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Protein

Uridine-cytidine kinase 2

Gene

UCK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N4-acetylcytidine, N4-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N4-anisoylcytidine.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: CTP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes CTP from cytidine.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Uridine-cytidine kinase, Uridine-cytidine kinase (UCK1), Uridine-cytidine kinase (UCK2), Uridine-cytidine kinase 1 (UCK1), Uridine-cytidine kinase 2 (UCK2), Uridine-cytidine kinase-like 1 (UCKL1)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway CTP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from cytidine, the pathway CTP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uridine.
Proteins known to be involved in this subpathway in this organism are:
  1. Uridine-cytidine kinase, Uridine-cytidine kinase (UCK1), Uridine-cytidine kinase (UCK2), Uridine-cytidine kinase 1 (UCK1), Uridine-cytidine kinase 2 (UCK2), Uridine-cytidine kinase-like 1 (UCKL1)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uridine, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei84Substrate1
Binding sitei112Substrate1
Binding sitei117Substrate1
Binding sitei166Substrate1
Binding sitei176Substrate1
Binding sitei184Substrate1
Binding sitei213ATP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi27 – 35ATP9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • nucleoside kinase activity Source: Reactome
  • uridine kinase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS07003-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.1.48 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-73614 Pyrimidine salvage

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q9BZX2

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00574;UER00637

UPA00579;UER00640

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uridine-cytidine kinase 2 (EC:2.7.1.48)
Short name:
UCK 2
Alternative name(s):
Cytidine monophosphokinase 2
Testis-specific protein TSA903
Uridine monophosphokinase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UCK2
Synonyms:UMPK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000143179.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12562 UCK2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609329 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BZX2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7371

Open Targets

More...
OpenTargetsi
ENSG00000143179

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA362

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2469

Drug and drug target database

More...
DrugBanki
DB04272 Citric Acid
DB02097 Cytidine
DB03403 Cytidine-5'-Monophosphate
DB02431 Cytidine-5'-Triphosphate
DB04005 Uridine 5'-Triphosphate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UCK2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20455356

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001644552 – 261Uridine-cytidine kinase 2Add BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei254PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BZX2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BZX2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BZX2

PeptideAtlas

More...
PeptideAtlasi
Q9BZX2

PRoteomics IDEntifications database

More...
PRIDEi
Q9BZX2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79917
79918 [Q9BZX2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BZX2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BZX2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

According to PubMed:8812458; testis-specific. According to PubMed:11306702, placenta-specific.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143179 Expressed in 187 organ(s), highest expression level in chorionic villus

CleanEx database of gene expression profiles

More...
CleanExi
HS_UCK2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BZX2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BZX2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA057128

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113217, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BZX2, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356853

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9BZX2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BZX2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9BZX2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the uridine kinase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IMEH Eukaryota
COG0572 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153855

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000262756

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG023339

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BZX2

KEGG Orthology (KO)

More...
KOi
K00876

Identification of Orthologs from Complete Genome Data

More...
OMAi
HHIWDIL

Database of Orthologous Groups

More...
OrthoDBi
EOG091G07OR

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BZX2

TreeFam database of animal gene trees

More...
TreeFami
TF316686

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02023 UMPK, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027417 P-loop_NTPase
IPR006083 PRK/URK
IPR029925 UCK-2
IPR000764 Uridine_kinase-like

The PANTHER Classification System

More...
PANTHERi
PTHR10285:SF124 PTHR10285:SF124, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00485 PRK, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00235 udk, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BZX2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGDSEQTLQ NHQQPNGGEP FLIGVSGGTA SGKSSVCAKI VQLLGQNEVD
60 70 80 90 100
YRQKQVVILS QDSFYRVLTS EQKAKALKGQ FNFDHPDAFD NELILKTLKE
110 120 130 140 150
ITEGKTVQIP VYDFVSHSRK EETVTVYPAD VVLFEGILAF YSQEVRDLFQ
160 170 180 190 200
MKLFVDTDAD TRLSRRVLRD ISERGRDLEQ ILSQYITFVK PAFEEFCLPT
210 220 230 240 250
KKYADVIIPR GADNLVAINL IVQHIQDILN GGPSKRQTNG CLNGYTPSRK
260
RQASESSSRP H
Length:261
Mass (Da):29,299
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i71791346F091EBFD
GO
Isoform 2 (identifier: Q9BZX2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-150: Missing.

