SIGLEC1

Functionⁱ

Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity).

Binds to SPN/CD43 on T-cells (By similarity).

May play a role in hemopoiesis.

By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	63	Sialic acidBy similarity		1
Binding siteⁱ	116	Sialic acidBy similarity		1

GO - Molecular functionⁱ

carbohydrate binding
Source: UniProtKB
Non-traceable author statementⁱ
- Ref.1
  "Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations."
  Hartnell A., Steel J., Turley H., Jones M., Jackson D.G., Crocker P.R.
  Blood 97:288-296(2001) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION.
virion binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion, Endocytosis
Ligand	Lectin

Enzyme and pathway databases

PathwayCommonsⁱ	Q9BZZ2
Reactomeⁱ	R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sialoadhesin Alternative name(s): Sialic acid-binding Ig-like lectin 1 Short name: Siglec-1 CD_antigen: CD169
Gene namesⁱ	Name:SIGLEC1 Synonyms:SN
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11127, SIGLEC1
MIMⁱ	600751, gene
neXtProtⁱ	NX_Q9BZZ2
VEuPathDBⁱ	HostDB:ENSG00000088827

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	20 – 1641	ExtracellularSequence analysisAdd BLAST	1622
Transmembraneⁱ	1642 – 1662	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	1663 – 1709	CytoplasmicSequence analysisAdd BLAST	47

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6614
Open Targets More...OpenTargetsⁱ	ENSG00000088827
PharmGKBⁱ	PA35976

Miscellaneous databases

Pharosⁱ	Q9BZZ2, Tbio

Pharosⁱ

Q9BZZ2, Tbio

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB02379, Beta-D-Glucose DB03721, N-acetyl-alpha-neuraminic acid

DrugBankⁱ

DB02379, Beta-D-Glucose
DB03721, N-acetyl-alpha-neuraminic acid

Genetic variation databases

BioMutaⁱ	SIGLEC1
DMDMⁱ	18202745

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	By similarityAdd BLAST		19
ChainⁱPRO_0000014968	20 – 1709	SialoadhesinAdd BLAST		1690

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	36 ↔ 166	PROSITE-ProRule annotation
Disulfide bondⁱ	41 ↔ 98	PROSITE-ProRule annotation
Glycosylationⁱ	159	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	160 ↔ 217	PROSITE-ProRule annotation
Disulfide bondⁱ	262 ↔ 305	PROSITE-ProRule annotation
Glycosylationⁱ	265	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	339	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	346 ↔ 390	PROSITE-ProRule annotation
Disulfide bondⁱ	433 ↔ 491	PROSITE-ProRule annotation
Glycosylationⁱ	499	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	531 ↔ 575	PROSITE-ProRule annotation
Disulfide bondⁱ	624 ↔ 689	PROSITE-ProRule annotation
Glycosylationⁱ	697	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	726	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	729 ↔ 774	PROSITE-ProRule annotation
Glycosylationⁱ	730	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	741	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	817 ↔ 876	PROSITE-ProRule annotation
Glycosylationⁱ	886	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	916 ↔ 960	PROSITE-ProRule annotation
Disulfide bondⁱ	1005 ↔ 1067	PROSITE-ProRule annotation
Glycosylationⁱ	1104	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	1107 ↔ 1149	PROSITE-ProRule annotation
Glycosylationⁱ	1138	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	1193 ↔ 1241	PROSITE-ProRule annotation
Glycosylationⁱ	1251	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	1281 ↔ 1324	PROSITE-ProRule annotation
Disulfide bondⁱ	1367 ↔ 1425	PROSITE-ProRule annotation
Glycosylationⁱ	1462	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	1465 ↔ 1511	PROSITE-ProRule annotation
Glycosylationⁱ	1476	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	1554 ↔ 1613	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

jPOSTⁱ	Q9BZZ2
MassIVEⁱ	Q9BZZ2
PaxDbⁱ	Q9BZZ2
PeptideAtlas More...PeptideAtlasⁱ	Q9BZZ2
PRIDEⁱ	Q9BZZ2
ProteomicsDBⁱ	79923 [Q9BZZ2-1] 79924 [Q9BZZ2-2] 79925 [Q9BZZ2-3]

PTM databases

GlyGenⁱ	Q9BZZ2, 14 sites
iPTMnetⁱ	Q9BZZ2
PhosphoSitePlusⁱ	Q9BZZ2

Expressionⁱ

Tissue specificityⁱ

Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis.

