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Protein

E3 ubiquitin-protein ligase TRIM31

Gene

TRIM31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity.By similarity1 Publication

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri90 – 131B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

  • innate immune response Source: UniProtKB
  • interferon-gamma-mediated signaling pathway Source: Reactome
  • negative regulation of viral entry into host cell Source: UniProtKB
  • negative regulation of viral transcription Source: UniProtKB
  • positive regulation of DNA binding transcription factor activity Source: UniProtKB
  • protein ubiquitination Source: UniProtKB-UniPathway
  • regulation of viral release from host cell Source: UniProtKB

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-877300 Interferon gamma signaling
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM31 (EC:2.3.2.27)
Alternative name(s):
RING-type E3 ubiquitin transferase TRIM31Curated
Tripartite motif-containing protein 31
Gene namesi
Name:TRIM31
Synonyms:C6orf13, RNF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204616.10
HGNCiHGNC:16289 TRIM31
MIMi609316 gene
neXtProtiNX_Q9BZY9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi11074
OpenTargetsiENSG00000204616
PharmGKBiPA38117

Polymorphism and mutation databases

BioMutaiTRIM31
DMDMi68068082

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562451 – 425E3 ubiquitin-protein ligase TRIM31Add BLAST425

Post-translational modificationi

Auto-ubiquitinated (in vitro).1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ9BZY9
PaxDbiQ9BZY9
PeptideAtlasiQ9BZY9
PRIDEiQ9BZY9
ProteomicsDBi79921
79922 [Q9BZY9-2]

PTM databases

iPTMnetiQ9BZY9
PhosphoSitePlusiQ9BZY9
SwissPalmiQ9BZY9

Expressioni

Tissue specificityi

Up-regulated in gastric adenocarcinomas.1 Publication

Gene expression databases

BgeeiENSG00000204616
ExpressionAtlasiQ9BZY9 baseline and differential
GenevisibleiQ9BZY9 HS

Organism-specific databases

HPAiHPA046400

Interactioni

Subunit structurei

Interacts with isoform p52shc of SHC1 (By similarity). May form oligomers.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MAGEA1P433554EBI-747544,EBI-740978

Protein-protein interaction databases

BioGridi116257, 22 interactors
CORUMiQ9BZY9
IntActiQ9BZY9, 12 interactors
STRINGi9606.ENSP00000365924

Structurei

Secondary structure

1425
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni17 – 19Combined sources3
Beta strandi24 – 28Combined sources5
Beta strandi32 – 35Combined sources4
Helixi37 – 46Combined sources10
Beta strandi54 – 56Combined sources3

3D structure databases

ProteinModelPortaliQ9BZY9
SMRiQ9BZY9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BZY9

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili126 – 162Sequence analysisAdd BLAST37
Coiled coili270 – 307Sequence analysisAdd BLAST38

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri90 – 131B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118838
HOVERGENiHBG083771
InParanoidiQ9BZY9
KOiK12011
OMAiEFQFLNP
OrthoDBiEOG091G07DI
PhylomeDBiQ9BZY9
TreeFamiTF338674

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR000315 Znf_B-box
IPR020457 Znf_B-box_chordata
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00643 zf-B_box, 1 hit
PRINTSiPR01406 BBOXZNFINGER
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Alpha (identifier: Q9BZY9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASGQFVNKL QEEVICPICL DILQKPVTID CGHNFCLKCI TQIGETSCGF
60 70 80 90 100
FKCPLCKTSV RKNAIRFNSL LRNLVEKIQA LQASEVQSKR KEATCPRHQE
110 120 130 140 150
MFHYFCEDDG KFLCFVCRES KDHKSHNVSL IEEAAQNYQG QIQEQIQVLQ
160 170 180 190 200
QKEKETVQVK AQGVHRVDVF TDQVEHEKQR ILTEFELLHQ VLEEEKNFLL
210 220 230 240 250
SRIYWLGHEG TEAGKHYVAS TEPQLNDLKK LVDSLKTKQN MPPRQLLEDI
260 270 280 290 300
KVVLCRSEEF QFLNPTPVPL ELEKKLSEAK SRHDSITGSL KKFKDQLQAD
310 320 330 340 350
RKKDENRFFK SMNKNDMKSW GLLQKNNHKM NKTSEPGSSS AGGRTTSGPP
360 370 380 390 400
NHHSSAPSHS LFRASSAGKV TFPVCLLASY DEISGQGASS QDTKTFDVAL
410 420
SEELHAALSE WLTAIRAWFC EVPSS
Length:425
Mass (Da):48,244
Last modified:June 21, 2005 - v2
Checksum:i8CCC0D07F2DBB52D
GO
Isoform Beta (identifier: Q9BZY9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     249-267: DIKVVLCRSEEFQFLNPTP → NWRKNSVKQNQDTTPSQGA
     268-425: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:267
Mass (Da):30,831
Checksum:iA5B06E3F28E451AB
GO

