UniProtKB - Q9BZV2 (S19A3_HUMAN)

BLAST

>sp|Q9BZV2|S19A3_HUMAN Thiamine transporter 2 OS=Homo sapiens OX=9606 GN=SLC19A3 PE=1 SV=1
MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGPDKNLTSAEITNEIFPVWT
YSYLVLLLPVFVLTDYVRYKPVIILQGISFIITWLLLLFGQGVKTMQVVEFFYGMVTAAE
VAYYAYIYSVVSPEHYQRVSGYCRSVTLAAYTAGSVLAQLLVSLANMSYFYLNVISLASV
SVAFLFSLFLPMPKKSMFFHAKPSREIKKSSSVNPVLEETHEGEAPGCEEQKPTSEILST
SGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWSLWWAFATAGFNQVLNYVQ
ILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWDLLGELALVVFSVVNAGSL
FLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVERYALVFGINTFIALVIQTI
MTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMRSMYITYSTKSQKDVQSPAPSENPD
VSHPEEESNIIMSTKL

Align
Format
Add to basket Added to basket
History
Entry version 137 (12 Sep 2018)
Sequence version 1 (01 Jun 2001)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Thiamine transporter 2

Gene

SLC19A3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity.1 Publication

GO - Molecular functionⁱ

thiamine transmembrane transporter activity Source: BHF-UCL

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

thiamine-containing compound metabolic process Source: Reactome
thiamine transmembrane transport Source: BHF-UCL
thiamine transport Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-196819 Vitamin B1 (thiamin) metabolism
SIGNORⁱ	Q9BZV2

Protein family/group databases

TCDBⁱ	2.A.48.1.4 the reduced folate carrier (rfc) family

TCDBⁱ

2.A.48.1.4 the reduced folate carrier (rfc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Thiamine transporter 2 Short name: ThTr-2 Short name: ThTr2 Alternative name(s): Solute carrier family 19 member 3
Gene namesⁱ	Name:SLC19A3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000135917.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16266 SLC19A3
MIMⁱ	606152 gene
neXtProtⁱ	NX_Q9BZV2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 7	CytoplasmicSequence analysis	7
Transmembraneⁱ	8 – 28	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	29 – 53	ExtracellularSequence analysisAdd BLAST	25
Transmembraneⁱ	54 – 74	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	75 – 81	CytoplasmicSequence analysis	7
Transmembraneⁱ	82 – 102	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	103 – 110	ExtracellularSequence analysis	8
Transmembraneⁱ	111 – 131	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	132 – 144	CytoplasmicSequence analysisAdd BLAST	13
Transmembraneⁱ	145 – 165	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	166 – 169	ExtracellularSequence analysis	4
Transmembraneⁱ	170 – 190	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	191 – 282	CytoplasmicSequence analysisAdd BLAST	92
Transmembraneⁱ	283 – 303	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	304 – 316	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	317 – 337	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	338 – 342	CytoplasmicSequence analysis	5
Transmembraneⁱ	343 – 363	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	364 – 375	ExtracellularSequence analysisAdd BLAST	12
Transmembraneⁱ	376 – 396	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	397 – 405	CytoplasmicSequence analysis	9
Transmembraneⁱ	406 – 426	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	427 – 434	ExtracellularSequence analysis	8
Transmembraneⁱ	435 – 455	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	456 – 496	CytoplasmicSequence analysisAdd BLAST	41

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Thiamine metabolism dysfunction syndrome 2, biotin- or thiamine-responsive type (THMD2)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive metabolic disorder characterized by episodic encephalopathy, often triggered by febrile illness, presenting as confusion, seizures, external ophthalmoplegia, dysphagia, and sometimes coma and death. If untreated, encephalopathies can result in permanent dystonia. Brain imaging may show characteristic bilateral lesions of the basal ganglia.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	80704
GeneReviewsⁱ	SLC19A3
MalaCards human disease database More...MalaCardsⁱ	SLC19A3
MIMⁱ	607483 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000135917
Orphanetⁱ	65284 Biotin-responsive basal ganglia disease 263410 Infantile spams - psychomotor retardation - progressive brain atrophy - basal ganglia disease 255241 Leigh syndrome with leukodystrophy 199348 Thiamine-responsive encephalopathy
PharmGKBⁱ	PA38397