Gene expression databases

Bgeeⁱ	ENSG00000088827, Expressed in tendon and 180 other tissues
ExpressionAtlasⁱ	Q9BZZ2, baseline and differential
Genevisibleⁱ	Q9BZZ2, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000088827, Tissue enhanced (lymphoid)

HPAⁱ

ENSG00000088827, Tissue enhanced (lymphoid)

Interactionⁱ

Protein-protein interaction databases

BioGRIDⁱ	112498, 1 interactor
STRINGⁱ	9606.ENSP00000341141

Miscellaneous databases

RNActⁱ	Q9BZZ2, protein

RNActⁱ

Q9BZZ2, protein

Structureⁱ

3D structure databases

SMRⁱ	Q9BZZ2
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	20 – 136	Ig-like V-typeAdd BLAST	117
Domainⁱ	139 – 233	Ig-like C2-type 1Add BLAST	95
Domainⁱ	238 – 320	Ig-like C2-type 2Add BLAST	83
Domainⁱ	326 – 405	Ig-like C2-type 3Add BLAST	80
Domainⁱ	411 – 507	Ig-like C2-type 4Add BLAST	97
Domainⁱ	511 – 593	Ig-like C2-type 5Add BLAST	83
Domainⁱ	601 – 705	Ig-like C2-type 6Add BLAST	105
Domainⁱ	708 – 785	Ig-like C2-type 7Add BLAST	78
Domainⁱ	799 – 894	Ig-like C2-type 8Add BLAST	96
Domainⁱ	898 – 977	Ig-like C2-type 9Add BLAST	80
Domainⁱ	984 – 1083	Ig-like C2-type 10Add BLAST	100
Domainⁱ	1085 – 1165	Ig-like C2-type 11Add BLAST	81
Domainⁱ	1176 – 1248	Ig-like C2-type 12Add BLAST	73
Domainⁱ	1259 – 1341	Ig-like C2-type 13Add BLAST	83
Domainⁱ	1350 – 1442	Ig-like C2-type 14Add BLAST	93
Domainⁱ	1445 – 1528	Ig-like C2-type 15Add BLAST	84
Domainⁱ	1536 – 1631	Ig-like C2-type 16Add BLAST	96

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	122 – 126	Sialic acid bindingBy similarity		5

Sequence similaritiesⁱ

Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4475, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT01040000240433
HOGENOMⁱ	CLU_243945_0_0_1
InParanoidⁱ	Q9BZZ2
OMAⁱ	FNSQKFE
Database of Orthologous Groups More...OrthoDBⁱ	54136at2759
PhylomeDBⁱ	Q9BZZ2
TreeFamⁱ	TF334827

