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Protein

Sodium channel protein

Gene

SCN3A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:SCN3AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei124 – 147HelicalUniRule annotationAdd BLAST24
Transmembranei192 – 211HelicalUniRule annotationAdd BLAST20
Transmembranei223 – 244HelicalUniRule annotationAdd BLAST22
Transmembranei250 – 270HelicalUniRule annotationAdd BLAST21
Transmembranei400 – 427HelicalUniRule annotationAdd BLAST28
Transmembranei712 – 730HelicalUniRule annotationAdd BLAST19
Transmembranei742 – 765HelicalUniRule annotationAdd BLAST24
Transmembranei822 – 850HelicalUniRule annotationAdd BLAST29
Transmembranei912 – 935HelicalUniRule annotationAdd BLAST24
Transmembranei1158 – 1176HelicalUniRule annotationAdd BLAST19
Transmembranei1197 – 1219HelicalUniRule annotationAdd BLAST23
Transmembranei1225 – 1245HelicalUniRule annotationAdd BLAST21
Transmembranei1274 – 1300HelicalUniRule annotationAdd BLAST27
Transmembranei1395 – 1419HelicalUniRule annotationAdd BLAST25
Transmembranei1478 – 1496HelicalUniRule annotationAdd BLAST19
Transmembranei1508 – 1526HelicalUniRule annotationAdd BLAST19
Transmembranei1538 – 1558HelicalUniRule annotationAdd BLAST21
Transmembranei1595 – 1623HelicalUniRule annotationAdd BLAST29
Transmembranei1699 – 1722HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35005

PTM / Processingi

Proteomic databases

PeptideAtlasiQ9C007
PRIDEiQ9C007

Expressioni

Gene expression databases

GenevisibleiQ9C007 HS

Structurei

3D structure databases

ProteinModelPortaliQ9C007
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini127 – 434Ion_transInterPro annotationAdd BLAST308
Domaini507 – 624Na_trans_cytoplInterPro annotationAdd BLAST118
Domaini712 – 940Ion_transInterPro annotationAdd BLAST229
Domaini949 – 1151Na_trans_assocInterPro annotationAdd BLAST203
Domaini1156 – 1427Ion_transInterPro annotationAdd BLAST272
Domaini1477 – 1732Ion_transInterPro annotationAdd BLAST256

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili22 – 42Sequence analysisAdd BLAST21
Coiled coili424 – 465Sequence analysisAdd BLAST42

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG410XNP6 LUCA
HOGENOMiHOG000231755
HOVERGENiHBG053100

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR000048 IQ_motif_EF-hand-BS
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit
PRINTSiPR00170 NACHANNEL
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit

Sequencei

Sequence statusi: Complete.

