Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Apoptosis facilitator Bcl-2-like protein 14

Gene

BCL2L14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in apoptosis.

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis facilitator Bcl-2-like protein 14
Short name:
Bcl2-L-14
Alternative name(s):
Apoptosis regulator Bcl-G
Gene namesi
Name:BCL2L14
Synonyms:BCLG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000121380.12
HGNCiHGNC:16657 BCL2L14
MIMi606126 gene
neXtProtiNX_Q9BZR8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79370
OpenTargetsiENSG00000121380
PharmGKBiPA134870762

Polymorphism and mutation databases

BioMutaiBCL2L14
DMDMi56748611

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001430751 – 327Apoptosis facilitator Bcl-2-like protein 14Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by MELK, leading to inhibit its pro-apoptotic function.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9BZR8
PeptideAtlasiQ9BZR8
PRIDEiQ9BZR8
ProteomicsDBi79895
79896 [Q9BZR8-2]
79897 [Q9BZR8-3]

PTM databases

iPTMnetiQ9BZR8
PhosphoSitePlusiQ9BZR8

Expressioni

Tissue specificityi

Isoform 1 is widely expressed. Isoform 2 is testis-specific.1 Publication

Gene expression databases

BgeeiENSG00000121380 Expressed in 79 organ(s), highest expression level in sperm
CleanExiHS_BCL2L14
ExpressionAtlasiQ9BZR8 baseline and differential
GenevisibleiQ9BZR8 HS

Organism-specific databases

HPAiHPA040665

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MELKQ146804EBI-1385773,EBI-1046702

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122658, 16 interactors
IntActiQ9BZR8, 5 interactors
MINTiQ9BZR8
STRINGi9606.ENSP00000309132

Structurei

3D structure databases

ProteinModelPortaliQ9BZR8
SMRiQ9BZR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi212 – 226BH3Add BLAST15
Motifi308 – 315BH28

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Phylogenomic databases

eggNOGiKOG4728 Eukaryota
ENOG41123S0 LUCA
GeneTreeiENSGT00390000007293
HOGENOMiHOG000013215
HOVERGENiHBG050649
InParanoidiQ9BZR8
PhylomeDBiQ9BZR8

Family and domain databases

Gene3Di1.10.437.10, 1 hit
InterProiView protein in InterPro
IPR002475 Bcl2-like
IPR033229 BCL2L14
IPR036834 Blc2-like_sf
PANTHERiPTHR14965:SF1 PTHR14965:SF1, 1 hit
SUPFAMiSSF56854 SSF56854, 1 hit
PROSITEiView protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9BZR8-1) [UniParc]FASTAAdd to basket
Also known as: Bcl-Gl, Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCSTSGCDLE EIPLDDDDLN TIEFKILAYY TRHHVFKSTP ALFSPKLLRT
60 70 80 90 100
RSLSQRGLGN CSANESWTEV SWPCRNSQSS EKAINLGKKK SSWKAFFGVV
110 120 130 140 150
EKEDSQSTPA KVSAQGQRTL EYQDSHSQQW SRCLSNVEQC LEHEAVDPKV
160 170 180 190 200
ISIANRVAEI VYSWPPPQAT QAGGFKSKEI FVTEGLSFQL QGHVPVASSS
210 220 230 240 250
KKDEEEQILA KIVELLKYSG DQLERKLKKD KALMGHFQDG LSYSVFKTIT
260 270 280 290 300
DQVLMGVDPR GESEVKAQGF KAALVIDVTA KLTAIDNHPM NRVLGFGTKY
310 320
LKENFSPWIQ QHGGWEKILG ISHEEVD
Length:327
Mass (Da):36,598
Last modified:June 1, 2001 - v1
Checksum:i155D43BA91BFB3EA
GO
Isoform 2 (identifier: Q9BZR8-2) [UniParc]FASTAAdd to basket
Also known as: Bcl-Gs, Short

The sequence of this isoform differs from the canonical sequence as follows:
     227-252: LKKDKALMGHFQDGLSYSVFKTITDQ → DTAFIPIPLVDTSIQGFPQDGLMACI
     253-327: Missing.

Show »
Length:252
Mass (Da):28,090
Checksum:i87D2E5123EFCB9E4
GO
Isoform 3 (identifier: Q9BZR8-3) [UniParc]FASTAAdd to basket
Also known as: Median

The sequence of this isoform differs from the canonical sequence as follows:
     227-276: LKKDKALMGH...AQGFKAALVI → EKEWEESAKT...LTPPGFSEHN
     277-327: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:276
Mass (Da):30,948
Checksum:i81559A7190F5598E
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EMX4K7EMX4_HUMAN
Apoptosis facilitator Bcl-2-like pr...
BCL2L14
360Annotation score:
C9K0Q9C9K0Q9_HUMAN
Apoptosis facilitator Bcl-2-like pr...
BCL2L14
125Annotation score:
C9J3S1C9J3S1_HUMAN
Apoptosis facilitator Bcl-2-like pr...
BCL2L14
57Annotation score:
K7EKK7K7EKK7_HUMAN
Apoptosis facilitator Bcl-2-like pr...
BCL2L14
176Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012241227 – 276LKKDK…AALVI → EKEWEESAKTKIKMALLWRS SGGGPRVLSIPEAFMKNSFT LTPPGFSEHN in isoform 3. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_012239227 – 252LKKDK…TITDQ → DTAFIPIPLVDTSIQGFPQD GLMACI in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_012240253 – 327Missing in isoform 2. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_012242277 – 327Missing in isoform 3. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281254 mRNA Translation: AAG59793.1
AF281255 mRNA Translation: AAG59794.1
AY040274 mRNA Translation: AAK72109.1
AK292995 mRNA Translation: BAF85684.1
CH471094 Genomic DNA Translation: EAW96247.1
BC025778 mRNA Translation: AAH25778.1
CCDSiCCDS8645.1 [Q9BZR8-1]
CCDS8646.1 [Q9BZR8-2]
RefSeqiNP_110393.1, NM_030766.1 [Q9BZR8-2]
NP_620048.1, NM_138722.1 [Q9BZR8-1]
NP_620049.1, NM_138723.1 [Q9BZR8-1]
XP_006719214.1, XM_006719151.3 [Q9BZR8-1]
XP_011519150.1, XM_011520848.1 [Q9BZR8-1]
XP_011519151.1, XM_011520849.1 [Q9BZR8-1]
XP_016875452.1, XM_017019963.1 [Q9BZR8-1]
UniGeneiHs.210343
Hs.734567

Genome annotation databases

EnsembliENST00000266434; ENSP00000266434; ENSG00000121380 [Q9BZR8-2]
ENST00000298566; ENSP00000298566; ENSG00000121380 [Q9BZR8-3]
ENST00000308721; ENSP00000309132; ENSG00000121380 [Q9BZR8-1]
ENST00000396367; ENSP00000379653; ENSG00000121380 [Q9BZR8-1]
ENST00000589718; ENSP00000467086; ENSG00000121380 [Q9BZR8-1]
ENST00000627413; ENSP00000486050; ENSG00000281449 [Q9BZR8-1]
ENST00000628315; ENSP00000485980; ENSG00000281449 [Q9BZR8-3]
ENST00000628783; ENSP00000487330; ENSG00000281449 [Q9BZR8-1]
ENST00000631251; ENSP00000486560; ENSG00000281449 [Q9BZR8-2]
ENST00000631317; ENSP00000486796; ENSG00000281449 [Q9BZR8-1]
GeneIDi79370
KEGGihsa:79370
UCSCiuc001rac.4 human [Q9BZR8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiB2L14_HUMAN
AccessioniPrimary (citable) accession number: Q9BZR8
Secondary accession number(s): A8KAD0, Q96QR5, Q9BZR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again