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Protein

Tripartite motif-containing protein 5

Gene

TRIM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV), equine infectious anemia virus (EIAV), simian immunodeficiency virus of macaques (SIVmac), feline immunodeficiency virus (FIV), and bovine immunodeficiency virus (BIV) (PubMed:17156811). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057). Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction (PubMed:25127057).8 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri15 – 59RING-typePROSITE-ProRule annotationAdd BLAST45
Zinc fingeri90 – 132B box-typePROSITE-ProRule annotationAdd BLAST43

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processAntiviral defense, Autophagy, Host-virus interaction, Immunity, Innate immunity, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.3.2.B10 2681
6.3.2.19 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-877300 Interferon gamma signaling

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
Q9C035 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tripartite motif-containing protein 5 (EC:2.3.2.27)
Alternative name(s):
RING finger protein 88
RING-type E3 ubiquitin transferase TRIM5Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM5
Synonyms:RNF88
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000132256.18

Human Gene Nomenclature Database

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HGNCi
HGNC:16276 TRIM5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608487 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9C035

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi15C → A: Abolishes E3 ligase activity. 1 Publication1
Mutagenesisi332R → A, G, H, P, Q or S: Increases strongly cell restriction against HIV-1 and SIVmac infection. 1 Publication1
Mutagenesisi332R → D, E or L: Increases strongly cell restriction against HIV-1 infection. 1 Publication1
Mutagenesisi332R → K: No effect on HIV-1 and SIVmac infection. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
85363

Open Targets

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OpenTargetsi
ENSG00000132256

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38109

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRIM5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
38605459

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000562012 – 493Tripartite motif-containing protein 5Add BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei86PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Degraded in a proteasome-independent fashion in the absence of viral infection but in a proteasome-dependent fashion following exposure to restriction sensitive virus.
Autoubiquitinated in a RING finger- and UBE2D2-dependent manner. Monoubiquitinated by TRIM21. Deubiquitinated by Yersinia YopJ. Ubiquitination may not lead to proteasomal degradation.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9C035

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9C035

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9C035

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9C035

PeptideAtlas

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PeptideAtlasi
Q9C035

PRoteomics IDEntifications database

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PRIDEi
Q9C035

ProteomicsDB human proteome resource

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ProteomicsDBi
79952
79953 [Q9C035-2]
79954 [Q9C035-3]
79955 [Q9C035-4]
79956 [Q9C035-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9C035

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9C035

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000132256 Expressed in 190 organ(s), highest expression level in lung

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9C035 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9C035 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB013497
HPA023420
HPA023422

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Isoform Delta interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70 (By similarity). Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3 (PubMed:21512573, PubMed:22078707). Interacts with SQSTM1 (PubMed:20357094, PubMed:25127057). Interacts with TRIM6 and TRIM34 (PubMed:21680743, PubMed:17156811). Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1 (PubMed:25127057).By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
124491, 60 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q9C035

Protein interaction database and analysis system

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IntActi
Q9C035, 29 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000369373

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1493
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ECVNMR-A1-78[»]
2YRGNMR-A86-129[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9C035

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9C035

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9C035

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini281 – 493B30.2/SPRYPROSITE-ProRule annotationAdd BLAST213

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni185 – 198Required for interaction with GABARAP and for autophagyBy similarityAdd BLAST14

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili130 – 241Sequence analysisAdd BLAST112

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The B box-type zinc finger domain and the coiled-coil domain contribute to the higher and low order multimerization respectively which is essential for restriction activity (PubMed:22482711). The coiled coil domain is important for higher order multimerization by promoting the initial dimerization (By similarity).By similarity1 Publication
The B30.2/SPRY domain acts as a capsid recognition domain. Polymorphisms in this domain explain the observed species-specific differences among orthologs (PubMed:22482711).1 Publication
The RING-type zinc finger domain confers E3 ubiquitin ligase activity and is essential for retrovirus restriction activity, autoubiquitination and higher-order multimerization.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 59RING-typePROSITE-ProRule annotationAdd BLAST45
Zinc fingeri90 – 132B box-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410ITG7 Eukaryota
ENOG410XWDC LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154647

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG001357

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9C035

KEGG Orthology (KO)

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KOi
K10648

Identification of Orthologs from Complete Genome Data

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OMAi
QNENYQP

Database of Orthologous Groups

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OrthoDBi
740493at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9C035

TreeFam database of animal gene trees

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TreeFami
TF338674

Family and domain databases

Conserved Domains Database

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CDDi
cd00021 BBOX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR003877 SPRY_dom
IPR032917 TRIM5
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

