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Entry version 135 (07 Oct 2020)
Sequence version 1 (01 Jun 2001)
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Protein

Testis-specific gene 10 protein

Gene

TSGA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in spermatogenesis (PubMed:28905369). When overexpressed, prevents nuclear localization of HIF1A (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cell projection assembly Source: Ensembl
  • spermatogenesis Source: UniProtKB

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9BZW7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Testis-specific gene 10 protein
Alternative name(s):
Testis development protein NYD-SP7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSGA10
Synonyms:CEP4L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000135951.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14927, TSGA10

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607166, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BZW7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spermatogenic failure 26 (SPGF26)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive infertility disorder caused by spermatogenesis defects that result in acephalic spermatozoa.
Related information in OMIM

Organism-specific databases

DisGeNET

More...
DisGeNETi
80705

MalaCards human disease database

More...
MalaCardsi
TSGA10
MIMi617961, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000135951

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37933

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BZW7, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TSGA10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74724919

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003071251 – 698Testis-specific gene 10 proteinAdd BLAST698

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei163PhosphoserineCombined sources1
Modified residuei688PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Processed into N-terminal 27-kDa and C-terminal 55-kDa fragments.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BZW7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9BZW7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BZW7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BZW7

PeptideAtlas

More...
PeptideAtlasi
Q9BZW7

PRoteomics IDEntifications database

More...
PRIDEi
Q9BZW7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
6998
79912 [Q9BZW7-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BZW7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BZW7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the testis, in spermatozoa (at protein level) (PubMed:11179690, PubMed:28905369). Expressed in actively dividing fetal tissues, including sternum, intestine, limb, kidney and stomach (PubMed:14585816).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135951, Expressed in sperm and 157 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9BZW7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BZW7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000135951, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HIF1A.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9BZW7
With#Exp.IntAct
AARD [Q4LEZ3]3EBI-744794,EBI-5463075
AXIN1 [A0A0S2Z4M1]3EBI-744794,EBI-16429430
AXIN2 [Q9Y2T1]3EBI-744794,EBI-4400025
BCL6B [A8KA13]3EBI-744794,EBI-10174813
BIRC2 [Q13490]4EBI-744794,EBI-514538
CBX8 [Q9HC52]3EBI-744794,EBI-712912
CBY2 [Q8NA61]3EBI-744794,EBI-741724
CCDC88B [A6NC98]3EBI-744794,EBI-347573
CCHCR1 - isoform 3 [Q8TD31-3]6EBI-744794,EBI-10175300
CDC73 [Q6P1J9]8EBI-744794,EBI-930143
CDK18 [Q07002]3EBI-744794,EBI-746238
CEP44 [Q9C0F1]6EBI-744794,EBI-744115
CEP57 - isoform 3 [Q86XR8-3]3EBI-744794,EBI-11752486
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-744794,EBI-10181988
COG6 [Q9Y2V7]3EBI-744794,EBI-3866319
CREB5 - isoform 3 [Q02930-3]3EBI-744794,EBI-10192698
DISC1 - isoform 2 [Q9NRI5-2]3EBI-744794,EBI-11988027
FAM161B [Q96MY7]3EBI-744794,EBI-7225287
FBF1 - isoform 6 [Q8TES7-6]3EBI-744794,EBI-10244131
FLJ38668 [C0H5X2]3EBI-744794,EBI-10176227
GOLGA2 [Q08379]3EBI-744794,EBI-618309
HDAC4 - isoform 2 [P56524-2]3EBI-744794,EBI-11953488
HDX [Q7Z353]3EBI-744794,EBI-1052734
HNRNPM [P52272]3EBI-744794,EBI-486809
HOOK2 - isoform 2 [Q96ED9-2]3EBI-744794,EBI-10961706
JRK - isoform 2 [O75564-2]3EBI-744794,EBI-17181882
KANK2 [Q63ZY3]3EBI-744794,EBI-2556193
KIAA1328 [Q86T90]3EBI-744794,EBI-3437878
KRT76 [Q01546]3EBI-744794,EBI-2952745
LZTS1 [Q9Y250]3EBI-744794,EBI-1216080
MAD1L1 [Q9Y6D9]3EBI-744794,EBI-742610
MATR3 [P43243]3EBI-744794,EBI-352602
MBD3L1 [Q8WWY6]3EBI-744794,EBI-12516603
MID2 - isoform 2 [Q9UJV3-2]3EBI-744794,EBI-10172526
NAB2 [Q15742]3EBI-744794,EBI-8641936
PAK5 [Q9P286]3EBI-744794,EBI-741896
PIBF1 [Q4G0R1]3EBI-744794,EBI-14066006
PKN1 [Q16512]3EBI-744794,EBI-602382
PLEKHA7 - isoform 2 [Q6IQ23-2]3EBI-744794,EBI-12069346
PPHLN1 [Q8NEY8]3EBI-744794,EBI-474076
PPP1R13B [Q96KQ4]3EBI-744794,EBI-1105153
PPP1R18 [Q6NYC8]3EBI-744794,EBI-2557469
PRDM14 [Q9GZV8]3EBI-744794,EBI-3957793
PRDM6 [Q9NQX0]3EBI-744794,EBI-11320284
PRPF31 [Q8WWY3]6EBI-744794,EBI-1567797
RBAK [Q9NYW8]3EBI-744794,EBI-1210429
RCOR3 [Q9P2K3]3EBI-744794,EBI-743428
RNF6 [A0A0S2Z4G9]3EBI-744794,EBI-16428950
RTP5 [Q14D33]3EBI-744794,EBI-10217913
SCEL [O95171]3EBI-744794,EBI-7543896
SORBS3 [O60504]3EBI-744794,EBI-741237
SYT6 - isoform 2 [Q5T7P8-2]3EBI-744794,EBI-10246152
TCEA2 [Q15560]3EBI-744794,EBI-710310
TLE5 [Q08117]3EBI-744794,EBI-717810
TP53BP2 [Q05BL1]3EBI-744794,EBI-11952721
TRIM14 [Q14142]3EBI-744794,EBI-2820256
ZBTB24 [O43167]3EBI-744794,EBI-744471
ZBTB26 [Q9HCK0]3EBI-744794,EBI-3918996
ZBTB39 [O15060]3EBI-744794,EBI-9995672
ZNF124 [Q15973]3EBI-744794,EBI-2555767
ZNF2 - isoform 2 [Q9BSG1-2]3EBI-744794,EBI-10297542
ZNF205 [O95201]3EBI-744794,EBI-747343
ZNF23 [P17027]3EBI-744794,EBI-5657766
ZNF410 [Q86VK4]3EBI-744794,EBI-720304
ZNF410 - isoform 3 [Q86VK4-3]3EBI-744794,EBI-11741890
ZNF417 [Q8TAU3]3EBI-744794,EBI-740727
ZNF426 [Q9BUY5]3EBI-744794,EBI-743265
ZNF438 [Q7Z4V0]3EBI-744794,EBI-11962468
ZNF490 [Q9ULM2]3EBI-744794,EBI-1105370
ZNF544 [Q6NX49]3EBI-744794,EBI-2841978
ZNF587 [Q96SQ5]3EBI-744794,EBI-6427977
ZNF599 [Q96NL3]3EBI-744794,EBI-8653994
ZNF670 [Q9BS34]3EBI-744794,EBI-745276
A0A1U9X8X83EBI-744794,EBI-17234977
Q9H6F03EBI-744794,EBI-10307481