Family and domain databases

Gene3Dⁱ	2.60.40.10, 17 hits
InterProⁱ	View protein in InterPro IPR013162, CD80_C2-set IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08205, C2-set_2, 1 hit PF07679, I-set, 2 hits PF13895, Ig_2, 6 hits PF07686, V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409, IG, 17 hits SM00408, IGc2, 14 hits
SUPFAMⁱ	SSF48726, SSF48726, 11 hits
PROSITEⁱ	View protein in PROSITE PS50835, IG_LIKE, 14 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9BZZ2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFLPKLLLL ASFFPAGQAS WGVSSPQDVQ GVKGSCLLIP CIFSFPADVE 
        60         70         80         90        100
VPDGITAIWY YDYSGQRQVV SHSADPKLVE ARFRGRTEFM GNPEHRVCNL 
       110        120        130        140        150
LLKDLQPEDS GSYNFRFEIS EVNRWSDVKG TLVTVTEEPR VPTIASPVEL 
       160        170        180        190        200
LEGTEVDFNC STPYVCLQEQ VRLQWQGQDP ARSVTFNSQK FEPTGVGHLE 
       210        220        230        240        250
TLHMAMSWQD HGRILRCQLS VANHRAQSEI HLQVKYAPKG VKILLSPSGR 
       260        270        280        290        300
NILPGELVTL TCQVNSSYPA VSSIKWLKDG VRLQTKTGVL HLPQAAWSDA 
       310        320        330        340        350
GVYTCQAENG VGSLVSPPIS LHIFMAEVQV SPAGPILENQ TVTLVCNTPN 
       360        370        380        390        400
EAPSDLRYSW YKNHVLLEDA HSHTLRLHLA TRADTGFYFC EVQNVHGSER 
       410        420        430        440        450
SGPVSVVVNH PPLTPVLTAF LETQAGLVGI LHCSVVSEPL ATLVLSHGGH 
       460        470        480        490        500
ILASTSGDSD HSPRFSGTSG PNSLRLEIRD LEETDSGEYK CSATNSLGNA 
       510        520        530        540        550
TSTLDFHANA ARLLISPAAE VVEGQAVTLS CRSGLSPTPD ARFSWYLNGA 
       560        570        580        590        600
LLHEGPGSSL LLPAASSTDA GSYHCRARDG HSASGPSSPA VLTVLYPPRQ 
       610        620        630        640        650
PTFTTRLDLD AAGAGAGRRG LLLCRVDSDP PARLQLLHKD RVVATSLPSG 
       660        670        680        690        700
GGCSTCGGCS PRMKVTKAPN LLRVEIHNPL LEEEGLYLCE ASNALGNAST 
       710        720        730        740        750
SATFNGQATV LAIAPSHTLQ EGTEANLTCN VSREAAGSPA NFSWFRNGVL 
