Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acidic mammalian chitinase

Gene

CHIA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei140Proton donorCurated1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei141ChitooligosaccharideBy similarity1
Binding sitei360ChitooligosaccharideBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chitinase activity Source: UniProtKB
  • chitin binding Source: GO_Central
  • kinase binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processApoptosis, Carbohydrate metabolism, Chitin degradation, Immunity, Inflammatory response, Polysaccharide degradation
LigandChitin-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.2.1.14 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-189085 Digestion of dietary carbohydrate

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM14 Carbohydrate-Binding Module Family 14
GH18 Glycoside Hydrolase Family 18

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Acidic mammalian chitinase (EC:3.2.1.14)
Short name:
AMCase
Alternative name(s):
Lung-specific protein TSA1902
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHIA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000134216.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17432 CHIA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606080 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BZP6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi138D → A: Loss of chitinase activity. No effect on protection against apoptosis or on AKT1 activation. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
27159

Open Targets

More...
OpenTargetsi
ENSG00000134216

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672117

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1293197

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2982

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CHIA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
37999771

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21By similarityAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001194422 – 476Acidic mammalian chitinaseAdd BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi26 ↔ 51PROSITE-ProRule annotation1 Publication
Disulfide bondi49 ↔ 394PROSITE-ProRule annotation1 Publication
Disulfide bondi307 ↔ 372PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BZP6

PeptideAtlas

More...
PeptideAtlasi
Q9BZP6

PRoteomics IDEntifications database

More...
PRIDEi
Q9BZP6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79883
79884 [Q9BZP6-2]
79885 [Q9BZP6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BZP6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BZP6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in lung epithelial cells from asthma patients (at protein level). Highly expressed in stomach. Detected at lower levels in lung.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in lung epithelial cells from asthma patients.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000134216 Expressed in 56 organ(s), highest expression level in fundus of stomach

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BZP6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BZP6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA059193

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EGFR.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP005332EBI-14357960,EBI-297353

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118039, 18 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BZP6, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000341828

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9BZP6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1476
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9BZP6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BZP6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9BZP6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini427 – 476Chitin-binding type-2PROSITE-ProRule annotationAdd BLAST50

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni70 – 71Chitooligosaccharide bindingCurated2
Regioni97 – 100Chitooligosaccharide bindingCurated4
Regioni210 – 213Chitooligosaccharide bindingCurated4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi415 – 420Poly-Ser6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2806 Eukaryota
COG3325 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154557

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG011684

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BZP6

KEGG Orthology (KO)

More...
KOi
K01183

Identification of Orthologs from Complete Genome Data

More...
OMAi
WIGYDGP

Database of Orthologous Groups

More...
OrthoDBi
EOG091G014W

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BZP6

TreeFam database of animal gene trees

More...
TreeFami
TF315610

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.50.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002557 Chitin-bd_dom
IPR036508 Chitin-bd_dom_sf
IPR011583 Chitinase_II
IPR029070 Chitinase_insertion_sf
IPR001223 Glyco_hydro18_cat
IPR001579 Glyco_hydro_18_chit_AS
IPR017853 Glycoside_hydrolase_SF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01607 CBM_14, 1 hit
PF00704 Glyco_hydro_18, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00494 ChtBD2, 1 hit
SM00636 Glyco_18, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51445 SSF51445, 1 hit
SSF54556 SSF54556, 1 hit
SSF57625 SSF57625, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50940 CHIT_BIND_II, 1 hit
PS01095 CHITINASE_18, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BZP6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTKLILLTGL VLILNLQLGS AYQLTCYFTN WAQYRPGLGR FMPDNIDPCL
60 70 80 90 100
CTHLIYAFAG RQNNEITTIE WNDVTLYQAF NGLKNKNSQL KTLLAIGGWN
110 120 130 140 150
FGTAPFTAMV STPENRQTFI TSVIKFLRQY EFDGLDFDWE YPGSRGSPPQ
160 170 180 190 200
DKHLFTVLVQ EMREAFEQEA KQINKPRLMV TAAVAAGISN IQSGYEIPQL
210 220 230 240 250
SQYLDYIHVM TYDLHGSWEG YTGENSPLYK YPTDTGSNAY LNVDYVMNYW
260 270 280 290 300
KDNGAPAEKL IVGFPTYGHN FILSNPSNTG IGAPTSGAGP AGPYAKESGI
310 320 330 340 350
WAYYEICTFL KNGATQGWDA PQEVPYAYQG NVWVGYDNIK SFDIKAQWLK
360 370 380 390 400
HNKFGGAMVW AIDLDDFTGT FCNQGKFPLI STLKKALGLQ SASCTAPAQP
410 420 430 440 450
IEPITAAPSG SGNGSGSSSS GGSSGGSGFC AVRANGLYPV ANNRNAFWHC
460 470
VNGVTYQQNC QAGLVFDTSC DCCNWA
Length:476
Mass (Da):52,271
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i92B27BAD2F7EB4CC
GO
Isoform 2 (identifier: Q9BZP6-2) [UniParc]FASTAAdd to basket
Also known as: TSA1902-L

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.

