UniProtKB - Q9BZY9 (TRI31_HUMAN)
Protein
E3 ubiquitin-protein ligase TRIM31
Gene
TRIM31
Organism
Homo sapiens (Human)
Status
Functioni
Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity.By similarity1 Publication
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 16 – 57 | RING-typePROSITE-ProRule annotationAdd BLAST | 42 | |
Zinc fingeri | 90 – 131 | B box-typePROSITE-ProRule annotationAdd BLAST | 42 |
GO - Molecular functioni
- transcription coactivator activity Source: ARUK-UCL
- ubiquitin protein ligase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- innate immune response Source: UniProtKB
- interferon-gamma-mediated signaling pathway Source: Reactome
- negative regulation of viral entry into host cell Source: UniProtKB
- negative regulation of viral transcription Source: UniProtKB
- positive regulation of DNA-binding transcription factor activity Source: UniProtKB
- protein ubiquitination Source: GO_Central
- regulation of gene expression Source: GO_Central
- regulation of viral release from host cell Source: UniProtKB
Keywordsi
Molecular function | Transferase |
Biological process | Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9BZY9 |
Reactomei | R-HSA-877300, Interferon gamma signaling |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein ligase TRIM31 (EC:2.3.2.27)Alternative name(s): RING-type E3 ubiquitin transferase TRIM31Curated Tripartite motif-containing protein 31 |
Gene namesi | Name:TRIM31 Synonyms:C6orf13, RNF |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16289, TRIM31 |
MIMi | 609316, gene |
neXtProti | NX_Q9BZY9 |
VEuPathDBi | HostDB:ENSG00000204616.10 |
Subcellular locationi
Mitochondrion
- Mitochondrion 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Note: Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria.
Cytosol
- cytosol Source: Reactome
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 11074 |
OpenTargetsi | ENSG00000204616 |
PharmGKBi | PA38117 |
Miscellaneous databases
Pharosi | Q9BZY9, Tbio |
Genetic variation databases
BioMutai | TRIM31 |
DMDMi | 68068082 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056245 | 1 – 425 | E3 ubiquitin-protein ligase TRIM31Add BLAST | 425 |
Post-translational modificationi
Auto-ubiquitinated (in vitro).1 Publication
Keywords - PTMi
Ubl conjugationProteomic databases
EPDi | Q9BZY9 |
MassIVEi | Q9BZY9 |
PaxDbi | Q9BZY9 |
PeptideAtlasi | Q9BZY9 |
PRIDEi | Q9BZY9 |
ProteomicsDBi | 79921 [Q9BZY9-1] 79922 [Q9BZY9-2] |
PTM databases
GlyGeni | Q9BZY9, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9BZY9 |
PhosphoSitePlusi | Q9BZY9 |
SwissPalmi | Q9BZY9 |
Expressioni
Tissue specificityi
Up-regulated in gastric adenocarcinomas.1 Publication
Gene expression databases
Bgeei | ENSG00000204616, Expressed in mucosa of transverse colon and 135 other tissues |
ExpressionAtlasi | Q9BZY9, baseline and differential |
Genevisiblei | Q9BZY9, HS |
Organism-specific databases
HPAi | ENSG00000204616, Tissue enhanced (intestine, lymphoid tissue, urinary bladder) |
Interactioni
Subunit structurei
Interacts with isoform p52shc of SHC1 (By similarity). May form oligomers.
By similarityBinary interactionsi
Hide detailsQ9BZY9
With | #Exp. | IntAct |
---|---|---|
CCT6A [P40227] | 3 | EBI-747544,EBI-356687 |
MAGEA1 [P43355] | 4 | EBI-747544,EBI-740978 |
UBE2K [P61086] | 11 | EBI-747544,EBI-473850 |
Protein-protein interaction databases
BioGRIDi | 116257, 27 interactors |
CORUMi | Q9BZY9 |
IntActi | Q9BZY9, 13 interactors |
STRINGi | 9606.ENSP00000365924 |
Miscellaneous databases
RNActi | Q9BZY9, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q9BZY9 |
SMRi | Q9BZY9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9BZY9 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 126 – 162 | Sequence analysisAdd BLAST | 37 | |
Coiled coili | 270 – 307 | Sequence analysisAdd BLAST | 38 |
Sequence similaritiesi
Belongs to the TRIM/RBCC family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 16 – 57 | RING-typePROSITE-ProRule annotationAdd BLAST | 42 | |
