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UniProtKB - Q9BZZ2 (SN_HUMAN)

Entry version 178 (02 Dec 2020)
Sequence version 2 (18 Oct 2001)
Previous versions | rss
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Protein

Sialoadhesin

Gene

SIGLEC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei63Sialic acidBy similarity1
Binding sitei116Sialic acidBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB
  • virion binding Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Endocytosis
LigandLectin

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BZZ2

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sialoadhesin
Alternative name(s):
Sialic acid-binding Ig-like lectin 1
Short name:
Siglec-1
CD_antigen: CD169
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SIGLEC1
Synonyms:SN
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000088827.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:11127, SIGLEC1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600751, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BZZ2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 1641ExtracellularSequence analysisAdd BLAST1622
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1642 – 1662HelicalSequence analysisAdd BLAST21
Topological domaini1663 – 1709CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6614

Open Targets

More...OpenTargetsi		ENSG00000088827

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35976

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BZZ2, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB02379, Beta-D-Glucose
DB03721, N-acetyl-alpha-neuraminic acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SIGLEC1

Domain mapping of disease mutations (DMDM)

More...DMDMi		18202745

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19By similarityAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001496820 – 1709SialoadhesinAdd BLAST1690

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi36 ↔ 166PROSITE-ProRule annotation
Disulfide bondi41 ↔ 98PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi160 ↔ 217PROSITE-ProRule annotation
Disulfide bondi262 ↔ 305PROSITE-ProRule annotation
Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi339N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi346 ↔ 390PROSITE-ProRule annotation
Disulfide bondi433 ↔ 491PROSITE-ProRule annotation
Glycosylationi499N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi531 ↔ 575PROSITE-ProRule annotation
Disulfide bondi624 ↔ 689PROSITE-ProRule annotation
Glycosylationi697N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi726N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi729 ↔ 774PROSITE-ProRule annotation
Glycosylationi730N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi741N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi817 ↔ 876PROSITE-ProRule annotation
Glycosylationi886N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi916 ↔ 960PROSITE-ProRule annotation
Disulfide bondi1005 ↔ 1067PROSITE-ProRule annotation
Glycosylationi1104N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1107 ↔ 1149PROSITE-ProRule annotation
Glycosylationi1138N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1193 ↔ 1241PROSITE-ProRule annotation
Glycosylationi1251N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1281 ↔ 1324PROSITE-ProRule annotation
Disulfide bondi1367 ↔ 1425PROSITE-ProRule annotation
Glycosylationi1462N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1465 ↔ 1511PROSITE-ProRule annotation
Glycosylationi1476N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1554 ↔ 1613PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BZZ2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BZZ2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BZZ2

PeptideAtlas

More...PeptideAtlasi		Q9BZZ2

PRoteomics IDEntifications database

More...PRIDEi		Q9BZZ2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		79923 [Q9BZZ2-1]
79924 [Q9BZZ2-2]
79925 [Q9BZZ2-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9BZZ2, 14 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BZZ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BZZ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000088827, Expressed in tendon and 179 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BZZ2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BZZ2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000088827, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000341141

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BZZ2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BZZ2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 136Ig-like V-typeAdd BLAST117
Domaini139 – 233Ig-like C2-type 1Add BLAST95
Domaini238 – 320Ig-like C2-type 2Add BLAST83
Domaini326 – 405Ig-like C2-type 3Add BLAST80
Domaini411 – 507Ig-like C2-type 4Add BLAST97
Domaini511 – 593Ig-like C2-type 5Add BLAST83
Domaini601 – 705Ig-like C2-type 6Add BLAST105
Domaini708 – 785Ig-like C2-type 7Add BLAST78
Domaini799 – 894Ig-like C2-type 8Add BLAST96
Domaini898 – 977Ig-like C2-type 9Add BLAST80
Domaini984 – 1083Ig-like C2-type 10Add BLAST100
Domaini1085 – 1165Ig-like C2-type 11Add BLAST81
Domaini1176 – 1248Ig-like C2-type 12Add BLAST73
Domaini1259 – 1341Ig-like C2-type 13Add BLAST83
Domaini1350 – 1442Ig-like C2-type 14Add BLAST93
Domaini1445 – 1528Ig-like C2-type 15Add BLAST84
Domaini1536 – 1631Ig-like C2-type 16Add BLAST96

