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Protein

Apoptosis facilitator Bcl-2-like protein 14

Gene

BCL2L14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in apoptosis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Apoptosis facilitator Bcl-2-like protein 14
Short name:
Bcl2-L-14
Alternative name(s):
Apoptosis regulator Bcl-G
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCL2L14
Synonyms:BCLG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000121380.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16657 BCL2L14

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606126 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BZR8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79370

Open Targets

More...
OpenTargetsi
ENSG00000121380

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134870762

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BCL2L14

Domain mapping of disease mutations (DMDM)

More...
DMDMi
56748611

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001430751 – 327Apoptosis facilitator Bcl-2-like protein 14Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei44PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by MELK, leading to inhibit its pro-apoptotic function.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9BZR8

PeptideAtlas

More...
PeptideAtlasi
Q9BZR8

PRoteomics IDEntifications database

More...
PRIDEi
Q9BZR8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79895
79896 [Q9BZR8-2]
79897 [Q9BZR8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BZR8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BZR8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is widely expressed. Isoform 2 is testis-specific.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000121380 Expressed in 79 organ(s), highest expression level in sperm

CleanEx database of gene expression profiles

More...
CleanExi
HS_BCL2L14

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BZR8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BZR8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040665

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MELKQ146804EBI-1385773,EBI-1046702

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122658, 16 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BZR8, 5 interactors

Molecular INTeraction database

More...
MINTi
Q9BZR8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000309132

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9BZR8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BZR8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi212 – 226BH3Add BLAST15
Motifi308 – 315BH28

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4728 Eukaryota
ENOG41123S0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154318

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000013215

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050649

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9BZR8

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BZR8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.437.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002475 Bcl2-like
IPR033229 BCL2L14
IPR036834 Blc2-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR14965:SF1 PTHR14965:SF1, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56854 SSF56854, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BZR8-1) [UniParc]FASTAAdd to basket
Also known as: Bcl-Gl, Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCSTSGCDLE EIPLDDDDLN TIEFKILAYY TRHHVFKSTP ALFSPKLLRT
60 70 80 90 100
RSLSQRGLGN CSANESWTEV SWPCRNSQSS EKAINLGKKK SSWKAFFGVV
110 120 130 140 150
EKEDSQSTPA KVSAQGQRTL EYQDSHSQQW SRCLSNVEQC LEHEAVDPKV
160 170 180 190 200
ISIANRVAEI VYSWPPPQAT QAGGFKSKEI FVTEGLSFQL QGHVPVASSS
210 220 230 240 250
KKDEEEQILA KIVELLKYSG DQLERKLKKD KALMGHFQDG LSYSVFKTIT
260 270 280 290 300
DQVLMGVDPR GESEVKAQGF KAALVIDVTA KLTAIDNHPM NRVLGFGTKY
310 320
LKENFSPWIQ QHGGWEKILG ISHEEVD
Length:327
Mass (Da):36,598
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i155D43BA91BFB3EA
GO
Isoform 2 (identifier: Q9BZR8-2) [UniParc]FASTAAdd to basket
Also known as: Bcl-Gs, Short

The sequence of this isoform differs from the canonical sequence as follows:
     227-252: LKKDKALMGHFQDGLSYSVFKTITDQ → DTAFIPIPLVDTSIQGFPQDGLMACI
     253-327: Missing.

Show »
Length:252
Mass (Da):28,090
Checksum:i87D2E5123EFCB9E4
GO
Isoform 3 (identifier: Q9BZR8-3) [UniParc]FASTAAdd to basket
Also known as: Median

The sequence of this isoform differs from the canonical sequence as follows:
     227-276: LKKDKALMGH...AQGFKAALVI → EKEWEESAKT...LTPPGFSEHN
     277-327: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:276
Mass (Da):30,948
Checksum:i81559A7190F5598E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EMX4K7EMX4_HUMAN
Apoptosis facilitator Bcl-2-like pr...
BCL2L14
360Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K0Q9C9K0Q9_HUMAN
Apoptosis facilitator Bcl-2-like pr...
BCL2L14
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J3S1C9J3S1_HUMAN
Apoptosis facilitator Bcl-2-like pr...
BCL2L14
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKK7K7EKK7_HUMAN
Apoptosis facilitator Bcl-2-like pr...
BCL2L14
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012241227 – 276LKKDK…AALVI → EKEWEESAKTKIKMALLWRS SGGGPRVLSIPEAFMKNSFT LTPPGFSEHN in isoform 3. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_012239227 – 252LKKDK…TITDQ → DTAFIPIPLVDTSIQGFPQD GLMACI in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_012240253 – 327Missing in isoform 2. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_012242277 – 327Missing in isoform 3. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF281254 mRNA Translation: AAG59793.1
AF281255 mRNA Translation: AAG59794.1
AY040274 mRNA Translation: AAK72109.1
AK292995 mRNA Translation: BAF85684.1
CH471094 Genomic DNA Translation: EAW96247.1
BC025778 mRNA Translation: AAH25778.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8645.1 [Q9BZR8-1]
CCDS8646.1 [Q9BZR8-2]

NCBI Reference Sequences

More...
RefSeqi
NP_110393.1, NM_030766.1 [Q9BZR8-2]
NP_620048.1, NM_138722.1 [Q9BZR8-1]
NP_620049.1, NM_138723.1 [Q9BZR8-1]
XP_006719214.1, XM_006719151.3 [Q9BZR8-1]
XP_011519150.1, XM_011520848.1 [Q9BZR8-1]
XP_011519151.1, XM_011520849.1 [Q9BZR8-1]
XP_016875452.1, XM_017019963.1 [Q9BZR8-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.210343
Hs.734567