Zinc fingeri | 90 – 131 | B box-typePROSITE-ProRule annotationAdd BLAST | 42 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000163585 |
HOGENOMi | CLU_013137_6_1_1 |
InParanoidi | Q9BZY9 |
OMAi | YFCEQDG |
PhylomeDBi | Q9BZY9 |
TreeFami | TF338674 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR000315, Znf_B-box IPR020457, Znf_B-box_chordata IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00643, zf-B_box, 1 hit |
PRINTSi | PR01406, BBOXZNFINGER |
SMARTi | View protein in SMART SM00336, BBOX, 1 hit SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform Alpha (identifier: Q9BZY9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASGQFVNKL QEEVICPICL DILQKPVTID CGHNFCLKCI TQIGETSCGF
60 70 80 90 100
FKCPLCKTSV RKNAIRFNSL LRNLVEKIQA LQASEVQSKR KEATCPRHQE
110 120 130 140 150
MFHYFCEDDG KFLCFVCRES KDHKSHNVSL IEEAAQNYQG QIQEQIQVLQ
160 170 180 190 200
QKEKETVQVK AQGVHRVDVF TDQVEHEKQR ILTEFELLHQ VLEEEKNFLL
210 220 230 240 250
SRIYWLGHEG TEAGKHYVAS TEPQLNDLKK LVDSLKTKQN MPPRQLLEDI
260 270 280 290 300
KVVLCRSEEF QFLNPTPVPL ELEKKLSEAK SRHDSITGSL KKFKDQLQAD
310 320 330 340 350
RKKDENRFFK SMNKNDMKSW GLLQKNNHKM NKTSEPGSSS AGGRTTSGPP
360 370 380 390 400
NHHSSAPSHS LFRASSAGKV TFPVCLLASY DEISGQGASS QDTKTFDVAL
410 420
SEELHAALSE WLTAIRAWFC EVPSS
Isoform Beta (identifier: Q9BZY9-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
249-267: DIKVVLCRSEEFQFLNPTP → NWRKNSVKQNQDTTPSQGA
268-425: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JJX2 | A0A0G2JJX2_HUMAN | E3 ubiquitin-protein ligase TRIM31 | TRIM31 | 425 | Annotation score: | ||
A0A140T9J6 | A0A140T9J6_HUMAN | E3 ubiquitin-protein ligase TRIM31 | TRIM31 | 248 | Annotation score: |
Sequence cautioni
The sequence AAH16866 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 37 – 38 | LK → PQ in AAG50165 (PubMed:11331580).Curated | 2 | |
Sequence conflicti | 37 – 38 | LK → PQ in AAG50166 (PubMed:11331580).Curated | 2 | |
Sequence conflicti | 37 – 38 | LK → PQ in CAA69165 (Ref. 6) Curated | 2 | |
Sequence conflicti | 62 – 63 | KN → RD in AAG50165 (PubMed:11331580).Curated | 2 | |
Sequence conflicti | 62 – 63 | KN → RD in AAG50166 (PubMed:11331580).Curated | 2 | |
Sequence conflicti | 62 – 63 | KN → RD in CAA69165 (Ref. 6) Curated | 2 | |
Sequence conflicti | 109 | D → G in BAD96449 (Ref. 3) Curated | 1 | |
Sequence conflicti | 219 – 236 | ASTEP…VDSLK → EIPLMPTVERSQEARCYP in CAA69165 (Ref. 6) CuratedAdd BLAST | 18 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052139 | 17 | P → R. Corresponds to variant dbSNP:rs36063651EnsemblClinVar. | 1 | |
Natural variantiVAR_022728 | 118 | R → C1 PublicationCorresponds to variant dbSNP:rs3734838Ensembl. | 1 | |
Natural variantiVAR_022729 | 232 | V → I1 PublicationCorresponds to variant dbSNP:rs2523989Ensembl. | 1 | |
Natural variantiVAR_052140 | 235 | L → P. Corresponds to variant dbSNP:rs35775852EnsemblClinVar. | 1 | |
Natural variantiVAR_019962 | 421 | E → K3 PublicationsCorresponds to variant dbSNP:rs1116221Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005764 | 249 – 267 | DIKVV…LNPTP → NWRKNSVKQNQDTTPSQGA in isoform Beta. 1 PublicationAdd BLAST | 19 | |
Alternative sequenceiVSP_005765 | 268 – 425 | Missing in isoform Beta. 1 PublicationAdd BLAST | 158 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF230386 mRNA Translation: AAG50165.1 AF230387 mRNA Translation: AAG50166.1 BT006675 mRNA Translation: AAP35321.1 AK222729 mRNA Translation: BAD96449.1 AL669914 Genomic DNA No translation available. AL671859 Genomic DNA No translation available. BX322644 Genomic DNA No translation available. CR753815 Genomic DNA No translation available. BC016866 mRNA Translation: AAH16866.1 Different initiation. BC017017 mRNA Translation: AAH17017.1 Y07828 mRNA Translation: CAA69165.1 |
CCDSi | CCDS34374.1 [Q9BZY9-1] |
RefSeqi | NP_008959.3, NM_007028.4 [Q9BZY9-1] |
Genome annotation databases