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123267, 91 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BZW7, 81 interactors

Molecular INTeraction database

More...
MINTi
Q9BZW7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377123

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BZW7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BZW7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni556 – 689Interaction with HIF1ABy similarityAdd BLAST134

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CEP135/TSGA10 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RJHC, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159205

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BZW7

Identification of Orthologs from Complete Genome Data

More...
OMAi
QIELICQ

Database of Orthologous Groups

More...
OrthoDBi
139407at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BZW7

TreeFam database of animal gene trees

More...
TreeFami
TF326518

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033323, TSGA10

The PANTHER Classification System

More...
PANTHERi
PTHR23159:SF14, PTHR23159:SF14, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BZW7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMRSRSKSPR RPSPTARGAN CDVELLKTTT RDREELKCML EKYERHLAEI
60 70 80 90 100
QGNVKVLKSE RDKIFLLYEQ AQEEITRLRR EMMKSCKSPK STTAHAILRR
110 120 130 140 150
VETERDVAFT DLRRMTTERD SLRERLKIAQ ETAFNEKAHL EQRIEELECT
160 170 180 190 200
VHNLDDERME QMSNMTLMKE TISTVEKEMK SLARKAMDTE SELGRQKAEN
210 220 230 240 250
NSLRLLYENT EKDLSDTQRH LAKKKYELQL TQEKIMCLDE KIDNFTRQNI
260 270 280 290 300
AQREEISILG GTLNDLAKEK ECLQACLDKK SENIASLGES LAMKEKTISG
310 320 330 340 350
MKNIIAEMEQ ASRQCTEALI VCEQDVSRMR RQLDETNDEL AQIARERDIL
360 370 380 390 400
AHDNDNLQEQ FAKAKQENQA LSKKLNDTHN ELNDIKQKVQ DTNLEVNKLK
410 420 430 440 450
NILKSEESEN RQMMEQLRKA NEDAENWENK ARQSEADNNT LKLELITAEA
460 470 480 490 500
EGNRLKEKVD SLNREVEQHL NAERSYKSQI STLHKSVVKM EEELQKVQFE
510 520 530 540 550
KVSALADLSS TRELCIKLDS SKELLNRQLV AKDQEIEMRE NELDSAHSEI
560 570 580 590 600
ELLRSQMANE RISMQNLEAL LVANRDKEYQ SQIALQEKES EIQLLKEHLC
610 620 630 640 650
LAENKMAIQS RDVAQFRNVV TQLEADLDIT KRQLGTERFE RERAVQELRR
660 670 680 690
QNYSSNAYHM SSTMKPNTKC HSPERAHHRS PDRGLDRSLE ENLCYRDF
Length:698
Mass (Da):81,421
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8338D7FAAA2F2473
GO
Isoform 2 (identifier: Q9BZW7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-297: EKT → TVY
     298-698: Missing.