       760        770        780        790        800
WAQGPLETVT LLPVARTDAA LYACRILTEA GAQLSTPVLL SVLYPPDRPK 
       810        820        830        840        850
LSALLDMGQG HMALFICTVD SRPLALLALF HGEHLLATSL GPQVPSHGRF 
       860        870        880        890        900
QAKAEANSLK LEVRELGLGD SGSYRCEATN VLGSSNTSLF FQVRGAWVQV 
       910        920        930        940        950
SPSPELQEGQ AVVLSCQVHT GVPEGTSYRW YRDGQPLQES TSATLRFAAI 
       960        970        980        990       1000
TLTQAGAYHC QAQAPGSATT SLAAPISLHV SYAPRHVTLT TLMDTGPGRL 
      1010       1020       1030       1040       1050
GLLLCRVDSD PPAQLRLLHG DRLVASTLQG VGGPEGSSPR LHVAVAPNTL 
      1060       1070       1080       1090       1100
RLEIHGAMLE DEGVYICEAS NTLGQASASA DFDAQAVNVQ VWPGATVREG 
      1110       1120       1130       1140       1150
QLVNLTCLVW TTHPAQLTYT WYQDGQQRLD AHSIPLPNVT VRDATSYRCG 
      1160       1170       1180       1190       1200
VGPPGRAPRL SRPITLDVLY APRNLRLTYL LESHGGQLAL VLCTVDSRPP 
      1210       1220       1230       1240       1250
AQLALSHAGR LLASSTAASV PNTLRLELRG PQPRDEGFYS CSARSPLGQA 
      1260       1270       1280       1290       1300
NTSLELRLEG VRVILAPEAA VPEGAPITVT CADPAAHAPT LYTWYHNGRW 
      1310       1320       1330       1340       1350
LQEGPAASLS FLVATRAHAG AYSCQAQDAQ GTRSSRPAAL QVLYAPQDAV 
      1360       1370       1380       1390       1400
LSSFRDSRAR SMAVIQCTVD SEPPAELALS HDGKVLATSS GVHSLASGTG 
      1410       1420       1430       1440       1450
HVQVARNALR LQVQDVPAGD DTYVCTAQNL LGSISTIGRL QVEGARVVAE 
      1460       1470       1480       1490       1500
PGLDVPEGAA LNLSCRLLGG PGPVGNSTFA WFWNDRRLHA EPVPTLAFTH 
      1510       1520       1530       1540       1550
VARAQAGMYH CLAELPTGAA ASAPVMLRVL YPPKTPTMMV FVEPEGGLRG 
      1560       1570       1580       1590       1600
ILDCRVDSEP LASLTLHLGS RLVASSQPQG APAEPHIHVL ASPNALRVDI 
      1610       1620       1630       1640       1650
EALRPSDQGE YICSASNVLG SASTSTYFGV RALHRLHQFQ QLLWVLGLLV 
      1660       1670       1680       1690       1700
GLLLLLLGLG ACYTWRRRRV CKQSMGENSV EMAFQKETTQ LIDPDAATCE 

