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UniProtKB - Q9C009 (FOXQ1_HUMAN)
Protein
Forkhead box protein Q1
Gene
FOXQ1
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in hair follicle differentiation.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 119 – 214 | Fork-headPROSITE-ProRule annotationAdd BLAST | 96 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- anatomical structure morphogenesis Source: GO_Central
- cell differentiation Source: GO_Central
- hair follicle morphogenesis Source: Ensembl
- negative regulation of neuron apoptotic process Source: ARUK-UCL
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9C009 |
SignaLinki | Q9C009 |
SIGNORi | Q9C009 |
Names & Taxonomyi
Protein namesi | Recommended name: Forkhead box protein Q1Alternative name(s): HNF-3/forkhead-like protein 1 Short name: HFH-1 Hepatocyte nuclear factor 3 forkhead homolog 1 |
Gene namesi | Name:FOXQ1 Synonyms:HFH1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20951, FOXQ1 |
MIMi | 612788, gene |
neXtProti | NX_Q9C009 |
VEuPathDBi | HostDB:ENSG00000164379 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 94234 |
OpenTargetsi | ENSG00000164379 |
PharmGKBi | PA134924898 |
Miscellaneous databases
Pharosi | Q9C009, Tbio |
Genetic variation databases
BioMutai | FOXQ1 |
DMDMi | 143811391 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000091890 | 1 – 403 | Forkhead box protein Q1Add BLAST | 403 |
Proteomic databases
jPOSTi | Q9C009 |
MassIVEi | Q9C009 |
MaxQBi | Q9C009 |
PaxDbi | Q9C009 |
PeptideAtlasi | Q9C009 |
PRIDEi | Q9C009 |
ProteomicsDBi | 79939 |
PTM databases
iPTMneti | Q9C009 |
PhosphoSitePlusi | Q9C009 |
Expressioni
Tissue specificityi
Expressed predominantly in the stomach, trachea, bladder and salivary gland.1 Publication
Gene expression databases
Bgeei | ENSG00000164379, Expressed in stomach and 166 other tissues |
Genevisiblei | Q9C009, HS |
Organism-specific databases
HPAi | ENSG00000164379, Tissue enhanced (stomach, urinary bladder) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 125147, 105 interactors |
IntActi | Q9C009, 105 interactors |
MINTi | Q9C009 |
STRINGi | 9606.ENSP00000296839 |
Miscellaneous databases
RNActi | Q9C009, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 75 | DisorderedSequence analysisAdd BLAST | 75 | |
Regioni | 94 – 116 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 216 – 266 | DisorderedSequence analysisAdd BLAST | 51 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 226 – 248 | Pro residuesSequence analysisAdd BLAST | 23 |
Phylogenomic databases
eggNOGi | KOG2294, Eukaryota |
GeneTreei | ENSGT00940000162937 |
HOGENOMi | CLU_055457_0_0_1 |
InParanoidi | Q9C009 |
OMAi | AYGMGEP |
OrthoDBi | 1270467at2759 |
PhylomeDBi | Q9C009 |
TreeFami | TF316127 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9C009-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLEVFVPRA AHGDKQGSDL EGAGGSDAPS PLSAAGDDSL GSDGDCAANS
60 70 80 90 100
PAAGGGARDT QGDGEQSAGG GPGAEEAIPA AAAAAVVAEG AEAGAAGPGA
110 120 130 140 150
GGAGSGEGAR SKPYTRRPKP PYSYIALIAM AIRDSAGGRL TLAEINEYLM
160 170 180 190 200
GKFPFFRGSY TGWRNSVRHN LSLNDCFVKV LRDPSRPWGK DNYWMLNPNS
210 220 230 240 250
EYTFADGVFR RRRKRLSHRA PVPAPGLRPE EAPGLPAAPP PAPAAPASPR
260 270 280 290 300
MRSPARQEER ASPAGKFSSS FAIDSILRKP FRSRRLRDTA PGTTLQWGAA
310 320 330 340 350
PCPPLPAFPA LLPAAPCRAL LPLCAYGAGE PARLGAREAE VPPTAPPLLL
360 370 380 390 400
APLPAAAPAK PLRGPAAGGA HLYCPLRLPA ALQAASVRRP GPHLPYPVET
