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Protein

Protein Niban

Gene

FAM129A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity).By similarity

Miscellaneous

'Niban' means 'second' in Japanese.

GO - Biological processi

Keywordsi

Biological processStress response, Translation regulation

Enzyme and pathway databases

SIGNORiQ9BZQ8

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Niban
Alternative name(s):
Cell growth-inhibiting gene 39 protein
Protein FAM129A
Gene namesi
Name:FAM129A
Synonyms:C1orf24, NIBAN
ORF Names:GIG39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000135842.16
HGNCiHGNC:16784 FAM129A
neXtProtiNX_Q9BZQ8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi116496
OpenTargetsiENSG00000135842
PharmGKBiPA162385951

Polymorphism and mutation databases

DMDMi22256936

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002131202 – 928Protein NibanAdd BLAST927

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei579PhosphoserineCombined sources1
Modified residuei582PhosphoserineCombined sources1
Modified residuei596PhosphoserineCombined sources1
Modified residuei602PhosphoserineCombined sources1
Modified residuei646PhosphoserineCombined sources1
Modified residuei708PhosphoserineCombined sources1
Modified residuei926PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9BZQ8
MaxQBiQ9BZQ8
PaxDbiQ9BZQ8
PeptideAtlasiQ9BZQ8
PRIDEiQ9BZQ8
ProteomicsDBi79893

PTM databases

iPTMnetiQ9BZQ8
PhosphoSitePlusiQ9BZQ8

Expressioni

Tissue specificityi

Expressed in various types of thyroid tumor such as papillary thyroid carcinomas and oxyphilic thyroid tumors but not in normal thyroid tissue (at protein level). Strongly expressed in heart, skeletal muscle, pancreas, white blood cells and prostate with moderate expression in colon and spleen. Expressed in renal carcinoma cells but not in normal kidney.2 Publications

Gene expression databases

BgeeiENSG00000135842 Expressed in 226 organ(s), highest expression level in heart right ventricle
CleanExiHS_FAM129A
ExpressionAtlasiQ9BZQ8 baseline and differential
GenevisibleiQ9BZQ8 HS

Organism-specific databases

HPAiHPA028172
HPA028231
HPA028657

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi125515, 5 interactors
IntActiQ9BZQ8, 3 interactors
MINTiQ9BZQ8
STRINGi9606.ENSP00000356481

Structurei

3D structure databases

ProteinModelPortaliQ9BZQ8
SMRiQ9BZQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi683 – 864Glu-richAdd BLAST182

Sequence similaritiesi

Belongs to the Niban family.Curated

Phylogenomic databases

eggNOGiENOG410IFR1 Eukaryota
ENOG41102BB LUCA
GeneTreeiENSGT00530000063284
HOVERGENiHBG108186
InParanoidiQ9BZQ8
OMAiMNLPLDS
OrthoDBiEOG091G02BX
PhylomeDBiQ9BZQ8
TreeFamiTF333351

Family and domain databases

InterProiView protein in InterPro
IPR026088 Niban-like
PANTHERiPTHR14392 PTHR14392, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9BZQ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGSASSQLD EGKCAYIRGK TEAAIKNFSP YYSRQYSVAF CNHVRTEVEQ
60 70 80 90 100
QRDLTSQFLK TKPPLAPGTI LYEAELSQFS EDIKKWKERY VVVKNDYAVE
110 120 130 140 150
SYENKEAYQR GAAPKCRILP AGGKVLTSED EYNLLSDRHF PDPLASSEKE
160 170 180 190 200
NTQPFVVLPK EFPVYLWQPF FRHGYFCFHE AADQKRFSAL LSDCVRHLNH
210 220 230 240 250
DYMKQMTFEA QAFLEAVQFF RQEKGHYGSW EMITGDEIQI LSNLVMEELL
260 270 280 290 300
PTLQTDLLPK MKGKKNDRKR TWLGLLEEAY TLVQHQVSEG LSALKEECRA
310 320 330 340 350
LTKGLEGTIR SDMDQIVNSK NYLIGKIKAM VAQPAEKSCL ESVQPFLASI
360 370 380 390 400
LEELMGPVSS GFSEVRVLFE KEVNEVSQNF QTTKDSVQLK EHLDRLMNLP
410 420 430 440 450
LHSVKMEPCY TKVNLLHERL QDLKSRFRFP HIDLVVQRTQ NYMQELMENA
460 470 480 490 500
VFTFEQLLSP HLQGEASKTA VAIEKVKLRV LKQYDYDSST IRKKIFQEAL
510 520 530 540 550
VQITLPTVQK ALASTCKPEL QKYEQFIFAD HTNMIHVENV YEEILHQILL
560 570 580 590 600
DETLKVIKEA AILKKHNLFE DNMALPSESV SSLTDLKPPT GSNQASPARR
610 620 630 640 650
ASAILPGVLG SETLSNEVFQ ESEEEKQPEV PSSLAKGESL SLPGPSPPPD
660 670 680 690 700
GTEQVIISRV DDPVVNPVAT EDTAGLPGTC SSELEFGGTL EDEEPAQEEP
710 720 730 740 750
EPITASGSLK ALRKLLTASV EVPVDSAPVM EEDTNGESHV PQENEEEEEK
760 770 780 790 800
EPSQAAAIHP DNCEESEVSE REAQPPCPEA HGEELGGFPE VGSPASPPAS
810 820 830 840 850
GGLTEEPLGP MEGELPGEAC TLTAHEGRGG KCTEEGDASQ QEGCTLGSDP
860 870 880 890 900
ICLSESQVSE EQEEMGGQSS AAQATASVNA EEIKVARIHE CQWVVEDAPN
910 920
PDVLLSHKDD VKEGEGGQES FPELPSEE
Length:928
Mass (Da):103,135
Last modified:June 1, 2001 - v1
Checksum:i93717F41336488FE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y7M9H0Y7M9_HUMAN
Protein Niban
FAM129A
100Annotation score:

