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UniProtKB - Q9BZY9 (TRI31_HUMAN)

Entry version 174 (07 Apr 2021)
Sequence version 2 (21 Jun 2005)
Previous versions | rss
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Protein

E3 ubiquitin-protein ligase TRIM31

Gene

TRIM31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity.By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri90 – 131B box-typePROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BZY9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-877300, Interferon gamma signaling

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM31 (EC:2.3.2.27)
Alternative name(s):
RING-type E3 ubiquitin transferase TRIM31Curated
Tripartite motif-containing protein 31
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM31
Synonyms:C6orf13, RNF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16289, TRIM31

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609316, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BZY9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000204616.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		11074

Open Targets

More...OpenTargetsi		ENSG00000204616

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38117

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BZY9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TRIM31

Domain mapping of disease mutations (DMDM)

More...DMDMi		68068082

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000562451 – 425E3 ubiquitin-protein ligase TRIM31Add BLAST425

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Auto-ubiquitinated (in vitro).1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9BZY9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BZY9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BZY9

PeptideAtlas

More...PeptideAtlasi		Q9BZY9

PRoteomics IDEntifications database

More...PRIDEi		Q9BZY9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		79921 [Q9BZY9-1]
79922 [Q9BZY9-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9BZY9, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BZY9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BZY9

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9BZY9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Up-regulated in gastric adenocarcinomas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000204616, Expressed in mucosa of transverse colon and 135 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BZY9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BZY9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000204616, Tissue enhanced (intestine, lymphoid tissue, urinary bladder)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with isoform p52shc of SHC1 (By similarity). May form oligomers.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116257, 27 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9BZY9

Protein interaction database and analysis system

More...IntActi		Q9BZY9, 13 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000365924

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BZY9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1425
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q9BZY9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BZY9

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9BZY9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili126 – 162Sequence analysisAdd BLAST37
Coiled coili270 – 307Sequence analysisAdd BLAST38

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri90 – 131B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2177, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163585

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013137_6_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BZY9

Identification of Orthologs from Complete Genome Data

More...OMAi		YFCEQDG

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BZY9

TreeFam database of animal gene trees

More...TreeFami		TF338674

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000315, Znf_B-box
IPR020457, Znf_B-box_chordata
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00643, zf-B_box, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01406, BBOXZNFINGER

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00336, BBOX, 1 hit
SM00184, RING, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50119, ZF_BBOX, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha (identifier: Q9BZY9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASGQFVNKL QEEVICPICL DILQKPVTID CGHNFCLKCI TQIGETSCGF 
        60         70         80         90        100
FKCPLCKTSV RKNAIRFNSL LRNLVEKIQA LQASEVQSKR KEATCPRHQE 
       110        120        130        140        150
MFHYFCEDDG KFLCFVCRES KDHKSHNVSL IEEAAQNYQG QIQEQIQVLQ 
       160        170        180        190        200
QKEKETVQVK AQGVHRVDVF TDQVEHEKQR ILTEFELLHQ VLEEEKNFLL 
       210        220        230        240        250
SRIYWLGHEG TEAGKHYVAS TEPQLNDLKK LVDSLKTKQN MPPRQLLEDI 
       260        270        280        290        300
KVVLCRSEEF QFLNPTPVPL ELEKKLSEAK SRHDSITGSL KKFKDQLQAD 
       310        320        330        340        350
RKKDENRFFK SMNKNDMKSW GLLQKNNHKM NKTSEPGSSS AGGRTTSGPP 
       360        370        380        390        400
NHHSSAPSHS LFRASSAGKV TFPVCLLASY DEISGQGASS QDTKTFDVAL 
       410        420 
SEELHAALSE WLTAIRAWFC EVPSS
Length:425
Mass (Da):48,244
Last modified:June 21, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8CCC0D07F2DBB52D
GO
Isoform Beta (identifier: Q9BZY9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     249-267: DIKVVLCRSEEFQFLNPTP → NWRKNSVKQNQDTTPSQGA
     268-425: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:267
Mass (Da):30,831
Checksum:iA5B06E3F28E451AB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JJX2A0A0G2JJX2_HUMAN
E3 ubiquitin-protein ligase TRIM31
TRIM31
425Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9J6A0A140T9J6_HUMAN
E3 ubiquitin-protein ligase TRIM31
TRIM31
248Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH16866 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti37 – 38LK → PQ in AAG50165 (PubMed:11331580).Curated2
Sequence conflicti37 – 38LK → PQ in AAG50166 (PubMed:11331580).Curated2
Sequence conflicti37 – 38LK → PQ in CAA69165 (Ref. 6) Curated2
Sequence conflicti62 – 63KN → RD in AAG50165 (PubMed:11331580).Curated2
Sequence conflicti62 – 63KN → RD in AAG50166 (PubMed:11331580).Curated2
Sequence conflicti62 – 63KN → RD in CAA69165 (Ref. 6) Curated2
Sequence conflicti109D → G in BAD96449 (Ref. 3) Curated1
Sequence conflicti219 – 236ASTEP…VDSLK → EIPLMPTVERSQEARCYP in CAA69165 (Ref. 6) CuratedAdd BLAST18

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05213917P → R. Corresponds to variant dbSNP:rs36063651EnsemblClinVar.1
Natural variantiVAR_022728118R → C1 PublicationCorresponds to variant dbSNP:rs3734838Ensembl.1
Natural variantiVAR_022729232V → I1 PublicationCorresponds to variant dbSNP:rs2523989Ensembl.1
Natural variantiVAR_052140235L → P. Corresponds to variant dbSNP:rs35775852EnsemblClinVar.1
Natural variantiVAR_019962421E → K3 PublicationsCorresponds to variant dbSNP:rs1116221Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_005764249 – 267DIKVV…LNPTP → NWRKNSVKQNQDTTPSQGA in isoform Beta. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_005765268 – 425Missing in isoform Beta. 1 PublicationAdd BLAST158