LLA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 49 – 52 | NSPA → KPS in AAF75586 (PubMed:11309849).Curated | 4 | |
Sequence conflicti | 386 | S → L in AAF75586 (PubMed:11309849).Curated | 1 | |
Sequence conflicti | 395 | P → S in AAF75586 (PubMed:11309849).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031606 | 60 | T → P2 PublicationsCorresponds to variant dbSNP:rs9502889Ensembl. | 1 | |
Natural variantiVAR_031607 | 61 | Q → P2 PublicationsCorresponds to variant dbSNP:rs9502890Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF225950 Genomic DNA Translation: AAK00639.1 AF153341 Genomic DNA Translation: AAF75586.1 BC053850 mRNA Translation: AAH53850.1 |
CCDSi | CCDS4471.1 |
RefSeqi | NP_150285.3, NM_033260.3 |
Genome annotation databases
Ensembli | ENST00000296839; ENSP00000296839; ENSG00000164379 |
GeneIDi | 94234 |
KEGGi | hsa:94234 |
MANE-Selecti | ENST00000296839.5; ENSP00000296839.2; NM_033260.4; NP_150285.3 |
UCSCi | uc003mtl.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF225950 Genomic DNA Translation: AAK00639.1 AF153341 Genomic DNA Translation: AAF75586.1 BC053850 mRNA Translation: AAH53850.1 |
CCDSi | CCDS4471.1 |
RefSeqi | NP_150285.3, NM_033260.3 |
3D structure databases
SMRi | Q9C009 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125147, 105 interactors |
IntActi | Q9C009, 105 interactors |
MINTi | Q9C009 |
STRINGi | 9606.ENSP00000296839 |
PTM databases
iPTMneti | Q9C009 |
PhosphoSitePlusi | Q9C009 |
Genetic variation databases
BioMutai | FOXQ1 |
DMDMi | 143811391 |
Proteomic databases
jPOSTi | Q9C009 |
MassIVEi | Q9C009 |
MaxQBi | Q9C009 |
PaxDbi | Q9C009 |
PeptideAtlasi | Q9C009 |
PRIDEi | Q9C009 |
ProteomicsDBi | 79939 |
Protocols and materials databases
Antibodypediai | 9198, 464 antibodies from 31 providers |
CPTCi | Q9C009, 2 antibodies |
DNASUi | 94234 |
Genome annotation databases
Ensembli | ENST00000296839; ENSP00000296839; ENSG00000164379 |
GeneIDi | 94234 |
KEGGi | hsa:94234 |
MANE-Selecti | ENST00000296839.5; ENSP00000296839.2; NM_033260.4; NP_150285.3 |
UCSCi | uc003mtl.5, human |
Organism-specific databases
CTDi | 94234 |
DisGeNETi | 94234 |
GeneCardsi | FOXQ1 |
HGNCi | HGNC:20951, FOXQ1 |
HPAi | ENSG00000164379, Tissue enhanced (stomach, urinary bladder) |
MIMi | 612788, gene |
neXtProti | NX_Q9C009 |
OpenTargetsi | ENSG00000164379 |
PharmGKBi | PA134924898 |
VEuPathDBi | HostDB:ENSG00000164379 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2294, Eukaryota |
GeneTreei | ENSGT00940000162937 |
HOGENOMi | CLU_055457_0_0_1 |
InParanoidi | Q9C009 |
OMAi | AYGMGEP |
OrthoDBi | 1270467at2759 |
PhylomeDBi | Q9C009 |
TreeFami | TF316127 |
Enzyme and pathway databases
PathwayCommonsi | Q9C009 |
SignaLinki | Q9C009 |
SIGNORi | Q9C009 |
Miscellaneous databases
BioGRID-ORCSi | 94234, 14 hits in 1064 CRISPR screens |
ChiTaRSi | FOXQ1, human |
GenomeRNAii | 94234 |
Pharosi | Q9C009, Tbio |
PROi | PR:Q9C009 |
RNActi | Q9C009, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164379, Expressed in stomach and 166 other tissues |
Genevisiblei | Q9C009, HS |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FOXQ1_HUMAN | |
Accessioni | Q9C009Primary (citable) accession number: Q9C009 Secondary accession number(s): Q9NS06 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 27, 2003 |
Last sequence update: | April 3, 2007 | |
Last modified: | February 23, 2022 | |
This is version 168 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot