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Entry version 103 (11 Dec 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Small integral membrane protein 3

Gene

SMIM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Small integral membrane protein 3
Alternative name(s):
NGF-induced differentiation clone 67 protein
Small membrane protein NID67
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SMIM3
Synonyms:C5orf62, NID67
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000256235.1

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30248 SMIM3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608324 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BZL3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 40HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000256235

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165660222

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BZL3 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SMIM3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000968161 – 60Small integral membrane protein 3Add BLAST60

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei19 – 20CleavageBy similarity2

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BZL3

PeptideAtlas

More...
PeptideAtlasi
Q9BZL3

PRoteomics IDEntifications database

More...
PRIDEi
Q9BZL3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79867

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By NGF.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000256235 Expressed in 175 organ(s), highest expression level in adipose tissue of abdominal region

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BZL3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA075345

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
124436, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BZL3, 48 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000436897

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BZL3 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BZL3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J2JQ Eukaryota
ENOG411180I LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009443

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000132849

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BZL3

Identification of Orthologs from Complete Genome Data

More...
OMAi
HILDVWV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BZL3

TreeFam database of animal gene trees

More...
TreeFami
TF354124

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035275 Smim3

The PANTHER Classification System

More...
PANTHERi
PTHR37859 PTHR37859, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17307 Smim3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9BZL3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAVSQVPME VVLPKHILDI WVIVLIILAT IVIMTSLLLC PATAVIIYRM
60
RTHPILSGAV
Length:60
Mass (Da):6,593
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFEE7DA7A6E02B08E
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI01839 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence AAI01841 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence AAI06041 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAC86114 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence EAW61705 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF313413 mRNA Translation: AAG53959.1
AK125286 mRNA Translation: BAC86114.1 Sequence problems.
AC010441 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61705.1 Sequence problems.
BC009719 mRNA Translation: AAH09719.1
BC101838 mRNA Translation: AAI01839.1 Sequence problems.
BC101840 mRNA Translation: AAI01841.1 Sequence problems.
BC106040 mRNA Translation: AAI06041.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47312.2

NCBI Reference Sequences

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RefSeqi
NP_116565.3, NM_032947.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000526627; ENSP00000436897; ENSG00000256235
ENST00000648745; ENSP00000496958; ENSG00000256235

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
85027

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:85027

UCSC genome browser

More...
UCSCi
uc003lsw.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313413 mRNA Translation: AAG53959.1
AK125286 mRNA Translation: BAC86114.1 Sequence problems.
AC010441 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61705.1 Sequence problems.
BC009719 mRNA Translation: AAH09719.1
BC101838 mRNA Translation: AAI01839.1 Sequence problems.
BC101840 mRNA Translation: AAI01841.1 Sequence problems.
BC106040 mRNA Translation: AAI06041.1 Sequence problems.
CCDSiCCDS47312.2
RefSeqiNP_116565.3, NM_032947.4

3D structure databases

SMRiQ9BZL3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124436, 10 interactors
IntActiQ9BZL3, 48 interactors
STRINGi9606.ENSP00000436897

Polymorphism and mutation databases

BioMutaiSMIM3

Proteomic databases

PaxDbiQ9BZL3
PeptideAtlasiQ9BZL3
PRIDEiQ9BZL3
ProteomicsDBi79867

Genome annotation databases

EnsembliENST00000526627; ENSP00000436897; ENSG00000256235
ENST00000648745; ENSP00000496958; ENSG00000256235
GeneIDi85027
KEGGihsa:85027
UCSCiuc003lsw.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
85027
EuPathDBiHostDB:ENSG00000256235.1

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SMIM3
HGNCiHGNC:30248 SMIM3
HPAiHPA075345
MIMi608324 gene
neXtProtiNX_Q9BZL3
OpenTargetsiENSG00000256235
PharmGKBiPA165660222

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J2JQ Eukaryota
ENOG411180I LUCA
GeneTreeiENSGT00390000009443
HOGENOMiHOG000132849
InParanoidiQ9BZL3
OMAiHILDVWV
PhylomeDBiQ9BZL3
TreeFamiTF354124

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SMIM3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
85027
PharosiQ9BZL3 Tdark

Protein Ontology

More...
PROi
PR:Q9BZL3
RNActiQ9BZL3 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000256235 Expressed in 175 organ(s), highest expression level in adipose tissue of abdominal region
GenevisibleiQ9BZL3 HS

Family and domain databases

InterProiView protein in InterPro
IPR035275 Smim3
PANTHERiPTHR37859 PTHR37859, 1 hit
PfamiView protein in Pfam
PF17307 Smim3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMIM3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BZL3
Secondary accession number(s): Q3MIG3, Q6ZUV4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: December 11, 2019
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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