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Entry version 129 (12 Aug 2020)
Sequence version 3 (30 Nov 2016)
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Protein

Testicular spindle-associated protein SHCBP1L

Gene

SHCBP1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Testis-specific spindle-associated factor that plays a role in spermatogenesis. In association with HSPA2, participates in the maintenance of spindle integrity during meiosis in male germ cells.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Spermatogenesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9BZQ2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Testicular spindle-associated protein SHCBP1LCurated
Alternative name(s):
SHC SH2 domain-binding protein 1-like proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SHCBP1LImported
Synonyms:C1orf14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000157060.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16788, SHCBP1L

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BZQ2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000157060

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25603

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BZQ2, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SHCBP1L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
145558866

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002848381 – 653Testicular spindle-associated protein SHCBP1LAdd BLAST653

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei8PhosphoserineCombined sources1
Modified residuei53PhosphoserineBy similarity1
Modified residuei570N6-acetyllysineBy similarity1
Modified residuei645N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BZQ2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BZQ2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BZQ2

PeptideAtlas

More...
PeptideAtlasi
Q9BZQ2

PRoteomics IDEntifications database

More...
PRIDEi
Q9BZQ2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79887 [Q9BZQ2-2]
79888 [Q9BZQ2-3]
79889 [Q9BZQ2-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BZQ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BZQ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in spermatocytes and elongating spermatids inside the seminiferous tubules (at protein level) (PubMed:24557841). Testis-specific (PubMed:11318611, PubMed:24557841).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000157060, Expressed in testis and 51 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BZQ2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000157060, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HSPA2; this interaction may promote the recruitment of HSPA2 to the spindle.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123561, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BZQ2, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356518

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BZQ2, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati493 – 514PbH1 1Add BLAST22
Repeati515 – 537PbH1 2Add BLAST23
Repeati538 – 571PbH1 3Add BLAST34
Repeati574 – 596PbH1 4Add BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili299 – 326Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi84 – 89Poly-Ala6

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QT5S, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161173

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_022717_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BZQ2

Identification of Orthologs from Complete Genome Data

More...
OMAi
MHLTLVQ

Database of Orthologous Groups

More...
OrthoDBi
1276823at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BZQ2

TreeFam database of animal gene trees

More...
TreeFami
TF329196

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.160.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039448, Beta_helix
IPR006633, Carb-bd_sugar_hydrolysis-dom
IPR006626, PbH1
IPR012334, Pectin_lyas_fold
IPR011050, Pectin_lyase_fold/virulence

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13229, Beta_helix, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00722, CASH, 1 hit
SM00710, PbH1, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51126, SSF51126, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 3 (identifier: Q9BZQ2-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASGSKASVP ADSFRTISPD RRGEKSASAV SGDTAAATTL KGTAIPVRSV
60 70 80 90 100
VASPRPVKGK AGRETARLRL QRLPAAQAED TGEAAAAAAE EPLLPVPEDE
110 120 130 140 150
EEAQPLPPVC VSRMRGMWRD EKVSLYCDEV LQDCKAEDAD EVMGKYLSEK
160 170 180 190 200
LKLKDKWLGV WKTNPSVFFV KYEEASIPFV GILVEVTCEP YQDSSSRFKV
210 220 230 240 250
TVSVAEPFSS NIANIPRDLV DEILEELEHS VPLLEVYPVE GQDTDIHVIA
260 270 280 290 300
LALEVVRFFY DFLWRDWDDE ESCENYTALI EERINLWCDI QDGTIPGPIA
310 320 330 340 350
QRFKKTLEKY KNKRVELIEY QSNIKEDPSA AEAVECWKKY YEIVMLCGLL
360 370 380 390 400
KMWEDLRLRV HGPFFPRILR RRKGKREFGK TITHIVAKMM TTEMIKDLSS
410 420 430 440 450
DTLLQQHGDL DLALDNCYSG DTVIIFPGEY QAANLALLTD DIIIKGVGKR
460 470 480 490 500
EEIMITSEPS RDSFVVSKAD NVKLMHLSLI QQGTVDGIVV VESGHMTLEN
510 520 530 540 550
CILKCEGTGV CVLTGAALTI TDSEITGAQG AGVELYPGSI AILERNEIHH
560 570 580 590 600
CNNLRTSNSS KSTLGGVNMK VLPAPKLKMT NNHIYSNKGY GVSILQPMEQ
610 620 630 640 650
FFIVAEEALN KRASSGDKKD DKMLFKVMQN LNLEMNNNKI EANVKGDIRI

VTS
Length:653
Mass (Da):72,632
Last modified:November 30, 2016 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i451E8593E0CCE4FA
GO
Isoform 2 (identifier: Q9BZQ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-119: Missing.
     120-135: DEKVSLYCDEVLQDCK → MGFLQLVRLDSNSRPQ

Show »
Length:534
Mass (Da):60,248
Checksum:i89F72F89F1DF3F25
GO
Isoform 4 (identifier: Q9BZQ2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-149: AEDADEVMGKYLSE → KMLMKLWVNTYQKN
     150-653: Missing.