The PANTHER Classification System

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PANTHERi
PTHR24103:SF426 PTHR24103:SF426, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01407 BUTYPHLNCDUF

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00336 BBOX, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha (identifier: Q9C035-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASGILVNVK EEVTCPICLE LLTQPLSLDC GHSFCQACLT ANHKKSMLDK
60 70 80 90 100
GESSCPVCRI SYQPENIRPN RHVANIVEKL REVKLSPEGQ KVDHCARHGE
110 120 130 140 150
KLLLFCQEDG KVICWLCERS QEHRGHHTFL TEEVAREYQV KLQAALEMLR
160 170 180 190 200
QKQQEAEELE ADIREEKASW KTQIQYDKTN VLADFEQLRD ILDWEESNEL
210 220 230 240 250
QNLEKEEEDI LKSLTNSETE MVQQTQSLRE LISDLEHRLQ GSVMELLQGV
260 270 280 290 300
DGVIKRTENV TLKKPETFPK NQRRVFRAPD LKGMLEVFRE LTDVRRYWVD
310 320 330 340 350
VTVAPNNISC AVISEDKRQV SSPKPQIIYG ARGTRYQTFV NFNYCTGILG
360 370 380 390 400
SQSITSGKHY WEVDVSKKTA WILGVCAGFQ PDAMCNIEKN ENYQPKYGYW
410 420 430 440 450
VIGLEEGVKC SAFQDSSFHT PSVPFIVPLS VIICPDRVGV FLDYEACTVS
460 470 480 490
FFNITNHGFL IYKFSHCSFS QPVFPYLNPR KCGVPMTLCS PSS
Length:493
Mass (Da):56,338
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8E61AAFD508AF6C0
GO
Isoform Beta (identifier: Q9C035-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     390-400: NENYQPKYGYW → KRFMILLPRHT
     401-493: Missing.

Note: Probable artifact.
Show »
Length:400
Mass (Da):46,038
Checksum:iE8AC7B014BF58488
GO
Isoform Gamma (identifier: Q9C035-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     299-347: VDVTVAPNNI...TFVNFNYCTG → GKEKSHYHKP...SKTHITYPSL
     348-493: Missing.

Show »
Length:347
Mass (Da):40,108
Checksum:i07B838DB840C4F55
GO
Isoform Delta (identifier: Q9C035-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     299-326: VDVTVAPNNISCAVISEDKRQVSSPKPQ → GWSAMARSRFTATSTSQIQAILLPQPPK
     327-493: Missing.

Show »
Length:326
Mass (Da):37,685
Checksum:iAB54B894549C8775
GO
Isoform Epsilon (identifier: Q9C035-5) [UniParc]FASTAAdd to basket
Also known as: Kappa

The sequence of this isoform differs from the canonical sequence as follows:
     249-271: GVDGVIKRTENVTLKKPETFPKN → DGERDLEEARNFSKKSKESVSSS
     272-493: Missing.

Show »
Length:271
Mass (Da):31,253
Checksum:iC988390B71D2B74F
GO
Isoform Iota (identifier: Q9C035-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     249-257: GVDGVIKRT → VKSGKKPEH
     258-493: Missing.

