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Protein

Ubiquitin-like protein 5

Gene

UBL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein tag Source: GO_Central

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like protein 5
Gene namesi
Name:UBL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000198258.10
HGNCiHGNC:13736 UBL5
MIMi606849 gene
neXtProtiNX_Q9BZL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi59286
OpenTargetsiENSG00000198258
PharmGKBiPA37805

Polymorphism and mutation databases

BioMutaiUBL5
DMDMi52082771

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001148661 – 73Ubiquitin-like protein 5Add BLAST73

Proteomic databases

EPDiQ9BZL1
MaxQBiQ9BZL1
PaxDbiQ9BZL1
PeptideAtlasiQ9BZL1
PRIDEiQ9BZL1
ProteomicsDBi79866

PTM databases

iPTMnetiQ9BZL1
PhosphoSitePlusiQ9BZL1

Expressioni

Tissue specificityi

Ubiquitous. Highest level of expression in heart, skeletal muscle, kidney, liver, iris and lymphoblasts.1 Publication

Gene expression databases

BgeeiENSG00000198258 Expressed in 225 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_UBL5
ExpressionAtlasiQ9BZL1 baseline and differential
GenevisibleiQ9BZL1 HS

Interactioni

Subunit structurei

Interacts with CLK1, CLK3 and CLK4.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi121872, 20 interactors
IntActiQ9BZL1, 57 interactors
MINTiQ9BZL1
STRINGi9606.ENSP00000351492

Structurei

Secondary structure

173
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BZL1
SMRiQ9BZL1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BZL1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 73Ubiquitin-likeAdd BLAST73

Phylogenomic databases

eggNOGiKOG3493 Eukaryota
ENOG4111UT0 LUCA
GeneTreeiENSGT00390000001945
HOVERGENiHBG055994
InParanoidiQ9BZL1
KOiK13113
OMAiCNEDDTV
OrthoDBiEOG091G127Z
PhylomeDBiQ9BZL1

Family and domain databases

InterProiView protein in InterPro
IPR039732 Hub1/Ubl5
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PANTHERiPTHR13042 PTHR13042, 1 hit
PfamiView protein in Pfam
PF00240 ubiquitin, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9BZL1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIEVVCNDRL GKKVRVKCNT DDTIGDLKKL IAAQTGTRWN KIVLKKWYTI
60 70
FKDHVSLGDY EIHDGMNLEL YYQ
Length:73
Mass (Da):8,547
Last modified:June 1, 2001 - v1
Checksum:iD68BC941536AA39F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQ43K7EQ43_HUMAN
Ubiquitin-like protein 5
UBL5
36Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313915 mRNA Translation: AAK14178.1
BT007355 mRNA Translation: AAP36019.1
BC007053 mRNA Translation: AAH07053.1
BC110839 mRNA Translation: AAI10840.1
CCDSiCCDS12219.1
RefSeqiNP_001041706.1, NM_001048241.2
NP_077268.1, NM_024292.3
UniGeneiHs.534477

Genome annotation databases

EnsembliENST00000358666; ENSP00000351492; ENSG00000198258
ENST00000586895; ENSP00000468656; ENSG00000198258
ENST00000590068; ENSP00000466910; ENSG00000198258
GeneIDi59286
KEGGihsa:59286
UCSCiuc002mmi.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313915 mRNA Translation: AAK14178.1
BT007355 mRNA Translation: AAP36019.1
BC007053 mRNA Translation: AAH07053.1
BC110839 mRNA Translation: AAI10840.1
CCDSiCCDS12219.1
RefSeqiNP_001041706.1, NM_001048241.2
NP_077268.1, NM_024292.3
UniGeneiHs.534477

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1P0RNMR-A1-73[»]
4PYUX-ray2.00A/B/G/K/O/S1-73[»]
ProteinModelPortaliQ9BZL1
SMRiQ9BZL1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121872, 20 interactors
IntActiQ9BZL1, 57 interactors
MINTiQ9BZL1
STRINGi9606.ENSP00000351492

PTM databases

iPTMnetiQ9BZL1
PhosphoSitePlusiQ9BZL1

Polymorphism and mutation databases

BioMutaiUBL5
DMDMi52082771

Proteomic databases

EPDiQ9BZL1
MaxQBiQ9BZL1
PaxDbiQ9BZL1
PeptideAtlasiQ9BZL1
PRIDEiQ9BZL1
ProteomicsDBi79866

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358666; ENSP00000351492; ENSG00000198258
ENST00000586895; ENSP00000468656; ENSG00000198258
ENST00000590068; ENSP00000466910; ENSG00000198258
GeneIDi59286
KEGGihsa:59286
UCSCiuc002mmi.3 human

Organism-specific databases

CTDi59286
DisGeNETi59286
EuPathDBiHostDB:ENSG00000198258.10
GeneCardsiUBL5
HGNCiHGNC:13736 UBL5
MIMi606849 gene
neXtProtiNX_Q9BZL1
OpenTargetsiENSG00000198258
PharmGKBiPA37805
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3493 Eukaryota
ENOG4111UT0 LUCA
GeneTreeiENSGT00390000001945
HOVERGENiHBG055994
InParanoidiQ9BZL1
KOiK13113
OMAiCNEDDTV
OrthoDBiEOG091G127Z
PhylomeDBiQ9BZL1

Miscellaneous databases

ChiTaRSiUBL5 human
EvolutionaryTraceiQ9BZL1
GeneWikiiUBL5
GenomeRNAii59286
PROiPR:Q9BZL1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198258 Expressed in 225 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_UBL5
ExpressionAtlasiQ9BZL1 baseline and differential
GenevisibleiQ9BZL1 HS

Family and domain databases

InterProiView protein in InterPro
IPR039732 Hub1/Ubl5
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PANTHERiPTHR13042 PTHR13042, 1 hit
PfamiView protein in Pfam
PF00240 ubiquitin, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUBL5_HUMAN
AccessioniPrimary (citable) accession number: Q9BZL1
Secondary accession number(s): Q2NL89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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