Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 171 (16 Oct 2019)
Sequence version 2 (18 Oct 2001)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Sialoadhesin

Gene

SIGLEC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei63Sialic acidBy similarity1
Binding sitei116Sialic acidBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Endocytosis
LigandLectin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sialoadhesin
Alternative name(s):
Sialic acid-binding Ig-like lectin 1
Short name:
Siglec-1
CD_antigen: CD169
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SIGLEC1
Synonyms:SN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11127 SIGLEC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600751 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BZZ2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 1641ExtracellularSequence analysisAdd BLAST1622
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1642 – 1662HelicalSequence analysisAdd BLAST21
Topological domaini1663 – 1709CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6614

Open Targets

More...
OpenTargetsi
ENSG00000088827

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35976

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BZZ2

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB02379 Beta-D-Glucose
DB03721 N-acetyl-alpha-neuraminic acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SIGLEC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
18202745

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19By similarityAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001496820 – 1709SialoadhesinAdd BLAST1690

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi36 ↔ 166PROSITE-ProRule annotation
Disulfide bondi41 ↔ 98PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi160 ↔ 217PROSITE-ProRule annotation
Disulfide bondi262 ↔ 305PROSITE-ProRule annotation
Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi339N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi346 ↔ 390PROSITE-ProRule annotation
Disulfide bondi433 ↔ 491PROSITE-ProRule annotation
Glycosylationi499N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi531 ↔ 575PROSITE-ProRule annotation
Disulfide bondi624 ↔ 689PROSITE-ProRule annotation
Glycosylationi697N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi726N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi729 ↔ 774PROSITE-ProRule annotation
Glycosylationi730N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi741N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi817 ↔ 876PROSITE-ProRule annotation
Glycosylationi886N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi916 ↔ 960PROSITE-ProRule annotation
Disulfide bondi1005 ↔ 1067PROSITE-ProRule annotation
Glycosylationi1104N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1107 ↔ 1149PROSITE-ProRule annotation
Glycosylationi1138N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1193 ↔ 1241PROSITE-ProRule annotation
Glycosylationi1251N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1281 ↔ 1324PROSITE-ProRule annotation
Disulfide bondi1367 ↔ 1425PROSITE-ProRule annotation
Glycosylationi1462N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1465 ↔ 1511PROSITE-ProRule annotation
Glycosylationi1476N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1554 ↔ 1613PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BZZ2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BZZ2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BZZ2

PeptideAtlas

More...
PeptideAtlasi
Q9BZZ2

PRoteomics IDEntifications database

More...
PRIDEi
Q9BZZ2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79923 [Q9BZZ2-1]
79924 [Q9BZZ2-2]
79925 [Q9BZZ2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BZZ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BZZ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000088827 Expressed in 166 organ(s), highest expression level in tendon

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BZZ2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BZZ2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA053457

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000341141

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BZZ2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 136Ig-like V-typeAdd BLAST117
Domaini139 – 233Ig-like C2-type 1Add BLAST95
Domaini238 – 320Ig-like C2-type 2Add BLAST83
Domaini326 – 405Ig-like C2-type 3Add BLAST80
Domaini411 – 507Ig-like C2-type 4Add BLAST97
Domaini511 – 593Ig-like C2-type 5Add BLAST83
Domaini601 – 705Ig-like C2-type 6Add BLAST105
Domaini708 – 785Ig-like C2-type 7Add BLAST78
Domaini799 – 894Ig-like C2-type 8Add BLAST96
Domaini898 – 977Ig-like C2-type 9Add BLAST80
Domaini984 – 1083Ig-like C2-type 10Add BLAST100
Domaini1085 – 1165Ig-like C2-type 11Add BLAST81
Domaini1176 – 1248Ig-like C2-type 12Add BLAST73
Domaini1259 – 1341Ig-like C2-type 13Add BLAST83
Domaini1350 – 1442Ig-like C2-type 14Add BLAST93
Domaini1445 – 1528Ig-like C2-type 15Add BLAST84
Domaini1536 – 1631Ig-like C2-type 16Add BLAST96

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni122 – 126Sialic acid bindingBy similarity5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IUGH Eukaryota
ENOG410ZJZH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182626

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154365

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BZZ2

KEGG Orthology (KO)

More...
KOi
K06548

Identification of Orthologs from Complete Genome Data

More...
OMAi
GACYTWR

Database of Orthologous Groups

More...
OrthoDBi
54136at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BZZ2

TreeFam database of animal gene trees

More...
TreeFami
TF334827

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 17 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08205 C2-set_2, 1 hit
PF07679 I-set, 2 hits
PF13895 Ig_2, 6 hits
PF07686 V-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 17 hits
SM00408 IGc2, 14 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 11 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 14 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BZZ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGFLPKLLLL ASFFPAGQAS WGVSSPQDVQ GVKGSCLLIP CIFSFPADVE
60 70 80 90 100
VPDGITAIWY YDYSGQRQVV SHSADPKLVE ARFRGRTEFM GNPEHRVCNL
110 120 130 140 150
LLKDLQPEDS GSYNFRFEIS EVNRWSDVKG TLVTVTEEPR VPTIASPVEL
160 170 180 190 200
LEGTEVDFNC STPYVCLQEQ VRLQWQGQDP ARSVTFNSQK FEPTGVGHLE
210 220 230 240 250
TLHMAMSWQD HGRILRCQLS VANHRAQSEI HLQVKYAPKG VKILLSPSGR
260 270 280 290 300
NILPGELVTL TCQVNSSYPA VSSIKWLKDG VRLQTKTGVL HLPQAAWSDA
310 320 330 340 350
GVYTCQAENG VGSLVSPPIS LHIFMAEVQV SPAGPILENQ TVTLVCNTPN
360 370 380 390 400
EAPSDLRYSW YKNHVLLEDA HSHTLRLHLA TRADTGFYFC EVQNVHGSER
410 420 430 440 450
SGPVSVVVNH PPLTPVLTAF LETQAGLVGI LHCSVVSEPL ATLVLSHGGH
460 470 480 490 500
ILASTSGDSD HSPRFSGTSG PNSLRLEIRD LEETDSGEYK CSATNSLGNA
510 520 530 540 550
TSTLDFHANA ARLLISPAAE VVEGQAVTLS CRSGLSPTPD ARFSWYLNGA
560 570 580 590 600
LLHEGPGSSL LLPAASSTDA GSYHCRARDG HSASGPSSPA VLTVLYPPRQ
610 620 630 640 650
PTFTTRLDLD AAGAGAGRRG LLLCRVDSDP PARLQLLHKD RVVATSLPSG
660 670 680 690 700
GGCSTCGGCS PRMKVTKAPN LLRVEIHNPL LEEEGLYLCE ASNALGNAST
710 720 730 740 750
SATFNGQATV LAIAPSHTLQ EGTEANLTCN VSREAAGSPA NFSWFRNGVL
760 770 780 790 800
WAQGPLETVT LLPVARTDAA LYACRILTEA GAQLSTPVLL SVLYPPDRPK
810 820 830 840 850
LSALLDMGQG HMALFICTVD SRPLALLALF HGEHLLATSL GPQVPSHGRF
860 870 880 890 900
QAKAEANSLK LEVRELGLGD SGSYRCEATN VLGSSNTSLF FQVRGAWVQV
910 920 930 940 950
SPSPELQEGQ AVVLSCQVHT GVPEGTSYRW YRDGQPLQES TSATLRFAAI
960 970 980 990 1000
TLTQAGAYHC QAQAPGSATT SLAAPISLHV SYAPRHVTLT TLMDTGPGRL
1010 1020 1030 1040 1050
GLLLCRVDSD PPAQLRLLHG DRLVASTLQG VGGPEGSSPR LHVAVAPNTL
1060 1070 1080 1090 1100
RLEIHGAMLE DEGVYICEAS NTLGQASASA DFDAQAVNVQ VWPGATVREG
1110 1120 1130 1140 1150
QLVNLTCLVW TTHPAQLTYT WYQDGQQRLD AHSIPLPNVT VRDATSYRCG
1160 1170 1180 1190 1200
VGPPGRAPRL SRPITLDVLY APRNLRLTYL LESHGGQLAL VLCTVDSRPP
1210 1220 1230 1240 1250
AQLALSHAGR LLASSTAASV PNTLRLELRG PQPRDEGFYS CSARSPLGQA
1260 1270 1280 1290 1300
NTSLELRLEG VRVILAPEAA VPEGAPITVT CADPAAHAPT LYTWYHNGRW
1310 1320 1330 1340 1350
LQEGPAASLS FLVATRAHAG AYSCQAQDAQ GTRSSRPAAL QVLYAPQDAV
1360 1370 1380 1390 1400
LSSFRDSRAR SMAVIQCTVD SEPPAELALS HDGKVLATSS GVHSLASGTG
1410 1420 1430 1440 1450
HVQVARNALR LQVQDVPAGD DTYVCTAQNL LGSISTIGRL QVEGARVVAE
1460 1470 1480 1490 1500
PGLDVPEGAA LNLSCRLLGG PGPVGNSTFA WFWNDRRLHA EPVPTLAFTH
1510 1520 1530 1540 1550
VARAQAGMYH CLAELPTGAA ASAPVMLRVL YPPKTPTMMV FVEPEGGLRG
1560 1570 1580 1590 1600
ILDCRVDSEP LASLTLHLGS RLVASSQPQG APAEPHIHVL ASPNALRVDI
1610 1620 1630 1640 1650
EALRPSDQGE YICSASNVLG SASTSTYFGV RALHRLHQFQ QLLWVLGLLV
1660 1670 1680 1690 1700
GLLLLLLGLG ACYTWRRRRV CKQSMGENSV EMAFQKETTQ LIDPDAATCE