Show »
Length:297
Mass (Da):34,728
Checksum:iB58D6DCB2544C48E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WA32F8WA32_HUMAN
Testis-specific gene 10 protein
TSGA10
690Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B8ZZZ9B8ZZZ9_HUMAN
Testis-specific gene 10 protein
TSGA10
620Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A669KBL0A0A669KBL0_HUMAN
Testis-specific gene 10 protein
TSGA10
789Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti28T → EP in AAK27309 (Ref. 2) Curated1
Sequence conflicti273L → M in AAH28366 (PubMed:15489334).Curated1
Sequence conflicti365K → N in AAK27309 (Ref. 2) Curated1
Sequence conflicti624E → G in AAK27309 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054409295 – 297EKT → TVY in isoform 2. 1 Publication3
Alternative sequenceiVSP_054410298 – 698Missing in isoform 2. 1 PublicationAdd BLAST401

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF254756 mRNA Translation: AAK13079.1
AY014284 mRNA Translation: AAK27309.1
AK304328 mRNA Translation: BAH14161.1
AC019097 Genomic DNA Translation: AAY14820.1
AC092587 Genomic DNA No translation available.
AC110083 Genomic DNA No translation available.
CH471127 Genomic DNA Translation: EAX01889.1
CH471127 Genomic DNA Translation: EAX01890.1
CH471127 Genomic DNA Translation: EAX01891.1
CH471127 Genomic DNA Translation: EAX01892.1
BC028366 mRNA Translation: AAH28366.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2037.1 [Q9BZW7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_079520.1, NM_025244.2 [Q9BZW7-1]
NP_878915.2, NM_182911.3 [Q9BZW7-1]
XP_005264080.1, XM_005264023.1 [Q9BZW7-1]
XP_005264081.1, XM_005264024.2 [Q9BZW7-1]
XP_005264082.1, XM_005264025.1 [Q9BZW7-1]
XP_005264083.1, XM_005264026.1 [Q9BZW7-1]
XP_005264084.1, XM_005264027.1 [Q9BZW7-1]
XP_005264086.1, XM_005264029.1 [Q9BZW7-1]
XP_006712844.1, XM_006712781.2 [Q9BZW7-1]
XP_011510239.1, XM_011511937.1 [Q9BZW7-1]
XP_011510241.1, XM_011511939.1 [Q9BZW7-1]
XP_011510242.1, XM_011511940.2
XP_011510243.1, XM_011511941.1 [Q9BZW7-1]
XP_011510244.1, XM_011511942.1 [Q9BZW7-1]
XP_011510245.1, XM_011511943.2
XP_016860528.1, XM_017005039.1 [Q9BZW7-1]
XP_016860529.1, XM_017005040.1 [Q9BZW7-1]
XP_016860530.1, XM_017005041.1 [Q9BZW7-1]
XP_016860531.1, XM_017005042.1 [Q9BZW7-1]
XP_016860532.1, XM_017005043.1 [Q9BZW7-1]
XP_016860533.1, XM_017005044.1 [Q9BZW7-1]
XP_016860534.1, XM_017005045.1 [Q9BZW7-1]
XP_016860535.1, XM_017005046.1 [Q9BZW7-1]
XP_016860536.1, XM_017005047.1 [Q9BZW7-1]
XP_016860537.1, XM_017005048.1 [Q9BZW7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355053; ENSP00000347161; ENSG00000135951 [Q9BZW7-1]
ENST00000393483; ENSP00000377123; ENSG00000135951 [Q9BZW7-1]
ENST00000410001; ENSP00000386956; ENSG00000135951 [Q9BZW7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
80705