TSTCAPPLG

Length:1,709

Mass (Da):182,624

Last modified:October 18, 2001 - v2

Checksum:ⁱ587C7CCA0B789A6D

GO

Isoform 2 (identifier: Q9BZZ2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1632-1709: ALHRLHQFQQ...ETSTCAPPLG → GEGRGLHLPGHSAQKPSS

« Hide

        10         20         30         40         50
MGFLPKLLLL ASFFPAGQAS WGVSSPQDVQ GVKGSCLLIP CIFSFPADVE 
        60         70         80         90        100
VPDGITAIWY YDYSGQRQVV SHSADPKLVE ARFRGRTEFM GNPEHRVCNL 
       110        120        130        140        150
LLKDLQPEDS GSYNFRFEIS EVNRWSDVKG TLVTVTEEPR VPTIASPVEL 
       160        170        180        190        200
LEGTEVDFNC STPYVCLQEQ VRLQWQGQDP ARSVTFNSQK FEPTGVGHLE 
       210        220        230        240        250
TLHMAMSWQD HGRILRCQLS VANHRAQSEI HLQVKYAPKG VKILLSPSGR 
       260        270        280        290        300
NILPGELVTL TCQVNSSYPA VSSIKWLKDG VRLQTKTGVL HLPQAAWSDA 
       310        320        330        340        350
GVYTCQAENG VGSLVSPPIS LHIFMAEVQV SPAGPILENQ TVTLVCNTPN 
       360        370        380        390        400
EAPSDLRYSW YKNHVLLEDA HSHTLRLHLA TRADTGFYFC EVQNVHGSER 
       410        420        430        440        450
SGPVSVVVNH PPLTPVLTAF LETQAGLVGI LHCSVVSEPL ATLVLSHGGH 
       460        470        480        490        500
ILASTSGDSD HSPRFSGTSG PNSLRLEIRD LEETDSGEYK CSATNSLGNA 
       510        520        530        540        550
TSTLDFHANA ARLLISPAAE VVEGQAVTLS CRSGLSPTPD ARFSWYLNGA 
       560        570        580        590        600
LLHEGPGSSL LLPAASSTDA GSYHCRARDG HSASGPSSPA VLTVLYPPRQ 
       610        620        630        640        650
PTFTTRLDLD AAGAGAGRRG LLLCRVDSDP PARLQLLHKD RVVATSLPSG 
       660        670        680        690        700
GGCSTCGGCS PRMKVTKAPN LLRVEIHNPL LEEEGLYLCE ASNALGNAST 
       710        720        730        740        750
SATFNGQATV LAIAPSHTLQ EGTEANLTCN VSREAAGSPA NFSWFRNGVL 
       760        770        780        790        800
WAQGPLETVT LLPVARTDAA LYACRILTEA GAQLSTPVLL SVLYPPDRPK 
       810        820        830        840        850
LSALLDMGQG HMALFICTVD SRPLALLALF HGEHLLATSL GPQVPSHGRF 
       860        870        880        890        900
QAKAEANSLK LEVRELGLGD SGSYRCEATN VLGSSNTSLF FQVRGAWVQV 
       910        920        930        940        950
SPSPELQEGQ AVVLSCQVHT GVPEGTSYRW YRDGQPLQES TSATLRFAAI 
       960        970        980        990       1000
TLTQAGAYHC QAQAPGSATT SLAAPISLHV SYAPRHVTLT TLMDTGPGRL 
      1010       1020       1030       1040       1050
GLLLCRVDSD PPAQLRLLHG DRLVASTLQG VGGPEGSSPR LHVAVAPNTL 
      1060       1070       1080       1090       1100
RLEIHGAMLE DEGVYICEAS NTLGQASASA DFDAQAVNVQ VWPGATVREG 
      1110       1120       1130       1140       1150
QLVNLTCLVW TTHPAQLTYT WYQDGQQRLD AHSIPLPNVT VRDATSYRCG 
      1160       1170       1180       1190       1200
VGPPGRAPRL SRPITLDVLY APRNLRLTYL LESHGGQLAL VLCTVDSRPP 
      1210       1220       1230       1240       1250
AQLALSHAGR LLASSTAASV PNTLRLELRG PQPRDEGFYS CSARSPLGQA 
      1260       1270       1280       1290       1300
NTSLELRLEG VRVILAPEAA VPEGAPITVT CADPAAHAPT LYTWYHNGRW 
      1310       1320       1330       1340       1350
LQEGPAASLS FLVATRAHAG AYSCQAQDAQ GTRSSRPAAL QVLYAPQDAV 
      1360       1370       1380       1390       1400
LSSFRDSRAR SMAVIQCTVD SEPPAELALS HDGKVLATSS GVHSLASGTG 
      1410       1420       1430       1440       1450
HVQVARNALR LQVQDVPAGD DTYVCTAQNL LGSISTIGRL QVEGARVVAE 
      1460       1470       1480       1490       1500
PGLDVPEGAA LNLSCRLLGG PGPVGNSTFA WFWNDRRLHA EPVPTLAFTH 
      1510       1520       1530       1540       1550
VARAQAGMYH CLAELPTGAA ASAPVMLRVL YPPKTPTMMV FVEPEGGLRG 
      1560       1570       1580       1590       1600
ILDCRVDSEP LASLTLHLGS RLVASSQPQG APAEPHIHVL ASPNALRVDI 
      1610       1620       1630       1640 
EALRPSDQGE YICSASNVLG SASTSTYFGV RGEGRGLHLP GHSAQKPSS