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000266434; ENSP00000266434; ENSG00000121380 [Q9BZR8-2]
ENST00000298566; ENSP00000298566; ENSG00000121380 [Q9BZR8-3]
ENST00000308721; ENSP00000309132; ENSG00000121380 [Q9BZR8-1]
ENST00000396367; ENSP00000379653; ENSG00000121380 [Q9BZR8-1]
ENST00000589718; ENSP00000467086; ENSG00000121380 [Q9BZR8-1]
ENST00000627413; ENSP00000486050; ENSG00000281449 [Q9BZR8-1]
ENST00000628315; ENSP00000485980; ENSG00000281449 [Q9BZR8-3]
ENST00000628783; ENSP00000487330; ENSG00000281449 [Q9BZR8-1]
ENST00000631251; ENSP00000486560; ENSG00000281449 [Q9BZR8-2]
ENST00000631317; ENSP00000486796; ENSG00000281449 [Q9BZR8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79370

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79370

UCSC genome browser

More...
UCSCi
uc001rac.4 human [Q9BZR8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281254 mRNA Translation: AAG59793.1
AF281255 mRNA Translation: AAG59794.1
AY040274 mRNA Translation: AAK72109.1
AK292995 mRNA Translation: BAF85684.1
CH471094 Genomic DNA Translation: EAW96247.1
BC025778 mRNA Translation: AAH25778.1
CCDSiCCDS8645.1 [Q9BZR8-1]
CCDS8646.1 [Q9BZR8-2]
RefSeqiNP_110393.1, NM_030766.1 [Q9BZR8-2]
NP_620048.1, NM_138722.1 [Q9BZR8-1]
NP_620049.1, NM_138723.1 [Q9BZR8-1]
XP_006719214.1, XM_006719151.3 [Q9BZR8-1]
XP_011519150.1, XM_011520848.1 [Q9BZR8-1]
XP_011519151.1, XM_011520849.1 [Q9BZR8-1]
XP_016875452.1, XM_017019963.1 [Q9BZR8-1]
UniGeneiHs.210343
Hs.734567

3D structure databases

ProteinModelPortaliQ9BZR8
SMRiQ9BZR8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122658, 16 interactors
IntActiQ9BZR8, 5 interactors
MINTiQ9BZR8
STRINGi9606.ENSP00000309132

PTM databases

iPTMnetiQ9BZR8
PhosphoSitePlusiQ9BZR8

Polymorphism and mutation databases

BioMutaiBCL2L14
DMDMi56748611

Proteomic databases

PaxDbiQ9BZR8
PeptideAtlasiQ9BZR8
PRIDEiQ9BZR8
ProteomicsDBi79895
79896 [Q9BZR8-2]
79897 [Q9BZR8-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
79370
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266434; ENSP00000266434; ENSG00000121380 [Q9BZR8-2]
ENST00000298566; ENSP00000298566; ENSG00000121380 [Q9BZR8-3]
ENST00000308721; ENSP00000309132; ENSG00000121380 [Q9BZR8-1]
ENST00000396367; ENSP00000379653; ENSG00000121380 [Q9BZR8-1]
ENST00000589718; ENSP00000467086; ENSG00000121380 [Q9BZR8-1]
ENST00000627413; ENSP00000486050; ENSG00000281449 [Q9BZR8-1]
ENST00000628315; ENSP00000485980; ENSG00000281449 [Q9BZR8-3]
ENST00000628783; ENSP00000487330; ENSG00000281449 [Q9BZR8-1]
ENST00000631251; ENSP00000486560; ENSG00000281449 [Q9BZR8-2]
ENST00000631317; ENSP00000486796; ENSG00000281449 [Q9BZR8-1]
GeneIDi79370
KEGGihsa:79370
UCSCiuc001rac.4 human [Q9BZR8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79370
DisGeNETi79370
EuPathDBiHostDB:ENSG00000121380.12

GeneCards: human genes, protein and diseases

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GeneCardsi
BCL2L14
HGNCiHGNC:16657 BCL2L14
HPAiHPA040665
MIMi606126 gene
neXtProtiNX_Q9BZR8
OpenTargetsiENSG00000121380
PharmGKBiPA134870762

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4728 Eukaryota
ENOG41123S0 LUCA
GeneTreeiENSGT00940000154318
HOGENOMiHOG000013215
HOVERGENiHBG050649
InParanoidiQ9BZR8
PhylomeDBiQ9BZR8

Enzyme and pathway databases

ReactomeiR-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
BCL2L14 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
BCL2L14

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79370

Protein Ontology

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PROi
PR:Q9BZR8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000121380 Expressed in 79 organ(s), highest expression level in sperm
CleanExiHS_BCL2L14
ExpressionAtlasiQ9BZR8 baseline and differential
GenevisibleiQ9BZR8 HS

Family and domain databases

Gene3Di1.10.437.10, 1 hit
InterProiView protein in InterPro
IPR002475 Bcl2-like
IPR033229 BCL2L14
IPR036834 Blc2-like_sf
PANTHERiPTHR14965:SF1 PTHR14965:SF1, 1 hit
SUPFAMiSSF56854 SSF56854, 1 hit
PROSITEiView protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB2L14_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BZR8
Secondary accession number(s): A8KAD0, Q96QR5, Q9BZR7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: June 1, 2001
Last modified: December 5, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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