Note: Has dominant-negative activity against TRIM5alpha. Does not inhibit HIV-1 replication.
Show »
Length:257
Mass (Da):29,677
Checksum:i8769CFD2E659BEF5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EQQ5E7EQQ5_HUMAN
Tripartite motif-containing protein...
TRIM5
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C134H7C134_HUMAN
Tripartite motif-containing protein...
TRIM5
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWN8C9JWN8_HUMAN
Tripartite motif-containing protein...
TRIM5
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti76I → L in BAB55218 (PubMed:15249690).Curated1
Sequence conflicti130L → P in BAB55218 (PubMed:15249690).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06070731G → S1 PublicationCorresponds to variant dbSNP:rs59896509Ensembl.1
Natural variantiVAR_01739743H → Y2 PublicationsCorresponds to variant dbSNP:rs3740996Ensembl.1
Natural variantiVAR_06070858C → Y1 PublicationCorresponds to variant dbSNP:rs61432120Ensembl.1
Natural variantiVAR_060709110G → E1 PublicationCorresponds to variant dbSNP:rs56348930Ensembl.1
Natural variantiVAR_030154112V → F1 PublicationCorresponds to variant dbSNP:rs11601507Ensembl.1
Natural variantiVAR_017398136R → Q4 PublicationsCorresponds to variant dbSNP:rs10838525Ensembl.1
Natural variantiVAR_030155249G → D2 PublicationsCorresponds to variant dbSNP:rs11038628Ensembl.1
Natural variantiVAR_030156419H → Y1 PublicationCorresponds to variant dbSNP:rs28381981Ensembl.1
Natural variantiVAR_060710467C → S1 PublicationCorresponds to variant dbSNP:rs59218593Ensembl.1
Natural variantiVAR_030157479P → L1 PublicationCorresponds to variant dbSNP:rs7104422Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009016249 – 271GVDGV…TFPKN → DGERDLEEARNFSKKSKESV SSS in isoform Epsilon. 2 PublicationsAdd BLAST23
Alternative sequenceiVSP_044095249 – 257GVDGVIKRT → VKSGKKPEH in isoform Iota. Curated9
Alternative sequenceiVSP_044096258 – 493Missing in isoform Iota. CuratedAdd BLAST236
Alternative sequenceiVSP_009017272 – 493Missing in isoform Epsilon. 2 PublicationsAdd BLAST222
Alternative sequenceiVSP_009012299 – 347VDVTV…NYCTG → GKEKSHYHKPPCGLSLLLSL SFRILCSLLGSCFKIYDSPS KTHITYPSL in isoform Gamma. 2 PublicationsAdd BLAST49
Alternative sequenceiVSP_009014299 – 326VDVTV…SPKPQ → GWSAMARSRFTATSTSQIQA ILLPQPPK in isoform Delta. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_009015327 – 493Missing in isoform Delta. 1 PublicationAdd BLAST167
Alternative sequenceiVSP_009013348 – 493Missing in isoform Gamma. 2 PublicationsAdd BLAST146
Alternative sequenceiVSP_009010390 – 400NENYQPKYGYW → KRFMILLPRHT in isoform Beta. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_009011401 – 493Missing in isoform Beta. 1 PublicationAdd BLAST93

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF220025 mRNA Translation: AAG53479.1
AF220026 mRNA Translation: AAG53480.1
AF220027 mRNA Translation: AAG53481.1
AF220028 mRNA Translation: AAG53482.1
AF220029 mRNA Translation: AAG53483.1
AY625000 mRNA Translation: AAT48101.1
DQ301444 Genomic DNA Translation: ABC00997.1
DQ301445 Genomic DNA Translation: ABC00998.1
DQ301446 Genomic DNA Translation: ABC00999.1
DQ301447 Genomic DNA Translation: ABC01000.1
DQ301448 Genomic DNA Translation: ABC01001.1
DQ301449 Genomic DNA Translation: ABC01002.1
DQ301450 Genomic DNA Translation: ABC01003.1
DQ301451 Genomic DNA Translation: ABC01004.1
DQ301452 Genomic DNA Translation: ABC01005.1
DQ301453 Genomic DNA Translation: ABC01006.1
DQ301454 Genomic DNA Translation: ABC01007.1
DQ301455 Genomic DNA Translation: ABC01008.1
DQ301456 Genomic DNA Translation: ABC01009.1
DQ301457 Genomic DNA Translation: ABC01010.1
DQ301458 Genomic DNA Translation: ABC01011.1
DQ301459 Genomic DNA Translation: ABC01012.1
DQ301460 Genomic DNA Translation: ABC01013.1
DQ301461 Genomic DNA Translation: ABC01014.1
DQ301462 Genomic DNA Translation: ABC01015.1
DQ301463 Genomic DNA Translation: ABC01016.1
DQ301464 Genomic DNA Translation: ABC01017.1
DQ301465 Genomic DNA Translation: ABC01018.1
DQ301466 Genomic DNA Translation: ABC01019.1
DQ301467 Genomic DNA Translation: ABC01020.1
DQ301468 Genomic DNA Translation: ABC01021.1
DQ301469 Genomic DNA Translation: ABC01022.1
DQ301470 Genomic DNA Translation: ABC01023.1
DQ301471 Genomic DNA Translation: ABC01024.1
DQ301472 Genomic DNA Translation: ABC01025.1
DQ301473 Genomic DNA Translation: ABC01026.1
DQ301474 Genomic DNA Translation: ABC01027.1
DQ301475 Genomic DNA Translation: ABC01028.1
DQ301476 Genomic DNA Translation: ABC01029.1
DQ301477 Genomic DNA Translation: ABC01030.1
DQ301478 Genomic DNA Translation: ABC01031.1
DQ301479 Genomic DNA Translation: ABC01032.1
DQ301480 Genomic DNA Translation: ABC01033.1
DQ288685 mRNA Translation: ABB90543.1
JF928461 mRNA Translation: AEN14475.1
JF928462 mRNA Translation: AEN14476.1
AK027593 mRNA Translation: BAB55218.1
AC015691 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68771.1
CH471064 Genomic DNA Translation: EAW68772.1
CH471064 Genomic DNA Translation: EAW68774.1
CH471064 Genomic DNA Translation: EAW68775.1
EU260465 Genomic DNA Translation: ABW96352.1
CH471064 Genomic DNA Translation: EAW68776.1
CH471064 Genomic DNA Translation: EAW68777.1
BC021258 mRNA Translation: AAH21258.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31392.1 [Q9C035-4]
CCDS31393.1 [Q9C035-1]
CCDS31394.1 [Q9C035-3]

