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Protein

G-protein coupled receptor 62

Gene

GPR62

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28827538). Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

SignaLinkiQ9BZJ7

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 62Curated
Alternative name(s):
G-protein coupled receptor GPCR8
Short name:
hGPCR8
G-protein coupled receptor KPG_005
Gene namesi
Name:GPR62
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000180929.5
HGNCiHGNC:13301 GPR62
MIMi606917 gene
neXtProtiNX_Q9BZJ7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18ExtracellularSequence analysisAdd BLAST18
Transmembranei19 – 39Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini40 – 53CytoplasmicSequence analysisAdd BLAST14
Transmembranei54 – 74Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini75 – 91ExtracellularSequence analysisAdd BLAST17
Transmembranei92 – 112Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini113 – 129CytoplasmicSequence analysisAdd BLAST17
Transmembranei130 – 150Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini151 – 177ExtracellularSequence analysisAdd BLAST27
Transmembranei178 – 198Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini199 – 239CytoplasmicSequence analysisAdd BLAST41
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 272ExtracellularSequence analysisAdd BLAST12
Transmembranei273 – 293Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini294 – 368CytoplasmicSequence analysisAdd BLAST75

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180929
PharmGKBiPA28906

Polymorphism and mutation databases

BioMutaiGPR62
DMDMi296434526

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695801 – 368G-protein coupled receptor 62Add BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BZJ7
PeptideAtlasiQ9BZJ7
PRIDEiQ9BZJ7
ProteomicsDBi79861

PTM databases

PhosphoSitePlusiQ9BZJ7

Expressioni

Tissue specificityi

Expressed in brain; detected in the basal forebrain, frontal cortex, caudate, putamen, thalamus and hippocampus.1 Publication

Gene expression databases

BgeeiENSG00000180929 Expressed in 71 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_GPR62
GenevisibleiQ9BZJ7 HS

Interactioni

Subunit structurei

Homodimers (By similarity). Forms heterodimer with MTNR1B (PubMed:28827538). Interacts with ARRB1 and ARRB2 in a spontaneous and agonist-independent manner; leading to the internalization of GPR62 in the endosomal compartment (PubMed:28827538).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9BZJ7, 1 interactor
MINTiQ9BZJ7
STRINGi9606.ENSP00000319250

Structurei

3D structure databases

ProteinModelPortaliQ9BZJ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi239 – 285Ala-richAdd BLAST47

Domaini

Lacks the conserved DRY and BBXXB motifs. The restoration of these motifs affects its constitutive activity.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00730000110969
HOGENOMiHOG000004832
HOVERGENiHBG051816
InParanoidiQ9BZJ7
KOiK08415
OMAiQAWHPRA
OrthoDBiEOG091G0TJJ
PhylomeDBiQ9BZJ7
TreeFamiTF332667

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BZJ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANSTGLNAS EVAGSLGLIL AAVVEVGALL GNGALLVVVL RTPGLRDALY
60 70 80 90 100
LAHLCVVDLL AAASIMPLGL LAAPPPGLGR VRLGPAPCRA ARFLSAALLP
110 120 130 140 150
ACTLGVAALG LARYRLIVHP LRPGSRPPPV LVLTAVWAAA GLLGALSLLG
160 170 180 190 200
TPPAPPPAPA RCSVLAGGLG PFRPLWALLA FALPALLLLG AYGGIFVVAR
210 220 230 240 250
RAALRPPRPA RGSRLHSDSL DSRLSILPPL RPRLPGGKAA LAPALAVGQF
260 270 280 290 300
AACWLPYGCA CLAPAARAAE AEAAVTWVAY SAFAAHPFLY GLLQRPVRLA
310 320 330 340 350
LGRLSRRALP GPVRACTPQA WHPRALLQCL QRPPEGPAVG PSEAPEQTPE
360
LAGGRSPAYQ GPPESSLS
Length:368
Mass (Da):37,614
Last modified:May 18, 2010 - v2
Checksum:iB06F91BF4C51757A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067702151T → P4 PublicationsCorresponds to variant dbSNP:rs28587738Ensembl.1
Natural variantiVAR_067703216H → R4 PublicationsCorresponds to variant dbSNP:rs28651222Ensembl.1
Natural variantiVAR_055920313V → L. Corresponds to variant dbSNP:rs323871Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317653 Genomic DNA Translation: AAK12638.1
AB032600 mRNA Translation: BAD83591.1
HQ709188 mRNA Translation: ADZ17395.1
AB083590 Genomic DNA Translation: BAB89303.1
AC115284 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65164.1
CCDSiCCDS2838.1
RefSeqiNP_543141.3, NM_080865.3
UniGeneiHs.232213

Genome annotation databases

EnsembliENST00000322241; ENSP00000319250; ENSG00000180929
GeneIDi118442
KEGGihsa:118442
UCSCiuc003dca.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317653 Genomic DNA Translation: AAK12638.1
AB032600 mRNA Translation: BAD83591.1
HQ709188 mRNA Translation: ADZ17395.1
AB083590 Genomic DNA Translation: BAB89303.1
AC115284 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65164.1
CCDSiCCDS2838.1
RefSeqiNP_543141.3, NM_080865.3
UniGeneiHs.232213

3D structure databases

ProteinModelPortaliQ9BZJ7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9BZJ7, 1 interactor
MINTiQ9BZJ7
STRINGi9606.ENSP00000319250

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ9BZJ7

Polymorphism and mutation databases

BioMutaiGPR62
DMDMi296434526

Proteomic databases

PaxDbiQ9BZJ7
PeptideAtlasiQ9BZJ7
PRIDEiQ9BZJ7
ProteomicsDBi79861

Protocols and materials databases

DNASUi118442
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322241; ENSP00000319250; ENSG00000180929
GeneIDi118442
KEGGihsa:118442
UCSCiuc003dca.4 human

Organism-specific databases

CTDi118442
EuPathDBiHostDB:ENSG00000180929.5
GeneCardsiGPR62
HGNCiHGNC:13301 GPR62
MIMi606917 gene
neXtProtiNX_Q9BZJ7
OpenTargetsiENSG00000180929
PharmGKBiPA28906
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00730000110969
HOGENOMiHOG000004832
HOVERGENiHBG051816
InParanoidiQ9BZJ7
KOiK08415
OMAiQAWHPRA
OrthoDBiEOG091G0TJJ
PhylomeDBiQ9BZJ7
TreeFamiTF332667

Enzyme and pathway databases

SignaLinkiQ9BZJ7

Miscellaneous databases

GeneWikiiGPR62
GenomeRNAii118442
PROiPR:Q9BZJ7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180929 Expressed in 71 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_GPR62
GenevisibleiQ9BZJ7 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPR62_HUMAN
AccessioniPrimary (citable) accession number: Q9BZJ7
Secondary accession number(s): F1DAM4, Q5KU27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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