Show »

Length:1,649

Mass (Da):175,727

Checksum:ⁱ460B32A6B1577C4F

GO

Isoform 3 (identifier: Q9BZZ2-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1666-1709: RRRRVCKQSM...ETSTCAPPLG → SSLILMQPHV...PSGGESGQNL

« Hide

        10         20         30         40         50
MGFLPKLLLL ASFFPAGQAS WGVSSPQDVQ GVKGSCLLIP CIFSFPADVE 
        60         70         80         90        100
VPDGITAIWY YDYSGQRQVV SHSADPKLVE ARFRGRTEFM GNPEHRVCNL 
       110        120        130        140        150
LLKDLQPEDS GSYNFRFEIS EVNRWSDVKG TLVTVTEEPR VPTIASPVEL 
       160        170        180        190        200
LEGTEVDFNC STPYVCLQEQ VRLQWQGQDP ARSVTFNSQK FEPTGVGHLE 
       210        220        230        240        250
TLHMAMSWQD HGRILRCQLS VANHRAQSEI HLQVKYAPKG VKILLSPSGR 
       260        270        280        290        300
NILPGELVTL TCQVNSSYPA VSSIKWLKDG VRLQTKTGVL HLPQAAWSDA 
       310        320        330        340        350
GVYTCQAENG VGSLVSPPIS LHIFMAEVQV SPAGPILENQ TVTLVCNTPN 
       360        370        380        390        400
EAPSDLRYSW YKNHVLLEDA HSHTLRLHLA TRADTGFYFC EVQNVHGSER 
       410        420        430        440        450
SGPVSVVVNH PPLTPVLTAF LETQAGLVGI LHCSVVSEPL ATLVLSHGGH 
       460        470        480        490        500
ILASTSGDSD HSPRFSGTSG PNSLRLEIRD LEETDSGEYK CSATNSLGNA 
       510        520        530        540        550
TSTLDFHANA ARLLISPAAE VVEGQAVTLS CRSGLSPTPD ARFSWYLNGA 
       560        570        580        590        600
LLHEGPGSSL LLPAASSTDA GSYHCRARDG HSASGPSSPA VLTVLYPPRQ 
       610        620        630        640        650
PTFTTRLDLD AAGAGAGRRG LLLCRVDSDP PARLQLLHKD RVVATSLPSG 
       660        670        680        690        700
GGCSTCGGCS PRMKVTKAPN LLRVEIHNPL LEEEGLYLCE ASNALGNAST 
       710        720        730        740        750
SATFNGQATV LAIAPSHTLQ EGTEANLTCN VSREAAGSPA NFSWFRNGVL 
       760        770        780        790        800
WAQGPLETVT LLPVARTDAA LYACRILTEA GAQLSTPVLL SVLYPPDRPK 
       810        820        830        840        850
LSALLDMGQG HMALFICTVD SRPLALLALF HGEHLLATSL GPQVPSHGRF 
       860        870        880        890        900
QAKAEANSLK LEVRELGLGD SGSYRCEATN VLGSSNTSLF FQVRGAWVQV 
       910        920        930        940        950
SPSPELQEGQ AVVLSCQVHT GVPEGTSYRW YRDGQPLQES TSATLRFAAI 
       960        970        980        990       1000
TLTQAGAYHC QAQAPGSATT SLAAPISLHV SYAPRHVTLT TLMDTGPGRL 
      1010       1020       1030       1040       1050
GLLLCRVDSD PPAQLRLLHG DRLVASTLQG VGGPEGSSPR LHVAVAPNTL 
      1060       1070       1080       1090       1100
RLEIHGAMLE DEGVYICEAS NTLGQASASA DFDAQAVNVQ VWPGATVREG 
      1110       1120       1130       1140       1150
QLVNLTCLVW TTHPAQLTYT WYQDGQQRLD AHSIPLPNVT VRDATSYRCG 
      1160       1170       1180       1190       1200
VGPPGRAPRL SRPITLDVLY APRNLRLTYL LESHGGQLAL VLCTVDSRPP 
      1210       1220       1230       1240       1250
AQLALSHAGR LLASSTAASV PNTLRLELRG PQPRDEGFYS CSARSPLGQA 
      1260       1270       1280       1290       1300
NTSLELRLEG VRVILAPEAA VPEGAPITVT CADPAAHAPT LYTWYHNGRW 
      1310       1320       1330       1340       1350
LQEGPAASLS FLVATRAHAG AYSCQAQDAQ GTRSSRPAAL QVLYAPQDAV 
      1360       1370       1380       1390       1400
LSSFRDSRAR SMAVIQCTVD SEPPAELALS HDGKVLATSS GVHSLASGTG 
      1410       1420       1430       1440       1450
HVQVARNALR LQVQDVPAGD DTYVCTAQNL LGSISTIGRL QVEGARVVAE 
      1460       1470       1480       1490       1500
PGLDVPEGAA LNLSCRLLGG PGPVGNSTFA WFWNDRRLHA EPVPTLAFTH 
      1510       1520       1530       1540       1550
VARAQAGMYH CLAELPTGAA ASAPVMLRVL YPPKTPTMMV FVEPEGGLRG 
      1560       1570       1580       1590       1600
ILDCRVDSEP LASLTLHLGS RLVASSQPQG APAEPHIHVL ASPNALRVDI 
      1610       1620       1630       1640       1650
EALRPSDQGE YICSASNVLG SASTSTYFGV RALHRLHQFQ QLLWVLGLLV 
      1660       1670       1680       1690       1700
GLLLLLLGLG ACYTWSSLIL MQPHVRPQPV PHPWADQWCC LPSGGESGQN 

L

Show »