Ensembli | ENST00000357569; ENSP00000350182; ENSG00000137397 ENST00000376734; ENSP00000365924; ENSG00000204616 [Q9BZY9-1] ENST00000433864; ENSP00000390551; ENSG00000233573 ENST00000445679; ENSP00000409501; ENSG00000224168 [Q9BZY9-1] ENST00000449412; ENSP00000398677; ENSG00000223531 [Q9BZY9-1] ENST00000453266; ENSP00000391685; ENSG00000225130 [Q9BZY9-1] |
GeneIDi | 11074 |
KEGGi | hsa:11074 |
UCSCi | uc003npg.2, human [Q9BZY9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF230386 mRNA Translation: AAG50165.1 AF230387 mRNA Translation: AAG50166.1 BT006675 mRNA Translation: AAP35321.1 AK222729 mRNA Translation: BAD96449.1 AL669914 Genomic DNA No translation available. AL671859 Genomic DNA No translation available. BX322644 Genomic DNA No translation available. CR753815 Genomic DNA No translation available. BC016866 mRNA Translation: AAH16866.1 Different initiation. BC017017 mRNA Translation: AAH17017.1 Y07828 mRNA Translation: CAA69165.1 |
CCDSi | CCDS34374.1 [Q9BZY9-1] |
RefSeqi | NP_008959.3, NM_007028.4 [Q9BZY9-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2YSJ | NMR | - | A | 1-56 | [»] | |
2YSL | NMR | - | A | 1-66 | [»] | |
BMRBi | Q9BZY9 | |||||
SMRi | Q9BZY9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116257, 27 interactors |
CORUMi | Q9BZY9 |
IntActi | Q9BZY9, 13 interactors |
STRINGi | 9606.ENSP00000365924 |
PTM databases
GlyGeni | Q9BZY9, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9BZY9 |
PhosphoSitePlusi | Q9BZY9 |
SwissPalmi | Q9BZY9 |
Genetic variation databases
BioMutai | TRIM31 |
DMDMi | 68068082 |
Proteomic databases
EPDi | Q9BZY9 |
MassIVEi | Q9BZY9 |
PaxDbi | Q9BZY9 |
PeptideAtlasi | Q9BZY9 |
PRIDEi | Q9BZY9 |
ProteomicsDBi | 79921 [Q9BZY9-1] 79922 [Q9BZY9-2] |
Protocols and materials databases
Antibodypediai | 11702, 190 antibodies |
DNASUi | 11074 |
Genome annotation databases
Ensembli | ENST00000357569; ENSP00000350182; ENSG00000137397 ENST00000376734; ENSP00000365924; ENSG00000204616 [Q9BZY9-1] ENST00000433864; ENSP00000390551; ENSG00000233573 ENST00000445679; ENSP00000409501; ENSG00000224168 [Q9BZY9-1] ENST00000449412; ENSP00000398677; ENSG00000223531 [Q9BZY9-1] ENST00000453266; ENSP00000391685; ENSG00000225130 [Q9BZY9-1] |
GeneIDi | 11074 |
KEGGi | hsa:11074 |
UCSCi | uc003npg.2, human [Q9BZY9-1] |
Organism-specific databases
CTDi | 11074 |
DisGeNETi | 11074 |
GeneCardsi | TRIM31 |
HGNCi | HGNC:16289, TRIM31 |
HPAi | ENSG00000204616, Tissue enhanced (intestine, lymphoid tissue, urinary bladder) |
MIMi | 609316, gene |
neXtProti | NX_Q9BZY9 |
OpenTargetsi | ENSG00000204616 |
PharmGKBi | PA38117 |
VEuPathDBi | HostDB:ENSG00000204616.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000163585 |
HOGENOMi | CLU_013137_6_1_1 |
InParanoidi | Q9BZY9 |
OMAi | YFCEQDG |
PhylomeDBi | Q9BZY9 |
TreeFami | TF338674 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q9BZY9 |
Reactomei | R-HSA-877300, Interferon gamma signaling |
Miscellaneous databases
BioGRID-ORCSi | 11074, 6 hits in 987 CRISPR screens |
ChiTaRSi | TRIM31, human |
EvolutionaryTracei | Q9BZY9 |
GeneWikii | TRIM31 |
GenomeRNAii | 11074 |
Pharosi | Q9BZY9, Tbio |
PROi | PR:Q9BZY9 |
RNActi | Q9BZY9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000204616, Expressed in mucosa of transverse colon and 135 other tissues |
ExpressionAtlasi | Q9BZY9, baseline and differential |
Genevisiblei | Q9BZY9, HS |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR000315, Znf_B-box IPR020457, Znf_B-box_chordata IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00643, zf-B_box, 1 hit |
PRINTSi | PR01406, BBOXZNFINGER |
SMARTi | View protein in SMART SM00336, BBOX, 1 hit SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRI31_HUMAN | |
Accessioni | Q9BZY9Primary (citable) accession number: Q9BZY9 Secondary accession number(s): A6NLX6 Q9BZY8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 6, 2002 |
Last sequence update: | June 21, 2005 | |
Last modified: | April 7, 2021 | |
This is version 174 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families