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Protein

Normal mucosa of esophagus-specific gene 1 protein

Gene

NMES1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Normal mucosa of esophagus-specific gene 1 protein
Alternative name(s):
Protein FOAP-11
Gene namesi
Name:NMES1
Synonyms:C15orf48
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000166920.10
HGNCiHGNC:29898 C15orf48
MIMi608409 gene
neXtProtiNX_Q9C002

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84419
OpenTargetsiENSG00000166920
PharmGKBiPA142672265

Polymorphism and mutation databases

BioMutaiNMES1
DMDMi23396774

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188231 – 83Normal mucosa of esophagus-specific gene 1 proteinAdd BLAST83

Proteomic databases

EPDiQ9C002
MaxQBiQ9C002
PaxDbiQ9C002
PeptideAtlasiQ9C002
PRIDEiQ9C002
ProteomicsDBi79935
TopDownProteomicsiQ9C002

PTM databases

iPTMnetiQ9C002
PhosphoSitePlusiQ9C002

Expressioni

Tissue specificityi

Expressed mainly in stomach, placenta, small intestine and colon, as well as in normal mucosa of esophagus. Down-regulated in esophageal squamous cell carcinoma.

Gene expression databases

BgeeiENSG00000166920 Expressed in 81 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_C15orf48
ExpressionAtlasiQ9C002 baseline and differential
GenevisibleiQ9C002 HS

Organism-specific databases

HPAiHPA012943

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DGLUCYQ7Z3D64EBI-3905285,EBI-2807872

Protein-protein interaction databases

BioGridi124071, 120 interactors
IntActiQ9C002, 6 interactors
STRINGi9606.ENSP00000341610

Structurei

3D structure databases

ProteinModelPortaliQ9C002
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA4 subunit family.Curated

Phylogenomic databases

eggNOGiENOG410J1F7 Eukaryota
ENOG410YXE9 LUCA
GeneTreeiENSGT00390000009277
HOGENOMiHOG000261679
HOVERGENiHBG052639
InParanoidiQ9C002
OMAiQWKPVET
PhylomeDBiQ9C002
TreeFamiTF106383

Family and domain databases

InterProiView protein in InterPro
IPR010530 B12D
PANTHERiPTHR14256 PTHR14256, 1 hit
PfamiView protein in Pfam
PF06522 B12D, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9C002-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFFQLLMKR KELIPLVVFM TVAAGGASSF AVYSLWKTDV ILDRKKNPEP
60 70 80
WETVDPTVPQ KLITINQQWK PIEELQNVQR VTK
Length:83
Mass (Da):9,617
Last modified:June 1, 2001 - v1
Checksum:i21884FE8A009C039
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YKW5H0YKW5_HUMAN
Chromosome 15 open reading frame 48
C15orf48
132Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228422 mRNA Translation: AAK00708.1
AB026707 mRNA Translation: BAB61021.1
BC021173 mRNA Translation: AAH21173.1
CCDSiCCDS10124.1
RefSeqiNP_115789.1, NM_032413.3
NP_922946.1, NM_197955.2
UniGeneiHs.112242

Genome annotation databases

EnsembliENST00000344300; ENSP00000341610; ENSG00000166920
ENST00000396650; ENSP00000379887; ENSG00000166920
GeneIDi84419
KEGGihsa:84419
UCSCiuc001zvg.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228422 mRNA Translation: AAK00708.1
AB026707 mRNA Translation: BAB61021.1
BC021173 mRNA Translation: AAH21173.1
CCDSiCCDS10124.1
RefSeqiNP_115789.1, NM_032413.3
NP_922946.1, NM_197955.2
UniGeneiHs.112242

3D structure databases

ProteinModelPortaliQ9C002
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124071, 120 interactors
IntActiQ9C002, 6 interactors
STRINGi9606.ENSP00000341610

PTM databases

iPTMnetiQ9C002
PhosphoSitePlusiQ9C002

Polymorphism and mutation databases

BioMutaiNMES1
DMDMi23396774

Proteomic databases

EPDiQ9C002
MaxQBiQ9C002
PaxDbiQ9C002
PeptideAtlasiQ9C002
PRIDEiQ9C002
ProteomicsDBi79935
TopDownProteomicsiQ9C002

Protocols and materials databases

DNASUi84419
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344300; ENSP00000341610; ENSG00000166920
ENST00000396650; ENSP00000379887; ENSG00000166920
GeneIDi84419
KEGGihsa:84419
UCSCiuc001zvg.5 human

Organism-specific databases

CTDi84419
DisGeNETi84419
EuPathDBiHostDB:ENSG00000166920.10
GeneCardsiC15orf48
HGNCiHGNC:29898 C15orf48
HPAiHPA012943
MIMi608409 gene
neXtProtiNX_Q9C002
OpenTargetsiENSG00000166920
PharmGKBiPA142672265
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1F7 Eukaryota
ENOG410YXE9 LUCA
GeneTreeiENSGT00390000009277
HOGENOMiHOG000261679
HOVERGENiHBG052639
InParanoidiQ9C002
OMAiQWKPVET
PhylomeDBiQ9C002
TreeFamiTF106383

Miscellaneous databases

GenomeRNAii84419
PROiPR:Q9C002
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166920 Expressed in 81 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_C15orf48
ExpressionAtlasiQ9C002 baseline and differential
GenevisibleiQ9C002 HS

Family and domain databases

InterProiView protein in InterPro
IPR010530 B12D
PANTHERiPTHR14256 PTHR14256, 1 hit
PfamiView protein in Pfam
PF06522 B12D, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNMES1_HUMAN
AccessioniPrimary (citable) accession number: Q9C002
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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