PLA2G2F

Functionⁱ

May play a role in lipid mediator production in inflammatory conditions, by providing arachidonic acid to downstream cyclooxygenases and lipoxygenases (By similarity). Phospholipase A2, which catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:11112443). Hydrolyzes phosphatidylethanolamine more efficiently than phosphatidylcholine, with only a modest preference for arachidonic acid versus linoelic acid at the sn-2 position. Comparable activity toward 1-palmitoyl-2-oleoyl-phosphatidylserine vesicles to that toward 1-palmitoyl-2-oleoyl-phosphatidylglycerol (By similarity). Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference (PubMed:11112443).By similarity1 Publication

Catalytic activityⁱ

Phosphatidylcholine + H₂O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation1 Publication

Cofactorⁱ

Ca²⁺1 PublicationNote: Binds 1 Ca²⁺ ion per subunit.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	47	Calcium; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	49	Calcium; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	51	Calcium; via carbonyl oxygenBy similarity	1
Active siteⁱ	67	PROSITE-ProRule annotation	1
Metal bindingⁱ	68	CalciumBy similarity	1
Active siteⁱ	114	PROSITE-ProRule annotation	1

GO - Molecular functionⁱ

calcium ion binding Source: InterPro
phospholipase A2 activity Source: Reactome
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) Source: UniProtKB-EC
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

arachidonic acid secretion Source: InterPro
innate immune response Source: UniProtKB-KW
lipid catabolic process Source: UniProtKB-KW
negative regulation of T cell proliferation Source: Ensembl
phosphatidic acid biosynthetic process Source: Reactome
phosphatidylcholine acyl-chain remodeling Source: Reactome
phosphatidylethanolamine acyl-chain remodeling Source: Reactome
phosphatidylglycerol acyl-chain remodeling Source: Reactome
phosphatidylinositol acyl-chain remodeling Source: Reactome
phosphatidylserine acyl-chain remodeling Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Immunity, Innate immunity, Lipid degradation, Lipid metabolism
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1482788 Acyl chain remodelling of PC R-HSA-1482801 Acyl chain remodelling of PS R-HSA-1482839 Acyl chain remodelling of PE R-HSA-1482922 Acyl chain remodelling of PI R-HSA-1482925 Acyl chain remodelling of PG R-HSA-1483166 Synthesis of PA

Reactomeⁱ

R-HSA-1482788 Acyl chain remodelling of PC
R-HSA-1482801 Acyl chain remodelling of PS
R-HSA-1482839 Acyl chain remodelling of PE
R-HSA-1482922 Acyl chain remodelling of PI
R-HSA-1482925 Acyl chain remodelling of PG
R-HSA-1483166 Synthesis of PA

Chemistry databases

SwissLipidsⁱ	SLP:000000654 [Q9BZM2-1]

SwissLipidsⁱ

SLP:000000654 [Q9BZM2-1]

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Group IIF secretory phospholipase A2 (EC:3.1.1.4) Short name: GIIF sPLA2 Short name: sPLA2-IIF Alternative name(s): Phosphatidylcholine 2-acylhydrolase 2F
Gene namesⁱ	Name:PLA2G2F
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000158786.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30040 PLA2G2F
neXtProtⁱ	NX_Q9BZM2

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	64600
Open Targets More...OpenTargetsⁱ	ENSG00000158786
PharmGKBⁱ	PA134931043

Chemistry databases

ChEMBLⁱ	CHEMBL4278
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1420

Polymorphism and mutation databases

BioMutaⁱ	PLA2G2F
DMDMⁱ	20139134

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST		20
ChainⁱPRO_0000022759	21 – 168	Group IIF secretory phospholipase A2Add BLAST		148

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	46 ↔ 138	By similarity
Disulfide bondⁱ	48 ↔ 64	By similarity
Disulfide bondⁱ	63 ↔ 120	By similarity
Disulfide bondⁱ	69 ↔ 145	By similarity
Disulfide bondⁱ	70 ↔ 113	By similarity
Disulfide bondⁱ	79 ↔ 106	By similarity
Glycosylationⁱ	92	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	98 ↔ 111	By similarity
Glycosylationⁱ	102	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	123	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	144	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q9BZM2
PeptideAtlas More...PeptideAtlasⁱ	Q9BZM2
PRIDEⁱ	Q9BZM2
ProteomicsDBⁱ	79874 79875 [Q9BZM2-2]

PTM databases

iPTMnetⁱ	Q9BZM2
PhosphoSitePlusⁱ	Q9BZM2

Expressionⁱ

Tissue specificityⁱ

Expressed at high levels in placenta, testis, thymus and at lower levels in heart, kidney, liver and prostate (PubMed:11112443). Highly expressed in rheumatoid arthritic tissues, including synovial lining cells in the intima, capillary endothelial cells and plasma cells (PubMed:11877435).2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000158786 Expressed in 20 organ(s), highest expression level in urinary bladder
CleanExⁱ	HS_PLA2G2F
Genevisibleⁱ	Q9BZM2 HS

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q9BZM2, 3 interactors
STRINGⁱ	9606.ENSP00000364243

Chemistry databases

BindingDBⁱ	Q9BZM2

BindingDBⁱ

Q9BZM2

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BZM2
SMRⁱ	Q9BZM2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	139 – 168	Required for localization on the plasma membraneBy similarityAdd BLAST		30

Sequence similaritiesⁱ

Belongs to the phospholipase A2 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG4087 Eukaryota ENOG411283D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119160
HOGENOMⁱ	HOG000231749
HOVERGENⁱ	HBG008137
InParanoidⁱ	Q9BZM2
KEGG Orthology (KO) More...KOⁱ	K01047
OMAⁱ	YCQGPTP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0UZ3
PhylomeDBⁱ	Q9BZM2
TreeFamⁱ	TF319283

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00125 PLA2c, 1 hit
Gene3Dⁱ	1.20.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR001211 PLipase_A2 IPR016090 PLipase_A2_dom IPR036444 PLipase_A2_dom_sf IPR033113 PLipase_A2_His_AS
PANTHERⁱ	PTHR11716 PTHR11716, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00068 Phospholip_A2_1, 1 hit
PRINTSⁱ	PR00389 PHPHLIPASEA2
SMARTⁱ	View protein in SMART SM00085 PA2c, 1 hit
SUPFAMⁱ	SSF48619 SSF48619, 1 hit
PROSITEⁱ	View protein in PROSITE PS00118 PA2_HIS, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9BZM2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKFFTVAIL AGSVLSTAHG SLLNLKAMVE AVTGRSAILS FVGYGCYCGL 
        60         70         80         90        100
GGRGQPKDEV DWCCHAHDCC YQELFDQGCH PYVDHYDHTI ENNTEIVCSD 
       110        120        130        140        150
LNKTECDKQT CMCDKNMVLC LMNQTYREEY RGFLNVYCQG PTPNCSIYEP 
       160 
PPEEVTCSHQ SPAPPAPP

Length:168

Mass (Da):18,658

Last modified:June 1, 2001 - v1

Checksum:ⁱ35B159298246A762

GO

Isoform 2 (identifier: Q9BZM2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MADGAKANPKGFKKKVLDRCFSGWRGPRFGASCPSRTSRSSLGM

« Hide

        10         20         30         40         50
MADGAKANPK GFKKKVLDRC FSGWRGPRFG ASCPSRTSRS SLGMKKFFTV 
        60         70         80         90        100
AILAGSVLST AHGSLLNLKA MVEAVTGRSA ILSFVGYGCY CGLGGRGQPK 
       110        120        130        140        150
DEVDWCCHAH DCCYQELFDQ GCHPYVDHYD HTIENNTEIV CSDLNKTECD 
       160        170        180        190        200
KQTCMCDKNM VLCLMNQTYR EEYRGFLNVY CQGPTPNCSI YEPPPEEVTC 
       210 
SHQSPAPPAP P

Note: No signal peptide could be predicted in this isoform, challenging its subcellular location within the secretory pathway and hence the formation of disulfide bonds, which are required for its activity. Gene prediction based on EST data. No experimental available.Curated

Show »

Length:211

Mass (Da):23,256

Checksum:ⁱ483B5E7850CB4248

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	149	E → G in BAC04210 (PubMed:14702039).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_037524	1	M → MADGAKANPKGFKKKVLDRC FSGWRGPRFGASCPSRTSRS SLGM in isoform 2. Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF306566 mRNA Translation: AAG50242.1 AK093645 mRNA Translation: BAC04210.1 AL158172 Genomic DNA No translation available. Z98257 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS204.2 [Q9BZM2-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_073730.3, NM_022819.3 [Q9BZM2-2] XP_011540258.1, XM_011541956.1 [Q9BZM2-2]
UniGeneⁱ	Hs.302034

Genome annotation databases

Ensemblⁱ	ENST00000375102; ENSP00000364243; ENSG00000158786 [Q9BZM2-2]
GeneIDⁱ	64600
KEGGⁱ	hsa:64600
UCSC genome browser More...UCSCⁱ	uc009vpp.2 human [Q9BZM2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BZM2	Isoform 2 of Group IIF secretory phospholipase A2		HUMAN		211	UniRef90_Q9BZM2
Phospholipase A(2)		CHLSB		223
Phospholipase A(2)		PONAB		211
Phospholipase A(2)		GORGO		211

Protein	Similar proteins		Species	Score	Length	Source
Q9BZM2	Group IIF secretory phospholipase A2		MOUSE		168	UniRef50_Q9BZM2
Isoform 2 of Group IIF secretory phospholipase A2		HUMAN		211
Phospholipase A(2)		CHLSB		223
Phospholipase A(2)		GORGO		211
Phospholipase A(2)		PONAB		211
+79

Entry informationⁱ

Entry nameⁱ	PA2GF_HUMAN
Accessionⁱ	Q9BZM2Primary (citable) accession number: Q9BZM2 Secondary accession number(s): Q5R385, Q8N217, Q9H506
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
	Last sequence update:	June 1, 2001
	Last modified:	September 12, 2018
	This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9BZM2 (PA2GF_HUMAN)

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Group IIF secretory phospholipase A2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Cytosol

Extracellular region or secreted

Plasma Membrane

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