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Entry version 159 (13 Feb 2019)
Sequence version 2 (28 Nov 2003)
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Protein

E3 ubiquitin-protein ligase TRIM7

Gene

TRIM7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri29 – 82RING-typePROSITE-ProRule annotationAdd BLAST54
Zinc fingeri125 – 166B box-typePROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM7Curated (EC:2.3.2.271 Publication)
Alternative name(s):
Glycogenin-interacting protein
RING finger protein 90
Tripartite motif-containing protein 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM7
Synonyms:GNIP, RNF90
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000146054.17

Human Gene Nomenclature Database

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HGNCi
HGNC:16278 TRIM7

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609315 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9C029

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi29C → A: Abolishes ubiquitination and stabilization of RNF187; when associated with A-32. 1 Publication1
Mutagenesisi32C → A: Abolishes ubiquitination and stabilization of RNF187; when associated with A-29. 1 Publication1
Mutagenesisi57W → A: Abolishes ubiquitination and stabilization of RNF187. 1 Publication1
Mutagenesisi107S → A: Abolishes phosphorylation by RPS6KA5/MSK1. Reduced ubiquitination activity towards RNF187. 1 Publication1

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000146054

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38398

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRIM7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
38605728

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000562041 – 511E3 ubiquitin-protein ligase TRIM7Add BLAST511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei107Phosphoserine; by RPS6KA51 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at Ser-107 by RPS6KA5/MSK1, which stimulates the ubiquitin ligase activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9C029

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9C029

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9C029

PeptideAtlas

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PeptideAtlasi
Q9C029

PRoteomics IDEntifications database

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PRIDEi
Q9C029

ProteomicsDB human proteome resource

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ProteomicsDBi
79946
79947 [Q9C029-1]
79948 [Q9C029-3]
79949 [Q9C029-4]

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q9C029-2 [Q9C029-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9C029

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9C029

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Skeletal muscle and placenta, at lower levels in heart, brain and pancreas. Isoform 1 is widely expressed with high level in testis, kidney and heart.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000146054 Expressed in 140 organ(s), highest expression level in muscle of leg

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9C029 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA039213

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homodimers, and heterodimers with GNIP2 (PubMed:14984203, PubMed:25851810). Interacts with GYG (PubMed:11916970, PubMed:14984203). Interacts with RNF187 (via C-terminus) (PubMed:25851810).3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SIAH1Q8IUQ43EBI-2813981,EBI-747107

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123579, 11 interactors

Protein interaction database and analysis system

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IntActi
Q9C029, 33 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000274773

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9C029

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9C029

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini324 – 511B30.2/SPRYPROSITE-ProRule annotationAdd BLAST188

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili166 – 263Sequence analysisAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi120 – 128Poly-Ala9

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The B30.2 domain mediates interaction with GYG.1 Publication
The coiled-coil region mediates homodimerization and heterodimerization.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri29 – 82RING-typePROSITE-ProRule annotationAdd BLAST54
Zinc fingeri125 – 166B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2177 Eukaryota
ENOG4111G04 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153316

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG001357

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9C029

KEGG Orthology (KO)

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KOi
K12000

Identification of Orthologs from Complete Genome Data

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OMAi
ARCWERP

Database of Orthologous Groups

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OrthoDBi
423686at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9C029

TreeFam database of animal gene trees

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TreeFami
TF342569

Family and domain databases

Conserved Domains Database

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CDDi
cd00021 BBOX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR020457 Znf_B-box_chordata
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

Pfam protein domain database

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Pfami
View protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01406 BBOXZNFINGER
PR01407 BUTYPHLNCDUF