Sequence cautioni

The sequence BAB17230 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27N → D in AAT52218 (Ref. 4) Curated1
Sequence conflicti106E → G in BAB14079 (PubMed:14702039).Curated1
Sequence conflicti201D → E in BAB14079 (PubMed:14702039).Curated1
Sequence conflicti609L → P in BAB84965 (Ref. 7) Curated1
Sequence conflicti858V → D in BAB14079 (PubMed:14702039).Curated1
Sequence conflicti863E → D in BAB14079 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053533633S → L. Corresponds to variant dbSNP:rs12750174Ensembl.1
Natural variantiVAR_053534692D → N1 PublicationCorresponds to variant dbSNP:rs35704242Ensembl.1
Natural variantiVAR_053535720V → M. Corresponds to variant dbSNP:rs17313374Ensembl.1
Natural variantiVAR_053536830G → S. Corresponds to variant dbSNP:rs35601690Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050477 mRNA Translation: BAB17230.1 Different initiation.
AF288391 mRNA Translation: AAG60611.1
AK022527 mRNA Translation: BAB14079.1
AY550972 mRNA Translation: AAT52218.1
AL096819 Genomic DNA No translation available.
AL109865 Genomic DNA No translation available.
AL109956 Genomic DNA No translation available.
AL136086 Genomic DNA No translation available.
BC030531 mRNA Translation: AAH30531.1
AK074139 mRNA Translation: BAB84965.1
CCDSiCCDS1364.1
RefSeqiNP_443198.1, NM_052966.3
UniGeneiHs.518662

Genome annotation databases

EnsembliENST00000367511; ENSP00000356481; ENSG00000135842
GeneIDi116496
KEGGihsa:116496
UCSCiuc001gra.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050477 mRNA Translation: BAB17230.1 Different initiation.
AF288391 mRNA Translation: AAG60611.1
AK022527 mRNA Translation: BAB14079.1
AY550972 mRNA Translation: AAT52218.1
AL096819 Genomic DNA No translation available.
AL109865 Genomic DNA No translation available.
AL109956 Genomic DNA No translation available.
AL136086 Genomic DNA No translation available.
BC030531 mRNA Translation: AAH30531.1
AK074139 mRNA Translation: BAB84965.1
CCDSiCCDS1364.1
RefSeqiNP_443198.1, NM_052966.3
UniGeneiHs.518662

3D structure databases

ProteinModelPortaliQ9BZQ8
SMRiQ9BZQ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125515, 5 interactors
IntActiQ9BZQ8, 3 interactors
MINTiQ9BZQ8
STRINGi9606.ENSP00000356481

PTM databases

iPTMnetiQ9BZQ8
PhosphoSitePlusiQ9BZQ8

Polymorphism and mutation databases

DMDMi22256936

Proteomic databases

EPDiQ9BZQ8
MaxQBiQ9BZQ8
PaxDbiQ9BZQ8
PeptideAtlasiQ9BZQ8
PRIDEiQ9BZQ8
ProteomicsDBi79893

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367511; ENSP00000356481; ENSG00000135842
GeneIDi116496
KEGGihsa:116496
UCSCiuc001gra.5 human

Organism-specific databases

CTDi116496
DisGeNETi116496
EuPathDBiHostDB:ENSG00000135842.16
GeneCardsiFAM129A
HGNCiHGNC:16784 FAM129A
HPAiHPA028172
HPA028231
HPA028657
neXtProtiNX_Q9BZQ8
OpenTargetsiENSG00000135842
PharmGKBiPA162385951
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFR1 Eukaryota
ENOG41102BB LUCA
GeneTreeiENSGT00530000063284
HOVERGENiHBG108186
InParanoidiQ9BZQ8
OMAiMNLPLDS
OrthoDBiEOG091G02BX
PhylomeDBiQ9BZQ8
TreeFamiTF333351

Enzyme and pathway databases

SIGNORiQ9BZQ8

Miscellaneous databases

ChiTaRSiFAM129A human
GeneWikiiFAM129A
GenomeRNAii116496
PROiPR:Q9BZQ8

Gene expression databases

BgeeiENSG00000135842 Expressed in 226 organ(s), highest expression level in heart right ventricle
CleanExiHS_FAM129A
ExpressionAtlasiQ9BZQ8 baseline and differential
GenevisibleiQ9BZQ8 HS

Family and domain databases

InterProiView protein in InterPro
IPR026088 Niban-like
PANTHERiPTHR14392 PTHR14392, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNIBAN_HUMAN
AccessioniPrimary (citable) accession number: Q9BZQ8
Secondary accession number(s): Q2TTR2
, Q5TEM8, Q8TEI5, Q9H593, Q9H9Y8, Q9HCB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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