UniProtKB - Q9BZZ2 (SN_HUMAN)
Protein
Sialoadhesin
Gene
SIGLEC1
Organism
Homo sapiens (Human)
Status
Functioni
Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 63 | Sialic acidBy similarity | 1 | |
Binding sitei | 116 | Sialic acidBy similarity | 1 |
GO - Molecular functioni
- carbohydrate binding Source: UniProtKB
- virion binding Source: GO_Central
GO - Biological processi
- cell-cell adhesion Source: UniProtKB
- cell-matrix adhesion Source: UniProtKB
- clathrin-dependent endocytosis of virus by host cell Source: GO_Central
- inflammatory response Source: UniProtKB
Keywordsi
Biological process | Cell adhesion, Endocytosis |
Ligand | Lectin |
Enzyme and pathway databases
PathwayCommonsi | Q9BZZ2 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Names & Taxonomyi
Protein namesi | Recommended name: SialoadhesinAlternative name(s): Sialic acid-binding Ig-like lectin 1 Short name: Siglec-1 CD_antigen: CD169 |
Gene namesi | Name:SIGLEC1 Synonyms:SN |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000088827.12 |
HGNCi | HGNC:11127, SIGLEC1 |
MIMi | 600751, gene |
neXtProti | NX_Q9BZZ2 |
Subcellular locationi
Plasma membrane
Extracellular region or secreted
Endosome
- early endosome Source: GO_Central
- late endosome Source: GO_Central
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 1641 | ExtracellularSequence analysisAdd BLAST | 1622 | |
Transmembranei | 1642 – 1662 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1663 – 1709 | CytoplasmicSequence analysisAdd BLAST | 47 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 6614 |
OpenTargetsi | ENSG00000088827 |
PharmGKBi | PA35976 |
Miscellaneous databases
Pharosi | Q9BZZ2, Tbio |
Chemistry databases
DrugBanki | DB02379, Beta-D-Glucose DB03721, N-acetyl-alpha-neuraminic acid |
Polymorphism and mutation databases
BioMutai | SIGLEC1 |
DMDMi | 18202745 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | By similarityAdd BLAST | 19 | |
ChainiPRO_0000014968 | 20 – 1709 | SialoadhesinAdd BLAST | 1690 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 36 ↔ 166 | PROSITE-ProRule annotation | ||
Disulfide bondi | 41 ↔ 98 | PROSITE-ProRule annotation | ||
Glycosylationi | 159 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 160 ↔ 217 | PROSITE-ProRule annotation | ||
Disulfide bondi | 262 ↔ 305 | PROSITE-ProRule annotation | ||
Glycosylationi | 265 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 339 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 346 ↔ 390 | PROSITE-ProRule annotation | ||
Disulfide bondi | 433 ↔ 491 | PROSITE-ProRule annotation | ||
Glycosylationi | 499 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 531 ↔ 575 | PROSITE-ProRule annotation | ||
Disulfide bondi | 624 ↔ 689 | PROSITE-ProRule annotation | ||
Glycosylationi | 697 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 726 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 729 ↔ 774 | PROSITE-ProRule annotation | ||
Glycosylationi | 730 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 741 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 817 ↔ 876 | PROSITE-ProRule annotation | ||
Glycosylationi | 886 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 916 ↔ 960 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1005 ↔ 1067 | PROSITE-ProRule annotation | ||
Glycosylationi | 1104 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1107 ↔ 1149 | PROSITE-ProRule annotation | ||
Glycosylationi | 1138 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1193 ↔ 1241 | PROSITE-ProRule annotation | ||
Glycosylationi | 1251 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1281 ↔ 1324 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1367 ↔ 1425 | PROSITE-ProRule annotation | ||
Glycosylationi | 1462 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1465 ↔ 1511 | PROSITE-ProRule annotation | ||
Glycosylationi | 1476 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1554 ↔ 1613 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q9BZZ2 |
MassIVEi | Q9BZZ2 |
PaxDbi | Q9BZZ2 |
PeptideAtlasi | Q9BZZ2 |
PRIDEi | Q9BZZ2 |
ProteomicsDBi | 79923 [Q9BZZ2-1] 79924 [Q9BZZ2-2] 79925 [Q9BZZ2-3] |
PTM databases
GlyGeni | Q9BZZ2, 14 sites |
iPTMneti | Q9BZZ2 |
PhosphoSitePlusi | Q9BZZ2 |
Expressioni
Tissue specificityi
Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis.
