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Entry version 160 (08 May 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Tripartite motif-containing protein 6

Gene

TRIM6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase which ubiquitinates MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (By similarity). Involved in the synthesis of unanchored K48-linked polyubiquitin chains which interact with and activate the serine/threonine kinase IKBKE, leading to phosphorylation of STAT1 and stimulation of an antiviral response (PubMed:24882218).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.By similarity EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri15 – 60RING-typePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri92 – 133B box-typePROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processHost-virus interaction, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-877300 Interferon gamma signaling

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tripartite motif-containing protein 6 (EC:2.3.2.27By similarity)
Alternative name(s):
RING finger protein 89
RING-type E3 ubiquitin transferase TRIM6Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM6
Synonyms:RNF89
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16277 TRIM6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607564 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9C030

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi15C → A: Abolishes binding of polyubiquitin to IKBKE. 1 Publication1
Mutagenesisi121R → E: Reduced higher order self-association and association with TRIM5. 1 Publication1

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000121236

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38110

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRIM6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
25009488

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000562021 – 488Tripartite motif-containing protein 6Add BLAST488

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9C030

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9C030

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9C030

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9C030

PeptideAtlas

More...
PeptideAtlasi
Q9C030

PRoteomics IDEntifications database

More...
PRIDEi
Q9C030

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79950
79951 [Q9C030-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9C030

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9C030

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000121236 Expressed in 150 organ(s), highest expression level in oocyte

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9C030 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9C030 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA060514

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer (PubMed:17156811). Forms heteromultimers (via B30.2/SPRY domain) with TRIM5 (PubMed:21680743). Interacts with MYC (By similarity). Interacts (via SPRY domain) with IKBKE (PubMed:24882218). Interacts with HIV-1 capsid complexes (PubMed:17156811).By similarity3 Publications
(Microbial infection) Interacts with ebolavirus protein VP35; this interaction plays an important role in promoting efficient viral replication.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125596, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000369440

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9C030

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini282 – 488B30.2/SPRYPROSITE-ProRule annotationAdd BLAST207

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili134 – 248Sequence analysisAdd BLAST115

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The B-box zinc finger and the linker region between the coiled coil and B30.2/SPRY domains contribute to higher order self-association.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 60RING-typePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri92 – 133B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ITG7 Eukaryota
ENOG410XWDC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163021

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234134

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9C030

KEGG Orthology (KO)

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KOi
K11999

Identification of Orthologs from Complete Genome Data

More...
OMAi
HHKHEYR

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9C030

TreeFam database of animal gene trees

More...
TreeFami
TF342569

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00021 BBOX, 1 hit
cd15823 SPRY_PRY_TRIM6, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR035828 PRY/SPRY_TRIM6
IPR003877 SPRY_dom
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01407 BUTYPHLNCDUF

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9C030-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSPVLVDIR EEVTCPICLE LLTEPLSIDC GHSFCQACIT PNGRESVIGQ
60 70 80 90 100
EGERSCPVCQ TSYQPGNLRP NRHLANIVRR LREVVLGPGK QLKAVLCADH
110 120 130 140 150
GEKLQLFCQE DGKVICWLCE RSQEHRGHHT FLVEEVAQEY QEKFQESLKK
160 170 180 190 200
LKNEEQEAEK LTAFIREKKT SWKNQMEPER CRIQTEFNQL RNILDRVEQR
210 220 230 240 250
ELKKLEQEEK KGLRIIEEAE NDLVHQTQSL RELISDLERR CQGSTMELLQ
260 270 280 290 300
DVSDVTERSE FWTLRKPEAL PTKLRSMFRA PDLKRMLRVC RELTDVQSYW
310 320 330 340 350
VDVTLNPHTA NLNLVLAKNR RQVRFVGAKV SGPSCLEKHY DCSVLGSQHF
360 370 380 390 400
SSGKHYWEVD VAKKTAWILG VCSNSLGPTF SFNHFAQNHS AYSRYQPQSG
410 420 430 440 450
YWVIGLQHNH EYRAYEDSSP SLLLSMTVPP RRVGVFLDYE AGTVSFYNVT
460 470 480
NHGFPIYTFS KYYFPTTLCP YFNPCNCVIP MTLRRPSS
Length:488
Mass (Da):56,400
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6AEC6BF578E9E72
GO
Isoform 2 (identifier: Q9C030-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MCGSERILQAGNILEIRVGQAGARRVATM

Show »
Length:516
Mass (Da):59,353
Checksum:i728D531A6FC6BABD
GO
Isoform 3 (identifier: Q9C030-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.