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF230386 mRNA Translation: AAG50165.1
AF230387 mRNA Translation: AAG50166.1
BT006675 mRNA Translation: AAP35321.1
AK222729 mRNA Translation: BAD96449.1
AL669914 Genomic DNA No translation available.
AL671859 Genomic DNA No translation available.
BX322644 Genomic DNA No translation available.
CR753815 Genomic DNA No translation available.
BC016866 mRNA Translation: AAH16866.1 Different initiation.
BC017017 mRNA Translation: AAH17017.1
Y07828 mRNA Translation: CAA69165.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34374.1 [Q9BZY9-1]

NCBI Reference Sequences

More...RefSeqi		NP_008959.3, NM_007028.4 [Q9BZY9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000357569; ENSP00000350182; ENSG00000137397
ENST00000376734; ENSP00000365924; ENSG00000204616 [Q9BZY9-1]
ENST00000433864; ENSP00000390551; ENSG00000233573
ENST00000445679; ENSP00000409501; ENSG00000224168 [Q9BZY9-1]
ENST00000449412; ENSP00000398677; ENSG00000223531 [Q9BZY9-1]
ENST00000453266; ENSP00000391685; ENSG00000225130 [Q9BZY9-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11074

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:11074

UCSC genome browser

More...UCSCi		uc003npg.2, human [Q9BZY9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230386 mRNA Translation: AAG50165.1
AF230387 mRNA Translation: AAG50166.1
BT006675 mRNA Translation: AAP35321.1
AK222729 mRNA Translation: BAD96449.1
AL669914 Genomic DNA No translation available.
AL671859 Genomic DNA No translation available.
BX322644 Genomic DNA No translation available.
CR753815 Genomic DNA No translation available.
BC016866 mRNA Translation: AAH16866.1 Different initiation.
BC017017 mRNA Translation: AAH17017.1
Y07828 mRNA Translation: CAA69165.1
CCDSiCCDS34374.1 [Q9BZY9-1]
RefSeqiNP_008959.3, NM_007028.4 [Q9BZY9-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YSJNMR-A1-56[»]
2YSLNMR-A1-66[»]
BMRBiQ9BZY9
SMRiQ9BZY9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116257, 27 interactors
CORUMiQ9BZY9
IntActiQ9BZY9, 13 interactors
STRINGi9606.ENSP00000365924

PTM databases

GlyGeniQ9BZY9, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9BZY9
PhosphoSitePlusiQ9BZY9
SwissPalmiQ9BZY9

Genetic variation databases

BioMutaiTRIM31
DMDMi68068082

Proteomic databases

EPDiQ9BZY9
MassIVEiQ9BZY9
PaxDbiQ9BZY9
PeptideAtlasiQ9BZY9
PRIDEiQ9BZY9
ProteomicsDBi79921 [Q9BZY9-1]
79922 [Q9BZY9-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11702, 190 antibodies

The DNASU plasmid repository

More...DNASUi		11074

Genome annotation databases

EnsembliENST00000357569; ENSP00000350182; ENSG00000137397
ENST00000376734; ENSP00000365924; ENSG00000204616 [Q9BZY9-1]
ENST00000433864; ENSP00000390551; ENSG00000233573
ENST00000445679; ENSP00000409501; ENSG00000224168 [Q9BZY9-1]
ENST00000449412; ENSP00000398677; ENSG00000223531 [Q9BZY9-1]
ENST00000453266; ENSP00000391685; ENSG00000225130 [Q9BZY9-1]
GeneIDi11074
KEGGihsa:11074
UCSCiuc003npg.2, human [Q9BZY9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		11074
DisGeNETi11074

GeneCards: human genes, protein and diseases

More...GeneCardsi		TRIM31
HGNCiHGNC:16289, TRIM31
HPAiENSG00000204616, Tissue enhanced (intestine, lymphoid tissue, urinary bladder)
MIMi609316, gene
neXtProtiNX_Q9BZY9
OpenTargetsiENSG00000204616
PharmGKBiPA38117
VEuPathDBiHostDB:ENSG00000204616.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2177, Eukaryota
GeneTreeiENSGT00940000163585
HOGENOMiCLU_013137_6_1_1
InParanoidiQ9BZY9
OMAiYFCEQDG
PhylomeDBiQ9BZY9
TreeFamiTF338674

Enzyme and pathway databases

UniPathwayiUPA00143
PathwayCommonsiQ9BZY9
ReactomeiR-HSA-877300, Interferon gamma signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11074, 6 hits in 987 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TRIM31, human
EvolutionaryTraceiQ9BZY9

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TRIM31

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		11074
PharosiQ9BZY9, Tbio

Protein Ontology

More...PROi		PR:Q9BZY9
RNActiQ9BZY9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000204616, Expressed in mucosa of transverse colon and 135 other tissues
ExpressionAtlasiQ9BZY9, baseline and differential
GenevisibleiQ9BZY9, HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR000315, Znf_B-box
IPR020457, Znf_B-box_chordata
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS
PfamiView protein in Pfam
PF00643, zf-B_box, 1 hit
PRINTSiPR01406, BBOXZNFINGER
SMARTiView protein in SMART
SM00336, BBOX, 1 hit
SM00184, RING, 1 hit
PROSITEiView protein in PROSITE
PS50119, ZF_BBOX, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRI31_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BZY9
Secondary accession number(s): A6NLX6
, A9R9Q4, Q53H52, Q5RI37, Q5SRJ7, Q5SRJ8, Q5SS28, Q96AK4, Q96AP8, Q99579, Q9BZY8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 21, 2005
Last modified: April 7, 2021
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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