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Protein

Forkhead box protein Q1

Gene

FOXQ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in hair follicle differentiation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi119 – 214Fork-headPROSITE-ProRule annotationAdd BLAST96

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiQ9C009

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein Q1
Alternative name(s):
HNF-3/forkhead-like protein 1
Short name:
HFH-1
Hepatocyte nuclear factor 3 forkhead homolog 1
Gene namesi
Name:FOXQ1
Synonyms:HFH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000164379.5
HGNCiHGNC:20951 FOXQ1
MIMi612788 gene
neXtProtiNX_Q9C009

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi94234
OpenTargetsiENSG00000164379
PharmGKBiPA134924898

Polymorphism and mutation databases

BioMutaiFOXQ1
DMDMi143811391

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918901 – 403Forkhead box protein Q1Add BLAST403

Proteomic databases

EPDiQ9C009
MaxQBiQ9C009
PaxDbiQ9C009
PeptideAtlasiQ9C009
PRIDEiQ9C009
ProteomicsDBi79939

PTM databases

iPTMnetiQ9C009
PhosphoSitePlusiQ9C009

Expressioni

Tissue specificityi

Expressed predominantly in the stomach, trachea, bladder and salivary gland.1 Publication

Gene expression databases

BgeeiENSG00000164379 Expressed in 151 organ(s), highest expression level in stomach
CleanExiHS_FOXQ1
GenevisibleiQ9C009 HS

Organism-specific databases

HPAiHPA059700

Interactioni

Protein-protein interaction databases

BioGridi125147, 105 interactors
IntActiQ9C009, 105 interactors
MINTiQ9C009
STRINGi9606.ENSP00000296839

Structurei

3D structure databases

ProteinModelPortaliQ9C009
SMRiQ9C009
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 103Ala/Gly-richAdd BLAST91
Compositional biasi221 – 397Pro-richAdd BLAST177

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00930000150834
HOGENOMiHOG000112634
HOVERGENiHBG051658
InParanoidiQ9C009
KOiK09410
OMAiMKLEVFT
OrthoDBiEOG091G0LMU
PhylomeDBiQ9C009
TreeFamiTF316127

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9C009-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLEVFVPRA AHGDKQGSDL EGAGGSDAPS PLSAAGDDSL GSDGDCAANS
60 70 80 90 100
PAAGGGARDT QGDGEQSAGG GPGAEEAIPA AAAAAVVAEG AEAGAAGPGA
110 120 130 140 150
GGAGSGEGAR SKPYTRRPKP PYSYIALIAM AIRDSAGGRL TLAEINEYLM
160 170 180 190 200
GKFPFFRGSY TGWRNSVRHN LSLNDCFVKV LRDPSRPWGK DNYWMLNPNS
210 220 230 240 250
EYTFADGVFR RRRKRLSHRA PVPAPGLRPE EAPGLPAAPP PAPAAPASPR
260 270 280 290 300
MRSPARQEER ASPAGKFSSS FAIDSILRKP FRSRRLRDTA PGTTLQWGAA
310 320 330 340 350
PCPPLPAFPA LLPAAPCRAL LPLCAYGAGE PARLGAREAE VPPTAPPLLL
360 370 380 390 400
APLPAAAPAK PLRGPAAGGA HLYCPLRLPA ALQAASVRRP GPHLPYPVET

LLA
Length:403
Mass (Da):41,526
Last modified:April 3, 2007 - v2
Checksum:i0709E0A6A0AE2174
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49 – 52NSPA → KPS in AAF75586 (PubMed:11309849).Curated4
Sequence conflicti386S → L in AAF75586 (PubMed:11309849).Curated1
Sequence conflicti395P → S in AAF75586 (PubMed:11309849).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03160660T → P2 PublicationsCorresponds to variant dbSNP:rs9502889Ensembl.1
Natural variantiVAR_03160761Q → P2 PublicationsCorresponds to variant dbSNP:rs9502890Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225950 Genomic DNA Translation: AAK00639.1
AF153341 Genomic DNA Translation: AAF75586.1
BC053850 mRNA Translation: AAH53850.1
CCDSiCCDS4471.1
RefSeqiNP_150285.3, NM_033260.3
UniGeneiHs.591352

Genome annotation databases

EnsembliENST00000296839; ENSP00000296839; ENSG00000164379
GeneIDi94234
KEGGihsa:94234
UCSCiuc003mtl.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225950 Genomic DNA Translation: AAK00639.1
AF153341 Genomic DNA Translation: AAF75586.1
BC053850 mRNA Translation: AAH53850.1
CCDSiCCDS4471.1
RefSeqiNP_150285.3, NM_033260.3
UniGeneiHs.591352

3D structure databases

ProteinModelPortaliQ9C009
SMRiQ9C009
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125147, 105 interactors
IntActiQ9C009, 105 interactors
MINTiQ9C009
STRINGi9606.ENSP00000296839

PTM databases

iPTMnetiQ9C009
PhosphoSitePlusiQ9C009

Polymorphism and mutation databases

BioMutaiFOXQ1
DMDMi143811391

Proteomic databases

EPDiQ9C009
MaxQBiQ9C009
PaxDbiQ9C009
PeptideAtlasiQ9C009
PRIDEiQ9C009
ProteomicsDBi79939

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296839; ENSP00000296839; ENSG00000164379
GeneIDi94234
KEGGihsa:94234
UCSCiuc003mtl.5 human

Organism-specific databases

CTDi94234
DisGeNETi94234
EuPathDBiHostDB:ENSG00000164379.5
GeneCardsiFOXQ1
H-InvDBiHIX0025221
HGNCiHGNC:20951 FOXQ1
HPAiHPA059700
MIMi612788 gene
neXtProtiNX_Q9C009
OpenTargetsiENSG00000164379
PharmGKBiPA134924898
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00930000150834
HOGENOMiHOG000112634
HOVERGENiHBG051658
InParanoidiQ9C009
KOiK09410
OMAiMKLEVFT
OrthoDBiEOG091G0LMU
PhylomeDBiQ9C009
TreeFamiTF316127

Enzyme and pathway databases

SignaLinkiQ9C009

Miscellaneous databases

ChiTaRSiFOXQ1 human
GenomeRNAii94234
PROiPR:Q9C009
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164379 Expressed in 151 organ(s), highest expression level in stomach
CleanExiHS_FOXQ1
GenevisibleiQ9C009 HS

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFOXQ1_HUMAN
AccessioniPrimary (citable) accession number: Q9C009
Secondary accession number(s): Q9NS06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: April 3, 2007
Last modified: November 7, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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