Length:1,701

Mass (Da):181,733

Checksum:ⁱCB39EDDAB09606E6

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H7C0M6	H7C0M6_HUMAN		Sialoadhesin Sialoadhesin	SIGLEC1	463	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	1349	A → T in AAK00757 (PubMed:11133773).Curated	1
Sequence conflictⁱ	1519	A → V in BAB15749 (PubMed:11214971).Curated	1
Sequence conflictⁱ	1519	A → V in BAB15769 (PubMed:11214971).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_049943	141	V → L. Corresponds to variant dbSNP:rs35953127Ensembl.	1
Natural variantⁱVAR_024502	221	V → M. Corresponds to variant dbSNP:rs6037651Ensembl.	1
Natural variantⁱVAR_014136	239	K → R. Corresponds to variant dbSNP:rs625372Ensembl.	1
Natural variantⁱVAR_049944	464	R → H. Corresponds to variant dbSNP:rs34924243Ensembl.	1
Natural variantⁱVAR_014137	919	H → P. Corresponds to variant dbSNP:rs709012Ensembl.	1
Natural variantⁱVAR_021926	974	A → V. Corresponds to variant dbSNP:rs3746638Ensembl.	1
Natural variantⁱVAR_021927	1335	S → Y. Corresponds to variant dbSNP:rs3746636Ensembl.	1
Natural variantⁱVAR_049945	1487	R → W. Corresponds to variant dbSNP:rs16988873Ensembl.	1
Natural variantⁱVAR_014138	1519	A → P. Corresponds to variant dbSNP:rs2853217Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_002571	1632 – 1709	ALHRL…APPLG → GEGRGLHLPGHSAQKPSS in isoform 2. 1 PublicationAdd BLAST		78
Alternative sequenceⁱVSP_002572	1666 – 1709	RRRRV…APPLG → SSLILMQPHVRPQPVPHPWA DQWCCLPSGGESGQNL in isoform 3. 1 PublicationAdd BLAST		44

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF230073 mRNA Translation: AAK00757.1 AL109804 Genomic DNA No translation available. AK024459 mRNA Translation: BAB15749.1 AK024462 mRNA Translation: BAB15752.1 AK024479 mRNA Translation: BAB15769.1 AK057560 mRNA Translation: BAB71527.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13060.1 [Q9BZZ2-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_075556.1, NM_023068.3 [Q9BZZ2-1] XP_006723673.1, XM_006723610.3 XP_011527626.1, XM_011529324.2 XP_011527627.1, XM_011529325.2 XP_011527628.1, XM_011529326.2 XP_011527629.1, XM_011529327.2 XP_011527630.1, XM_011529328.2 XP_011527631.1, XM_011529329.1

Genome annotation databases

Ensemblⁱ	ENST00000344754; ENSP00000341141; ENSG00000088827 [Q9BZZ2-1]
GeneIDⁱ	6614
KEGGⁱ	hsa:6614
UCSC genome browser More...UCSCⁱ	uc002wja.3, human [Q9BZZ2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BZZ2	Sialic acid binding Ig like lectin 1		CERAT		1709	UniRef90_Q9BZZ2
Uncharacterized protein		RHIRO		1709
Sialic acid binding Ig like lectin 1		MACMU		1709
Sialic acid binding Ig like lectin 1		PAPAN		1709
Sialic acid binding Ig like lectin 1		MACFA		1709
+43

Protein	Similar proteins		Species	Score	Length	Source
Q9BZZ2	Sialoadhesin	)	MOUSE		1695	UniRef50_Q62230
Sialoadhesin		PIG		1730
sialoadhesin isoform X1		MUSCR		1719
SN protein (Fragment)		CROCR		1662
sialoadhesin		PUMCO		1757
+415

Cross-referencesⁱ

Web resourcesⁱ

Functional Glycomics Gateway - Glycan Binding

Siglec-1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF230073 mRNA Translation: AAK00757.1 AL109804 Genomic DNA No translation available. AK024459 mRNA Translation: BAB15749.1 AK024462 mRNA Translation: BAB15752.1 AK024479 mRNA Translation: BAB15769.1 AK057560 mRNA Translation: BAB71527.1
CCDSⁱ	CCDS13060.1 [Q9BZZ2-1]
RefSeqⁱ	NP_075556.1, NM_023068.3 [Q9BZZ2-1] XP_006723673.1, XM_006723610.3 XP_011527626.1, XM_011529324.2 XP_011527627.1, XM_011529325.2 XP_011527628.1, XM_011529326.2 XP_011527629.1, XM_011529327.2 XP_011527630.1, XM_011529328.2 XP_011527631.1, XM_011529329.1