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00151 L-Cysteine

DrugBankⁱ

DB00151 L-Cysteine

Polymorphism and mutation databases

BioMutaⁱ	SLC19A3
DMDMⁱ	74733486

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000232656	1 – 496	Thiamine transporter 2Add BLAST		496

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	45	N-linked (GlcNAc...) asparagine1 Publication		1
Glycosylationⁱ	166	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	Q9BZV2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BZV2
PaxDbⁱ	Q9BZV2
PeptideAtlas More...PeptideAtlasⁱ	Q9BZV2
PRIDEⁱ	Q9BZV2
ProteomicsDBⁱ	79906

PTM databases

iPTMnetⁱ	Q9BZV2
PhosphoSitePlusⁱ	Q9BZV2

Expressionⁱ

Tissue specificityⁱ

Gene expression databases

Bgeeⁱ	ENSG00000135917 Expressed in 120 organ(s), highest expression level in adipose tissue of abdominal region
CleanExⁱ	HS_SLC19A3
ExpressionAtlasⁱ	Q9BZV2 baseline and differential
Genevisibleⁱ	Q9BZV2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA038898

HPAⁱ

HPA038898

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	123266, 5 interactors
IntActⁱ	Q9BZV2, 12 interactors
Molecular INTeraction database More...MINTⁱ	Q9BZV2
STRINGⁱ	9606.ENSP00000258403

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BZV2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3810 Eukaryota ENOG410XT34 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046382
HOGENOMⁱ	HOG000001583
HOVERGENⁱ	HBG054198
InParanoidⁱ	Q9BZV2
KEGG Orthology (KO) More...KOⁱ	K14610
OMAⁱ	ECYSSKH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BSJ
PhylomeDBⁱ	Q9BZV2
TreeFamⁱ	TF313684

Family and domain databases

InterProⁱ	View protein in InterPro IPR002666 Folate_carrier IPR036259 MFS_trans_sf IPR028337 ThTr-2
PANTHERⁱ	PTHR10686 PTHR10686, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01770 Folate_carrier, 1 hit
PIRSFⁱ	PIRSF028739 Folate_carrier, 1 hit PIRSF500795 Thiamine_transporter_2, 1 hit
SUPFAMⁱ	SSF103473 SSF103473, 2 hits
TIGRFAMsⁱ	TIGR00806 rfc, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show all Align All

Q9BZV2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDCYRTSLSS SWIYPTVILC LFGFFSMMRP SEPFLIPYLS GPDKNLTSAE 
        60         70         80         90        100
ITNEIFPVWT YSYLVLLLPV FVLTDYVRYK PVIILQGISF IITWLLLLFG 
       110        120        130        140        150
QGVKTMQVVE FFYGMVTAAE VAYYAYIYSV VSPEHYQRVS GYCRSVTLAA 
       160        170        180        190        200
YTAGSVLAQL LVSLANMSYF YLNVISLASV SVAFLFSLFL PMPKKSMFFH 
       210        220        230        240        250
AKPSREIKKS SSVNPVLEET HEGEAPGCEE QKPTSEILST SGKLNKGQLN 
       260        270        280        290        300
SLKPSNVTVD VFVQWFQDLK ECYSSKRLFY WSLWWAFATA GFNQVLNYVQ 
       310        320        330        340        350
ILWDYKAPSQ DSSIYNGAVE AIATFGGAVA AFAVGYVKVN WDLLGELALV 
       360        370        380        390        400
VFSVVNAGSL FLMHYTANIW ACYAGYLIFK SSYMLLITIA VFQIAVNLNV 
       410        420        430        440        450
ERYALVFGIN TFIALVIQTI MTVIVVDQRG LNLPVSIQFL VYGSYFAVIA 
       460        470        480        490 
GIFLMRSMYI TYSTKSQKDV QSPAPSENPD VSHPEEESNI IMSTKL

