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Protein

Tripartite motif-containing protein 15

Gene

TRIM15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 61RING-typePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri78 – 119B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Protein family/group databases

MoonDBiQ9C019 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 15
Alternative name(s):
RING finger protein 93
Zinc finger protein 178
Zinc finger protein B7
Gene namesi
Name:TRIM15
Synonyms:RNF93, ZNF178, ZNFB7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204610.12
HGNCiHGNC:16284 TRIM15
neXtProtiNX_Q9C019

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi89870
OpenTargetsiENSG00000204610
PharmGKBiPA38114

Polymorphism and mutation databases

BioMutaiTRIM15
DMDMi25009482

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562181 – 465Tripartite motif-containing protein 15Add BLAST465

Proteomic databases

MaxQBiQ9C019
PaxDbiQ9C019
PeptideAtlasiQ9C019
PRIDEiQ9C019
ProteomicsDBi79941
79942 [Q9C019-2]

PTM databases

iPTMnetiQ9C019
PhosphoSitePlusiQ9C019

Expressioni

Gene expression databases

BgeeiENSG00000204610 Expressed in 81 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_TRIM15
ExpressionAtlasiQ9C019 baseline and differential
GenevisibleiQ9C019 HS

Organism-specific databases

HPAiHPA047527

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi124626, 42 interactors
IntActiQ9C019, 11 interactors
STRINGi9606.ENSP00000365884

Structurei

3D structure databases

ProteinModelPortaliQ9C019
SMRiQ9C019
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini276 – 465B30.2/SPRYPROSITE-ProRule annotationAdd BLAST190

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili126 – 229Sequence analysisAdd BLAST104

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 61RING-typePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri78 – 119B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118838
HOGENOMiHOG000234133
HOVERGENiHBG001357
InParanoidiQ9C019
KOiK12005
OMAiHRWQVEV
OrthoDBiEOG091G05W2
PhylomeDBiQ9C019
TreeFamiTF342569

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR018957 Znf_C3HC4_RING-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PF00097 zf-C3HC4, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9C019-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPATPSLKVV HELPACTLCA GPLEDAVTIP CGHTFCRLCL PALSQMGAQS
60 70 80 90 100
SGKILLCPLC QEEEQAETPM APVPLGPLGE TYCEEHGEKI YFFCENDAEF
110 120 130 140 150
LCVFCREGPT HQAHTVGFLD EAIQPYRDRL RSRLEALSTE RDEIEDVKCQ
160 170 180 190 200
EDQKLQVLLT QIESKKHQVE TAFERLQQEL EQQRCLLLAR LRELEQQIWK
210 220 230 240 250
ERDEYITKVS EEVTRLGAQV KELEEKCQQP ASELLQDVRV NQSRCEMKTF
260 270 280 290 300
VSPEAISPDL VKKIRDFHRK ILTLPEMMRM FSENLAHHLE IDSGVITLDP
310 320 330 340 350
QTASRSLVLS EDRKSVRYTR QKKSLPDSPL RFDGLPAVLG FPGFSSGRHR
360 370 380 390 400
WQVDLQLGDG GGCTVGVAGE GVRRKGEMGL SAEDGVWAVI ISHQQCWAST
410 420 430 440 450
SPGTDLPLSE IPRGVRVALD YEAGQVTLHN AQTQEPIFTF TASFSGKVFP
460
FFAVWKKGSC LTLKG
Length:465
Mass (Da):52,113
Last modified:June 1, 2001 - v1
Checksum:i303B8BF8623CB00A
GO
Isoform 2 (identifier: Q9C019-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     103-115: VFCREGPTHQAHT → TSECRTTDGFGCA
     116-465: Missing.

Show »
Length:115
Mass (Da):12,315
Checksum:i797B6EAA4B95283E
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X199A0A087X199_HUMAN
Tripartite motif-containing protein...
TRIM15
396Annotation score:
A0A0G2JJP1A0A0G2JJP1_HUMAN
TRIM15
TRIM15
465Annotation score:
A0A0G2JL27A0A0G2JL27_HUMAN
Tripartite motif-containing protein...
TRIM15
396Annotation score:
H0Y5R0H0Y5R0_HUMAN
Tripartite motif-containing protein...
TRIM15
164Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01422829I → V3 PublicationsCorresponds to variant dbSNP:rs17194460Ensembl.1
Natural variantiVAR_05212942A → T. Corresponds to variant dbSNP:rs17194467Ensembl.1
Natural variantiVAR_05213084E → Q. Corresponds to variant dbSNP:rs17194474Ensembl.1
Natural variantiVAR_052131235L → V. Corresponds to variant dbSNP:rs34823152Ensembl.1
Natural variantiVAR_052132324S → N2 PublicationsCorresponds to variant dbSNP:rs929156Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005760103 – 115VFCRE…HQAHT → TSECRTTDGFGCA in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_005761116 – 465Missing in isoform 2. 1 PublicationAdd BLAST350

