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Entry version 147 (16 Oct 2019)
Sequence version 3 (19 Oct 2011)
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Protein

Apoptosis inhibitor 5

Gene

API5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Apoptosis inhibitor 5
Short name:
API-5
Alternative name(s):
Antiapoptosis clone 11 protein
Short name:
AAC-11
Cell migration-inducing gene 8 protein
Fibroblast growth factor 2-interacting factor
Short name:
FIF
Protein XAGL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:API5
ORF Names:MIG8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:594 API5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609774 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BZZ5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8539

Open Targets

More...
OpenTargetsi
ENSG00000166181

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24881

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BZZ5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
API5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
353526346

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000646342 – 524Apoptosis inhibitor 5Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei251N6-acetyllysine1 Publication1
Modified residuei399PhosphothreonineCombined sources1
Modified residuei462PhosphoserineCombined sources1
Modified residuei464PhosphoserineCombined sources1
Modified residuei469PhosphoserineBy similarity1
Modified residuei500Omega-N-methylarginineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylation at Lys-251 impairs antiapoptotic function.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BZZ5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BZZ5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BZZ5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BZZ5

PeptideAtlas

More...
PeptideAtlasi
Q9BZZ5

PRoteomics IDEntifications database

More...
PRIDEi
Q9BZZ5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79926 [Q9BZZ5-4]
79927 [Q9BZZ5-1]
79928 [Q9BZZ5-2]
79929 [Q9BZZ5-3]
79930 [Q9BZZ5-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BZZ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BZZ5

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9BZZ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer.5 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166181 Expressed in 239 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BZZ5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BZZ5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA026598

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

Interacts with FGF2 and ACIN1.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9UKV3-32EBI-1048422,EBI-6976596

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114109, 125 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9BZZ5

Protein interaction database and analysis system

More...
IntActi
Q9BZZ5, 22 interactors

Molecular INTeraction database

More...
MINTi
Q9BZZ5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000431391

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1524
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BZZ5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 360ARM-like and Heat-like helical repeatsAdd BLAST359
Regioni370 – 391Leucine-zipperAdd BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi454 – 475Nuclear localization signal1 PublicationAdd BLAST22

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Two regions, an N-terminal (aa 96-107) and a C-terminal (aa 274-311) are required for binding FGF2.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the API5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2213 Eukaryota
ENOG410XSH0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010991

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000239017

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BZZ5

Identification of Orthologs from Complete Genome Data

More...
OMAi
FIQCATA

Database of Orthologous Groups

More...
OrthoDBi
1385954at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BZZ5

TreeFam database of animal gene trees

More...
TreeFami
TF324283

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008383 API5
IPR016024 ARM-type_fold

The PANTHER Classification System

More...
PANTHERi
PTHR12758 PTHR12758, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05918 API5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: Q9BZZ5-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPTVEELYRN YGILADATEQ VGQHKDAYQV ILDGVKGGTK EKRLAAQFIP
60 70 80 90 100
KFFKHFPELA DSAINAQLDL CEDEDVSIRR QAIKELPQFA TGENLPRVAD
110 120 130 140 150
ILTQLLQTDD SAEFNLVNNA LLSIFKMDAK GTLGGLFSQI LQGEDIVRER
160 170 180 190 200
AIKFLSTKLK TLPDEVLTKE VEELILTESK KVLEDVTGEE FVLFMKILSG
210 220 230 240 250
LKSLQTVSGR QQLVELVAEQ ADLEQTFNPS DPDCVDRLLQ CTRQAVPLFS
260 270 280 290 300
KNVHSTRFVT YFCEQVLPNL GTLTTPVEGL DIQLEVLKLL AEMSSFCGDM
310 320 330 340 350
EKLETNLRKL FDKLLEYMPL PPEEAENGEN AGNEEPKLQF SYVECLLYSF
360 370 380 390 400
HQLGRKLPDF LTAKLNAEKL KDFKIRLQYF ARGLQVYIRQ LRLALQGKTG
410 420 430 440 450
EALKTEENKI KVVALKITNN INVLIKDLFH IPPSYKSTVT LSWKPVQKVE
460 470 480 490 500
IGQKRASEDT TSGSPPKKSS AGPKRDARQI YNPPSGKYSS NLGNFNYEQR
510 520
GAFRGSRGGR GWGTRGNRSR GRLY
Length:524
Mass (Da):59,005
Last modified:October 19, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2EA6BE4D8318BB9
GO
Isoform 1 (identifier: Q9BZZ5-1) [UniParc]FASTAAdd to basket
Also known as: FIF-510

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.
     498-510: EQRGAFRGSRGGR → GERFRLGTRNMRD
     511-524: Missing.