Length:496

Mass (Da):55,665

Last modified:June 1, 2001 - v1

Checksum:ⁱB102651C205F0F16

Computationally mapped potential isoform sequencesⁱ

There are 9 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A2R8YHG5	A0A2R8YHG5_HUMAN	Thiamine transporter 2 Thiamine transporter 2	SLC19A3	508	Annotation score:
C9IZI1	C9IZI1_HUMAN	Thiamine transporter 2 Thiamine transporter 2	SLC19A3	229	Annotation score:
E7EM61	E7EM61_HUMAN	Thiamine transporter 2 Thiamine transporter 2	SLC19A3	56	Annotation score:
C9J4J5	C9J4J5_HUMAN	Thiamine transporter 2 Thiamine transporter 2	SLC19A3	64	Annotation score:
B8ZZW1	B8ZZW1_HUMAN	Thiamine transporter 2 Thiamine transporter 2	SLC19A3	92	Annotation score:
B8ZZ39	B8ZZ39_HUMAN	Thiamine transporter 2 Thiamine transporter 2	SLC19A3	54	Annotation score:
A0A2R8YFC5	A0A2R8YFC5_HUMAN	Thiamine transporter 2 Thiamine transporter 2	SLC19A3	286	Annotation score:
A0A2R8Y694	A0A2R8Y694_HUMAN	Thiamine transporter 2 Thiamine transporter 2	SLC19A3	56	Annotation score:
A0A2R8Y655	A0A2R8Y655_HUMAN	Thiamine transporter 2 Thiamine transporter 2	SLC19A3	60	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_025992	23	G → V in THMD2. 1 PublicationCorresponds to variant dbSNP:rs121917882EnsemblClinVar.	1
Natural variantⁱVAR_061864	174	V → I. Corresponds to variant dbSNP:rs59736804EnsemblClinVar.	1
Natural variantⁱVAR_052405	350	V → A. Corresponds to variant dbSNP:rs34507036EnsemblClinVar.	1
Natural variantⁱVAR_025993	422	T → A in THMD2. 1 PublicationCorresponds to variant dbSNP:rs121917884EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF271633 mRNA Translation: AAG53879.1 AF283317 mRNA Translation: AAK69539.1 AC064853 Genomic DNA Translation: AAX93157.1 BC032014 mRNA Translation: AAH32014.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2468.1
NCBI Reference Sequences More...RefSeqⁱ	NP_079519.1, NM_025243.3 XP_011510234.1, XM_011511932.1 XP_011510235.1, XM_011511933.1
UniGeneⁱ	Hs.221597

Genome annotation databases

Ensemblⁱ	ENST00000258403; ENSP00000258403; ENSG00000135917 ENST00000644224; ENSP00000495385; ENSG00000135917
GeneIDⁱ	80704
KEGGⁱ	hsa:80704
UCSC genome browser More...UCSCⁱ	uc002vpi.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BZV2	Thiamine transporter 2		HUMAN		508	UniRef100_Q9BZV2
SLC19A3 isoform 4 (Fragment)		PANTR		54
Thiamine transporter 2 (Fragment)		HUMAN		54
SLC19A3 isoform 7 (Fragment)		PANTR		132
Thiamine transporter 2 (Fragment)		HUMAN		64
+1

Protein	Similar proteins		Species	Score	Length	Source
Q9BZV2	Thiamine transporter 2		MACFA		496	UniRef90_Q9BZV2
Thiamine transporter 2		HUMAN		508
SLC19A3 isoform 4 (Fragment)		PANTR		54
Solute carrier family 19 member 3		PONAB		515
Uncharacterized protein		AOTNA		498
+28

Protein	Similar proteins		Species	Score	Length	Source
Q9BZV2	Thiamine transporter 2		MACFA		496	UniRef50_Q9BZV2
Thiamine transporter 2		HUMAN		508
SLC19A3 isoform 4 (Fragment)		PANTR		54
Solute carrier family 19 member 3		PONAB		515
Uncharacterized protein		AOTNA		498
+96

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF271633 mRNA Translation: AAG53879.1 AF283317 mRNA Translation: AAK69539.1 AC064853 Genomic DNA Translation: AAX93157.1 BC032014 mRNA Translation: AAH32014.1
CCDSⁱ	CCDS2468.1
RefSeqⁱ	NP_079519.1, NM_025243.3 XP_011510234.1, XM_011511932.1 XP_011510235.1, XM_011511933.1
UniGeneⁱ	Hs.221597