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220132 mRNA Translation: AAG53505.1
AF220133 mRNA Translation: AAG53506.1
U34249 mRNA Translation: AAD03787.1
BA000025 Genomic DNA Translation: BAB63331.1
AB088089 Genomic DNA Translation: BAC54922.1
BX248419 Genomic DNA No translation available.
BX005441 Genomic DNA No translation available.
CR759838 Genomic DNA No translation available.
BC038585 mRNA Translation: AAH38585.1
CCDSiCCDS4677.1 [Q9C019-1]
RefSeqiNP_150232.2, NM_033229.2 [Q9C019-1]
UniGeneiHs.591789
Hs.606488

Genome annotation databases

EnsembliENST00000259930; ENSP00000259930; ENSG00000137384 [Q9C019-1]
ENST00000376688; ENSP00000365878; ENSG00000204610 [Q9C019-2]
ENST00000376694; ENSP00000365884; ENSG00000204610 [Q9C019-1]
ENST00000414873; ENSP00000415480; ENSG00000235259 [Q9C019-1]
ENST00000421984; ENSP00000413961; ENSG00000227147 [Q9C019-1]
ENST00000427091; ENSP00000411683; ENSG00000235960 [Q9C019-1]
ENST00000431059; ENSP00000403221; ENSG00000233599 [Q9C019-1]
ENST00000550400; ENSP00000447500; ENSG00000233599 [Q9C019-2]
ENST00000552676; ENSP00000449686; ENSG00000235905 [Q9C019-2]
ENST00000552836; ENSP00000449617; ENSG00000224145 [Q9C019-2]
GeneIDi89870
KEGGihsa:89870
UCSCiuc010jrx.4 human [Q9C019-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220132 mRNA Translation: AAG53505.1
AF220133 mRNA Translation: AAG53506.1
U34249 mRNA Translation: AAD03787.1
BA000025 Genomic DNA Translation: BAB63331.1
AB088089 Genomic DNA Translation: BAC54922.1
BX248419 Genomic DNA No translation available.
BX005441 Genomic DNA No translation available.
CR759838 Genomic DNA No translation available.
BC038585 mRNA Translation: AAH38585.1
CCDSiCCDS4677.1 [Q9C019-1]
RefSeqiNP_150232.2, NM_033229.2 [Q9C019-1]
UniGeneiHs.591789
Hs.606488

3D structure databases

ProteinModelPortaliQ9C019
SMRiQ9C019
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124626, 42 interactors
IntActiQ9C019, 11 interactors
STRINGi9606.ENSP00000365884

Protein family/group databases

MoonDBiQ9C019 Predicted

PTM databases

iPTMnetiQ9C019
PhosphoSitePlusiQ9C019

Polymorphism and mutation databases

BioMutaiTRIM15
DMDMi25009482

Proteomic databases

MaxQBiQ9C019
PaxDbiQ9C019
PeptideAtlasiQ9C019
PRIDEiQ9C019
ProteomicsDBi79941
79942 [Q9C019-2]

Protocols and materials databases

DNASUi89870
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259930; ENSP00000259930; ENSG00000137384 [Q9C019-1]
ENST00000376688; ENSP00000365878; ENSG00000204610 [Q9C019-2]
ENST00000376694; ENSP00000365884; ENSG00000204610 [Q9C019-1]
ENST00000414873; ENSP00000415480; ENSG00000235259 [Q9C019-1]
ENST00000421984; ENSP00000413961; ENSG00000227147 [Q9C019-1]
ENST00000427091; ENSP00000411683; ENSG00000235960 [Q9C019-1]
ENST00000431059; ENSP00000403221; ENSG00000233599 [Q9C019-1]
ENST00000550400; ENSP00000447500; ENSG00000233599 [Q9C019-2]
ENST00000552676; ENSP00000449686; ENSG00000235905 [Q9C019-2]
ENST00000552836; ENSP00000449617; ENSG00000224145 [Q9C019-2]
GeneIDi89870
KEGGihsa:89870
UCSCiuc010jrx.4 human [Q9C019-1]

Organism-specific databases

CTDi89870
DisGeNETi89870
EuPathDBiHostDB:ENSG00000204610.12
GeneCardsiTRIM15
HGNCiHGNC:16284 TRIM15
HPAiHPA047527
neXtProtiNX_Q9C019
OpenTargetsiENSG00000204610
PharmGKBiPA38114
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118838
HOGENOMiHOG000234133
HOVERGENiHBG001357
InParanoidiQ9C019
KOiK12005
OMAiHRWQVEV
OrthoDBiEOG091G05W2
PhylomeDBiQ9C019
TreeFamiTF342569

Miscellaneous databases

ChiTaRSiTRIM15 human
GeneWikiiTRIM15
GenomeRNAii89870
PROiPR:Q9C019

Gene expression databases

BgeeiENSG00000204610 Expressed in 81 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_TRIM15
ExpressionAtlasiQ9C019 baseline and differential
GenevisibleiQ9C019 HS

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR018957 Znf_C3HC4_RING-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PF00097 zf-C3HC4, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRI15_HUMAN
AccessioniPrimary (citable) accession number: Q9C019
Secondary accession number(s): A2BEC9
, O95604, Q8IUX9, Q9C018
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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