UniProtKB - Q9BZJ4 (S2539_HUMAN)
Probable mitochondrial glutathione transporter SLC25A39
SLC25A39
Functioni
Mitochondrial transporter required for glutahione import into mitochondria (PubMed:34707288).
Glutahione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles (PubMed:34707288).
Mitochondrial glutahione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis (PubMed:34707288).
1 PublicationGO - Biological processi
- heme biosynthetic process Source: UniProtKB-KW
- mitochondrial transmembrane transport Source: InterPro
Keywordsi
Biological process | Heme biosynthesis, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9BZJ4 |
SignaLinki | Q9BZJ4 |
Protein family/group databases
TCDBi | 2.A.29.14.8, the mitochondrial carrier (mc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Probable mitochondrial glutathione transporter SLC25A39CuratedAlternative name(s): Solute carrier family 25 member 39Curated |
Gene namesi | ORF Names:CGI-691 Publication, PRO21631 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24279, SLC25A39 |
MIMi | 610820, gene |
neXtProti | NX_Q9BZJ4 |
VEuPathDBi | HostDB:ENSG00000013306 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 2 Publications; Multi-pass membrane protein Sequence analysis
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 15 – 35 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 122 – 142 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 161 – 181 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 215 – 235 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Transmembranei | 259 – 279 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 318 – 338 | Helical; Name=6Sequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 226 | D → A: Abolished glutahione import into mitochondria without affecting the levels of NAD. 1 Publication | 1 | |
Mutagenesisi | 329 | K → A: Abolished glutahione import into mitochondria without affecting the levels of NAD. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 51629 |
OpenTargetsi | ENSG00000013306 |
PharmGKBi | PA162403626 |
Miscellaneous databases
Pharosi | Q9BZJ4, Tdark |
Genetic variation databases
BioMutai | SLC25A39 |
DMDMi | 317373277 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090596 | 1 – 359 | Probable mitochondrial glutathione transporter SLC25A39Add BLAST | 359 |
Proteomic databases
jPOSTi | Q9BZJ4 |
MassIVEi | Q9BZJ4 |
MaxQBi | Q9BZJ4 |
PaxDbi | Q9BZJ4 |
PeptideAtlasi | Q9BZJ4 |
PRIDEi | Q9BZJ4 |
ProteomicsDBi | 79858 [Q9BZJ4-1] 79859 [Q9BZJ4-2] |
PTM databases
iPTMneti | Q9BZJ4 |
PhosphoSitePlusi | Q9BZJ4 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000013306, Expressed in blood and 205 other tissues |
ExpressionAtlasi | Q9BZJ4, baseline and differential |
Genevisiblei | Q9BZJ4, HS |
Organism-specific databases
HPAi | ENSG00000013306, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 119645, 8 interactors |
IntActi | Q9BZJ4, 3 interactors |
MINTi | Q9BZJ4 |
STRINGi | 9606.ENSP00000366299 |
Miscellaneous databases
RNActi | Q9BZJ4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 9 – 151 | Solcar 1Add BLAST | 143 | |
Repeati | 159 – 243 | Solcar 2Add BLAST | 85 | |
Repeati | 253 – 347 | Solcar 3Add BLAST | 95 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0761, Eukaryota |
GeneTreei | ENSGT00940000156382 |
HOGENOMi | CLU_015166_0_0_1 |
InParanoidi | Q9BZJ4 |
OMAi | DQTSVGA |
OrthoDBi | 1007936at2759 |
PhylomeDBi | Q9BZJ4 |
TreeFami | TF314720 |
Family and domain databases
Gene3Di | 1.50.40.10, 2 hits |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf IPR045315, Mtm1-like |
PANTHERi | PTHR45760, PTHR45760, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADQDPAGIS PLQQMVASGT GAVVTSLFMT PLDVVKVRLQ SQRPSMASEL
60 70 80 90 100
MPSSRLWSLS YTKLPSSLQS TGKCLLYCNG VLEPLYLCPN GARCATWFQD
110 120 130 140 150
PTRFTGTMDA FVKIVRHEGT RTLWSGLPAT LVMTVPATAI YFTAYDQLKA
160 170 180 190 200
FLCGRALTSD LYAPMVAGAL ARLGTVTVIS PLELMRTKLQ AQHVSYRELG
210 220 230 240 250
ACVRTAVAQG GWRSLWLGWG PTALRDVPFS ALYWFNYELV KSWLNGFRPK
260 270 280 290 300
DQTSVGMSFV AGGISGTVAA VLTLPFDVVK TQRQVALGAM EAVRVNPLHV
310 320 330 340 350
DSTWLLLRRI RAESGTKGLF AGFLPRIIKA APSCAIMIST YEFGKSFFQR
LNQDRLLGG