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:80705

UCSC genome browser

More...
UCSCi
uc002szg.5, human [Q9BZW7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254756 mRNA Translation: AAK13079.1
AY014284 mRNA Translation: AAK27309.1
AK304328 mRNA Translation: BAH14161.1
AC019097 Genomic DNA Translation: AAY14820.1
AC092587 Genomic DNA No translation available.
AC110083 Genomic DNA No translation available.
CH471127 Genomic DNA Translation: EAX01889.1
CH471127 Genomic DNA Translation: EAX01890.1
CH471127 Genomic DNA Translation: EAX01891.1
CH471127 Genomic DNA Translation: EAX01892.1
BC028366 mRNA Translation: AAH28366.1
CCDSiCCDS2037.1 [Q9BZW7-1]
RefSeqiNP_079520.1, NM_025244.2 [Q9BZW7-1]
NP_878915.2, NM_182911.3 [Q9BZW7-1]
XP_005264080.1, XM_005264023.1 [Q9BZW7-1]
XP_005264081.1, XM_005264024.2 [Q9BZW7-1]
XP_005264082.1, XM_005264025.1 [Q9BZW7-1]
XP_005264083.1, XM_005264026.1 [Q9BZW7-1]
XP_005264084.1, XM_005264027.1 [Q9BZW7-1]
XP_005264086.1, XM_005264029.1 [Q9BZW7-1]
XP_006712844.1, XM_006712781.2 [Q9BZW7-1]
XP_011510239.1, XM_011511937.1 [Q9BZW7-1]
XP_011510241.1, XM_011511939.1 [Q9BZW7-1]
XP_011510242.1, XM_011511940.2
XP_011510243.1, XM_011511941.1 [Q9BZW7-1]
XP_011510244.1, XM_011511942.1 [Q9BZW7-1]
XP_011510245.1, XM_011511943.2
XP_016860528.1, XM_017005039.1 [Q9BZW7-1]
XP_016860529.1, XM_017005040.1 [Q9BZW7-1]
XP_016860530.1, XM_017005041.1 [Q9BZW7-1]
XP_016860531.1, XM_017005042.1 [Q9BZW7-1]
XP_016860532.1, XM_017005043.1 [Q9BZW7-1]
XP_016860533.1, XM_017005044.1 [Q9BZW7-1]
XP_016860534.1, XM_017005045.1 [Q9BZW7-1]
XP_016860535.1, XM_017005046.1 [Q9BZW7-1]
XP_016860536.1, XM_017005047.1 [Q9BZW7-1]
XP_016860537.1, XM_017005048.1 [Q9BZW7-1]

3D structure databases

SMRiQ9BZW7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123267, 91 interactors
IntActiQ9BZW7, 81 interactors
MINTiQ9BZW7
STRINGi9606.ENSP00000377123

PTM databases

iPTMnetiQ9BZW7
PhosphoSitePlusiQ9BZW7

Polymorphism and mutation databases

BioMutaiTSGA10
DMDMi74724919

Proteomic databases

EPDiQ9BZW7
jPOSTiQ9BZW7
MassIVEiQ9BZW7
PaxDbiQ9BZW7
PeptideAtlasiQ9BZW7
PRIDEiQ9BZW7
ProteomicsDBi6998
79912 [Q9BZW7-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32767, 129 antibodies

The DNASU plasmid repository

More...
DNASUi
80705

Genome annotation databases

EnsembliENST00000355053; ENSP00000347161; ENSG00000135951 [Q9BZW7-1]
ENST00000393483; ENSP00000377123; ENSG00000135951 [Q9BZW7-1]
ENST00000410001; ENSP00000386956; ENSG00000135951 [Q9BZW7-1]
GeneIDi80705
KEGGihsa:80705
UCSCiuc002szg.5, human [Q9BZW7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80705
DisGeNETi80705
EuPathDBiHostDB:ENSG00000135951.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TSGA10
HGNCiHGNC:14927, TSGA10
HPAiENSG00000135951, Tissue enhanced (testis)
MalaCardsiTSGA10
MIMi607166, gene
617961, phenotype
neXtProtiNX_Q9BZW7
OpenTargetsiENSG00000135951
PharmGKBiPA37933

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RJHC, Eukaryota
GeneTreeiENSGT00940000159205
InParanoidiQ9BZW7
OMAiQIELICQ
OrthoDBi139407at2759
PhylomeDBiQ9BZW7
TreeFamiTF326518

Enzyme and pathway databases

PathwayCommonsiQ9BZW7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
80705, 5 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TSGA10, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80705
PharosiQ9BZW7, Tbio

Protein Ontology

More...
PROi
PR:Q9BZW7
RNActiQ9BZW7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135951, Expressed in sperm and 157 other tissues
ExpressionAtlasiQ9BZW7, baseline and differential
GenevisibleiQ9BZW7, HS

Family and domain databases

InterProiView protein in InterPro
IPR033323, TSGA10
PANTHERiPTHR23159:SF14, PTHR23159:SF14, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSG10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BZW7
Secondary accession number(s): B7Z925
, D3DVH7, Q8NEP0, Q9BWX0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 1, 2001
Last modified: October 7, 2020
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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