3D structure databases

ProteinModelPortalⁱ	Q9BZV2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123266, 5 interactors
IntActⁱ	Q9BZV2, 12 interactors
MINTⁱ	Q9BZV2
STRINGⁱ	9606.ENSP00000258403

Chemistry databases

DrugBankⁱ	DB00151 L-Cysteine

DrugBankⁱ

DB00151 L-Cysteine

Protein family/group databases

TCDBⁱ	2.A.48.1.4 the reduced folate carrier (rfc) family

TCDBⁱ

2.A.48.1.4 the reduced folate carrier (rfc) family

PTM databases

iPTMnetⁱ	Q9BZV2
PhosphoSitePlusⁱ	Q9BZV2

Polymorphism and mutation databases

BioMutaⁱ	SLC19A3
DMDMⁱ	74733486

Proteomic databases

EPDⁱ	Q9BZV2
MaxQBⁱ	Q9BZV2
PaxDbⁱ	Q9BZV2
PeptideAtlasⁱ	Q9BZV2
PRIDEⁱ	Q9BZV2
ProteomicsDBⁱ	79906

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	80704
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000258403; ENSP00000258403; ENSG00000135917 ENST00000644224; ENSP00000495385; ENSG00000135917
GeneIDⁱ	80704
KEGGⁱ	hsa:80704
UCSCⁱ	uc002vpi.4 human

Organism-specific databases

CTDⁱ	80704
DisGeNETⁱ	80704
EuPathDBⁱ	HostDB:ENSG00000135917.13
GeneCardsⁱ	SLC19A3
GeneReviewsⁱ	SLC19A3
HGNCⁱ	HGNC:16266 SLC19A3
HPAⁱ	HPA038898
MalaCardsⁱ	SLC19A3
MIMⁱ	606152 gene 607483 phenotype
neXtProtⁱ	NX_Q9BZV2
OpenTargetsⁱ	ENSG00000135917
Orphanetⁱ	65284 Biotin-responsive basal ganglia disease 263410 Infantile spams - psychomotor retardation - progressive brain atrophy - basal ganglia disease 255241 Leigh syndrome with leukodystrophy 199348 Thiamine-responsive encephalopathy
PharmGKBⁱ	PA38397
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3810 Eukaryota ENOG410XT34 LUCA
GeneTreeⁱ	ENSGT00510000046382
HOGENOMⁱ	HOG000001583
HOVERGENⁱ	HBG054198
InParanoidⁱ	Q9BZV2
KOⁱ	K14610
OMAⁱ	ECYSSKH
OrthoDBⁱ	EOG091G0BSJ
PhylomeDBⁱ	Q9BZV2
TreeFamⁱ	TF313684

Enzyme and pathway databases

Reactomeⁱ	R-HSA-196819 Vitamin B1 (thiamin) metabolism
SIGNORⁱ	Q9BZV2

Miscellaneous databases

ChiTaRSⁱ	SLC19A3 human
GeneWikiⁱ	SLC19A3
GenomeRNAiⁱ	80704
Protein Ontology More...PROⁱ	PR:Q9BZV2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000135917 Expressed in 120 organ(s), highest expression level in adipose tissue of abdominal region
CleanExⁱ	HS_SLC19A3
ExpressionAtlasⁱ	Q9BZV2 baseline and differential
Genevisibleⁱ	Q9BZV2 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR002666 Folate_carrier IPR036259 MFS_trans_sf IPR028337 ThTr-2
PANTHERⁱ	PTHR10686 PTHR10686, 1 hit
Pfamⁱ	View protein in Pfam PF01770 Folate_carrier, 1 hit
PIRSFⁱ	PIRSF028739 Folate_carrier, 1 hit PIRSF500795 Thiamine_transporter_2, 1 hit
SUPFAMⁱ	SSF103473 SSF103473, 2 hits
TIGRFAMsⁱ	TIGR00806 rfc, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S19A3_HUMAN
Accessionⁱ	Q9BZV2Primary (citable) accession number: Q9BZV2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 18, 2006
	Last sequence update:	June 1, 2001
	Last modified:	September 12, 2018
	This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9BZV2 (S19A3_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Thiamine transporter 2

SLC19A3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