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Protein

Testis-specific gene 10 protein

Gene

TSGA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the sperm tail fibrous sheath, a major sperm tail structure.By similarity

GO - Biological processi

  • cell projection assembly Source: Ensembl
  • spermatogenesis Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific gene 10 protein
Alternative name(s):
Testis development protein NYD-SP7
Gene namesi
Name:TSGA10
Synonyms:CEP4L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000135951.14
HGNCiHGNC:14927 TSGA10
MIMi607166 gene
neXtProtiNX_Q9BZW7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi80705
OpenTargetsiENSG00000135951
PharmGKBiPA37933

Polymorphism and mutation databases

BioMutaiTSGA10
DMDMi74724919

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003071251 – 698Testis-specific gene 10 proteinAdd BLAST698

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei163PhosphoserineCombined sources1
Modified residuei688PhosphoserineBy similarity1

Post-translational modificationi

Appears to be processed in a 27 kDa and a 55 kDa peptide containing respectively the N-terminal and the C-terminal part of the precursor.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BZW7
PaxDbiQ9BZW7
PeptideAtlasiQ9BZW7
PRIDEiQ9BZW7
ProteomicsDBi79912

PTM databases

iPTMnetiQ9BZW7
PhosphoSitePlusiQ9BZW7

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiENSG00000135951 Expressed in 138 organ(s), highest expression level in sperm
CleanExiHS_TSGA10
ExpressionAtlasiQ9BZW7 baseline and differential
GenevisibleiQ9BZW7 HS

Organism-specific databases

HPAiHPA036879

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi123267, 48 interactors
IntActiQ9BZW7, 76 interactors
MINTiQ9BZW7
STRINGi9606.ENSP00000347161

Structurei

3D structure databases

ProteinModelPortaliQ9BZW7
SMRiQ9BZW7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni556 – 689Interaction with HIF1ABy similarityAdd BLAST134

Sequence similaritiesi

Belongs to the CEP135/TSGA10 family.Curated

Phylogenomic databases

eggNOGiENOG410IFB3 Eukaryota
ENOG410ZW66 LUCA
GeneTreeiENSGT00530000063949
HOGENOMiHOG000082666
HOVERGENiHBG108603
InParanoidiQ9BZW7
OMAiIMCLDEK
OrthoDBiEOG091G032W
PhylomeDBiQ9BZW7
TreeFamiTF326518

Family and domain databases

InterProiView protein in InterPro
IPR033323 TSGA10
PANTHERiPTHR23159:SF14 PTHR23159:SF14, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9BZW7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMRSRSKSPR RPSPTARGAN CDVELLKTTT RDREELKCML EKYERHLAEI
60 70 80 90 100
QGNVKVLKSE RDKIFLLYEQ AQEEITRLRR EMMKSCKSPK STTAHAILRR
110 120 130 140 150
VETERDVAFT DLRRMTTERD SLRERLKIAQ ETAFNEKAHL EQRIEELECT
160 170 180 190 200
VHNLDDERME QMSNMTLMKE TISTVEKEMK SLARKAMDTE SELGRQKAEN
210 220 230 240 250
NSLRLLYENT EKDLSDTQRH LAKKKYELQL TQEKIMCLDE KIDNFTRQNI
260 270 280 290 300
AQREEISILG GTLNDLAKEK ECLQACLDKK SENIASLGES LAMKEKTISG
310 320 330 340 350
MKNIIAEMEQ ASRQCTEALI VCEQDVSRMR RQLDETNDEL AQIARERDIL
360 370 380 390 400
AHDNDNLQEQ FAKAKQENQA LSKKLNDTHN ELNDIKQKVQ DTNLEVNKLK
410 420 430 440 450
NILKSEESEN RQMMEQLRKA NEDAENWENK ARQSEADNNT LKLELITAEA
460 470 480 490 500
EGNRLKEKVD SLNREVEQHL NAERSYKSQI STLHKSVVKM EEELQKVQFE
510 520 530 540 550
KVSALADLSS TRELCIKLDS SKELLNRQLV AKDQEIEMRE NELDSAHSEI
560 570 580 590 600
ELLRSQMANE RISMQNLEAL LVANRDKEYQ SQIALQEKES EIQLLKEHLC
610 620 630 640 650
LAENKMAIQS RDVAQFRNVV TQLEADLDIT KRQLGTERFE RERAVQELRR
660 670 680 690
QNYSSNAYHM SSTMKPNTKC HSPERAHHRS PDRGLDRSLE ENLCYRDF
Length:698
Mass (Da):81,421
Last modified:June 1, 2001 - v1
Checksum:i8338D7FAAA2F2473
GO
Isoform 2 (identifier: Q9BZW7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-297: EKT → TVY
     298-698: Missing.

