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Protein

Reticulon-4 receptor

Gene

RTN4R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for RTN4, OMG and MAG (PubMed:12037567, PubMed:12068310, PubMed:12426574, PubMed:12089450, PubMed:16712417, PubMed:18411262, PubMed:12839991, PubMed:19052207). Functions as receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR (PubMed:12426574). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:16712417, PubMed:22325200). Mediates axonal growth inhibition (PubMed:12839991, PubMed:19052207, PubMed:28892071). Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200).By similarity8 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-193634 Axonal growth inhibition (RHOA activation)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Reticulon-4 receptor
Alternative name(s):
Nogo receptor
Short name:
NgR
Nogo-66 receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RTN4R
Synonyms:NOGOR
ORF Names:UNQ330/PRO526
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000040608.13

Human Gene Nomenclature Database

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HGNCi
HGNC:18601 RTN4R

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605566 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BZR6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Schizophrenia (SCZD)3 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
See also OMIM:181500
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_079154119R → W in SCZD; associated with disease susceptibility; unable to mediate down-regulation of axonal growth; decreased interaction with MAG and OMG; no effect on interaction with RTN4. 2 PublicationsCorresponds to variant dbSNP:rs74315508EnsemblClinVar.1
Natural variantiVAR_079155196R → H in SCZD; associated with disease susceptibility; unable to mediate down-regulation of axonal growth; does not affect interaction with MAG, RTN4 and OMG. 2 PublicationsCorresponds to variant dbSNP:rs74315509EnsemblClinVar.1
Natural variantiVAR_079227227R → C in SCZD; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs754793885Ensembl.1
Natural variantiVAR_079231292R → H in SCZD; associated with disease susceptibility; unable to mediate down-regulation of axonal growth. 1 Publication1
Natural variantiVAR_079235377R → Q in SCZD; associated with disease susceptibility; unable to mediate down-regulation of axonal growth; does not affect interaction with MAG, RTN4, OMG, NGFR and LINGO1. 1 PublicationCorresponds to variant dbSNP:rs779384862Ensembl.1
Natural variantiVAR_079236377R → W in SCZD; associated with disease susceptibility; unable to mediate down-regulation of axonal growth; does not affect interaction with MAG, RTN4, OMG, NGFR and LINGO1. 1 PublicationCorresponds to variant dbSNP:rs748655075Ensembl.1
Natural variantiVAR_079237399R → W in SCZD; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200119628Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi151R → E: Impaired ganglioside binding. 1 Publication1
Mutagenesisi199R → E: Impaired ganglioside binding. 1 Publication1
Mutagenesisi277K → A: No effect on interaction with MAG. 1 Publication1
Mutagenesisi277K → D: Decreases interaction with MAG; when associated with D-279. 1 Publication1
Mutagenesisi279R → A: Mildly decreases interaction with MAG. 1 Publication1
Mutagenesisi279R → D: Decreases interaction with MAG; when associated with D-277. 1 Publication1
Mutagenesisi279R → E: Impaired ganglioside binding. 1 Publication1

Keywords - Diseasei

Disease mutation, Schizophrenia

Organism-specific databases

DisGeNET

More...
DisGeNETi
65078

MalaCards human disease database

More...
MalaCardsi
RTN4R
MIMi181500 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000040608

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38600

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RTN4R

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 261 PublicationAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002225327 – 447Reticulon-4 receptorAdd BLAST421
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000022254448 – 473Removed in mature formSequence analysisAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi27 ↔ 33Combined sources2 Publications
Disulfide bondi31 ↔ 43Combined sources2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi82N-linked (GlcNAc...) asparagineCombined sources2 Publications1
Glycosylationi179N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi264 ↔ 287Combined sources2 Publications
Disulfide bondi266 ↔ 335By similarity
Disulfide bondi309 ↔ 336By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi447GPI-anchor amidated serineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated. O-glycosylated. Contains terminal sialic acid groups on its glycan chains.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9BZR6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9BZR6

PeptideAtlas

More...
PeptideAtlasi
Q9BZR6

PRoteomics IDEntifications database

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PRIDEi
Q9BZR6

ProteomicsDB human proteome resource

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ProteomicsDBi
79894

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9BZR6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widespread in the brain but highest levels in the gray matter. Low levels in heart and kidney; not expressed in oligodendrocytes (white matter).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000040608 Expressed in 109 organ(s), highest expression level in right hemisphere of cerebellum

CleanEx database of gene expression profiles

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CleanExi
HS_RTN4R

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9BZR6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9BZR6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB012443