Note: Incomplete sequence.
Show »
Length:438
Mass (Da):49,497
Checksum:i1EEDA88187A989A2
GO
Isoform 2 (identifier: Q9BZZ5-2) [UniParc]FASTAAdd to basket
Also known as: FIF-504

The sequence of this isoform differs from the canonical sequence as follows:
     499-504: QRGAFR → RSLQGK
     505-524: Missing.

Show »
Length:504
Mass (Da):56,770
Checksum:iD4A0D283CDFC4A87
GO
Isoform 3 (identifier: Q9BZZ5-3) [UniParc]FASTAAdd to basket
Also known as: FIF C1

The sequence of this isoform differs from the canonical sequence as follows:
     427-431: DLFHI → AKESQ
     432-510: Missing.

Note: No experimental confirmation available.
Show »
Length:445
Mass (Da):50,310
Checksum:i43B0F4BC4F78FDC3
GO
Isoform 5 (identifier: Q9BZZ5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-77: Missing.
     499-504: QRGAFR → RSLQGK
     505-524: Missing.

Note: No experimental confirmation available.
Show »
Length:450
Mass (Da):50,740
Checksum:iD09D2CC020A382CC
GO
Isoform 6 (identifier: Q9BZZ5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MPTVEELYRNYGILADATEQVGQ → MKQRWRENGIGK

Note: No experimental confirmation available.
Show »
Length:513
Mass (Da):57,909
Checksum:i11634F148F8009C2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V1C3G3V1C3_HUMAN
Apoptosis inhibitor 5
API5
510Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YER7H0YER7_HUMAN
Apoptosis inhibitor 5
API5
294Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQK6E9PQK6_HUMAN
Apoptosis inhibitor 5
API5
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB86528 differs from that shown. Reason: Frameshift.Curated
The sequence AAB86528 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti371 – 373KDF → HES in AAB86528 (PubMed:9307294).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021519276P → S1 Publication1
Natural variantiVAR_021520300M → V1 PublicationCorresponds to variant dbSNP:rs5743240Ensembl.1
Natural variantiVAR_021521493G → S1 PublicationCorresponds to variant dbSNP:rs2862934Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0419681 – 72Missing in isoform 1. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_0574121 – 23MPTVE…EQVGQ → MKQRWRENGIGK in isoform 6. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_04328924 – 77Missing in isoform 5. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_039761427 – 431DLFHI → AKESQ in isoform 3. 1 Publication5
Alternative sequenceiVSP_039762432 – 510Missing in isoform 3. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_041969498 – 510EQRGA…SRGGR → GERFRLGTRNMRD in isoform 1. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_041970499 – 504QRGAFR → RSLQGK in isoform 2 and isoform 5. 6 Publications6
Alternative sequenceiVSP_041971505 – 524Missing in isoform 2 and isoform 5. 6 PublicationsAdd BLAST20
Alternative sequenceiVSP_041972511 – 524Missing in isoform 1. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U83857 mRNA Translation: AAB86528.1 Sequence problems.
Y15906 mRNA Translation: CAA75867.1
AF229253 mRNA Translation: AAK00737.1
AF229254 mRNA Translation: AAK00738.1
AY311389 mRNA Translation: AAQ76714.1
BT007093 mRNA Translation: AAP35756.1
AY265973 Genomic DNA Translation: AAO89077.1
AK294724 mRNA Translation: BAG57871.1
AK299288 mRNA Translation: BAG61304.1
AK304157 mRNA Translation: BAG65045.1
AC087276 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68098.1
CH471064 Genomic DNA Translation: EAW68099.1
BC017709 mRNA Translation: AAH17709.1
W40304 mRNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS31465.1 [Q9BZZ5-2]
CCDS44572.1 [Q9BZZ5-4]
CCDS44573.1 [Q9BZZ5-5]

NCBI Reference Sequences

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RefSeqi
NP_001136402.1, NM_001142930.1 [Q9BZZ5-4]
NP_001136403.1, NM_001142931.1 [Q9BZZ5-5]
NP_001230676.1, NM_001243747.1
NP_006586.1, NM_006595.3 [Q9BZZ5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000378852; ENSP00000368129; ENSG00000166181 [Q9BZZ5-2]
ENST00000420461; ENSP00000402540; ENSG00000166181 [Q9BZZ5-5]
ENST00000455725; ENSP00000399341; ENSG00000166181 [Q9BZZ5-6]
ENST00000531273; ENSP00000431391; ENSG00000166181 [Q9BZZ5-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8539