Show »
Length:368
Mass (Da):40,139
Checksum:iFC2558C4CEA48609
GO
Isoform 3 (identifier: Q9BZP6-3) [UniParc]FASTAAdd to basket
Also known as: TSA1902-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-161: Missing.

Show »
Length:315
Mass (Da):33,906
Checksum:i61D614709B577CAD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VUV5Q5VUV5_HUMAN
Acidic mammalian chitinase
CHIA
420Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXH6H7BXH6_HUMAN
Acidic mammalian chitinase
CHIA
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLJ2E9PLJ2_HUMAN
Acidic mammalian chitinase
CHIA
287Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti203Y → C in AAX81431 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06303045N → D Increased chitinase activity; when associated with N-47 and M-61. 1 PublicationCorresponds to variant dbSNP:rs41282492Ensembl.1
Natural variantiVAR_06303147D → N Increased chitinase activity; when associated with D-45 and M-61. 1 PublicationCorresponds to variant dbSNP:rs41282494Ensembl.1
Natural variantiVAR_06303261R → M Increased chitinase activity; when associated with D-45 and N-47. 1 PublicationCorresponds to variant dbSNP:rs41282496Ensembl.1
Natural variantiVAR_049192102G → R1 PublicationCorresponds to variant dbSNP:rs3818822Ensembl.1
Natural variantiVAR_063033125K → R1 PublicationCorresponds to variant dbSNP:rs61756687Ensembl.1
Natural variantiVAR_033730324V → G. Corresponds to variant dbSNP:rs2256721Ensembl.1
Natural variantiVAR_049193339I → V2 PublicationsCorresponds to variant dbSNP:rs2275253Ensembl.1
Natural variantiVAR_049194354F → S1 PublicationCorresponds to variant dbSNP:rs2275254Ensembl.1
Natural variantiVAR_049195377F → L. Corresponds to variant dbSNP:rs36011905Ensembl.1
Natural variantiVAR_049196432V → G2 PublicationsCorresponds to variant dbSNP:rs2256721Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0086341 – 161Missing in isoform 3. 2 PublicationsAdd BLAST161
Alternative sequenceiVSP_0086351 – 108Missing in isoform 2. 3 PublicationsAdd BLAST108

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB025008 mRNA Translation: BAA86980.1
AB025009 mRNA Translation: BAA86981.1
AF290004 mRNA Translation: AAG60019.1
AY789444 mRNA Translation: AAX81431.1
AY789445 mRNA Translation: AAX81432.1
AL513202 Genomic DNA No translation available.
AL356387 Genomic DNA No translation available.
BC047336 mRNA Translation: AAH47336.2
BC036339 mRNA Translation: AAH36339.2
BC106910 mRNA Translation: AAI06911.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41368.1 [Q9BZP6-1]
CCDS58017.1 [Q9BZP6-3]
CCDS832.1 [Q9BZP6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001035713.1, NM_001040623.2 [Q9BZP6-3]
NP_001244930.1, NM_001258001.1 [Q9BZP6-2]
NP_001244931.1, NM_001258002.1 [Q9BZP6-3]
NP_001244932.1, NM_001258003.1 [Q9BZP6-2]
NP_001244933.1, NM_001258004.1 [Q9BZP6-3]
NP_001244934.1, NM_001258005.1 [Q9BZP6-3]
NP_068569.2, NM_021797.3 [Q9BZP6-2]
NP_970615.2, NM_201653.3 [Q9BZP6-1]
XP_006710640.1, XM_006710577.3 [Q9BZP6-3]
XP_016856536.1, XM_017001047.1 [Q9BZP6-3]
XP_016856537.1, XM_017001048.1 [Q9BZP6-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.128814

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000343320; ENSP00000341828; ENSG00000134216 [Q9BZP6-1]
ENST00000353665; ENSP00000338970; ENSG00000134216 [Q9BZP6-3]
ENST00000369740; ENSP00000358755; ENSG00000134216 [Q9BZP6-1]
ENST00000430615; ENSP00000391132; ENSG00000134216 [Q9BZP6-2]
ENST00000451398; ENSP00000390476; ENSG00000134216 [Q9BZP6-3]
ENST00000483391; ENSP00000436946; ENSG00000134216 [Q9BZP6-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
27159