Gene expression databases
Bgeei | ENSG00000088827, Expressed in tendon and 179 other tissues |
ExpressionAtlasi | Q9BZZ2, baseline and differential |
Genevisiblei | Q9BZZ2, HS |
Organism-specific databases
HPAi | ENSG00000088827, Tissue enhanced (lymphoid) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000341141 |
Miscellaneous databases
RNActi | Q9BZZ2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 136 | Ig-like V-typeAdd BLAST | 117 | |
Domaini | 139 – 233 | Ig-like C2-type 1Add BLAST | 95 | |
Domaini | 238 – 320 | Ig-like C2-type 2Add BLAST | 83 | |
Domaini | 326 – 405 | Ig-like C2-type 3Add BLAST | 80 | |
Domaini | 411 – 507 | Ig-like C2-type 4Add BLAST | 97 | |
Domaini | 511 – 593 | Ig-like C2-type 5Add BLAST | 83 | |
Domaini | 601 – 705 | Ig-like C2-type 6Add BLAST | 105 | |
Domaini | 708 – 785 | Ig-like C2-type 7Add BLAST | 78 | |
Domaini | 799 – 894 | Ig-like C2-type 8Add BLAST | 96 | |
Domaini | 898 – 977 | Ig-like C2-type 9Add BLAST | 80 | |
Domaini | 984 – 1083 | Ig-like C2-type 10Add BLAST | 100 | |
Domaini | 1085 – 1165 | Ig-like C2-type 11Add BLAST | 81 | |
Domaini | 1176 – 1248 | Ig-like C2-type 12Add BLAST | 73 | |
Domaini | 1259 – 1341 | Ig-like C2-type 13Add BLAST | 83 | |
Domaini | 1350 – 1442 | Ig-like C2-type 14Add BLAST | 93 | |
Domaini | 1445 – 1528 | Ig-like C2-type 15Add BLAST | 84 | |
Domaini | 1536 – 1631 | Ig-like C2-type 16Add BLAST | 96 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 122 – 126 | Sialic acid bindingBy similarity | 5 |
Sequence similaritiesi
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.Curated
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4475, Eukaryota |
GeneTreei | ENSGT01000000214496 |
HOGENOMi | CLU_243945_0_0_1 |
InParanoidi | Q9BZZ2 |
OMAi | FWNDRRL |
OrthoDBi | 54136at2759 |
PhylomeDBi | Q9BZZ2 |
TreeFami | TF334827 |
Family and domain databases
Gene3Di | 2.60.40.10, 17 hits |
InterProi | View protein in InterPro IPR013162, CD80_C2-set IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF08205, C2-set_2, 1 hit PF07679, I-set, 2 hits PF13895, Ig_2, 6 hits PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 17 hits SM00408, IGc2, 14 hits |
SUPFAMi | SSF48726, SSF48726, 11 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 14 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketNote: Additional isoforms seem to exist.