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9C029-2) [UniParc]FASTAAdd to basket
Also known as: GNIP1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVGPRTGP GTGAEALALA AELQGEATCS ICLELFREPV SVECGHSFCR
60 70 80 90 100
ACIGRCWERP GAGSVGAATR APPFPLPCPQ CREPARPSQL RPNRQLAAVA
110 120 130 140 150
TLLRRFSLPA AAPGEHGSQA AAARAAAARC GQHGEPFKLY CQDDGRAICV
160 170 180 190 200
VCDRAREHRE HAVLPLDEAV QEAKELLESR LRVLKKELED CEVFRSTEKK
210 220 230 240 250
ESKELLKQMA AEQEKVGAEF QALRAFLVEQ EGRLLGRLEE LSREVAQKQN
260 270 280 290 300
ENLAQLGVEI TQLSKLSSQI QETAQKPDLD FLQEFKSTLS RCSNVPGPKP
310 320 330 340 350
TTVSSEMKNK VWNVSLKTFV LKGMLKKFKE DLRGELEKEE KVELTLDPDT
360 370 380 390 400
ANPRLILSLD LKGVRLGERA QDLPNHPCRF DTNTRVLASC GFSSGRHHWE
410 420 430 440 450
VEVGSKDGWA FGVARESVRR KGLTPFTPEE GVWALQLNGG QYWAVTSPER
460 470 480 490 500
SPLSCGHLSR VRVALDLEVG AVSFYAVEDM RHLYTFRVNF QERVFPLFSV
510
CSTGTYLRIW P
Length:511
Mass (Da):56,631
Last modified:November 28, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i05C37C837A462597
GO
Isoform 2 (identifier: Q9C029-3) [UniParc]FASTAAdd to basket
Also known as: GNIP2

The sequence of this isoform differs from the canonical sequence as follows:
     1-208: Missing.

Show »
Length:303
Mass (Da):34,213
Checksum:iEE42B77E99C93883
GO
Isoform 3 (identifier: Q9C029-4) [UniParc]FASTAAdd to basket
Also known as: GNIP3

The sequence of this isoform differs from the canonical sequence as follows:
     1-182: Missing.
     183-206: VLKKELEDCEVFRSTEKKESKELL → MTQATGQMLCLHVQVPLQLLLLGQ

Show »
Length:329
Mass (Da):37,088
Checksum:i307859A40C440AC6
GO
Isoform 4 (identifier: Q9C029-1) [UniParc]FASTAAdd to basket
Also known as: TRIM7

The sequence of this isoform differs from the canonical sequence as follows:
     207-221: KQMAAEQEKVGAEFQ → VSQAPAGPPWDITEA
     222-511: Missing.

Show »
Length:221
Mass (Da):23,700
Checksum:i7DB1D43D798BA92B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01739918A → S. Corresponds to variant dbSNP:rs3857300Ensembl.1
Natural variantiVAR_01740073P → S. Corresponds to variant dbSNP:rs2770946Ensembl.1
Natural variantiVAR_01740195Q → E1 PublicationCorresponds to variant dbSNP:rs2770945Ensembl.1
Natural variantiVAR_052125258V → A. Corresponds to variant dbSNP:rs416574Ensembl.1
Natural variantiVAR_052126363G → S. Corresponds to variant dbSNP:rs254460Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0090201 – 208Missing in isoform 2. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_0090181 – 182Missing in isoform 3. 1 PublicationAdd BLAST182
Alternative sequenceiVSP_009019183 – 206VLKKE…SKELL → MTQATGQMLCLHVQVPLQLL LLGQ in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_009021207 – 221KQMAA…GAEFQ → VSQAPAGPPWDITEA in isoform 4. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_009022222 – 511Missing in isoform 4. 2 PublicationsAdd BLAST290

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF220032 mRNA Translation: AAG53486.1
AF396651 mRNA Translation: AAK85377.1
AF396652 mRNA Translation: AAK85378.1
AF396653 mRNA Translation: AAK85379.1
AF396654 mRNA Translation: AAK85380.1
AF396655 mRNA Translation: AAK85381.1
CH471165 Genomic DNA Translation: EAW53718.1
CH471165 Genomic DNA Translation: EAW53716.1
CH471165 Genomic DNA Translation: EAW53717.1
CH471165 Genomic DNA Translation: EAW53719.1
BC011567 mRNA Translation: AAH11567.1
BC080553 mRNA Translation: AAH80553.1
BC132863 mRNA Translation: AAI32864.1
BC132867 mRNA Translation: AAI32868.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS43414.1 [Q9C029-4]
CCDS4462.1 [Q9C029-2]
CCDS4463.1 [Q9C029-3]
CCDS4464.1 [Q9C029-1]

NCBI Reference Sequences

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RefSeqi
NP_203128.1, NM_033342.3 [Q9C029-1]
NP_976038.1, NM_203293.2 [Q9C029-2]
NP_976039.1, NM_203294.1 [Q9C029-3]
NP_976040.1, NM_203295.1 [Q9C029-3]
NP_976041.1, NM_203296.1 [Q9C029-3]
NP_976042.1, NM_203297.1 [Q9C029-4]
XP_016865392.1, XM_017009903.1 [Q9C029-3]
XP_016865393.1, XM_017009904.1 [Q9C029-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.487412

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000274773; ENSP00000274773; ENSG00000146054 [Q9C029-2]
ENST00000334421; ENSP00000334666; ENSG00000146054 [Q9C029-1]
ENST00000393315; ENSP00000376991; ENSG00000146054 [Q9C029-3]
ENST00000393319; ENSP00000376994; ENSG00000146054 [Q9C029-4]
ENST00000422067; ENSP00000391458; ENSG00000146054 [Q9C029-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
81786

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:81786

UCSC genome browser

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UCSCi
uc003mmv.2 human [Q9C029-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220032 mRNA Translation: AAG53486.1
AF396651 mRNA Translation: AAK85377.1
AF396652 mRNA Translation: AAK85378.1
AF396653 mRNA Translation: AAK85379.1
AF396654 mRNA Translation: AAK85380.1
AF396655 mRNA Translation: AAK85381.1
CH471165 Genomic DNA Translation: EAW53718.1
CH471165 Genomic DNA Translation: EAW53716.1
CH471165 Genomic DNA Translation: EAW53717.1
CH471165 Genomic DNA Translation: EAW53719.1
BC011567 mRNA Translation: AAH11567.1
BC080553 mRNA Translation: AAH80553.1
BC132863 mRNA Translation: AAI32864.1
BC132867 mRNA Translation: AAI32868.1
CCDSiCCDS43414.1 [Q9C029-4]
CCDS4462.1 [Q9C029-2]
CCDS4463.1 [Q9C029-3]
CCDS4464.1 [Q9C029-1]
RefSeqiNP_203128.1, NM_033342.3 [Q9C029-1]
NP_976038.1, NM_203293.2 [Q9C029-2]
NP_976039.1, NM_203294.1 [Q9C029-3]
NP_976040.1, NM_203295.1 [Q9C029-3]
NP_976041.1, NM_203296.1 [Q9C029-3]
NP_976042.1, NM_203297.1 [Q9C029-4]
XP_016865392.1, XM_017009903.1 [Q9C029-3]
XP_016865393.1, XM_017009904.1 [Q9C029-1]
UniGeneiHs.487412

3D structure databases

ProteinModelPortaliQ9C029
SMRiQ9C029
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123579, 11 interactors
IntActiQ9C029, 33 interactors
STRINGi9606.ENSP00000274773

PTM databases

iPTMnetiQ9C029
PhosphoSitePlusiQ9C029

Polymorphism and mutation databases

BioMutaiTRIM7
DMDMi38605728

Proteomic databases

EPDiQ9C029
jPOSTiQ9C029
PaxDbiQ9C029
PeptideAtlasiQ9C029
PRIDEiQ9C029
ProteomicsDBi79946
79947 [Q9C029-1]
79948 [Q9C029-3]
79949 [Q9C029-4]
TopDownProteomicsiQ9C029-2 [Q9C029-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
81786
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274773; ENSP00000274773; ENSG00000146054 [Q9C029-2]
ENST00000334421; ENSP00000334666; ENSG00000146054 [Q9C029-1]
ENST00000393315; ENSP00000376991; ENSG00000146054 [Q9C029-3]
ENST00000393319; ENSP00000376994; ENSG00000146054 [Q9C029-4]
ENST00000422067; ENSP00000391458; ENSG00000146054 [Q9C029-3]
GeneIDi81786
KEGGihsa:81786
UCSCiuc003mmv.2 human [Q9C029-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
81786
EuPathDBiHostDB:ENSG00000146054.17

GeneCards: human genes, protein and diseases

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GeneCardsi
TRIM7
HGNCiHGNC:16278 TRIM7
HPAiHPA039213
MIMi609315 gene
neXtProtiNX_Q9C029
OpenTargetsiENSG00000146054
PharmGKBiPA38398

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00940000153316
HOVERGENiHBG001357
InParanoidiQ9C029
KOiK12000
OMAiARCWERP
OrthoDBi423686at2759
PhylomeDBiQ9C029
TreeFamiTF342569

Enzyme and pathway databases

UniPathwayi
UPA00143

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
81786

Protein Ontology

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PROi
PR:Q9C029

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000146054 Expressed in 140 organ(s), highest expression level in muscle of leg
GenevisibleiQ9C029 HS

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR020457 Znf_B-box_chordata
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01406 BBOXZNFINGER
PR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRIM7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C029
Secondary accession number(s): A2RUE4
, D3DWR7, Q969F5, Q96F67, Q96J89, Q96J90
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: November 28, 2003
Last modified: February 13, 2019
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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