Q9C007-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDNDDENKPK
60 70 80 90 100
PNSDLEAGKN LPFIYGDIPP EMVSEPLEDL DPYYINKKTF IVMNKGKAIF
110 120 130 140 150
RFSATSALYI LTPLNPVRKI AIKILVHSLF SMLIMCTILT NCVFMTLSNP
160 170 180 190 200
PDWTKNVEYT FTGIYTFESL IKILARGFCL EDFTFLRDPW NWLDFSVIVM
210 220 230 240 250
AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL IQSVKKLSDV
260 270 280 290 300
MILTVFCLSV FALIGLQLFM GNLRNKCLQW PPSDSAFETN TTSYFNGTMD
310 320 330 340 350
SNGTFVNVTM STFNWKDYIG DDSHFYVLDG QKDPLLCGNG SDAGQCPEGY
360 370 380 390 400
ICVKAGRNPN YGYTSFDTFS WAFLSLFRLM TQDYWENLYQ LTLRAAGKTY
410 420 430 440 450
MIFFVLVIFL GSFYLVNLIL AVVAMAYEEQ NQATLEEAEQ KEAEFQQMLE
460 470 480 490 500
QLKKQQEEAQ AVAAASAASR DFSGVGGLGE LLESSSEASK LSSKGAKEWR
510 520 530 540 550
NRRKKRRQRE HLEGNNKGER DSFPKSESED SVKRSSFLFS MDGNRLTSDK
560 570 580 590 600
KFCSPHQSLL SIRGSLFSPR RNSKTSIFSF RGRAKDVGSE NDFADDEHST
610 620 630 640 650
FEDSESRRDS LFVPHRHGER RNSNGTTTET EVRKRRLSSY QISMEMLEDS
660 670 680 690 700
SGRQRAVSIA SILTNTMEEL EESRQKCPPC WYRFANVFLI WDCCDAWLKV
710 720 730 740 750
KHLVNLIVMD PFVDLAITIC IVLNTLFMAM EHYPMTEQFS SVLTVGNLVF
760 770 780 790 800
TGIFTAEMVL KIIAMDPYYY FQEGWNIFDG IIVSLSLMEL GLSNVEGLSV
810 820 830 840 850
LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV
860 870 880 890 900
GMQLFGKSYK ECVCKINDDC TLPRWHMNDF FHSFLIVFRV LCGEWIETMW
910 920 930 940 950
DCMEVAGQTM CLIVFMLVMV IGNLVVLNLF LALLLSSFSS DNLAATDDDN
960 970 980 990 1000
EMNNLQIAVG RMQKGIDYVK NKMRECFQKA FFRKPKVIEI HEGNKIDSCM
1010 1020 1030 1040 1050
SNNTGIEISK ELNYLRDGNG TTSGVGTGSS VEKYVIDEND YMSFINNPSL
1060 1070 1080 1090 1100
TVTVPIAVGE SDFENLNTEE FSSESELEES KEKLNATSSS EGSTVDVVLP
1110 1120 1130 1140 1150
REGEQAETEP EEDFKPEACF TEGCIKKFPF CQVSTEEGKG KIWWNLRKTC
1160 1170 1180 1190 1200
YSIVEHNWFE TFIVFMILLS SGALAFEDIY IEQRKTIKTM LEYADKVFTY
1210 1220 1230 1240 1250
IFILEMLLKW VAYGFQTYFT NAWCWLDFLI VDVSLVSLVA NALGYSELGA
1260 1270 1280 1290 1300
IKSLRTLRAL RPLRALSRFE GMRVVVNALV GAIPSIMNVL LVCLIFWLIF
1310 1320 1330 1340 1350
SIMGVNLFAG KFYHCVNMTT GNMFDISDVN NLSDCQALGK QARWKNVKVN
1360 1370 1380 1390 1400
FDNVGAGYLA LLQVATFKGW MDIMYAAVDS RDVKLQPVYE ENLYMYLYFV
1410 1420 1430 1440 1450
IFIIFGSFFT LNLFIGVIID NFNQQKKKFG GQDIFMTEEQ KKYYNAMKKL
1460 1470 1480 1490 1500
GSKKPQKPIP RPANKFQGMV FDFVTRQVFD ISIMILICLN MVTMMVETDD
1510 1520 1530 1540 1550
QGKYMTLVLS RINLVFIVLF TGEFVLKLVS LRHYYFTIGW NIFDFVVVIL
1560 1570 1580 1590 1600
SIVGMFLAEM IEKYSVSPTL FRVIRLARIG RILRLIKGAK GIRTLLFALM
1610 1620 1630 1640 1650
MSLPALFNIG LLLFLVMFIY AIFGMSNFAY VKKEAGIDDM FNFETFGNSM
1660 1670 1680 1690 1700
ICLFQITTSA GWDGLLAPIL NSAPPDCDPD TIHPGSSVKG DRGDPSVGIF
1710 1720 1730 1740 1750
FFVSYIIISF LVVVNMYIAV ILENFSVATE ESAEPLSEDD FEMFYEVWEK
1760 1770 1780 1790 1800
FDPDATQFIE FSKLSDFAAA LDPPLLIAKP NKVQLIAMDL PMVSGDRIHC
1810 1820 1830 1840 1850
LDILFAFTKR VLCESGEMDA LRIQMEDRFM ASNPSKVSYE PITTTLKRKQ
1860 1870 1880 1890 1900
EEVSAAIIQR NFRCYLLKQR LKNISSNYNK EAIKGRIDLP IKQDMIIDKL
1910 1920 1930 1940 1950
NGNSTPEKTD GSSSTTSPPS YDSVTKPDKE KFEKDKPEKE SKGKEVRENQ

K
Length:1,951
Mass (Da):221,520
Last modified:June 1, 2001 - v1
Checksum:i99AD4C032CE124AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225986 mRNA Translation: AAK00218.1
RefSeqiNP_001075145.1, NM_001081676.1
UniGeneiHs.435274

Genome annotation databases

GeneIDi6328

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225986 mRNA Translation: AAK00218.1
RefSeqiNP_001075145.1, NM_001081676.1
UniGeneiHs.435274

3D structure databases

ProteinModelPortaliQ9C007
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ9C007
PRIDEiQ9C007

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6328

Organism-specific databases

CTDi6328
PharmGKBiPA35005

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG410XNP6 LUCA
HOGENOMiHOG000231755
HOVERGENiHBG053100

Miscellaneous databases

ChiTaRSiSCN3A human
GenomeRNAii6328

Gene expression databases

GenevisibleiQ9C007 HS

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR000048 IQ_motif_EF-hand-BS
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit
PRINTSiPR00170 NACHANNEL
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ9C007_HUMAN
AccessioniPrimary (citable) accession number: Q9C007
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: February 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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