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Protein

UL16-binding protein 1

Gene

ULBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.1 Publication

Miscellaneous

UL16-binding proteins (ULBPs) are unusual members of the extended MHC class I superfamily. They do not contain the alpha 3 domain and lack a transmembrane domain.Curated

GO - Molecular functioni

  • natural killer cell lectin-like receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
UL16-binding protein 1
Alternative name(s):
ALCAN-beta
NKG2D ligand 1
Short name:
N2DL-1
Short name:
NKG2DL1
Retinoic acid early transcript 1I
Gene namesi
Name:ULBP1
Synonyms:N2DL1, RAET1I
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000111981.4
HGNCiHGNC:14893 ULBP1
MIMi605697 gene
neXtProtiNX_Q9BZM6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi80329
OpenTargetsiENSG00000111981
PharmGKBiPA37915

Polymorphism and mutation databases

BioMutaiULBP1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25By similarityAdd BLAST25
ChainiPRO_000001901526 – 216UL16-binding protein 1Add BLAST191
PropeptideiPRO_0000019016217 – 244Removed in mature formSequence analysisAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 66By similarity
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi127 ↔ 190By similarity
Lipidationi216GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ9BZM6
PeptideAtlasiQ9BZM6
PRIDEiQ9BZM6
ProteomicsDBi79879

Expressioni

Tissue specificityi

Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.

Gene expression databases

BgeeiENSG00000111981 Expressed in 58 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_ULBP1
GenevisibleiQ9BZM6 HS

Organism-specific databases

HPAiHPA007547
HPA071005

Interactioni

Subunit structurei

Interacts with KLRK1/NKG2D (PubMed:11777960). Does not bind to beta2-microglobulin (PubMed:12782710).2 Publications
(Microbial infection) In CMV-infected cells, interacts with the viral glycoprotein UL16; this interaction causes ULBP1 retention in the endoplasmic reticulum and cis-Golgi and prevents binding to and activation of KLRK1/NKG2D, providing CMV with an immune evasion mechanism.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
KLRK1P267182EBI-16365037,EBI-458344

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123241, 8 interactors
CORUMiQ9BZM6
IntActiQ9BZM6, 1 interactor
STRINGi9606.ENSP00000229708

Structurei

3D structure databases

ProteinModelPortaliQ9BZM6
SMRiQ9BZM6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 117MHC class I alpha-1 likeAdd BLAST92
Regioni118 – 208MHC class I alpha-2 likeAdd BLAST91

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4VC Eukaryota
ENOG41113ZC LUCA
GeneTreeiENSGT00390000003472
HOGENOMiHOG000070028
HOVERGENiHBG052564
InParanoidiQ9BZM6
KOiK07986
OMAiCKMWLEE
OrthoDBiEOG091G0I62
PhylomeDBiQ9BZM6
TreeFamiTF341724

Family and domain databases

Gene3Di3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PfamiView protein in Pfam
PF00129 MHC_I, 1 hit
SUPFAMiSSF54452 SSF54452, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BZM6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAASPAFL LCLPLLHLLS GWSRAGWVDT HCLCYDFIIT PKSRPEPQWC
60 70 80 90 100
EVQGLVDERP FLHYDCVNHK AKAFASLGKK VNVTKTWEEQ TETLRDVVDF
110 120 130 140 150
LKGQLLDIQV ENLIPIEPLT LQARMSCEHE AHGHGRGSWQ FLFNGQKFLL
160 170 180 190 200
FDSNNRKWTA LHPGAKKMTE KWEKNRDVTM FFQKISLGDC KMWLEEFLMY
210 220 230 240
WEQMLDPTKP PSLAPGTTQP KAMATTLSPW SLLIIFLCFI LAGR
Length:244
Mass (Da):27,997
Last modified:June 1, 2001 - v1
Checksum:i6094B17CE383DC6D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050407101L → I. Corresponds to variant dbSNP:rs6903584Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF304377 mRNA Translation: AAK13081.1
AB052907 mRNA Translation: BAB61049.1
AF346416 mRNA Translation: AAL76416.1
AK292519 mRNA Translation: BAF85208.1
AK316582 mRNA Translation: BAG38170.1
AL355497 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47776.1
BC035416 mRNA Translation: AAH35416.1
AF425265 mRNA Translation: AAN32759.1
AF346595 mRNA Translation: AAN40838.1
CCDSiCCDS5223.1
RefSeqiNP_001304018.1, NM_001317089.1
NP_079494.1, NM_025218.3
UniGeneiHs.653255

Genome annotation databases

EnsembliENST00000229708; ENSP00000229708; ENSG00000111981
GeneIDi80329
KEGGihsa:80329
UCSCiuc003qnp.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF304377 mRNA Translation: AAK13081.1
AB052907 mRNA Translation: BAB61049.1
AF346416 mRNA Translation: AAL76416.1
AK292519 mRNA Translation: BAF85208.1
AK316582 mRNA Translation: BAG38170.1
AL355497 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47776.1
BC035416 mRNA Translation: AAH35416.1
AF425265 mRNA Translation: AAN32759.1
AF346595 mRNA Translation: AAN40838.1
CCDSiCCDS5223.1
RefSeqiNP_001304018.1, NM_001317089.1
NP_079494.1, NM_025218.3
UniGeneiHs.653255

3D structure databases

ProteinModelPortaliQ9BZM6
SMRiQ9BZM6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123241, 8 interactors
CORUMiQ9BZM6
IntActiQ9BZM6, 1 interactor
STRINGi9606.ENSP00000229708

Polymorphism and mutation databases

BioMutaiULBP1

Proteomic databases

PaxDbiQ9BZM6
PeptideAtlasiQ9BZM6
PRIDEiQ9BZM6
ProteomicsDBi79879

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229708; ENSP00000229708; ENSG00000111981
GeneIDi80329
KEGGihsa:80329
UCSCiuc003qnp.5 human

Organism-specific databases

CTDi80329
DisGeNETi80329
EuPathDBiHostDB:ENSG00000111981.4
GeneCardsiULBP1
HGNCiHGNC:14893 ULBP1
HPAiHPA007547
HPA071005
MIMi605697 gene
neXtProtiNX_Q9BZM6
OpenTargetsiENSG00000111981
PharmGKBiPA37915
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4VC Eukaryota
ENOG41113ZC LUCA
GeneTreeiENSGT00390000003472
HOGENOMiHOG000070028
HOVERGENiHBG052564
InParanoidiQ9BZM6
KOiK07986
OMAiCKMWLEE
OrthoDBiEOG091G0I62
PhylomeDBiQ9BZM6
TreeFamiTF341724

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

GeneWikiiULBP1
GenomeRNAii80329
PROiPR:Q9BZM6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111981 Expressed in 58 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_ULBP1
GenevisibleiQ9BZM6 HS

Family and domain databases

Gene3Di3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PfamiView protein in Pfam
PF00129 MHC_I, 1 hit
SUPFAMiSSF54452 SSF54452, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiULBP1_HUMAN
AccessioniPrimary (citable) accession number: Q9BZM6
Secondary accession number(s): Q5VY81, Q8IZW3, Q8IZX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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