Show »
Length:149
Mass (Da):16,024
Checksum:iF1B47E5852E0A111
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG60617 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti198F → L in AAG60616 (PubMed:11318611).Curated1
Sequence conflicti198F → L in AAG60617 (PubMed:11318611).Curated1
Sequence conflicti249I → L in AAG60616 (PubMed:11318611).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031836491V → M. Corresponds to variant dbSNP:rs12138972Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0246731 – 119Missing in isoform 2. 1 PublicationAdd BLAST119
Alternative sequenceiVSP_024676120 – 135DEKVS…LQDCK → MGFLQLVRLDSNSRPQ in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_024677136 – 149AEDAD…KYLSE → KMLMKLWVNTYQKN in isoform 4. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_024678150 – 653Missing in isoform 4. 1 PublicationAdd BLAST504

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF288397 mRNA Translation: AAG60616.1
AF288398 mRNA Translation: AAG60617.1 Frameshift.
AF297023 AF312863 Genomic DNA Translation: AAG45336.1
AL662837 Genomic DNA No translation available.
AL450304 Genomic DNA No translation available.
BC026084 mRNA Translation: AAH26084.1
BC050305 mRNA Translation: AAH50305.1
BC132764 mRNA Translation: AAI32765.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30955.1 [Q9BZQ2-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001332857.1, NM_001345928.1 [Q9BZQ2-2]
NP_112195.2, NM_030933.3 [Q9BZQ2-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367547; ENSP00000356518; ENSG00000157060 [Q9BZQ2-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
81626

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:81626

UCSC genome browser

More...
UCSCi
uc001gpu.4, human [Q9BZQ2-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288397 mRNA Translation: AAG60616.1
AF288398 mRNA Translation: AAG60617.1 Frameshift.
AF297023 AF312863 Genomic DNA Translation: AAG45336.1
AL662837 Genomic DNA No translation available.
AL450304 Genomic DNA No translation available.
BC026084 mRNA Translation: AAH26084.1
BC050305 mRNA Translation: AAH50305.1
BC132764 mRNA Translation: AAI32765.1
CCDSiCCDS30955.1 [Q9BZQ2-3]
RefSeqiNP_001332857.1, NM_001345928.1 [Q9BZQ2-2]
NP_112195.2, NM_030933.3 [Q9BZQ2-3]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi123561, 2 interactors
IntActiQ9BZQ2, 3 interactors
STRINGi9606.ENSP00000356518

PTM databases

iPTMnetiQ9BZQ2
PhosphoSitePlusiQ9BZQ2

Polymorphism and mutation databases

BioMutaiSHCBP1L
DMDMi145558866

Proteomic databases

jPOSTiQ9BZQ2
MassIVEiQ9BZQ2
PaxDbiQ9BZQ2
PeptideAtlasiQ9BZQ2
PRIDEiQ9BZQ2
ProteomicsDBi79887 [Q9BZQ2-2]
79888 [Q9BZQ2-3]
79889 [Q9BZQ2-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
50328, 44 antibodies

The DNASU plasmid repository

More...
DNASUi
81626

Genome annotation databases

EnsembliENST00000367547; ENSP00000356518; ENSG00000157060 [Q9BZQ2-3]
GeneIDi81626
KEGGihsa:81626
UCSCiuc001gpu.4, human [Q9BZQ2-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
81626
EuPathDBiHostDB:ENSG00000157060.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SHCBP1L
HGNCiHGNC:16788, SHCBP1L
HPAiENSG00000157060, Tissue enriched (testis)
neXtProtiNX_Q9BZQ2
OpenTargetsiENSG00000157060
PharmGKBiPA25603

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QT5S, Eukaryota
GeneTreeiENSGT00940000161173
HOGENOMiCLU_022717_0_0_1
InParanoidiQ9BZQ2
OMAiMHLTLVQ
OrthoDBi1276823at2759
PhylomeDBiQ9BZQ2
TreeFamiTF329196

Enzyme and pathway databases

PathwayCommonsiQ9BZQ2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
81626, 6 hits in 861 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SHCBP1L, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
81626
PharosiQ9BZQ2, Tdark

Protein Ontology

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PROi
PR:Q9BZQ2
RNActiQ9BZQ2, protein

Gene expression databases

BgeeiENSG00000157060, Expressed in testis and 51 other tissues
GenevisibleiQ9BZQ2, HS

Family and domain databases

Gene3Di2.160.20.10, 1 hit
InterProiView protein in InterPro
IPR039448, Beta_helix
IPR006633, Carb-bd_sugar_hydrolysis-dom
IPR006626, PbH1
IPR012334, Pectin_lyas_fold
IPR011050, Pectin_lyase_fold/virulence
PfamiView protein in Pfam
PF13229, Beta_helix, 1 hit
SMARTiView protein in SMART
SM00722, CASH, 1 hit
SM00710, PbH1, 4 hits
SUPFAMiSSF51126, SSF51126, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHP1L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BZQ2
Secondary accession number(s): Q4G195, Q9BZQ3, Q9H2B6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 30, 2016
Last modified: August 12, 2020
This is version 129 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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