This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9BZZ2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGFLPKLLLL ASFFPAGQAS WGVSSPQDVQ GVKGSCLLIP CIFSFPADVE
60 70 80 90 100
VPDGITAIWY YDYSGQRQVV SHSADPKLVE ARFRGRTEFM GNPEHRVCNL
110 120 130 140 150
LLKDLQPEDS GSYNFRFEIS EVNRWSDVKG TLVTVTEEPR VPTIASPVEL
160 170 180 190 200
LEGTEVDFNC STPYVCLQEQ VRLQWQGQDP ARSVTFNSQK FEPTGVGHLE
210 220 230 240 250
TLHMAMSWQD HGRILRCQLS VANHRAQSEI HLQVKYAPKG VKILLSPSGR
260 270 280 290 300
NILPGELVTL TCQVNSSYPA VSSIKWLKDG VRLQTKTGVL HLPQAAWSDA
310 320 330 340 350
GVYTCQAENG VGSLVSPPIS LHIFMAEVQV SPAGPILENQ TVTLVCNTPN
360 370 380 390 400
EAPSDLRYSW YKNHVLLEDA HSHTLRLHLA TRADTGFYFC EVQNVHGSER
410 420 430 440 450
SGPVSVVVNH PPLTPVLTAF LETQAGLVGI LHCSVVSEPL ATLVLSHGGH
460 470 480 490 500
ILASTSGDSD HSPRFSGTSG PNSLRLEIRD LEETDSGEYK CSATNSLGNA
510 520 530 540 550
TSTLDFHANA ARLLISPAAE VVEGQAVTLS CRSGLSPTPD ARFSWYLNGA
560 570 580 590 600
LLHEGPGSSL LLPAASSTDA GSYHCRARDG HSASGPSSPA VLTVLYPPRQ
610 620 630 640 650
PTFTTRLDLD AAGAGAGRRG LLLCRVDSDP PARLQLLHKD RVVATSLPSG
660 670 680 690 700
GGCSTCGGCS PRMKVTKAPN LLRVEIHNPL LEEEGLYLCE ASNALGNAST
710 720 730 740 750
SATFNGQATV LAIAPSHTLQ EGTEANLTCN VSREAAGSPA NFSWFRNGVL
760 770 780 790 800
WAQGPLETVT LLPVARTDAA LYACRILTEA GAQLSTPVLL SVLYPPDRPK
810 820 830 840 850
LSALLDMGQG HMALFICTVD SRPLALLALF HGEHLLATSL GPQVPSHGRF
860 870 880 890 900
QAKAEANSLK LEVRELGLGD SGSYRCEATN VLGSSNTSLF FQVRGAWVQV
910 920 930 940 950
SPSPELQEGQ AVVLSCQVHT GVPEGTSYRW YRDGQPLQES TSATLRFAAI
960 970 980 990 1000
TLTQAGAYHC QAQAPGSATT SLAAPISLHV SYAPRHVTLT TLMDTGPGRL
1010 1020 1030 1040 1050
GLLLCRVDSD PPAQLRLLHG DRLVASTLQG VGGPEGSSPR LHVAVAPNTL
1060 1070 1080 1090 1100
RLEIHGAMLE DEGVYICEAS NTLGQASASA DFDAQAVNVQ VWPGATVREG
1110 1120 1130 1140 1150
QLVNLTCLVW TTHPAQLTYT WYQDGQQRLD AHSIPLPNVT VRDATSYRCG
1160 1170 1180 1190 1200
VGPPGRAPRL SRPITLDVLY APRNLRLTYL LESHGGQLAL VLCTVDSRPP
1210 1220 1230 1240 1250
AQLALSHAGR LLASSTAASV PNTLRLELRG PQPRDEGFYS CSARSPLGQA
1260 1270 1280 1290 1300
NTSLELRLEG VRVILAPEAA VPEGAPITVT CADPAAHAPT LYTWYHNGRW
1310 1320 1330 1340 1350
LQEGPAASLS FLVATRAHAG AYSCQAQDAQ GTRSSRPAAL QVLYAPQDAV
1360 1370 1380 1390 1400
LSSFRDSRAR SMAVIQCTVD SEPPAELALS HDGKVLATSS GVHSLASGTG
1410 1420 1430 1440 1450
HVQVARNALR LQVQDVPAGD DTYVCTAQNL LGSISTIGRL QVEGARVVAE
1460 1470 1480 1490 1500
PGLDVPEGAA LNLSCRLLGG PGPVGNSTFA WFWNDRRLHA EPVPTLAFTH
1510 1520 1530 1540 1550
VARAQAGMYH CLAELPTGAA ASAPVMLRVL YPPKTPTMMV FVEPEGGLRG
1560 1570 1580 1590 1600
ILDCRVDSEP LASLTLHLGS RLVASSQPQG APAEPHIHVL ASPNALRVDI
1610 1620 1630 1640 1650
EALRPSDQGE YICSASNVLG SASTSTYFGV RALHRLHQFQ QLLWVLGLLV
1660 1670 1680 1690 1700
GLLLLLLGLG ACYTWRRRRV CKQSMGENSV EMAFQKETTQ LIDPDAATCE