Note: No experimental confirmation available.
Show »
Length:313
Mass (Da):36,400
Checksum:iBC1F6158D0815F6A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PFM0E9PFM0_HUMAN
Tripartite motif-containing protein...
TRIM6
462Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JNQ0C9JNQ0_HUMAN
Tripartite motif-containing protein...
TRIM6
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB17050 differs from that shown. Chimeric cDNA. The in vivo relevance of this transcript of the TRIM34 (AC Q9BYJ4) and TRIM6 genes that codes for a chimeric protein of 842 residues is uncertain.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti68 – 69LR → FG in BAB17050 (PubMed:11013086).Curated2
Sequence conflicti184Q → K in AAH47564 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061823154E → K. Corresponds to variant dbSNP:rs57856328Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0469241 – 175Missing in isoform 3. 1 PublicationAdd BLAST175
Alternative sequenceiVSP_0120871M → MCGSERILQAGNILEIRVGQ AGARRVATM in isoform 2. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF220030 mRNA Translation: AAG53484.1
AK027664 mRNA Translation: BAB55276.1
AK290172 mRNA Translation: BAF82861.1
AK293295 mRNA Translation: BAG56816.1
AK298301 mRNA Translation: BAG60556.1
AK316178 mRNA Translation: BAH14549.1
AK316289 mRNA Translation: BAH14660.1
AC015691 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68783.1
CH471064 Genomic DNA Translation: EAW68785.1
BC047564 mRNA Translation: AAH47564.1
AB039903 mRNA Translation: BAB17050.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31389.1 [Q9C030-2]
CCDS31390.1 [Q9C030-1]
CCDS55738.1 [Q9C030-3]

NCBI Reference Sequences

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RefSeqi
NP_001003818.1, NM_001003818.2 [Q9C030-2]
NP_001185573.1, NM_001198644.1 [Q9C030-3]
NP_001185574.1, NM_001198645.1 [Q9C030-3]
NP_477514.1, NM_058166.4 [Q9C030-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000278302; ENSP00000278302; ENSG00000121236 [Q9C030-1]
ENST00000380097; ENSP00000369440; ENSG00000121236 [Q9C030-2]
ENST00000445329; ENSP00000399215; ENSG00000121236 [Q9C030-3]
ENST00000506134; ENSP00000421079; ENSG00000121236 [Q9C030-3]
ENST00000507320; ENSP00000427704; ENSG00000121236 [Q9C030-3]
ENST00000515022; ENSP00000421802; ENSG00000121236 [Q9C030-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
117854

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:117854

UCSC genome browser

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UCSCi
uc001mbc.3 human [Q9C030-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220030 mRNA Translation: AAG53484.1
AK027664 mRNA Translation: BAB55276.1
AK290172 mRNA Translation: BAF82861.1
AK293295 mRNA Translation: BAG56816.1
AK298301 mRNA Translation: BAG60556.1
AK316178 mRNA Translation: BAH14549.1
AK316289 mRNA Translation: BAH14660.1
AC015691 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68783.1
CH471064 Genomic DNA Translation: EAW68785.1
BC047564 mRNA Translation: AAH47564.1
AB039903 mRNA Translation: BAB17050.1 Sequence problems.
CCDSiCCDS31389.1 [Q9C030-2]
CCDS31390.1 [Q9C030-1]
CCDS55738.1 [Q9C030-3]
RefSeqiNP_001003818.1, NM_001003818.2 [Q9C030-2]
NP_001185573.1, NM_001198644.1 [Q9C030-3]
NP_001185574.1, NM_001198645.1 [Q9C030-3]
NP_477514.1, NM_058166.4 [Q9C030-1]

3D structure databases

SMRiQ9C030
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125596, 10 interactors
STRINGi9606.ENSP00000369440

PTM databases

iPTMnetiQ9C030
PhosphoSitePlusiQ9C030

Polymorphism and mutation databases

BioMutaiTRIM6
DMDMi25009488

Proteomic databases

EPDiQ9C030
jPOSTiQ9C030
MaxQBiQ9C030
PaxDbiQ9C030
PeptideAtlasiQ9C030
PRIDEiQ9C030
ProteomicsDBi79950
79951 [Q9C030-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278302; ENSP00000278302; ENSG00000121236 [Q9C030-1]
ENST00000380097; ENSP00000369440; ENSG00000121236 [Q9C030-2]
ENST00000445329; ENSP00000399215; ENSG00000121236 [Q9C030-3]
ENST00000506134; ENSP00000421079; ENSG00000121236 [Q9C030-3]
ENST00000507320; ENSP00000427704; ENSG00000121236 [Q9C030-3]
ENST00000515022; ENSP00000421802; ENSG00000121236 [Q9C030-3]
GeneIDi117854
KEGGihsa:117854
UCSCiuc001mbc.3 human [Q9C030-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
117854

GeneCards: human genes, protein and diseases

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GeneCardsi
TRIM6
HGNCiHGNC:16277 TRIM6
HPAiHPA060514
MIMi607564 gene
neXtProtiNX_Q9C030
OpenTargetsiENSG00000121236
PharmGKBiPA38110

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ITG7 Eukaryota
ENOG410XWDC LUCA
GeneTreeiENSGT00940000163021
HOGENOMiHOG000234134
InParanoidiQ9C030
KOiK11999
OMAiHHKHEYR
PhylomeDBiQ9C030
TreeFamiTF342569

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-HSA-877300 Interferon gamma signaling

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TRIM6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
117854

Protein Ontology

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PROi
PR:Q9C030

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000121236 Expressed in 150 organ(s), highest expression level in oocyte
ExpressionAtlasiQ9C030 baseline and differential
GenevisibleiQ9C030 HS

Family and domain databases

CDDicd00021 BBOX, 1 hit
cd15823 SPRY_PRY_TRIM6, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR035828 PRY/SPRY_TRIM6
IPR003877 SPRY_dom
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRIM6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C030
Secondary accession number(s): A8K2A7
, B4DDQ5, Q86WZ8, Q9HCR1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 2001
Last modified: May 8, 2019
This is version 160 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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