FOXQ1

Protein namesⁱ	Recommended name: Forkhead box protein Q1 Alternative name(s): HNF-3/forkhead-like protein 1 Short name: HFH-1 Hepatocyte nuclear factor 3 forkhead homolog 1
Gene namesⁱ	Name:FOXQ1 Synonyms:HFH1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000164379.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20951 FOXQ1
MIMⁱ	612788 gene
neXtProtⁱ	NX_Q9C009

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	94234
Open Targets More...OpenTargetsⁱ	ENSG00000164379
PharmGKBⁱ	PA134924898

Polymorphism and mutation databases

BioMutaⁱ	FOXQ1
DMDMⁱ	143811391

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000091890	1 – 403	Forkhead box protein Q1Add BLAST		403

Proteomic databases

EPDⁱ	Q9C009
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9C009
PaxDbⁱ	Q9C009
PeptideAtlas More...PeptideAtlasⁱ	Q9C009
PRIDEⁱ	Q9C009
ProteomicsDBⁱ	79939

PTM databases

iPTMnetⁱ	Q9C009
PhosphoSitePlusⁱ	Q9C009

Expressionⁱ

Tissue specificityⁱ

Expressed predominantly in the stomach, trachea, bladder and salivary gland.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000164379 Expressed in 151 organ(s), highest expression level in stomach
CleanExⁱ	HS_FOXQ1
Genevisibleⁱ	Q9C009 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA059700

HPAⁱ

HPA059700

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	125147, 105 interactors
IntActⁱ	Q9C009, 105 interactors
Molecular INTeraction database More...MINTⁱ	Q9C009
STRINGⁱ	9606.ENSP00000296839

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9C009
SMRⁱ	Q9C009
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	13 – 103	Ala/Gly-richAdd BLAST		91
Compositional biasⁱ	221 – 397	Pro-richAdd BLAST		177

Phylogenomic databases

eggNOGⁱ	KOG2294 Eukaryota COG5025 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150834
HOGENOMⁱ	HOG000112634
HOVERGENⁱ	HBG051658
InParanoidⁱ	Q9C009
KEGG Orthology (KO) More...KOⁱ	K09410
OMAⁱ	MKLEVFT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LMU
PhylomeDBⁱ	Q9C009
TreeFamⁱ	TF316127

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00059 FH, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR001766 Fork_head_dom IPR018122 TF_fork_head_CS_1 IPR030456 TF_fork_head_CS_2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00250 Forkhead, 1 hit
PRINTSⁱ	PR00053 FORKHEAD
SMARTⁱ	View protein in SMART SM00339 FH, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00657 FORK_HEAD_1, 1 hit PS00658 FORK_HEAD_2, 1 hit PS50039 FORK_HEAD_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9C009-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKLEVFVPRA AHGDKQGSDL EGAGGSDAPS PLSAAGDDSL GSDGDCAANS 
        60         70         80         90        100
PAAGGGARDT QGDGEQSAGG GPGAEEAIPA AAAAAVVAEG AEAGAAGPGA 
       110        120        130        140        150
GGAGSGEGAR SKPYTRRPKP PYSYIALIAM AIRDSAGGRL TLAEINEYLM 
       160        170        180        190        200
GKFPFFRGSY TGWRNSVRHN LSLNDCFVKV LRDPSRPWGK DNYWMLNPNS 
       210        220        230        240        250
EYTFADGVFR RRRKRLSHRA PVPAPGLRPE EAPGLPAAPP PAPAAPASPR 
       260        270        280        290        300
MRSPARQEER ASPAGKFSSS FAIDSILRKP FRSRRLRDTA PGTTLQWGAA 
       310        320        330        340        350
PCPPLPAFPA LLPAAPCRAL LPLCAYGAGE PARLGAREAE VPPTAPPLLL 
       360        370        380        390        400
APLPAAAPAK PLRGPAAGGA HLYCPLRLPA ALQAASVRRP GPHLPYPVET 

LLA

Length:403

Mass (Da):41,526

Last modified:April 3, 2007 - v2

Checksum:ⁱ0709E0A6A0AE2174

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	49 – 52	NSPA → KPS in AAF75586 (PubMed:11309849).Curated	4
Sequence conflictⁱ	386	S → L in AAF75586 (PubMed:11309849).Curated	1
Sequence conflictⁱ	395	P → S in AAF75586 (PubMed:11309849).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_031606	60	T → P2 PublicationsCorresponds to variant dbSNP:rs9502889Ensembl.		1
Natural variantⁱVAR_031607	61	Q → P2 PublicationsCorresponds to variant dbSNP:rs9502890Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF225950 Genomic DNA Translation: AAK00639.1 AF153341 Genomic DNA Translation: AAF75586.1 BC053850 mRNA Translation: AAH53850.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4471.1
NCBI Reference Sequences More...RefSeqⁱ	NP_150285.3, NM_033260.3
UniGeneⁱ	Hs.591352