Sequence cautioni

The sequence AAH16866 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37 – 38LK → PQ in AAG50165 (PubMed:11331580).Curated2
Sequence conflicti37 – 38LK → PQ in AAG50166 (PubMed:11331580).Curated2
Sequence conflicti37 – 38LK → PQ in CAA69165 (Ref. 6) Curated2
Sequence conflicti62 – 63KN → RD in AAG50165 (PubMed:11331580).Curated2
Sequence conflicti62 – 63KN → RD in AAG50166 (PubMed:11331580).Curated2
Sequence conflicti62 – 63KN → RD in CAA69165 (Ref. 6) Curated2
Sequence conflicti109D → G in BAD96449 (Ref. 3) Curated1
Sequence conflicti219 – 236ASTEP…VDSLK → EIPLMPTVERSQEARCYP in CAA69165 (Ref. 6) CuratedAdd BLAST18

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05213917P → R. Corresponds to variant dbSNP:rs36063651Ensembl.1
Natural variantiVAR_022728118R → C1 PublicationCorresponds to variant dbSNP:rs3734838Ensembl.1
Natural variantiVAR_022729232V → I1 PublicationCorresponds to variant dbSNP:rs2523989Ensembl.1
Natural variantiVAR_052140235L → P. Corresponds to variant dbSNP:rs35775852Ensembl.1
Natural variantiVAR_019962421E → K3 PublicationsCorresponds to variant dbSNP:rs1116221Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005764249 – 267DIKVV…LNPTP → NWRKNSVKQNQDTTPSQGA in isoform Beta. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_005765268 – 425Missing in isoform Beta. 1 PublicationAdd BLAST158

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230386 mRNA Translation: AAG50165.1
AF230387 mRNA Translation: AAG50166.1
BT006675 mRNA Translation: AAP35321.1
AK222729 mRNA Translation: BAD96449.1
AL669914 Genomic DNA No translation available.
AL671859 Genomic DNA No translation available.
BX322644 Genomic DNA No translation available.
CR753815 Genomic DNA No translation available.
BC016866 mRNA Translation: AAH16866.1 Different initiation.
BC017017 mRNA Translation: AAH17017.1
Y07828 mRNA Translation: CAA69165.1
CCDSiCCDS34374.1 [Q9BZY9-1]
RefSeqiNP_008959.3, NM_007028.4 [Q9BZY9-1]
UniGeneiHs.493275

Genome annotation databases

EnsembliENST00000357569; ENSP00000350182; ENSG00000137397
ENST00000376734; ENSP00000365924; ENSG00000204616 [Q9BZY9-1]
ENST00000433864; ENSP00000390551; ENSG00000233573
ENST00000445679; ENSP00000409501; ENSG00000224168 [Q9BZY9-1]
ENST00000449412; ENSP00000398677; ENSG00000223531 [Q9BZY9-1]
ENST00000453266; ENSP00000391685; ENSG00000225130 [Q9BZY9-1]
ENST00000551027; ENSP00000446675; ENSG00000137397
GeneIDi11074
KEGGihsa:11074
UCSCiuc003npg.2 human [Q9BZY9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTRI31_HUMAN
AccessioniPrimary (citable) accession number: Q9BZY9
Secondary accession number(s): A6NLX6
, A9R9Q4, Q53H52, Q5RI37, Q5SRJ7, Q5SRJ8, Q5SS28, Q96AK4, Q96AP8, Q99579, Q9BZY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 21, 2005
Last modified: July 18, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

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