TSTCAPPLG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C0M6 | H7C0M6_HUMAN | Sialoadhesin | SIGLEC1 | 463 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1349 | A → T in AAK00757 (PubMed:11133773).Curated | 1 | |
Sequence conflicti | 1519 | A → V in BAB15749 (PubMed:11214971).Curated | 1 | |
Sequence conflicti | 1519 | A → V in BAB15769 (PubMed:11214971).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049943 | 141 | V → L. Corresponds to variant dbSNP:rs35953127Ensembl. | 1 | |
Natural variantiVAR_024502 | 221 | V → M. Corresponds to variant dbSNP:rs6037651Ensembl. | 1 | |
Natural variantiVAR_014136 | 239 | K → R. Corresponds to variant dbSNP:rs625372Ensembl. | 1 | |
Natural variantiVAR_049944 | 464 | R → H. Corresponds to variant dbSNP:rs34924243Ensembl. | 1 | |
Natural variantiVAR_014137 | 919 | H → P. Corresponds to variant dbSNP:rs709012Ensembl. | 1 | |
Natural variantiVAR_021926 | 974 | A → V. Corresponds to variant dbSNP:rs3746638Ensembl. | 1 | |
Natural variantiVAR_021927 | 1335 | S → Y. Corresponds to variant dbSNP:rs3746636Ensembl. | 1 | |
Natural variantiVAR_049945 | 1487 | R → W. Corresponds to variant dbSNP:rs16988873Ensembl. | 1 | |
Natural variantiVAR_014138 | 1519 | A → P. Corresponds to variant dbSNP:rs2853217Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002571 | 1632 – 1709 | ALHRL…APPLG → GEGRGLHLPGHSAQKPSS in isoform 2. 1 PublicationAdd BLAST | 78 | |
Alternative sequenceiVSP_002572 | 1666 – 1709 | RRRRV…APPLG → SSLILMQPHVRPQPVPHPWA DQWCCLPSGGESGQNL in isoform 3. 1 PublicationAdd BLAST | 44 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF230073 mRNA Translation: AAK00757.1 AL109804 Genomic DNA No translation available. AK024459 mRNA Translation: BAB15749.1 AK024462 mRNA Translation: BAB15752.1 AK024479 mRNA Translation: BAB15769.1 AK057560 mRNA Translation: BAB71527.1 |
CCDSi | CCDS13060.1 [Q9BZZ2-1] |
RefSeqi | NP_075556.1, NM_023068.3 [Q9BZZ2-1] XP_006723673.1, XM_006723610.3 XP_011527626.1, XM_011529324.2 XP_011527627.1, XM_011529325.2 XP_011527628.1, XM_011529326.2 XP_011527629.1, XM_011529327.2 XP_011527630.1, XM_011529328.2 XP_011527631.1, XM_011529329.1 |
Genome annotation databases
Ensembli | ENST00000344754; ENSP00000341141; ENSG00000088827 [Q9BZZ2-1] |
GeneIDi | 6614 |
KEGGi | hsa:6614 |
UCSCi | uc002wja.3, human [Q9BZZ2-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Functional Glycomics Gateway - Glycan Binding Siglec-1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF230073 mRNA Translation: AAK00757.1 AL109804 Genomic DNA No translation available. AK024459 mRNA Translation: BAB15749.1 AK024462 mRNA Translation: BAB15752.1 AK024479 mRNA Translation: BAB15769.1 AK057560 mRNA Translation: BAB71527.1 |
CCDSi | CCDS13060.1 [Q9BZZ2-1] |