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni122 – 126Sialic acid bindingBy similarity5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4475, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01000000214496

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_243945_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BZZ2

Identification of Orthologs from Complete Genome Data

More...OMAi		FWNDRRL

Database of Orthologous Groups

More...OrthoDBi		54136at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BZZ2

TreeFam database of animal gene trees

More...TreeFami		TF334827

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 17 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013162, CD80_C2-set
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08205, C2-set_2, 1 hit
PF07679, I-set, 2 hits
PF13895, Ig_2, 6 hits
PF07686, V-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 17 hits
SM00408, IGc2, 14 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 11 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 14 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BZZ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGFLPKLLLL ASFFPAGQAS WGVSSPQDVQ GVKGSCLLIP CIFSFPADVE 
        60         70         80         90        100
VPDGITAIWY YDYSGQRQVV SHSADPKLVE ARFRGRTEFM GNPEHRVCNL 
       110        120        130        140        150
LLKDLQPEDS GSYNFRFEIS EVNRWSDVKG TLVTVTEEPR VPTIASPVEL 
       160        170        180        190        200
LEGTEVDFNC STPYVCLQEQ VRLQWQGQDP ARSVTFNSQK FEPTGVGHLE 
       210        220        230        240        250
TLHMAMSWQD HGRILRCQLS VANHRAQSEI HLQVKYAPKG VKILLSPSGR 
       260        270        280        290        300
NILPGELVTL TCQVNSSYPA VSSIKWLKDG VRLQTKTGVL HLPQAAWSDA 
       310        320        330        340        350
GVYTCQAENG VGSLVSPPIS LHIFMAEVQV SPAGPILENQ TVTLVCNTPN 
       360        370        380        390        400
EAPSDLRYSW YKNHVLLEDA HSHTLRLHLA TRADTGFYFC EVQNVHGSER 
       410        420        430        440        450
SGPVSVVVNH PPLTPVLTAF LETQAGLVGI LHCSVVSEPL ATLVLSHGGH 
       460        470        480        490        500
ILASTSGDSD HSPRFSGTSG PNSLRLEIRD LEETDSGEYK CSATNSLGNA 
       510        520        530        540        550
TSTLDFHANA ARLLISPAAE VVEGQAVTLS CRSGLSPTPD ARFSWYLNGA 
       560        570        580        590        600
LLHEGPGSSL LLPAASSTDA GSYHCRARDG HSASGPSSPA VLTVLYPPRQ 
       610        620        630        640        650
PTFTTRLDLD AAGAGAGRRG LLLCRVDSDP PARLQLLHKD RVVATSLPSG 
       660        670        680        690        700
GGCSTCGGCS PRMKVTKAPN LLRVEIHNPL LEEEGLYLCE ASNALGNAST 
       710        720        730        740        750
SATFNGQATV LAIAPSHTLQ EGTEANLTCN VSREAAGSPA NFSWFRNGVL 
       760        770        780        790        800
WAQGPLETVT LLPVARTDAA LYACRILTEA GAQLSTPVLL SVLYPPDRPK 
       810        820        830        840        850
LSALLDMGQG HMALFICTVD SRPLALLALF HGEHLLATSL GPQVPSHGRF 
       860        870        880        890        900
QAKAEANSLK LEVRELGLGD SGSYRCEATN VLGSSNTSLF FQVRGAWVQV 
       910        920        930        940        950
SPSPELQEGQ AVVLSCQVHT GVPEGTSYRW YRDGQPLQES TSATLRFAAI 
       960        970        980        990       1000
TLTQAGAYHC QAQAPGSATT SLAAPISLHV SYAPRHVTLT TLMDTGPGRL 
      1010       1020       1030       1040       1050
GLLLCRVDSD PPAQLRLLHG DRLVASTLQG VGGPEGSSPR LHVAVAPNTL 
      1060       1070       1080       1090       1100
RLEIHGAMLE DEGVYICEAS NTLGQASASA DFDAQAVNVQ VWPGATVREG 
      1110       1120       1130       1140       1150
QLVNLTCLVW TTHPAQLTYT WYQDGQQRLD AHSIPLPNVT VRDATSYRCG 
      1160       1170       1180       1190       1200
VGPPGRAPRL SRPITLDVLY APRNLRLTYL LESHGGQLAL VLCTVDSRPP 
      1210       1220       1230       1240       1250
AQLALSHAGR LLASSTAASV PNTLRLELRG PQPRDEGFYS CSARSPLGQA 
      1260       1270       1280       1290       1300
NTSLELRLEG VRVILAPEAA VPEGAPITVT CADPAAHAPT LYTWYHNGRW 
      1310       1320       1330       1340       1350
LQEGPAASLS FLVATRAHAG AYSCQAQDAQ GTRSSRPAAL QVLYAPQDAV 
      1360       1370       1380       1390       1400
LSSFRDSRAR SMAVIQCTVD SEPPAELALS HDGKVLATSS GVHSLASGTG 
      1410       1420       1430       1440       1450
HVQVARNALR LQVQDVPAGD DTYVCTAQNL LGSISTIGRL QVEGARVVAE 
      1460       1470       1480       1490       1500
PGLDVPEGAA LNLSCRLLGG PGPVGNSTFA WFWNDRRLHA EPVPTLAFTH 
      1510       1520       1530       1540       1550
VARAQAGMYH CLAELPTGAA ASAPVMLRVL YPPKTPTMMV FVEPEGGLRG 
      1560       1570       1580       1590       1600
ILDCRVDSEP LASLTLHLGS RLVASSQPQG APAEPHIHVL ASPNALRVDI 
      1610       1620       1630       1640       1650
EALRPSDQGE YICSASNVLG SASTSTYFGV RALHRLHQFQ QLLWVLGLLV 
      1660       1670       1680       1690       1700
GLLLLLLGLG ACYTWRRRRV CKQSMGENSV EMAFQKETTQ LIDPDAATCE 

TSTCAPPLG
Length:1,709
Mass (Da):182,624
Last modified:October 18, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i587C7CCA0B789A6D
GO
Isoform 2 (identifier: Q9BZZ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1632-1709: ALHRLHQFQQ...ETSTCAPPLG → GEGRGLHLPGHSAQKPSS

Show »
Length:1,649
Mass (Da):175,727
Checksum:i460B32A6B1577C4F
GO
Isoform 3 (identifier: Q9BZZ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1666-1709: RRRRVCKQSM...ETSTCAPPLG → SSLILMQPHV...PSGGESGQNL

Show »
Length:1,701
Mass (Da):181,733
Checksum:iCB39EDDAB09606E6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C0M6H7C0M6_HUMAN
Sialoadhesin
SIGLEC1
463Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1349A → T in AAK00757 (PubMed:11133773).Curated1
Sequence conflicti1519A → V in BAB15749 (PubMed:11214971).Curated1
Sequence conflicti1519A → V in BAB15769 (PubMed:11214971).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049943141V → L. Corresponds to variant dbSNP:rs35953127Ensembl.1
Natural variantiVAR_024502221V → M. Corresponds to variant dbSNP:rs6037651Ensembl.1
Natural variantiVAR_014136239K → R. Corresponds to variant dbSNP:rs625372Ensembl.1
Natural variantiVAR_049944464R → H. Corresponds to variant dbSNP:rs34924243Ensembl.1
Natural variantiVAR_014137919H → P. Corresponds to variant dbSNP:rs709012Ensembl.1
Natural variantiVAR_021926974A → V. Corresponds to variant dbSNP:rs3746638Ensembl.1
Natural variantiVAR_0219271335S → Y. Corresponds to variant dbSNP:rs3746636Ensembl.1
Natural variantiVAR_0499451487R → W. Corresponds to variant dbSNP:rs16988873Ensembl.1
Natural variantiVAR_0141381519A → P. Corresponds to variant dbSNP:rs2853217Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0025711632 – 1709ALHRL…APPLG → GEGRGLHLPGHSAQKPSS in isoform 2. 1 PublicationAdd BLAST78
Alternative sequenceiVSP_0025721666 – 1709RRRRV…APPLG → SSLILMQPHVRPQPVPHPWA DQWCCLPSGGESGQNL in isoform 3. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF230073 mRNA Translation: AAK00757.1
AL109804 Genomic DNA No translation available.
AK024459 mRNA Translation: BAB15749.1
AK024462 mRNA Translation: BAB15752.1
AK024479 mRNA Translation: BAB15769.1
AK057560 mRNA Translation: BAB71527.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13060.1 [Q9BZZ2-1]

