 23
Alternative name(s):
Cytokeratin-23
Short name:
CK-23
Keratin-23
Short name:
K23
Gene namesi
Name:KRT23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108244.16
HGNCiHGNC:6438 KRT23
MIMi606194 gene
neXtProtiNX_Q9C075

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

DisGeNETi25984
OpenTargetsiENSG00000108244
PharmGKBiPA134914537

Polymorphism and mutation databases

BioMutaiKRT23
DMDMi143811410

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636771 – 422Keratin, type I cytoskeletal 23Add BLAST422

Proteomic databases

PaxDbiQ9C075
PeptideAtlasiQ9C075
PRIDEiQ9C075
ProteomicsDBi79963

PTM databases

iPTMnetiQ9C075
PhosphoSitePlusiQ9C075
SwissPalmiQ9C075

Expressioni

Gene expression databases

BgeeiENSG00000108244 Expressed in 123 organ(s), highest expression level in parotid gland
CleanExiHS_KRT23
ExpressionAtlasiQ9C075 baseline and differential
GenevisibleiQ9C075 HS

Organism-specific databases

HPAiCAB017091
HPA012050
HPA016959

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.By similarity

Protein-protein interaction databases

BioGridi117467, 3 interactors
IntActiQ9C075, 2 interactors
STRINGi9606.ENSP00000209718

Structurei

3D structure databases

ProteinModelPortaliQ9C075
SMRiQ9C075
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 382IF rodPROSITE-ProRule annotationAdd BLAST311

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 71HeadAdd BLAST71
Regioni72 – 107Coil 1AAdd BLAST36
Regioni108 – 125Linker 1Add BLAST18
Regioni126 – 217Coil 1BAdd BLAST92
Regioni218 – 240Linker 12Add BLAST23
Regioni241 – 378Coil 2Add BLAST138
Regioni379 – 422Rod-like helical tailAdd BLAST44

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IK9C Eukaryota
ENOG4111DWD LUCA
GeneTreeiENSGT00930000151010
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiQ9C075
KOiK07604
OMAiIKKKHQD
OrthoDBiEOG091G087I
PhylomeDBiQ9C075
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9C075-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNSGHSFSQT PSASFHGAGG GWGRPRSFPR APTVHGGAGG ARISLSFTTR
60 70 80 90 100
SCPPPGGSWG SGRSSPLLGG NGKATMQNLN DRLASYLEKV RALEEANMKL
110 120 130 140 150
ESRILKWHQQ RDPGSKKDYS QYEENITHLQ EQIVDGKMTN AQIILLIDNA
160 170 180 190 200
RMAVDDFNLK YENEHSFKKD LEIEVEGLRR TLDNLTIVTT DLEQEVEGMR
210 220 230 240 250
KELILMKKHH EQEMEKHHVP SDFNVNVKVD TGPREDLIKV LEDMRQEYEL
260 270 280 290 300
IIKKKHRDLD TWYKEQSAAM SQEAASPATV QSRQGDIHEL KRTFQALEID
310 320 330 340 350
LQTQYSTKSA LENMLSETQS RYSCKLQDMQ EIISHYEEEL TQLRHELERQ
360 370 380 390 400
NNEYQVLLGI KTHLEKEITT YRRLLEGESE GTREESKSSM KVSATPKIKA
410 420
ITQETINGRL VLCQVNEIQK HA
Length:422
Mass (Da):48,131
Last modified:April 3, 2007 - v2
Checksum:iA43876CCBA9CBE7D
GO
Isoform 2 (identifier: Q9C075-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-137: Missing.

Note: No experimental confirmation available.
Show »
Length:285
Mass (Da):33,341
Checksum:i66974FC5BAB7C436
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QR55J3QR55_HUMAN
Keratin, type I cytoskeletal 23
KRT23
149Annotation score:
K7EPI0K7EPI0_HUMAN
Keratin, type I cytoskeletal 23
KRT23
52Annotation score:
Q9UFN7Q9UFN7_HUMAN
Keratin, type I cytoskeletal 23
KRT23 DKFZp434G032
37Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137K → N in AAK00050 (PubMed:11135429).Curated1
Sequence conflicti208K → E in BAA92054 (PubMed:14702039).Curated1
Sequence conflicti216K → E in BAA92054 (PubMed:14702039).Curated1
Sequence conflicti322Y → N in AAK00050 (PubMed:11135429).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031608303T → A1 PublicationCorresponds to variant dbSNP:rs9257Ensembl.1
Natural variantiVAR_049785393S → F. Corresponds to variant dbSNP:rs17856805Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0556621 – 137Missing in isoform 2. 1 PublicationAdd BLAST137