RefSeqi | NP_075556.1, NM_023068.3 [Q9BZZ2-1] XP_006723673.1, XM_006723610.3 XP_011527626.1, XM_011529324.2 XP_011527627.1, XM_011529325.2 XP_011527628.1, XM_011529326.2 XP_011527629.1, XM_011529327.2 XP_011527630.1, XM_011529328.2 XP_011527631.1, XM_011529329.1 |
3D structure databases
SMRi | Q9BZZ2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000341141 |
Chemistry databases
DrugBanki | DB02379, Beta-D-Glucose DB03721, N-acetyl-alpha-neuraminic acid |
PTM databases
GlyGeni | Q9BZZ2, 14 sites |
iPTMneti | Q9BZZ2 |
PhosphoSitePlusi | Q9BZZ2 |
Polymorphism and mutation databases
BioMutai | SIGLEC1 |
DMDMi | 18202745 |
Proteomic databases
jPOSTi | Q9BZZ2 |
MassIVEi | Q9BZZ2 |
PaxDbi | Q9BZZ2 |
PeptideAtlasi | Q9BZZ2 |
PRIDEi | Q9BZZ2 |
ProteomicsDBi | 79923 [Q9BZZ2-1] 79924 [Q9BZZ2-2] 79925 [Q9BZZ2-3] |
Protocols and materials databases
Antibodypediai | 7559, 698 antibodies |
Genome annotation databases
Ensembli | ENST00000344754; ENSP00000341141; ENSG00000088827 [Q9BZZ2-1] |
GeneIDi | 6614 |
KEGGi | hsa:6614 |
UCSCi | uc002wja.3, human [Q9BZZ2-1] |
Organism-specific databases
CTDi | 6614 |
DisGeNETi | 6614 |
EuPathDBi | HostDB:ENSG00000088827.12 |
GeneCardsi | SIGLEC1 |
HGNCi | HGNC:11127, SIGLEC1 |
HPAi | ENSG00000088827, Tissue enhanced (lymphoid) |
MIMi | 600751, gene |
neXtProti | NX_Q9BZZ2 |
OpenTargetsi | ENSG00000088827 |
PharmGKBi | PA35976 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4475, Eukaryota |
GeneTreei | ENSGT01000000214496 |
HOGENOMi | CLU_243945_0_0_1 |
InParanoidi | Q9BZZ2 |
OMAi | FWNDRRL |
OrthoDBi | 54136at2759 |
PhylomeDBi | Q9BZZ2 |
TreeFami | TF334827 |
Enzyme and pathway databases
PathwayCommonsi | Q9BZZ2 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Miscellaneous databases
BioGRID-ORCSi | 6614, 10 hits in 842 CRISPR screens |
ChiTaRSi | SIGLEC1, human |
GenomeRNAii | 6614 |
Pharosi | Q9BZZ2, Tbio |
PROi | PR:Q9BZZ2 |
RNActi | Q9BZZ2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000088827, Expressed in tendon and 179 other tissues |
ExpressionAtlasi | Q9BZZ2, baseline and differential |
Genevisiblei | Q9BZZ2, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 17 hits |
InterProi | View protein in InterPro IPR013162, CD80_C2-set IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF08205, C2-set_2, 1 hit PF07679, I-set, 2 hits PF13895, Ig_2, 6 hits PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 17 hits SM00408, IGc2, 14 hits |
SUPFAMi | SSF48726, SSF48726, 11 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 14 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SN_HUMAN | |
Accessioni | Q9BZZ2Primary (citable) accession number: Q9BZZ2 Secondary accession number(s): Q96DL4 Q9H7L7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 18, 2001 |
Last sequence update: | October 18, 2001 | |
Last modified: | December 2, 2020 | |
This is version 178 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries