UniProtKB - Q9C019 (TRI15_HUMAN)
Protein
Tripartite motif-containing protein 15
Gene
TRIM15
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 16 – 61 | RING-typePROSITE-ProRule annotationAdd BLAST | 46 | |
Zinc fingeri | 78 – 119 | B box-typePROSITE-ProRule annotationAdd BLAST | 42 |
GO - Molecular functioni
- ubiquitin protein ligase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- innate immune response Source: UniProtKB
- mesodermal cell fate determination Source: ProtInc
- negative regulation of intracellular transport of viral material Source: UniProtKB
- negative regulation of viral release from host cell Source: UniProtKB
- positive regulation of DNA-binding transcription factor activity Source: UniProtKB
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of RIG-I signaling pathway Source: UniProtKB
- positive regulation of type I interferon production Source: UniProtKB
- protein ubiquitination Source: GO_Central
- regulation of gene expression Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9C019 |
Protein family/group databases
MoonDBi | Q9C019, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Tripartite motif-containing protein 15Alternative name(s): RING finger protein 93 Zinc finger protein 178 Zinc finger protein B7 |
Gene namesi | Name:TRIM15 Synonyms:RNF93, ZNF178, ZNFB7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16284, TRIM15 |
neXtProti | NX_Q9C019 |
VEuPathDBi | HostDB:ENSG00000204610.12 |
Subcellular locationi
Other locations
- cytoplasm Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 89870 |
OpenTargetsi | ENSG00000204610 |
PharmGKBi | PA38114 |
Miscellaneous databases
Pharosi | Q9C019, Tbio |
Genetic variation databases
BioMutai | TRIM15 |
DMDMi | 25009482 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056218 | 1 – 465 | Tripartite motif-containing protein 15Add BLAST | 465 |
Proteomic databases
MassIVEi | Q9C019 |
MaxQBi | Q9C019 |
PaxDbi | Q9C019 |
PeptideAtlasi | Q9C019 |
PRIDEi | Q9C019 |
ProteomicsDBi | 79941 [Q9C019-1] 79942 [Q9C019-2] |
PTM databases
iPTMneti | Q9C019 |
PhosphoSitePlusi | Q9C019 |
Expressioni
Gene expression databases
Bgeei | ENSG00000204610, Expressed in duodenum and 100 other tissues |
ExpressionAtlasi | Q9C019, baseline and differential |
Genevisiblei | Q9C019, HS |
Organism-specific databases
HPAi | ENSG00000204610, Group enriched (gallbladder, intestine, liver) |
Interactioni
Binary interactionsi
Hide detailsQ9C019
Protein-protein interaction databases
BioGRIDi | 124626, 47 interactors |
IntActi | Q9C019, 11 interactors |
STRINGi | 9606.ENSP00000365884 |
Miscellaneous databases
RNActi | Q9C019, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 276 – 465 | B30.2/SPRYPROSITE-ProRule annotationAdd BLAST | 190 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 126 – 229 | Sequence analysisAdd BLAST | 104 |
Sequence similaritiesi
Belongs to the TRIM/RBCC family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 16 – 61 | RING-typePROSITE-ProRule annotationAdd BLAST | 46 | |
Zinc fingeri | 78 – 119 | B box-typePROSITE-ProRule annotationAdd BLAST | 42 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000162589 |
HOGENOMi | CLU_013137_0_3_1 |
InParanoidi | Q9C019 |
OMAi | CWASTCP |
PhylomeDBi | Q9C019 |
TreeFami | TF342569 |
Family and domain databases
CDDi | cd00021, BBOX, 1 hit |
Gene3Di | 2.60.120.920, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013320, ConA-like_dom_sf IPR006574, PRY IPR003877, SPRY_dom IPR000315, Znf_B-box IPR018957, Znf_C3HC4_RING-type IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF13765, PRY, 1 hit PF00622, SPRY, 1 hit PF00643, zf-B_box, 1 hit PF00097, zf-C3HC4, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00336, BBOX, 1 hit SM00589, PRY, 1 hit SM00184, RING, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9C019-1) [UniParc]FASTAAdd to basket
Also known as: Alpha
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPATPSLKVV HELPACTLCA GPLEDAVTIP CGHTFCRLCL PALSQMGAQS
60 70 80 90 100
SGKILLCPLC QEEEQAETPM APVPLGPLGE TYCEEHGEKI YFFCENDAEF
110 120 130 140 150
LCVFCREGPT HQAHTVGFLD EAIQPYRDRL RSRLEALSTE RDEIEDVKCQ
160 170 180 190 200
EDQKLQVLLT QIESKKHQVE TAFERLQQEL EQQRCLLLAR LRELEQQIWK
210 220 230 240 250
ERDEYITKVS EEVTRLGAQV KELEEKCQQP ASELLQDVRV NQSRCEMKTF
260 270 280 290 300
VSPEAISPDL VKKIRDFHRK ILTLPEMMRM FSENLAHHLE IDSGVITLDP
310 320 330 340 350
QTASRSLVLS EDRKSVRYTR QKKSLPDSPL RFDGLPAVLG FPGFSSGRHR
360 370 380 390 400
WQVDLQLGDG GGCTVGVAGE GVRRKGEMGL SAEDGVWAVI ISHQQCWAST
410 420 430 440 450
SPGTDLPLSE IPRGVRVALD YEAGQVTLHN AQTQEPIFTF TASFSGKVFP
460
FFAVWKKGSC LTLKG
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y5R0 | H0Y5R0_HUMAN | Tripartite motif-containing protein... | TRIM15 | 164 | Annotation score: | ||
A0A087X199 | A0A087X199_HUMAN | Tripartite motif-containing protein... | TRIM15 | 396 | Annotation score: | ||
A0A0G2JJP1 | A0A0G2JJP1_HUMAN | TRIM15 | TRIM15 | 465 | Annotation score: | ||
A0A0G2JL27 | A0A0G2JL27_HUMAN | Tripartite motif-containing protein... | TRIM15 | 396 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014228 | 29 | I → V3 PublicationsCorresponds to variant dbSNP:rs17194460Ensembl. | 1 | |
Natural variantiVAR_052129 | 42 | A → T. Corresponds to variant dbSNP:rs17194467Ensembl. | 1 | |
Natural variantiVAR_052130 | 84 | E → Q. Corresponds to variant dbSNP:rs17194474Ensembl. | 1 | |
Natural variantiVAR_052131 | 235 | L → V. Corresponds to variant dbSNP:rs34823152Ensembl. | 1 | |
Natural variantiVAR_052132 | 324 | S → N2 PublicationsCorresponds to variant dbSNP:rs929156Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005760 | 103 – 115 | VFCRE…HQAHT → TSECRTTDGFGCA in isoform 2. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_005761 | 116 – 465 | Missing in isoform 2. 1 PublicationAdd BLAST | 350 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF220132 mRNA Translation: AAG53505.1 AF220133 mRNA Translation: AAG53506.1 U34249 mRNA Translation: AAD03787.1 BA000025 Genomic DNA Translation: BAB63331.1 AB088089 Genomic DNA Translation: BAC54922.1 BX248419 Genomic DNA No translation available. BX005441 Genomic DNA No translation available. CR759838 Genomic DNA No translation available. BC038585 mRNA Translation: AAH38585.1 |
CCDSi | CCDS4677.1 [Q9C019-1] |
RefSeqi | NP_150232.2, NM_033229.2 [Q9C019-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF220132 mRNA Translation: AAG53505.1 AF220133 mRNA Translation: AAG53506.1 U34249 mRNA Translation: AAD03787.1 BA000025 Genomic DNA Translation: BAB63331.1 AB088089 Genomic DNA Translation: BAC54922.1 BX248419 Genomic DNA No translation available. BX005441 Genomic DNA No translation available. CR759838 Genomic DNA No translation available. BC038585 mRNA Translation: AAH38585.1 |
CCDSi | CCDS4677.1 [Q9C019-1] |
RefSeqi | NP_150232.2, NM_033229.2 [Q9C019-1] |
3D structure databases
SMRi | Q9C019 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124626, 47 interactors |
IntActi | Q9C019, 11 interactors |
STRINGi | 9606.ENSP00000365884 |
Protein family/group databases
MoonDBi | Q9C019, Predicted |
PTM databases
iPTMneti | Q9C019 |
PhosphoSitePlusi | Q9C019 |
Genetic variation databases
BioMutai | TRIM15 |
DMDMi | 25009482 |
Proteomic databases
MassIVEi | Q9C019 |
MaxQBi | Q9C019 |
PaxDbi | Q9C019 |
PeptideAtlasi | Q9C019 |
PRIDEi | Q9C019 |
ProteomicsDBi | 79941 [Q9C019-1] 79942 [Q9C019-2] |
Protocols and materials databases
Antibodypediai | 26243, 168 antibodies |
DNASUi | 89870 |
Genome annotation databases
Organism-specific databases
CTDi | 89870 |
DisGeNETi | 89870 |
GeneCardsi | TRIM15 |
HGNCi | HGNC:16284, TRIM15 |
HPAi | ENSG00000204610, Group enriched (gallbladder, intestine, liver) |
neXtProti | NX_Q9C019 |
OpenTargetsi | ENSG00000204610 |
PharmGKBi | PA38114 |
VEuPathDBi | HostDB:ENSG00000204610.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000162589 |
HOGENOMi | CLU_013137_0_3_1 |
InParanoidi | Q9C019 |
OMAi | CWASTCP |
PhylomeDBi | Q9C019 |
TreeFami | TF342569 |
Enzyme and pathway databases
PathwayCommonsi | Q9C019 |
Miscellaneous databases
BioGRID-ORCSi | 89870, 5 hits in 874 CRISPR screens |
ChiTaRSi | TRIM15, human |
GeneWikii | TRIM15 |
GenomeRNAii | 89870 |
Pharosi | Q9C019, Tbio |
PROi | PR:Q9C019 |
RNActi | Q9C019, protein |
Gene expression databases
Bgeei | ENSG00000204610, Expressed in duodenum and 100 other tissues |
ExpressionAtlasi | Q9C019, baseline and differential |
Genevisiblei | Q9C019, HS |
Family and domain databases
CDDi | cd00021, BBOX, 1 hit |
Gene3Di | 2.60.120.920, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013320, ConA-like_dom_sf IPR006574, PRY IPR003877, SPRY_dom IPR000315, Znf_B-box IPR018957, Znf_C3HC4_RING-type IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF13765, PRY, 1 hit PF00622, SPRY, 1 hit PF00643, zf-B_box, 1 hit PF00097, zf-C3HC4, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00336, BBOX, 1 hit SM00589, PRY, 1 hit SM00184, RING, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRI15_HUMAN | |
Accessioni | Q9C019Primary (citable) accession number: Q9C019 Secondary accession number(s): A2BEC9 Q9C018 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2002 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families