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Entry version 110 (08 May 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Protein FAM117A

Gene

FAM117A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM117A
Alternative name(s):
C/EBP-induced protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM117A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:24179 FAM117A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9C073

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000121104

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145008393

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM117A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74733494

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002649881 – 453Protein FAM117AAdd BLAST453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei29PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei178PhosphoserineCombined sources1
Modified residuei193PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei213PhosphoserineCombined sources1
Modified residuei299PhosphothreonineCombined sources1
Modified residuei319PhosphoserineBy similarity1
Modified residuei327PhosphoserineBy similarity1
Modified residuei354PhosphothreonineCombined sources1
Modified residuei413PhosphoserineBy similarity1
Modified residuei428PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9C073

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9C073

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9C073

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9C073

PeptideAtlas

More...
PeptideAtlasi
Q9C073

PRoteomics IDEntifications database

More...
PRIDEi
Q9C073

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79962

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9C073

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9C073

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000121104 Expressed in 210 organ(s), highest expression level in trabecular bone tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9C073 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9C073 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA022531

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123522, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q9C073, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000240364

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili149 – 175Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi402 – 444Pro-richAdd BLAST43

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM117 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEAU Eukaryota
ENOG4111PY2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183046

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000252927

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9C073

Identification of Orthologs from Complete Genome Data

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OMAi
PPQSGSC

Database of Orthologous Groups

More...
OrthoDBi
1132072at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9C073

TreeFam database of animal gene trees

More...
TreeFami
TF333159

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR026642 Glcci1/FAM117

The PANTHER Classification System

More...
PANTHERi
PTHR14972 PTHR14972, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15388 FAM117, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9C073-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGAAAGGRG GGAWGPGRGG AGGLRRGCSP PAPAGSPRAG LQPLRATIPF
60 70 80 90 100
QLQQPHQRRD GGGRAASVPC SVAPEKSVCR PQPLQVRRTF SLDTILSSYL
110 120 130 140 150
LGQWPRDADG AFTCCTNDKA TQTPLSWQEL EGERASSCAH KRSASWGSTD
160 170 180 190 200
HRKEISKLKQ QLQRTKLSRS GKEKERGSPL LGDHAVRGAL RASPPSFPSG
210 220 230 240 250
SPVLRLSPCL HRSLEGLNQE LEEVFVKEQG EEELLRILDI PDGHRAPAPP
260 270 280 290 300
QSGSCDHPLL LLEPGNLASS PSMSLASPQP CGLASHEEHR GAAEELASTP
310 320 330 340 350
NDKASSPGHP AFLEDGSPSP VLAFAASPRP NHSYIFKREP PEGCEKVRVF
360 370 380 390 400
EEATSPGPDL AFLTSCPDKN KVHFNPTGSA FCPVNLMKPL FPGMGFIFRN
410 420 430 440 450
CPSNPGSPLP PASPRPPPRK DPEASKASPL PFEPWQRTPP SEEPVLFQSS

LMV
Length:453
Mass (Da):48,319
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i93B83B4E293BBC7E
GO
Isoform 2 (identifier: Q9C073-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-272: Missing.

Note: No experimental confirmation available.
Show »
Length:181
Mass (Da):19,436
Checksum:iBDE1115CA65EBA3D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RJ87D6RJ87_HUMAN
Protein FAM117A
FAM117A
230Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RFX7D6RFX7_HUMAN
Protein FAM117A
FAM117A
223Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENS5K7ENS5_HUMAN
Protein FAM117A
FAM117A
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0561291 – 272Missing in isoform 2. 1 PublicationAdd BLAST272

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF123073 mRNA Translation: AAK01477.1
AK302376 mRNA Translation: BAH13689.1
AC015795 Genomic DNA No translation available.
BC037572 mRNA Translation: AAH37572.1
BC065199 mRNA Translation: AAH65199.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11553.1 [Q9C073-1]

NCBI Reference Sequences

More...
RefSeqi
NP_110429.1, NM_030802.3 [Q9C073-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000240364; ENSP00000240364; ENSG00000121104 [Q9C073-1]
ENST00000513602; ENSP00000465808; ENSG00000121104 [Q9C073-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
81558

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:81558

UCSC genome browser

More...
UCSCi
uc002ipk.4 human [Q9C073-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123073 mRNA Translation: AAK01477.1
AK302376 mRNA Translation: BAH13689.1
AC015795 Genomic DNA No translation available.
BC037572 mRNA Translation: AAH37572.1
BC065199 mRNA Translation: AAH65199.1
CCDSiCCDS11553.1 [Q9C073-1]
RefSeqiNP_110429.1, NM_030802.3 [Q9C073-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi123522, 5 interactors
IntActiQ9C073, 2 interactors
STRINGi9606.ENSP00000240364

PTM databases

iPTMnetiQ9C073
PhosphoSitePlusiQ9C073

Polymorphism and mutation databases

BioMutaiFAM117A
DMDMi74733494

Proteomic databases

EPDiQ9C073
jPOSTiQ9C073
MaxQBiQ9C073
PaxDbiQ9C073
PeptideAtlasiQ9C073
PRIDEiQ9C073
ProteomicsDBi79962

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240364; ENSP00000240364; ENSG00000121104 [Q9C073-1]
ENST00000513602; ENSP00000465808; ENSG00000121104 [Q9C073-2]
GeneIDi81558
KEGGihsa:81558
UCSCiuc002ipk.4 human [Q9C073-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
81558

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM117A
HGNCiHGNC:24179 FAM117A
HPAiHPA022531
neXtProtiNX_Q9C073
OpenTargetsiENSG00000121104
PharmGKBiPA145008393

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEAU Eukaryota
ENOG4111PY2 LUCA
GeneTreeiENSGT00950000183046
HOGENOMiHOG000252927
InParanoidiQ9C073
OMAiPPQSGSC
OrthoDBi1132072at2759
PhylomeDBiQ9C073
TreeFamiTF333159

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
81558

Protein Ontology

More...
PROi
PR:Q9C073

Gene expression databases

BgeeiENSG00000121104 Expressed in 210 organ(s), highest expression level in trabecular bone tissue
ExpressionAtlasiQ9C073 baseline and differential
GenevisibleiQ9C073 HS

Family and domain databases

InterProiView protein in InterPro
IPR026642 Glcci1/FAM117
PANTHERiPTHR14972 PTHR14972, 1 hit
PfamiView protein in Pfam
PF15388 FAM117, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF117A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C073
Secondary accession number(s): B7Z7Q3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2001
Last modified: May 8, 2019
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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