TSTCAPPLG
Length:1,709
Mass (Da):182,624
Last modified:October 18, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i587C7CCA0B789A6D
GO
Isoform 2 (identifier: Q9BZZ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1632-1709: ALHRLHQFQQ...ETSTCAPPLG → GEGRGLHLPGHSAQKPSS

Show »
Length:1,649
Mass (Da):175,727
Checksum:i460B32A6B1577C4F
GO
Isoform 3 (identifier: Q9BZZ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1666-1709: RRRRVCKQSM...ETSTCAPPLG → SSLILMQPHV...PSGGESGQNL

Note: No experimental confirmation available.
Show »
Length:1,701
Mass (Da):181,733
Checksum:iCB39EDDAB09606E6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C0M6H7C0M6_HUMAN
Sialoadhesin
SIGLEC1
463Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1349A → T in AAK00757 (PubMed:11133773).Curated1
Sequence conflicti1519A → V in BAB15749 (PubMed:11214971).Curated1
Sequence conflicti1519A → V in BAB15769 (PubMed:11214971).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049943141V → L. Corresponds to variant dbSNP:rs35953127Ensembl.1
Natural variantiVAR_024502221V → M. Corresponds to variant dbSNP:rs6037651Ensembl.1
Natural variantiVAR_014136239K → R. Corresponds to variant dbSNP:rs625372Ensembl.1
Natural variantiVAR_049944464R → H. Corresponds to variant dbSNP:rs34924243Ensembl.1
Natural variantiVAR_014137919H → P. Corresponds to variant dbSNP:rs709012Ensembl.1
Natural variantiVAR_021926974A → V. Corresponds to variant dbSNP:rs3746638Ensembl.1
Natural variantiVAR_0219271335S → Y. Corresponds to variant dbSNP:rs3746636Ensembl.1
Natural variantiVAR_0499451487R → W. Corresponds to variant dbSNP:rs16988873Ensembl.1
Natural variantiVAR_0141381519A → P. Corresponds to variant dbSNP:rs2853217Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0025711632 – 1709ALHRL…APPLG → GEGRGLHLPGHSAQKPSS in isoform 2. 1 PublicationAdd BLAST78
Alternative sequenceiVSP_0025721666 – 1709RRRRV…APPLG → SSLILMQPHVRPQPVPHPWA DQWCCLPSGGESGQNL in isoform 3. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF230073 mRNA Translation: AAK00757.1
AL109804 Genomic DNA No translation available.
AK024459 mRNA Translation: BAB15749.1
AK024462 mRNA Translation: BAB15752.1
AK024479 mRNA Translation: BAB15769.1
AK057560 mRNA Translation: BAB71527.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13060.1 [Q9BZZ2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_075556.1, NM_023068.3 [Q9BZZ2-1]
XP_006723673.1, XM_006723610.3
XP_011527626.1, XM_011529324.2
XP_011527627.1, XM_011529325.2
XP_011527628.1, XM_011529326.2
XP_011527629.1, XM_011529327.2
XP_011527630.1, XM_011529328.2
XP_011527631.1, XM_011529329.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000344754; ENSP00000341141; ENSG00000088827 [Q9BZZ2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6614

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6614

UCSC genome browser

More...
UCSCi
uc002wja.3 human [Q9BZZ2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Siglec-1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230073 mRNA Translation: AAK00757.1
AL109804 Genomic DNA No translation available.
AK024459 mRNA Translation: BAB15749.1
AK024462 mRNA Translation: BAB15752.1
AK024479 mRNA Translation: BAB15769.1
AK057560 mRNA Translation: BAB71527.1
CCDSiCCDS13060.1 [Q9BZZ2-1]
RefSeqiNP_075556.1, NM_023068.3 [Q9BZZ2-1]
XP_006723673.1, XM_006723610.3
XP_011527626.1, XM_011529324.2
XP_011527627.1, XM_011529325.2
XP_011527628.1, XM_011529326.2
XP_011527629.1, XM_011529327.2
XP_011527630.1, XM_011529328.2
XP_011527631.1, XM_011529329.1

3D structure databases

SMRiQ9BZZ2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341141

Chemistry databases

DrugBankiDB02379 Beta-D-Glucose
DB03721 N-acetyl-alpha-neuraminic acid

PTM databases

iPTMnetiQ9BZZ2
PhosphoSitePlusiQ9BZZ2

Polymorphism and mutation databases

BioMutaiSIGLEC1
DMDMi18202745

Proteomic databases

jPOSTiQ9BZZ2
MassIVEiQ9BZZ2
PaxDbiQ9BZZ2
PeptideAtlasiQ9BZZ2
PRIDEiQ9BZZ2
ProteomicsDBi79923 [Q9BZZ2-1]
79924 [Q9BZZ2-2]
79925 [Q9BZZ2-3]

Genome annotation databases

EnsembliENST00000344754; ENSP00000341141; ENSG00000088827 [Q9BZZ2-1]
GeneIDi6614
KEGGihsa:6614
UCSCiuc002wja.3 human [Q9BZZ2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6614
DisGeNETi6614

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SIGLEC1
HGNCiHGNC:11127 SIGLEC1
HPAiHPA053457
MIMi600751 gene
neXtProtiNX_Q9BZZ2
OpenTargetsiENSG00000088827
PharmGKBiPA35976

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IUGH Eukaryota
ENOG410ZJZH LUCA
GeneTreeiENSGT00950000182626
HOGENOMiHOG000154365
InParanoidiQ9BZZ2
KOiK06548
OMAiGACYTWR
OrthoDBi54136at2759
PhylomeDBiQ9BZZ2
TreeFamiTF334827

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SIGLEC1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6614
PharosiQ9BZZ2

Protein Ontology

More...
PROi
PR:Q9BZZ2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000088827 Expressed in 166 organ(s), highest expression level in tendon
ExpressionAtlasiQ9BZZ2 baseline and differential
GenevisibleiQ9BZZ2 HS

Family and domain databases

Gene3Di2.60.40.10, 17 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF07679 I-set, 2 hits
PF13895 Ig_2, 6 hits
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 17 hits
SM00408 IGc2, 14 hits
SUPFAMiSSF48726 SSF48726, 11 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 14 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BZZ2
Secondary accession number(s): Q96DL4
, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 18, 2001
Last modified: October 16, 2019
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again