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Protein

cAMP-dependent protein kinase inhibitor beta

Gene

PKIB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei23Important for inhibitionBy similarity1
Sitei26Important for inhibitionBy similarity1
Sitei27Important for inhibitionBy similarity1

GO - Molecular functioni

  • cAMP-dependent protein kinase inhibitor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionProtein kinase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-dependent protein kinase inhibitor beta
Short name:
PKI-beta
Gene namesi
Name:PKIB
Synonyms:PRKACN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000135549.14
HGNCiHGNC:9018 PKIB
MIMi606914 gene
neXtProtiNX_Q9C010

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi5570
OpenTargetsiENSG00000135549
PharmGKBiPA33350

Polymorphism and mutation databases

BioMutaiPKIB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001545381 – 78cAMP-dependent protein kinase inhibitor betaAdd BLAST78

Proteomic databases

EPDiQ9C010
MaxQBiQ9C010
PaxDbiQ9C010
PeptideAtlasiQ9C010
PRIDEiQ9C010
ProteomicsDBi79940

PTM databases

iPTMnetiQ9C010
PhosphoSitePlusiQ9C010

Expressioni

Gene expression databases

BgeeiENSG00000135549 Expressed in 160 organ(s), highest expression level in cerebellar vermis
CleanExiHS_PKIB
ExpressionAtlasiQ9C010 baseline and differential
GenevisibleiQ9C010 HS

Organism-specific databases

HPAiHPA030156

Interactioni

Protein-protein interaction databases

BioGridi111557, 5 interactors
IntActiQ9C010, 5 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9C010
SMRiQ9C010
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PKI family.Curated

Phylogenomic databases

eggNOGiENOG410JF7B Eukaryota
ENOG410Y067 LUCA
GeneTreeiENSGT00530000064264
HOGENOMiHOG000059641
HOVERGENiHBG003541
InParanoidiQ9C010
PhylomeDBiQ9C010
TreeFamiTF330809

Family and domain databases

InterProiView protein in InterPro
IPR004171 cAMP_dep_PKI
PANTHERiPTHR15416 PTHR15416, 1 hit
PfamiView protein in Pfam
PF02827 PKI, 1 hit
PIRSFiPIRSF001667 PKI, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010366 cAMP_dep_PKI, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9C010-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRTDSSKMTD VESGVANFAS SARAGRRNAL PDIQSSAATD GTSDLPLKLE
60 70
ALSVKEDAKE KDEKTTQDQL EKPQNEEK
Length:78
Mass (Da):8,468
Last modified:June 1, 2001 - v1
Checksum:iCA4AE267B9ECCD81
GO
Isoform 2 (identifier: Q9C010-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSHQDVAM

Note: Gene prediction based on EST data.
Show »
Length:85
Mass (Da):9,237
Checksum:iA05D93A815C69A40
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T0Z6Q5T0Z6_HUMAN
cAMP-dependent protein kinase inhib...
PKIB
87Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0469221M → MSHQDVAM in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225513 mRNA Translation: AAK00638.1
AK315151 mRNA Translation: BAG37599.1
AF087873 mRNA Translation: AAM10501.1
AL512283 Genomic DNA No translation available.
AL513481 Genomic DNA No translation available.
Z99129 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48171.1
BC036011 mRNA Translation: AAH36011.1
BC093027 mRNA Translation: AAH93027.1
CCDSiCCDS5126.1 [Q9C010-1]
CCDS59033.1 [Q9C010-2]
RefSeqiNP_001257322.1, NM_001270393.1 [Q9C010-1]
NP_001257323.1, NM_001270394.1 [Q9C010-2]
NP_001257324.1, NM_001270395.1 [Q9C010-2]
NP_115860.1, NM_032471.5 [Q9C010-1]
NP_861459.1, NM_181794.2 [Q9C010-1]
NP_861460.1, NM_181795.2 [Q9C010-1]
XP_011534232.1, XM_011535930.2 [Q9C010-2]
XP_011534233.1, XM_011535931.2 [Q9C010-2]
XP_011534234.1, XM_011535932.2 [Q9C010-2]
XP_011534235.1, XM_011535933.2 [Q9C010-2]
XP_011534236.1, XM_011535934.2
XP_011534237.1, XM_011535935.2 [Q9C010-1]
XP_011534238.1, XM_011535936.1 [Q9C010-1]
XP_011534239.1, XM_011535937.2 [Q9C010-1]
UniGeneiHs.741340
Hs.744965