3D structure databases

SMRⁱ	Q9BZZ2
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	112498, 1 interactor
STRINGⁱ	9606.ENSP00000341141

Chemistry databases

DrugBankⁱ	DB02379, Beta-D-Glucose DB03721, N-acetyl-alpha-neuraminic acid

DrugBankⁱ

DB02379, Beta-D-Glucose
DB03721, N-acetyl-alpha-neuraminic acid

PTM databases

GlyGenⁱ	Q9BZZ2, 14 sites
iPTMnetⁱ	Q9BZZ2
PhosphoSitePlusⁱ	Q9BZZ2

Genetic variation databases

BioMutaⁱ	SIGLEC1
DMDMⁱ	18202745

Proteomic databases

jPOSTⁱ	Q9BZZ2
MassIVEⁱ	Q9BZZ2
PaxDbⁱ	Q9BZZ2
PeptideAtlasⁱ	Q9BZZ2
PRIDEⁱ	Q9BZZ2
ProteomicsDBⁱ	79923 [Q9BZZ2-1] 79924 [Q9BZZ2-2] 79925 [Q9BZZ2-3]

Protocols and materials databases

Antibodypediaⁱ	7559, 707 antibodies
The CPTC Antibody Portal More...CPTCⁱ	Q9BZZ2, 1 antibody
The DNASU plasmid repository More...DNASUⁱ	6614

Genome annotation databases

Ensemblⁱ	ENST00000344754; ENSP00000341141; ENSG00000088827 [Q9BZZ2-1]
GeneIDⁱ	6614
KEGGⁱ	hsa:6614
UCSCⁱ	uc002wja.3, human [Q9BZZ2-1]

Organism-specific databases

CTDⁱ	6614
DisGeNETⁱ	6614
GeneCardsⁱ	SIGLEC1
HGNCⁱ	HGNC:11127, SIGLEC1
HPAⁱ	ENSG00000088827, Tissue enhanced (lymphoid)
MIMⁱ	600751, gene
neXtProtⁱ	NX_Q9BZZ2
OpenTargetsⁱ	ENSG00000088827
PharmGKBⁱ	PA35976
VEuPathDBⁱ	HostDB:ENSG00000088827
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4475, Eukaryota
GeneTreeⁱ	ENSGT01040000240433
HOGENOMⁱ	CLU_243945_0_0_1
InParanoidⁱ	Q9BZZ2
OMAⁱ	FNSQKFE
OrthoDBⁱ	54136at2759
PhylomeDBⁱ	Q9BZZ2
TreeFamⁱ	TF334827

Enzyme and pathway databases

PathwayCommonsⁱ	Q9BZZ2
Reactomeⁱ	R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

BioGRID-ORCSⁱ	6614, 12 hits in 1007 CRISPR screens
ChiTaRSⁱ	SIGLEC1, human
GenomeRNAiⁱ	6614
Pharosⁱ	Q9BZZ2, Tbio
Protein Ontology More...PROⁱ	PR:Q9BZZ2
RNActⁱ	Q9BZZ2, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000088827, Expressed in tendon and 180 other tissues
ExpressionAtlasⁱ	Q9BZZ2, baseline and differential
Genevisibleⁱ	Q9BZZ2, HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 17 hits
InterProⁱ	View protein in InterPro IPR013162, CD80_C2-set IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set
Pfamⁱ	View protein in Pfam PF08205, C2-set_2, 1 hit PF07679, I-set, 2 hits PF13895, Ig_2, 6 hits PF07686, V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409, IG, 17 hits SM00408, IGc2, 14 hits
SUPFAMⁱ	SSF48726, SSF48726, 11 hits
PROSITEⁱ	View protein in PROSITE PS50835, IG_LIKE, 14 hits
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SN_HUMAN
Accessionⁱ	Q9BZZ2Primary (citable) accession number: Q9BZZ2 Secondary accession number(s): Q96DL4 , Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
	Last sequence update:	October 18, 2001
	Last modified:	September 29, 2021
	This is version 182 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

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Supporting data

UniProtKB - Q9BZZ2 (SN_HUMAN)

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Sialoadhesin

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Endosome

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