NCBI Reference Sequences

More...
RefSeqi
NP_149023.2, NM_033034.2 [Q9C035-1]
NP_149083.2, NM_033092.2 [Q9C035-3]
NP_149084.2, NM_033093.2 [Q9C035-4]
XP_005253240.1, XM_005253183.2 [Q9C035-1]
XP_005253241.1, XM_005253184.2 [Q9C035-4]
XP_011518729.1, XM_011520427.1 [Q9C035-5]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.125300

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000380027; ENSP00000369366; ENSG00000132256 [Q9C035-4]
ENST00000380034; ENSP00000369373; ENSG00000132256 [Q9C035-1]
ENST00000396847; ENSP00000380058; ENSG00000132256 [Q9C035-3]
ENST00000433961; ENSP00000393052; ENSG00000132256 [Q9C035-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
85363

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:85363

UCSC genome browser

More...
UCSCi
uc001mbm.3 human [Q9C035-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220025 mRNA Translation: AAG53479.1
AF220026 mRNA Translation: AAG53480.1
AF220027 mRNA Translation: AAG53481.1
AF220028 mRNA Translation: AAG53482.1
AF220029 mRNA Translation: AAG53483.1
AY625000 mRNA Translation: AAT48101.1
DQ301444 Genomic DNA Translation: ABC00997.1
DQ301445 Genomic DNA Translation: ABC00998.1
DQ301446 Genomic DNA Translation: ABC00999.1
DQ301447 Genomic DNA Translation: ABC01000.1
DQ301448 Genomic DNA Translation: ABC01001.1
DQ301449 Genomic DNA Translation: ABC01002.1
DQ301450 Genomic DNA Translation: ABC01003.1
DQ301451 Genomic DNA Translation: ABC01004.1
DQ301452 Genomic DNA Translation: ABC01005.1
DQ301453 Genomic DNA Translation: ABC01006.1
DQ301454 Genomic DNA Translation: ABC01007.1
DQ301455 Genomic DNA Translation: ABC01008.1
DQ301456 Genomic DNA Translation: ABC01009.1
DQ301457 Genomic DNA Translation: ABC01010.1
DQ301458 Genomic DNA Translation: ABC01011.1
DQ301459 Genomic DNA Translation: ABC01012.1
DQ301460 Genomic DNA Translation: ABC01013.1
DQ301461 Genomic DNA Translation: ABC01014.1
DQ301462 Genomic DNA Translation: ABC01015.1
DQ301463 Genomic DNA Translation: ABC01016.1
DQ301464 Genomic DNA Translation: ABC01017.1
DQ301465 Genomic DNA Translation: ABC01018.1
DQ301466 Genomic DNA Translation: ABC01019.1
DQ301467 Genomic DNA Translation: ABC01020.1
DQ301468 Genomic DNA Translation: ABC01021.1
DQ301469 Genomic DNA Translation: ABC01022.1
DQ301470 Genomic DNA Translation: ABC01023.1
DQ301471 Genomic DNA Translation: ABC01024.1
DQ301472 Genomic DNA Translation: ABC01025.1
DQ301473 Genomic DNA Translation: ABC01026.1
DQ301474 Genomic DNA Translation: ABC01027.1
DQ301475 Genomic DNA Translation: ABC01028.1
DQ301476 Genomic DNA Translation: ABC01029.1
DQ301477 Genomic DNA Translation: ABC01030.1
DQ301478 Genomic DNA Translation: ABC01031.1
DQ301479 Genomic DNA Translation: ABC01032.1
DQ301480 Genomic DNA Translation: ABC01033.1
DQ288685 mRNA Translation: ABB90543.1
JF928461 mRNA Translation: AEN14475.1
JF928462 mRNA Translation: AEN14476.1
AK027593 mRNA Translation: BAB55218.1
AC015691 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68771.1
CH471064 Genomic DNA Translation: EAW68772.1
CH471064 Genomic DNA Translation: EAW68774.1
CH471064 Genomic DNA Translation: EAW68775.1
EU260465 Genomic DNA Translation: ABW96352.1
CH471064 Genomic DNA Translation: EAW68776.1
CH471064 Genomic DNA Translation: EAW68777.1
BC021258 mRNA Translation: AAH21258.1
CCDSiCCDS31392.1 [Q9C035-4]
CCDS31393.1 [Q9C035-1]
CCDS31394.1 [Q9C035-3]
RefSeqiNP_149023.2, NM_033034.2 [Q9C035-1]
NP_149083.2, NM_033092.2 [Q9C035-3]
NP_149084.2, NM_033093.2 [Q9C035-4]
XP_005253240.1, XM_005253183.2 [Q9C035-1]
XP_005253241.1, XM_005253184.2 [Q9C035-4]
XP_011518729.1, XM_011520427.1 [Q9C035-5]
UniGeneiHs.125300