Genome annotation databases

EnsembliENST00000258014; ENSP00000258014; ENSG00000135549 [Q9C010-2]
ENST00000354275; ENSP00000346227; ENSG00000135549 [Q9C010-1]
ENST00000368448; ENSP00000357433; ENSG00000135549 [Q9C010-1]
ENST00000368452; ENSP00000357437; ENSG00000135549 [Q9C010-1]
ENST00000392490; ENSP00000376280; ENSG00000135549 [Q9C010-1]
ENST00000392491; ENSP00000376281; ENSG00000135549 [Q9C010-1]
ENST00000615438; ENSP00000480824; ENSG00000135549 [Q9C010-2]
GeneIDi5570
KEGGihsa:5570
UCSCiuc003pyz.4 human [Q9C010-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225513 mRNA Translation: AAK00638.1
AK315151 mRNA Translation: BAG37599.1
AF087873 mRNA Translation: AAM10501.1
AL512283 Genomic DNA No translation available.
AL513481 Genomic DNA No translation available.
Z99129 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48171.1
BC036011 mRNA Translation: AAH36011.1
BC093027 mRNA Translation: AAH93027.1
CCDSiCCDS5126.1 [Q9C010-1]
CCDS59033.1 [Q9C010-2]
RefSeqiNP_001257322.1, NM_001270393.1 [Q9C010-1]
NP_001257323.1, NM_001270394.1 [Q9C010-2]
NP_001257324.1, NM_001270395.1 [Q9C010-2]
NP_115860.1, NM_032471.5 [Q9C010-1]
NP_861459.1, NM_181794.2 [Q9C010-1]
NP_861460.1, NM_181795.2 [Q9C010-1]
XP_011534232.1, XM_011535930.2 [Q9C010-2]
XP_011534233.1, XM_011535931.2 [Q9C010-2]
XP_011534234.1, XM_011535932.2 [Q9C010-2]
XP_011534235.1, XM_011535933.2 [Q9C010-2]
XP_011534236.1, XM_011535934.2
XP_011534237.1, XM_011535935.2 [Q9C010-1]
XP_011534238.1, XM_011535936.1 [Q9C010-1]
XP_011534239.1, XM_011535937.2 [Q9C010-1]
UniGeneiHs.741340
Hs.744965

3D structure databases

ProteinModelPortaliQ9C010
SMRiQ9C010
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111557, 5 interactors
IntActiQ9C010, 5 interactors

PTM databases

iPTMnetiQ9C010
PhosphoSitePlusiQ9C010

Polymorphism and mutation databases

BioMutaiPKIB

Proteomic databases

EPDiQ9C010
MaxQBiQ9C010
PaxDbiQ9C010
PeptideAtlasiQ9C010
PRIDEiQ9C010
ProteomicsDBi79940

Protocols and materials databases

DNASUi5570
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258014; ENSP00000258014; ENSG00000135549 [Q9C010-2]
ENST00000354275; ENSP00000346227; ENSG00000135549 [Q9C010-1]
ENST00000368448; ENSP00000357433; ENSG00000135549 [Q9C010-1]
ENST00000368452; ENSP00000357437; ENSG00000135549 [Q9C010-1]
ENST00000392490; ENSP00000376280; ENSG00000135549 [Q9C010-1]
ENST00000392491; ENSP00000376281; ENSG00000135549 [Q9C010-1]
ENST00000615438; ENSP00000480824; ENSG00000135549 [Q9C010-2]
GeneIDi5570
KEGGihsa:5570
UCSCiuc003pyz.4 human [Q9C010-1]

Organism-specific databases

CTDi5570
DisGeNETi5570
EuPathDBiHostDB:ENSG00000135549.14
GeneCardsiPKIB
HGNCiHGNC:9018 PKIB
HPAiHPA030156
MIMi606914 gene
neXtProtiNX_Q9C010
OpenTargetsiENSG00000135549
PharmGKBiPA33350
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JF7B Eukaryota
ENOG410Y067 LUCA
GeneTreeiENSGT00530000064264
HOGENOMiHOG000059641
HOVERGENiHBG003541
InParanoidiQ9C010
PhylomeDBiQ9C010
TreeFamiTF330809

Miscellaneous databases

ChiTaRSiPKIB human
GeneWikiiPKIB
GenomeRNAii5570
PROiPR:Q9C010
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135549 Expressed in 160 organ(s), highest expression level in cerebellar vermis
CleanExiHS_PKIB
ExpressionAtlasiQ9C010 baseline and differential
GenevisibleiQ9C010 HS

Family and domain databases

InterProiView protein in InterPro
IPR004171 cAMP_dep_PKI
PANTHERiPTHR15416 PTHR15416, 1 hit
PfamiView protein in Pfam
PF02827 PKI, 1 hit
PIRSFiPIRSF001667 PKI, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010366 cAMP_dep_PKI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIPKB_HUMAN
AccessioniPrimary (citable) accession number: Q9C010
Secondary accession number(s): B2RCK2, Q567T9, Q5T0Z7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: October 10, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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