Note: No experimental confirmation available.
Show »
Length:297
Mass (Da):34,728
Checksum:iB58D6DCB2544C48E
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZZ9B8ZZZ9_HUMAN
Testis-specific gene 10 protein
TSGA10
620Annotation score:
F8WA32F8WA32_HUMAN
Testis-specific gene 10 protein
TSGA10
690Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28T → EP in AAK27309 (Ref. 2) Curated1
Sequence conflicti273L → M in AAH28366 (PubMed:15489334).Curated1
Sequence conflicti365K → N in AAK27309 (Ref. 2) Curated1
Sequence conflicti624E → G in AAK27309 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054409295 – 297EKT → TVY in isoform 2. 1 Publication3
Alternative sequenceiVSP_054410298 – 698Missing in isoform 2. 1 PublicationAdd BLAST401

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254756 mRNA Translation: AAK13079.1
AY014284 mRNA Translation: AAK27309.1
AK304328 mRNA Translation: BAH14161.1
AC019097 Genomic DNA Translation: AAY14820.1
AC092587 Genomic DNA No translation available.
AC110083 Genomic DNA No translation available.
CH471127 Genomic DNA Translation: EAX01889.1
CH471127 Genomic DNA Translation: EAX01890.1
CH471127 Genomic DNA Translation: EAX01891.1
CH471127 Genomic DNA Translation: EAX01892.1
BC028366 mRNA Translation: AAH28366.1
CCDSiCCDS2037.1 [Q9BZW7-1]
RefSeqiNP_079520.1, NM_025244.2 [Q9BZW7-1]
NP_878915.2, NM_182911.3 [Q9BZW7-1]
XP_005264080.1, XM_005264023.1 [Q9BZW7-1]
XP_005264081.1, XM_005264024.2 [Q9BZW7-1]
XP_005264082.1, XM_005264025.1 [Q9BZW7-1]
XP_005264083.1, XM_005264026.1 [Q9BZW7-1]
XP_005264084.1, XM_005264027.1 [Q9BZW7-1]
XP_005264086.1, XM_005264029.1 [Q9BZW7-1]
XP_006712844.1, XM_006712781.2 [Q9BZW7-1]
XP_011510239.1, XM_011511937.1 [Q9BZW7-1]
XP_011510241.1, XM_011511939.1 [Q9BZW7-1]
XP_011510242.1, XM_011511940.2 [Q9BZW7-1]
XP_011510243.1, XM_011511941.1 [Q9BZW7-1]
XP_011510244.1, XM_011511942.1 [Q9BZW7-1]
XP_011510245.1, XM_011511943.2 [Q9BZW7-1]
XP_016860528.1, XM_017005039.1 [Q9BZW7-1]
XP_016860529.1, XM_017005040.1 [Q9BZW7-1]
XP_016860530.1, XM_017005041.1 [Q9BZW7-1]
XP_016860531.1, XM_017005042.1 [Q9BZW7-1]
XP_016860532.1, XM_017005043.1 [Q9BZW7-1]
XP_016860533.1, XM_017005044.1 [Q9BZW7-1]
XP_016860534.1, XM_017005045.1 [Q9BZW7-1]
XP_016860535.1, XM_017005046.1 [Q9BZW7-1]
XP_016860536.1, XM_017005047.1 [Q9BZW7-1]
XP_016860537.1, XM_017005048.1 [Q9BZW7-1]
UniGeneiHs.120267
Hs.721218

Genome annotation databases

EnsembliENST00000355053; ENSP00000347161; ENSG00000135951 [Q9BZW7-1]
ENST00000393483; ENSP00000377123; ENSG00000135951 [Q9BZW7-1]
ENST00000410001; ENSP00000386956; ENSG00000135951 [Q9BZW7-1]
GeneIDi80705
KEGGihsa:80705
UCSCiuc002szg.5 human [Q9BZW7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTSG10_HUMAN
AccessioniPrimary (citable) accession number: Q9BZW7
Secondary accession number(s): B7Z925
, D3DVH7, Q8NEP0, Q9BWX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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