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8539

UCSC genome browser

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UCSCi
uc001mxf.3 human [Q9BZZ5-4]
uc010rfg.2 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83857 mRNA Translation: AAB86528.1 Sequence problems.
Y15906 mRNA Translation: CAA75867.1
AF229253 mRNA Translation: AAK00737.1
AF229254 mRNA Translation: AAK00738.1
AY311389 mRNA Translation: AAQ76714.1
BT007093 mRNA Translation: AAP35756.1
AY265973 Genomic DNA Translation: AAO89077.1
AK294724 mRNA Translation: BAG57871.1
AK299288 mRNA Translation: BAG61304.1
AK304157 mRNA Translation: BAG65045.1
AC087276 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68098.1
CH471064 Genomic DNA Translation: EAW68099.1
BC017709 mRNA Translation: AAH17709.1
W40304 mRNA No translation available.
CCDSiCCDS31465.1 [Q9BZZ5-2]
CCDS44572.1 [Q9BZZ5-4]
CCDS44573.1 [Q9BZZ5-5]
RefSeqiNP_001136402.1, NM_001142930.1 [Q9BZZ5-4]
NP_001136403.1, NM_001142931.1 [Q9BZZ5-5]
NP_001230676.1, NM_001243747.1
NP_006586.1, NM_006595.3 [Q9BZZ5-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3U0RX-ray2.50A1-498[»]
3V6AX-ray2.60A1-454[»]
SMRiQ9BZZ5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi114109, 125 interactors
CORUMiQ9BZZ5
IntActiQ9BZZ5, 22 interactors
MINTiQ9BZZ5
STRINGi9606.ENSP00000431391

PTM databases

iPTMnetiQ9BZZ5
PhosphoSitePlusiQ9BZZ5
SwissPalmiQ9BZZ5

Polymorphism and mutation databases

BioMutaiAPI5
DMDMi353526346

Proteomic databases

EPDiQ9BZZ5
jPOSTiQ9BZZ5
MassIVEiQ9BZZ5
PaxDbiQ9BZZ5
PeptideAtlasiQ9BZZ5
PRIDEiQ9BZZ5
ProteomicsDBi79926 [Q9BZZ5-4]
79927 [Q9BZZ5-1]
79928 [Q9BZZ5-2]
79929 [Q9BZZ5-3]
79930 [Q9BZZ5-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8539

Genome annotation databases

EnsembliENST00000378852; ENSP00000368129; ENSG00000166181 [Q9BZZ5-2]
ENST00000420461; ENSP00000402540; ENSG00000166181 [Q9BZZ5-5]
ENST00000455725; ENSP00000399341; ENSG00000166181 [Q9BZZ5-6]
ENST00000531273; ENSP00000431391; ENSG00000166181 [Q9BZZ5-4]
GeneIDi8539
KEGGihsa:8539
UCSCiuc001mxf.3 human [Q9BZZ5-4]
uc010rfg.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8539
DisGeNETi8539

GeneCards: human genes, protein and diseases

More...
GeneCardsi
API5
HGNCiHGNC:594 API5
HPAiHPA026598
MIMi609774 gene
neXtProtiNX_Q9BZZ5
OpenTargetsiENSG00000166181
PharmGKBiPA24881

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2213 Eukaryota
ENOG410XSH0 LUCA
GeneTreeiENSGT00390000010991
HOGENOMiHOG000239017
InParanoidiQ9BZZ5
OMAiFIQCATA
OrthoDBi1385954at2759
PhylomeDBiQ9BZZ5
TreeFamiTF324283

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
API5 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
API5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8539
PharosiQ9BZZ5

Protein Ontology

More...
PROi
PR:Q9BZZ5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166181 Expressed in 239 organ(s), highest expression level in frontal cortex
ExpressionAtlasiQ9BZZ5 baseline and differential
GenevisibleiQ9BZZ5 HS

Family and domain databases

InterProiView protein in InterPro
IPR008383 API5
IPR016024 ARM-type_fold
PANTHERiPTHR12758 PTHR12758, 1 hit
PfamiView protein in Pfam
PF05918 API5, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPI5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BZZ5
Secondary accession number(s): B4DGR0
, B4DRJ2, B4E283, D3DR21, O15441, Q9Y4J7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: October 19, 2011
Last modified: October 16, 2019
This is version 147 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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