Show »
Length:111
Mass (Da):12,587
Checksum:iE6688B1B86F432A9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y653A0A2R8Y653_HUMAN
Uridine-cytidine kinase 2
UCK2
240Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti202K → Q in BAA11349 (PubMed:8812458).Curated1
Sequence conflicti222V → E in BAA11349 (PubMed:8812458).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0142621 – 150Missing in isoform 2. 3 PublicationsAdd BLAST150

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D78335 mRNA Translation: BAA11349.1
AF236637 mRNA Translation: AAK14053.1
BT006860 mRNA Translation: AAP35506.1
CR456857 mRNA Translation: CAG33138.1
AL451074 Genomic DNA No translation available.
AL358115 Genomic DNA No translation available.
BC002906 mRNA Translation: AAH02906.2
AB062451 mRNA Translation: BAB56162.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1252.1 [Q9BZX2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_036606.2, NM_012474.4 [Q9BZX2-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.458360

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367879; ENSP00000356853; ENSG00000143179 [Q9BZX2-1]
ENST00000469256; ENSP00000476692; ENSG00000143179 [Q9BZX2-2]
ENST00000470820; ENSP00000476327; ENSG00000143179 [Q9BZX2-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7371

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7371

UCSC genome browser

More...
UCSCi
uc021pec.2 human [Q9BZX2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78335 mRNA Translation: BAA11349.1
AF236637 mRNA Translation: AAK14053.1
BT006860 mRNA Translation: AAP35506.1
CR456857 mRNA Translation: CAG33138.1
AL451074 Genomic DNA No translation available.
AL358115 Genomic DNA No translation available.
BC002906 mRNA Translation: AAH02906.2
AB062451 mRNA Translation: BAB56162.1
CCDSiCCDS1252.1 [Q9BZX2-1]
RefSeqiNP_036606.2, NM_012474.4 [Q9BZX2-1]
UniGeneiHs.458360

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UDWX-ray2.60A/B1-250[»]
1UEIX-ray2.60A/B1-250[»]
1UEJX-ray2.61A/B1-250[»]
1UFQX-ray2.50A/B/C/D1-250[»]
1UJ2X-ray1.80A/B1-250[»]
1XRJX-ray2.00A/B1-261[»]
ProteinModelPortaliQ9BZX2
SMRiQ9BZX2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113217, 14 interactors
IntActiQ9BZX2, 4 interactors
STRINGi9606.ENSP00000356853

Chemistry databases

ChEMBLiCHEMBL2469
DrugBankiDB04272 Citric Acid
DB02097 Cytidine
DB03403 Cytidine-5'-Monophosphate
DB02431 Cytidine-5'-Triphosphate
DB04005 Uridine 5'-Triphosphate

PTM databases

iPTMnetiQ9BZX2
PhosphoSitePlusiQ9BZX2

Polymorphism and mutation databases

BioMutaiUCK2
DMDMi20455356

Proteomic databases

EPDiQ9BZX2
MaxQBiQ9BZX2
PaxDbiQ9BZX2
PeptideAtlasiQ9BZX2
PRIDEiQ9BZX2
ProteomicsDBi79917
79918 [Q9BZX2-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7371
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367879; ENSP00000356853; ENSG00000143179 [Q9BZX2-1]
ENST00000469256; ENSP00000476692; ENSG00000143179 [Q9BZX2-2]
ENST00000470820; ENSP00000476327; ENSG00000143179 [Q9BZX2-2]
GeneIDi7371
KEGGihsa:7371
UCSCiuc021pec.2 human [Q9BZX2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7371
DisGeNETi7371
EuPathDBiHostDB:ENSG00000143179.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
UCK2
HGNCiHGNC:12562 UCK2
HPAiHPA057128
MIMi609329 gene
neXtProtiNX_Q9BZX2
OpenTargetsiENSG00000143179
PharmGKBiPA362

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IMEH Eukaryota
COG0572 LUCA
GeneTreeiENSGT00940000153855
HOGENOMiHOG000262756
HOVERGENiHBG023339
InParanoidiQ9BZX2
KOiK00876
OMAiHHIWDIL
OrthoDBiEOG091G07OR
PhylomeDBiQ9BZX2
TreeFamiTF316686

Enzyme and pathway databases

UniPathwayi
UPA00574;UER00637

UPA00579;UER00640

BioCyciMetaCyc:HS07003-MONOMER
BRENDAi2.7.1.48 2681
ReactomeiR-HSA-73614 Pyrimidine salvage
SABIO-RKiQ9BZX2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
UCK2 human
EvolutionaryTraceiQ9BZX2

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
UCK2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7371

Protein Ontology

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PROi
PR:Q9BZX2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143179 Expressed in 187 organ(s), highest expression level in chorionic villus
CleanExiHS_UCK2
ExpressionAtlasiQ9BZX2 baseline and differential
GenevisibleiQ9BZX2 HS

Family and domain databases

CDDicd02023 UMPK, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR006083 PRK/URK
IPR029925 UCK-2
IPR000764 Uridine_kinase-like
PANTHERiPTHR10285:SF124 PTHR10285:SF124, 1 hit
PfamiView protein in Pfam
PF00485 PRK, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00235 udk, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUCK2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BZX2
Secondary accession number(s): Q5VV91
, Q7KZV3, Q92528, Q96KG5, Q9BU42
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: June 1, 2001
Last modified: December 5, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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