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:18411262). Interacts with MAG (PubMed:12089450, PubMed:12839991, PubMed:18411262, PubMed:19052207). Interacts with RTN4 (PubMed:12839991, PubMed:19052207). Interacts with NGFR (PubMed:12426574, PubMed:18411262, PubMed:19052207). Interacts with LINGO1 (PubMed:14966521, PubMed:19052207). Interacts with KIAA0319L (PubMed:20697954). Interacts with OLFM1; this inhibits interaction with LINGO1 and NGFR (By similarity). Interacts with OMG (PubMed:12068310, PubMed:12839991, PubMed:19052207).By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
KIAA0319LQ8IZA04EBI-5240240,EBI-5240269

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122388, 7 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9BZR6

Protein interaction database and analysis system

More...
IntActi
Q9BZR6, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000043402

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1473
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9BZR6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9BZR6

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9BZR6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 54LRRNTAdd BLAST28
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati55 – 79LRR 1Sequence analysisAdd BLAST25
Repeati81 – 103LRR 2Sequence analysisAdd BLAST23
Repeati104 – 128LRR 3Sequence analysisAdd BLAST25
Repeati129 – 152LRR 4Sequence analysisAdd BLAST24
Repeati153 – 176LRR 5Sequence analysisAdd BLAST24
Repeati178 – 200LRR 6Sequence analysisAdd BLAST23
Repeati202 – 224LRR 7Sequence analysisAdd BLAST23
Repeati225 – 248LRR 8Sequence analysisAdd BLAST24
Repeati250 – 273LRR 9Sequence analysisAdd BLAST24
Domaini260 – 310LRRCTSequence analysisAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi435 – 442Poly-Gly8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Nogo receptor family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619 Eukaryota
COG4886 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160711

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000116109

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG063707

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9BZR6

KEGG Orthology (KO)

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KOi
K16659

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9BZR6

TreeFam database of animal gene trees

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TreeFami
TF330080

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855 LRR_8, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00369 LRR_TYP, 8 hits
SM00082 LRRCT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9BZR6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRASAGGSR LLAWVLWLQA WQVAAPCPGA CVCYNEPKVT TSCPQQGLQA
60 70 80 90 100
VPVGIPAASQ RIFLHGNRIS HVPAASFRAC RNLTILWLHS NVLARIDAAA
110 120 130 140 150
FTGLALLEQL DLSDNAQLRS VDPATFHGLG RLHTLHLDRC GLQELGPGLF
160 170 180 190 200
RGLAALQYLY LQDNALQALP DDTFRDLGNL THLFLHGNRI SSVPERAFRG
210 220 230 240 250
LHSLDRLLLH QNRVAHVHPH AFRDLGRLMT LYLFANNLSA LPTEALAPLR
260 270 280 290 300
ALQYLRLNDN PWVCDCRARP LWAWLQKFRG SSSEVPCSLP QRLAGRDLKR
310 320 330 340 350
LAANDLQGCA VATGPYHPIW TGRATDEEPL GLPKCCQPDA ADKASVLEPG
360 370 380 390 400
RPASAGNALK GRVPPGDSPP GNGSGPRHIN DSPFGTLPGS AEPPLTAVRP
410 420 430 440 450
EGSEPPGFPT SGPRRRPGCS RKNRTRSHCR LGQAGSGGGG TGDSEGSGAL
460 470
PSLTCSLTPL GLALVLWTVL GPC
Length:473
Mass (Da):50,708
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA5624B24C584702
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C0V4H7C0V4_HUMAN
Reticulon-4 receptor
RTN4R
493Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C215H7C215_HUMAN
Reticulon-4 receptor
RTN4R
559Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07922453V → M1 PublicationCorresponds to variant dbSNP:rs145292678Ensembl.1
Natural variantiVAR_07922568R → H2 PublicationsCorresponds to variant dbSNP:rs145773589Ensembl.1
Natural variantiVAR_079154119R → W in SCZD; associated with disease susceptibility; unable to mediate down-regulation of axonal growth; decreased interaction with MAG and OMG; no effect on interaction with RTN4. 2 PublicationsCorresponds to variant dbSNP:rs74315508EnsemblClinVar.1
Natural variantiVAR_079226141G → S1 PublicationCorresponds to variant dbSNP:rs760855779Ensembl.1
Natural variantiVAR_079155196R → H in SCZD; associated with disease susceptibility; unable to mediate down-regulation of axonal growth; does not affect interaction with MAG, RTN4 and OMG. 2 PublicationsCorresponds to variant dbSNP:rs74315509EnsemblClinVar.1
Natural variantiVAR_079227227R → C in SCZD; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs754793885Ensembl.1
Natural variantiVAR_079228227R → H1 PublicationCorresponds to variant dbSNP:rs576939822Ensembl.1
Natural variantiVAR_079229259D → N1 PublicationCorresponds to variant dbSNP:rs3747073Ensembl.1
Natural variantiVAR_079230263V → M1 PublicationCorresponds to variant dbSNP:rs752810777Ensembl.1
Natural variantiVAR_079231292R → H in SCZD; associated with disease susceptibility; unable to mediate down-regulation of axonal growth. 1 Publication1
Natural variantiVAR_079232314G → S1 PublicationCorresponds to variant dbSNP:rs112151786Ensembl.1
Natural variantiVAR_079233329P → L1 PublicationCorresponds to variant dbSNP:rs757507039Ensembl.1
Natural variantiVAR_079234363V → M2 PublicationsCorresponds to variant dbSNP:rs149231717Ensembl.1
Natural variantiVAR_079235377R → Q in SCZD; associated with disease susceptibility; unable to mediate down-regulation of axonal growth; does not affect interaction with MAG, RTN4, OMG, NGFR and LINGO1. 1 PublicationCorresponds to variant dbSNP:rs779384862Ensembl.1
Natural variantiVAR_079236377R → W in SCZD; associated with disease susceptibility; unable to mediate down-regulation of axonal growth; does not affect interaction with MAG, RTN4, OMG, NGFR and LINGO1. 1 PublicationCorresponds to variant dbSNP:rs748655075Ensembl.1
Natural variantiVAR_079237399R → W in SCZD; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200119628Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF283463 mRNA Translation: AAG53612.1
AL834449 mRNA Translation: CAD39109.1
AY358297 mRNA Translation: AAQ88664.1
CR456360 mRNA Translation: CAG30246.1
AC058790 Genomic DNA No translation available.
AC007663 Genomic DNA No translation available.
CH471176 Genomic DNA Translation: EAX02975.1
CH471176 Genomic DNA Translation: EAX02976.1
BC011787 mRNA Translation: AAH11787.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13777.1

NCBI Reference Sequences

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RefSeqi
NP_075380.1, NM_023004.5

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.30868

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000043402; ENSP00000043402; ENSG00000040608

Database of genes from NCBI RefSeq genomes

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GeneIDi
65078

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:65078

UCSC genome browser

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UCSCi
uc002zrv.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Nerve regrowth: nipped by a no-go - Issue 69 of April 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF283463 mRNA Translation: AAG53612.1
AL834449 mRNA Translation: CAD39109.1
AY358297 mRNA Translation: AAQ88664.1
CR456360 mRNA Translation: CAG30246.1
AC058790 Genomic DNA No translation available.
AC007663 Genomic DNA No translation available.
CH471176 Genomic DNA Translation: EAX02975.1
CH471176 Genomic DNA Translation: EAX02976.1
BC011787 mRNA Translation: AAH11787.1
CCDSiCCDS13777.1
RefSeqiNP_075380.1, NM_023004.5
UniGeneiHs.30868

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OZNX-ray1.52A26-310[»]
1P8TX-ray3.20A27-311[»]
ProteinModelPortaliQ9BZR6
SMRiQ9BZR6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122388, 7 interactors
CORUMiQ9BZR6
IntActiQ9BZR6, 3 interactors
STRINGi9606.ENSP00000043402

PTM databases

iPTMnetiQ9BZR6

Polymorphism and mutation databases

BioMutaiRTN4R

Proteomic databases

EPDiQ9BZR6
PaxDbiQ9BZR6
PeptideAtlasiQ9BZR6
PRIDEiQ9BZR6
ProteomicsDBi79894

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
65078
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000043402; ENSP00000043402; ENSG00000040608
GeneIDi65078
KEGGihsa:65078
UCSCiuc002zrv.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
65078
DisGeNETi65078
EuPathDBiHostDB:ENSG00000040608.13

GeneCards: human genes, protein and diseases

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GeneCardsi
RTN4R
HGNCiHGNC:18601 RTN4R
HPAiCAB012443
MalaCardsiRTN4R
MIMi181500 phenotype
605566 gene
neXtProtiNX_Q9BZR6
OpenTargetsiENSG00000040608
PharmGKBiPA38600

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000160711
HOGENOMiHOG000116109
HOVERGENiHBG063707
InParanoidiQ9BZR6
KOiK16659
PhylomeDBiQ9BZR6
TreeFamiTF330080

Enzyme and pathway databases

ReactomeiR-HSA-193634 Axonal growth inhibition (RHOA activation)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RTN4R human
EvolutionaryTraceiQ9BZR6

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Reticulon_4_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
65078

Protein Ontology

More...
PROi
PR:Q9BZR6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000040608 Expressed in 109 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_RTN4R
ExpressionAtlasiQ9BZR6 baseline and differential
GenevisibleiQ9BZR6 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00082 LRRCT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRTN4R_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BZR6
Secondary accession number(s): D3DX28
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: June 1, 2001
Last modified: December 5, 2018
This is version 173 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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