Genome annotation databases

Ensemblⁱ	ENST00000296839; ENSP00000296839; ENSG00000164379
GeneIDⁱ	94234
KEGGⁱ	hsa:94234
UCSC genome browser More...UCSCⁱ	uc003mtl.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9C009	Forkhead box Q1		CALJA		408	UniRef50_Q9C009
Uncharacterized protein		CHLSB		405
FOXQ1 isoform 1		PANTR		403
Uncharacterized protein		CERAT		403
FOXQ1 isoform 1		PONAB		403
+7

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF225950 Genomic DNA Translation: AAK00639.1 AF153341 Genomic DNA Translation: AAF75586.1 BC053850 mRNA Translation: AAH53850.1
CCDSⁱ	CCDS4471.1
RefSeqⁱ	NP_150285.3, NM_033260.3
UniGeneⁱ	Hs.591352

3D structure databases

ProteinModelPortalⁱ	Q9C009
SMRⁱ	Q9C009
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125147, 105 interactors
IntActⁱ	Q9C009, 105 interactors
MINTⁱ	Q9C009
STRINGⁱ	9606.ENSP00000296839

PTM databases

iPTMnetⁱ	Q9C009
PhosphoSitePlusⁱ	Q9C009

Polymorphism and mutation databases

BioMutaⁱ	FOXQ1
DMDMⁱ	143811391

Proteomic databases

EPDⁱ	Q9C009
MaxQBⁱ	Q9C009
PaxDbⁱ	Q9C009
PeptideAtlasⁱ	Q9C009
PRIDEⁱ	Q9C009
ProteomicsDBⁱ	79939

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000296839; ENSP00000296839; ENSG00000164379
GeneIDⁱ	94234
KEGGⁱ	hsa:94234
UCSCⁱ	uc003mtl.5 human

Organism-specific databases

CTDⁱ	94234
DisGeNETⁱ	94234
EuPathDBⁱ	HostDB:ENSG00000164379.5
GeneCardsⁱ	FOXQ1
H-InvDBⁱ	HIX0025221
HGNCⁱ	HGNC:20951 FOXQ1
HPAⁱ	HPA059700
MIMⁱ	612788 gene
neXtProtⁱ	NX_Q9C009
OpenTargetsⁱ	ENSG00000164379
PharmGKBⁱ	PA134924898
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2294 Eukaryota COG5025 LUCA
GeneTreeⁱ	ENSGT00930000150834
HOGENOMⁱ	HOG000112634
HOVERGENⁱ	HBG051658
InParanoidⁱ	Q9C009
KOⁱ	K09410
OMAⁱ	MKLEVFT
OrthoDBⁱ	EOG091G0LMU
PhylomeDBⁱ	Q9C009
TreeFamⁱ	TF316127

Enzyme and pathway databases

SignaLinkⁱ	Q9C009

SignaLinkⁱ

Q9C009

Miscellaneous databases

ChiTaRSⁱ	FOXQ1 human
GenomeRNAiⁱ	94234
Protein Ontology More...PROⁱ	PR:Q9C009
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000164379 Expressed in 151 organ(s), highest expression level in stomach
CleanExⁱ	HS_FOXQ1
Genevisibleⁱ	Q9C009 HS

Family and domain databases

CDDⁱ	cd00059 FH, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR001766 Fork_head_dom IPR018122 TF_fork_head_CS_1 IPR030456 TF_fork_head_CS_2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00250 Forkhead, 1 hit
PRINTSⁱ	PR00053 FORKHEAD
SMARTⁱ	View protein in SMART SM00339 FH, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00657 FORK_HEAD_1, 1 hit PS00658 FORK_HEAD_2, 1 hit PS50039 FORK_HEAD_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FOXQ1_HUMAN
Accessionⁱ	Q9C009Primary (citable) accession number: Q9C009 Secondary accession number(s): Q9NS06
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 27, 2003
	Last sequence update:	April 3, 2007
	Last modified:	November 7, 2018
	This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9C009 (FOXQ1_HUMAN)

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Forkhead box protein Q1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