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102848 mRNA Translation: AAK00050.1
AK002047 mRNA Translation: BAA92054.1
AK289449 mRNA Translation: BAF82138.1
AK302109 mRNA Translation: BAH13628.1
AC004231 Genomic DNA No translation available.
CCDSiCCDS11380.1 [Q9C075-1]
CCDS62182.1 [Q9C075-2]
RefSeqiNP_001269362.1, NM_001282433.1 [Q9C075-2]
NP_056330.3, NM_015515.4 [Q9C075-1]
XP_005257257.1, XM_005257200.4 [Q9C075-2]
XP_011522897.1, XM_011524595.1 [Q9C075-2]
UniGeneiHs.9029

Genome annotation databases

EnsembliENST00000209718; ENSP00000209718; ENSG00000108244 [Q9C075-1]
ENST00000436344; ENSP00000414056; ENSG00000108244 [Q9C075-2]
ENST00000571258; ENSP00000460637; ENSG00000263309 [Q9C075-2]
ENST00000574480; ENSP00000459021; ENSG00000263309 [Q9C075-1]
GeneIDi25984
KEGGihsa:25984
UCSCiuc002hvm.3 human [Q9C075-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102848 mRNA Translation: AAK00050.1
AK002047 mRNA Translation: BAA92054.1
AK289449 mRNA Translation: BAF82138.1
AK302109 mRNA Translation: BAH13628.1
AC004231 Genomic DNA No translation available.
CCDSiCCDS11380.1 [Q9C075-1]
CCDS62182.1 [Q9C075-2]
RefSeqiNP_001269362.1, NM_001282433.1 [Q9C075-2]
NP_056330.3, NM_015515.4 [Q9C075-1]
XP_005257257.1, XM_005257200.4 [Q9C075-2]
XP_011522897.1, XM_011524595.1 [Q9C075-2]
UniGeneiHs.9029

3D structure databases

ProteinModelPortaliQ9C075
SMRiQ9C075
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117467, 3 interactors
IntActiQ9C075, 2 interactors
STRINGi9606.ENSP00000209718

PTM databases

iPTMnetiQ9C075
PhosphoSitePlusiQ9C075
SwissPalmiQ9C075

Polymorphism and mutation databases

BioMutaiKRT23
DMDMi143811410

Proteomic databases

PaxDbiQ9C075
PeptideAtlasiQ9C075
PRIDEiQ9C075
ProteomicsDBi79963

Protocols and materials databases

DNASUi25984
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000209718; ENSP00000209718; ENSG00000108244 [Q9C075-1]
ENST00000436344; ENSP00000414056; ENSG00000108244 [Q9C075-2]
ENST00000571258; ENSP00000460637; ENSG00000263309 [Q9C075-2]
ENST00000574480; ENSP00000459021; ENSG00000263309 [Q9C075-1]
GeneIDi25984
KEGGihsa:25984
UCSCiuc002hvm.3 human [Q9C075-1]

Organism-specific databases

CTDi25984
DisGeNETi25984
EuPathDBiHostDB:ENSG00000108244.16
GeneCardsiKRT23
HGNCiHGNC:6438 KRT23
HPAiCAB017091
HPA012050
HPA016959
MIMi606194 gene
neXtProtiNX_Q9C075
OpenTargetsiENSG00000108244
PharmGKBiPA134914537
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK9C Eukaryota
ENOG4111DWD LUCA
GeneTreeiENSGT00930000151010
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiQ9C075
KOiK07604
OMAiIKKKHQD
OrthoDBiEOG091G087I
PhylomeDBiQ9C075
TreeFamiTF332742

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Miscellaneous databases

ChiTaRSiKRT23 human
GeneWikiiKRT23
GenomeRNAii25984
PROiPR:Q9C075
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108244 Expressed in 123 organ(s), highest expression level in parotid gland
CleanExiHS_KRT23
ExpressionAtlasiQ9C075 baseline and differential
GenevisibleiQ9C075 HS

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK1C23_HUMAN
AccessioniPrimary (citable) accession number: Q9C075
Secondary accession number(s): A8K084
, B7Z7J2, I3L3Q6, Q9NUR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: April 3, 2007
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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