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ECVNMR-A1-78[»]
2YRGNMR-A86-129[»]
ProteinModelPortaliQ9C035
SMRiQ9C035
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124491, 60 interactors
ELMiQ9C035
IntActiQ9C035, 29 interactors
STRINGi9606.ENSP00000369373

Protein family/group databases

MoonDBiQ9C035 Predicted

PTM databases

iPTMnetiQ9C035
PhosphoSitePlusiQ9C035

Polymorphism and mutation databases

BioMutaiTRIM5
DMDMi38605459

Proteomic databases

EPDiQ9C035
jPOSTiQ9C035
MaxQBiQ9C035
PaxDbiQ9C035
PeptideAtlasiQ9C035
PRIDEiQ9C035
ProteomicsDBi79952
79953 [Q9C035-2]
79954 [Q9C035-3]
79955 [Q9C035-4]
79956 [Q9C035-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
85363
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380027; ENSP00000369366; ENSG00000132256 [Q9C035-4]
ENST00000380034; ENSP00000369373; ENSG00000132256 [Q9C035-1]
ENST00000396847; ENSP00000380058; ENSG00000132256 [Q9C035-3]
ENST00000433961; ENSP00000393052; ENSG00000132256 [Q9C035-5]
GeneIDi85363
KEGGihsa:85363
UCSCiuc001mbm.3 human [Q9C035-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
85363
DisGeNETi85363
EuPathDBiHostDB:ENSG00000132256.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TRIM5

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0009393
HGNCiHGNC:16276 TRIM5
HPAiCAB013497
HPA023420
HPA023422
MIMi608487 gene
neXtProtiNX_Q9C035
OpenTargetsiENSG00000132256
PharmGKBiPA38109

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ITG7 Eukaryota
ENOG410XWDC LUCA
GeneTreeiENSGT00940000154647
HOVERGENiHBG001357
InParanoidiQ9C035
KOiK10648
OMAiQNENYQP
OrthoDBi740493at2759
PhylomeDBiQ9C035
TreeFamiTF338674

Enzyme and pathway databases

UniPathwayi
UPA00143

BRENDAi2.3.2.B10 2681
6.3.2.19 2681
ReactomeiR-HSA-877300 Interferon gamma signaling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TRIM5 human
EvolutionaryTraceiQ9C035

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TRIM5alpha

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
85363

Protein Ontology

More...
PROi
PR:Q9C035

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000132256 Expressed in 190 organ(s), highest expression level in lung
ExpressionAtlasiQ9C035 baseline and differential
GenevisibleiQ9C035 HS

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR003877 SPRY_dom
IPR032917 TRIM5
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR24103:SF426 PTHR24103:SF426, 1 hit
PfamiView protein in Pfam
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRIM5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C035
Secondary accession number(s): A6NGQ1
, A8WFA8, D3DQS8, D3DQS9, G3GJY1, Q2MLV4, Q2MLV8, Q2MLV9, Q2MLW1, Q2MLW3, Q2MLW4, Q2MLW6, Q2MLW7, Q2MLX1, Q2MLX2, Q2MLX3, Q2MLX5, Q2MLY3, Q2MLY4, Q2V6Q6, Q6GX26, Q8WU46, Q96SR5, Q9C031, Q9C032, Q9C033, Q9C034
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2001
Last modified: January 16, 2019
This is version 181 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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