NCBI Reference Sequences

More...RefSeqi		NP_075556.1, NM_023068.3 [Q9BZZ2-1]
XP_006723673.1, XM_006723610.3
XP_011527626.1, XM_011529324.2
XP_011527627.1, XM_011529325.2
XP_011527628.1, XM_011529326.2
XP_011527629.1, XM_011529327.2
XP_011527630.1, XM_011529328.2
XP_011527631.1, XM_011529329.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000344754; ENSP00000341141; ENSG00000088827 [Q9BZZ2-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6614

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6614

UCSC genome browser

More...UCSCi		uc002wja.3, human [Q9BZZ2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Siglec-1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230073 mRNA Translation: AAK00757.1
AL109804 Genomic DNA No translation available.
AK024459 mRNA Translation: BAB15749.1
AK024462 mRNA Translation: BAB15752.1
AK024479 mRNA Translation: BAB15769.1
AK057560 mRNA Translation: BAB71527.1
CCDSiCCDS13060.1 [Q9BZZ2-1]
RefSeqiNP_075556.1, NM_023068.3 [Q9BZZ2-1]
XP_006723673.1, XM_006723610.3
XP_011527626.1, XM_011529324.2
XP_011527627.1, XM_011529325.2
XP_011527628.1, XM_011529326.2
XP_011527629.1, XM_011529327.2
XP_011527630.1, XM_011529328.2
XP_011527631.1, XM_011529329.1

3D structure databases

SMRiQ9BZZ2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341141

Chemistry databases

DrugBankiDB02379, Beta-D-Glucose
DB03721, N-acetyl-alpha-neuraminic acid

PTM databases

GlyGeniQ9BZZ2, 14 sites
iPTMnetiQ9BZZ2
PhosphoSitePlusiQ9BZZ2

Polymorphism and mutation databases

BioMutaiSIGLEC1
DMDMi18202745

Proteomic databases

jPOSTiQ9BZZ2
MassIVEiQ9BZZ2
PaxDbiQ9BZZ2
PeptideAtlasiQ9BZZ2
PRIDEiQ9BZZ2
ProteomicsDBi79923 [Q9BZZ2-1]
79924 [Q9BZZ2-2]
79925 [Q9BZZ2-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		7559, 698 antibodies

Genome annotation databases

EnsembliENST00000344754; ENSP00000341141; ENSG00000088827 [Q9BZZ2-1]
GeneIDi6614
KEGGihsa:6614
UCSCiuc002wja.3, human [Q9BZZ2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6614
DisGeNETi6614
EuPathDBiHostDB:ENSG00000088827.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		SIGLEC1
HGNCiHGNC:11127, SIGLEC1
HPAiENSG00000088827, Tissue enhanced (lymphoid)
MIMi600751, gene
neXtProtiNX_Q9BZZ2
OpenTargetsiENSG00000088827
PharmGKBiPA35976

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4475, Eukaryota
GeneTreeiENSGT01000000214496
HOGENOMiCLU_243945_0_0_1
InParanoidiQ9BZZ2
OMAiFWNDRRL
OrthoDBi54136at2759
PhylomeDBiQ9BZZ2
TreeFamiTF334827

Enzyme and pathway databases

PathwayCommonsiQ9BZZ2
ReactomeiR-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6614, 10 hits in 842 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SIGLEC1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6614
PharosiQ9BZZ2, Tbio

Protein Ontology

More...PROi		PR:Q9BZZ2
RNActiQ9BZZ2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000088827, Expressed in tendon and 179 other tissues
ExpressionAtlasiQ9BZZ2, baseline and differential
GenevisibleiQ9BZZ2, HS

Family and domain databases

Gene3Di2.60.40.10, 17 hits
InterProiView protein in InterPro
IPR013162, CD80_C2-set
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set
PfamiView protein in Pfam
PF08205, C2-set_2, 1 hit
PF07679, I-set, 2 hits
PF13895, Ig_2, 6 hits
PF07686, V-set, 1 hit
SMARTiView protein in SMART
SM00409, IG, 17 hits
SM00408, IGc2, 14 hits
SUPFAMiSSF48726, SSF48726, 11 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 14 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSN_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BZZ2
Secondary accession number(s): Q96DL4
, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 18, 2001
Last modified: December 2, 2020
This is version 178 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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