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:27159

UCSC genome browser

More...
UCSCi
uc001eas.5 human [Q9BZP6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025008 mRNA Translation: BAA86980.1
AB025009 mRNA Translation: BAA86981.1
AF290004 mRNA Translation: AAG60019.1
AY789444 mRNA Translation: AAX81431.1
AY789445 mRNA Translation: AAX81432.1
AL513202 Genomic DNA No translation available.
AL356387 Genomic DNA No translation available.
BC047336 mRNA Translation: AAH47336.2
BC036339 mRNA Translation: AAH36339.2
BC106910 mRNA Translation: AAI06911.1
CCDSiCCDS41368.1 [Q9BZP6-1]
CCDS58017.1 [Q9BZP6-3]
CCDS832.1 [Q9BZP6-2]
RefSeqiNP_001035713.1, NM_001040623.2 [Q9BZP6-3]
NP_001244930.1, NM_001258001.1 [Q9BZP6-2]
NP_001244931.1, NM_001258002.1 [Q9BZP6-3]
NP_001244932.1, NM_001258003.1 [Q9BZP6-2]
NP_001244933.1, NM_001258004.1 [Q9BZP6-3]
NP_001244934.1, NM_001258005.1 [Q9BZP6-3]
NP_068569.2, NM_021797.3 [Q9BZP6-2]
NP_970615.2, NM_201653.3 [Q9BZP6-1]
XP_006710640.1, XM_006710577.3 [Q9BZP6-3]
XP_016856536.1, XM_017001047.1 [Q9BZP6-3]
XP_016856537.1, XM_017001048.1 [Q9BZP6-2]
UniGeneiHs.128814

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YBTX-ray2.22A/B/C/D/E/F21-398[»]
2YBUX-ray2.25A/B/C/D/E/F21-398[»]
3FXYX-ray2.00A/B/C/D22-408[»]
3FY1X-ray1.70A/B22-408[»]
3RM4X-ray1.90A/B22-408[»]
3RM8X-ray1.80A/B22-408[»]
3RM9X-ray2.10A/B22-408[»]
3RMEX-ray1.80A/B22-408[»]
ProteinModelPortaliQ9BZP6
SMRiQ9BZP6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118039, 18 interactors
IntActiQ9BZP6, 4 interactors
STRINGi9606.ENSP00000341828

Chemistry databases

BindingDBiQ9BZP6
ChEMBLiCHEMBL1293197
GuidetoPHARMACOLOGYi2982

Protein family/group databases

CAZyiCBM14 Carbohydrate-Binding Module Family 14
GH18 Glycoside Hydrolase Family 18

PTM databases

iPTMnetiQ9BZP6
PhosphoSitePlusiQ9BZP6

Polymorphism and mutation databases

BioMutaiCHIA
DMDMi37999771

Proteomic databases

PaxDbiQ9BZP6
PeptideAtlasiQ9BZP6
PRIDEiQ9BZP6
ProteomicsDBi79883
79884 [Q9BZP6-2]
79885 [Q9BZP6-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343320; ENSP00000341828; ENSG00000134216 [Q9BZP6-1]
ENST00000353665; ENSP00000338970; ENSG00000134216 [Q9BZP6-3]
ENST00000369740; ENSP00000358755; ENSG00000134216 [Q9BZP6-1]
ENST00000430615; ENSP00000391132; ENSG00000134216 [Q9BZP6-2]
ENST00000451398; ENSP00000390476; ENSG00000134216 [Q9BZP6-3]
ENST00000483391; ENSP00000436946; ENSG00000134216 [Q9BZP6-3]
GeneIDi27159
KEGGihsa:27159
UCSCiuc001eas.5 human [Q9BZP6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27159
DisGeNETi27159
EuPathDBiHostDB:ENSG00000134216.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CHIA
HGNCiHGNC:17432 CHIA
HPAiHPA059193
MIMi606080 gene
neXtProtiNX_Q9BZP6
OpenTargetsiENSG00000134216
PharmGKBiPA142672117

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2806 Eukaryota
COG3325 LUCA
GeneTreeiENSGT00940000154557
HOVERGENiHBG011684
InParanoidiQ9BZP6
KOiK01183
OMAiWIGYDGP
OrthoDBiEOG091G014W
PhylomeDBiQ9BZP6
TreeFamiTF315610

Enzyme and pathway databases

BRENDAi3.2.1.14 2681
ReactomeiR-HSA-189085 Digestion of dietary carbohydrate

Miscellaneous databases

EvolutionaryTraceiQ9BZP6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
27159

Protein Ontology

More...
PROi
PR:Q9BZP6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000134216 Expressed in 56 organ(s), highest expression level in fundus of stomach
ExpressionAtlasiQ9BZP6 baseline and differential
GenevisibleiQ9BZP6 HS

Family and domain databases

Gene3Di3.10.50.10, 1 hit
InterProiView protein in InterPro
IPR002557 Chitin-bd_dom
IPR036508 Chitin-bd_dom_sf
IPR011583 Chitinase_II
IPR029070 Chitinase_insertion_sf
IPR001223 Glyco_hydro18_cat
IPR001579 Glyco_hydro_18_chit_AS
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF01607 CBM_14, 1 hit
PF00704 Glyco_hydro_18, 1 hit
SMARTiView protein in SMART
SM00494 ChtBD2, 1 hit
SM00636 Glyco_18, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
SSF54556 SSF54556, 1 hit
SSF57625 SSF57625, 1 hit
PROSITEiView protein in PROSITE
PS50940 CHIT_BIND_II, 1 hit
PS01095 CHITINASE_18, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHIA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BZP6
Secondary accession number(s): Q32W79
, Q32W80, Q3B866, Q5U5Z5, Q5VUV4, Q86UD8, Q9ULY3, Q9ULY4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: June 1, 2001
Last modified: December 5, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again