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB4DFG5 | B4DFG5_HUMAN | Probable mitochondrial glutathione ... | SLC25A39 | 336 | Annotation score: | ||
K7EMR4 | K7EMR4_HUMAN | Probable mitochondrial glutathione ... | SLC25A39 | 266 | Annotation score: | ||
K7ELM7 | K7ELM7_HUMAN | Probable mitochondrial glutathione ... | SLC25A39 | 72 | Annotation score: | ||
K7EKC2 | K7EKC2_HUMAN | Probable mitochondrial glutathione ... | SLC25A39 | 143 | Annotation score: | ||
K7EMW3 | K7EMW3_HUMAN | Probable mitochondrial glutathione ... | SLC25A39 | 227 | Annotation score: | ||
K7EJI2 | K7EJI2_HUMAN | Probable mitochondrial glutathione ... | SLC25A39 | 164 | Annotation score: | ||
K7EQS4 | K7EQS4_HUMAN | Probable mitochondrial glutathione ... | SLC25A39 | 93 | Annotation score: | ||
K7EKF4 | K7EKF4_HUMAN | Probable mitochondrial glutathione ... | SLC25A39 | 99 | Annotation score: | ||
K7EQS8 | K7EQS8_HUMAN | Probable mitochondrial glutathione ... | SLC25A39 | 61 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 266 | G → R in AAF69618 (Ref. 7) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_012756 | 247 | F → L5 PublicationsCorresponds to variant dbSNP:rs2011951Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003264 | 64 – 72 | LPSSLQSTG → W in isoform 2. 6 Publications | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF317711 mRNA Translation: AAG60687.1 AF151827 mRNA Translation: AAD34064.1 AL133584 mRNA Translation: CAB63728.1 AK026060 mRNA Translation: BAB15341.1 AK289357 mRNA Translation: BAF82046.1 CH471178 Genomic DNA Translation: EAW51602.1 CH471178 Genomic DNA Translation: EAW51603.1 CH471178 Genomic DNA Translation: EAW51604.1 CH471178 Genomic DNA Translation: EAW51605.1 CH471178 Genomic DNA Translation: EAW51606.1 CH471178 Genomic DNA Translation: EAW51607.1 BC001398 mRNA Translation: AAH01398.1 BC009330 mRNA Translation: AAH09330.1 BC096819 mRNA Translation: AAH96819.1 AF119864 mRNA Translation: AAF69618.1 Different initiation. |
CCDSi | CCDS11482.1 [Q9BZJ4-2] CCDS45700.1 [Q9BZJ4-1] |
PIRi | T43493 |
RefSeqi | NP_001137252.1, NM_001143780.2 [Q9BZJ4-1] NP_057100.1, NM_016016.3 [Q9BZJ4-2] |
Genome annotation databases
Ensembli | ENST00000225308.12; ENSP00000225308.8; ENSG00000013306.16 [Q9BZJ4-2] ENST00000377095.10; ENSP00000366299.4; ENSG00000013306.16 ENST00000590194.5; ENSP00000467681.1; ENSG00000013306.16 [Q9BZJ4-2] |
GeneIDi | 51629 |
KEGGi | hsa:51629 |
MANE-Selecti | ENST00000377095.10; ENSP00000366299.4; NM_001143780.3; NP_001137252.1 |
UCSCi | uc002igm.3, human [Q9BZJ4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF317711 mRNA Translation: AAG60687.1 AF151827 mRNA Translation: AAD34064.1 AL133584 mRNA Translation: CAB63728.1 AK026060 mRNA Translation: BAB15341.1 AK289357 mRNA Translation: BAF82046.1 CH471178 Genomic DNA Translation: EAW51602.1 CH471178 Genomic DNA Translation: EAW51603.1 CH471178 Genomic DNA Translation: EAW51604.1 CH471178 Genomic DNA Translation: EAW51605.1 CH471178 Genomic DNA Translation: EAW51606.1 CH471178 Genomic DNA Translation: EAW51607.1 BC001398 mRNA Translation: AAH01398.1 BC009330 mRNA Translation: AAH09330.1 BC096819 mRNA Translation: AAH96819.1 AF119864 mRNA Translation: AAF69618.1 Different initiation. |
CCDSi | CCDS11482.1 [Q9BZJ4-2] CCDS45700.1 [Q9BZJ4-1] |
PIRi | T43493 |
RefSeqi | NP_001137252.1, NM_001143780.2 [Q9BZJ4-1] NP_057100.1, NM_016016.3 [Q9BZJ4-2] |
3D structure databases
AlphaFoldDBi | Q9BZJ4 |
SMRi | Q9BZJ4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119645, 8 interactors |
IntActi | Q9BZJ4, 3 interactors |
MINTi | Q9BZJ4 |
STRINGi | 9606.ENSP00000366299 |
Protein family/group databases
TCDBi | 2.A.29.14.8, the mitochondrial carrier (mc) family |
PTM databases
iPTMneti | Q9BZJ4 |
PhosphoSitePlusi | Q9BZJ4 |
Genetic variation databases
BioMutai | SLC25A39 |
DMDMi | 317373277 |
Proteomic databases
jPOSTi | Q9BZJ4 |
MassIVEi | Q9BZJ4 |
MaxQBi | Q9BZJ4 |
PaxDbi | Q9BZJ4 |
PeptideAtlasi | Q9BZJ4 |
PRIDEi | Q9BZJ4 |
ProteomicsDBi | 79858 [Q9BZJ4-1] 79859 [Q9BZJ4-2] |
Protocols and materials databases
Antibodypediai | 17434, 41 antibodies from 16 providers |
DNASUi | 51629 |
Genome annotation databases
Ensembli | ENST00000225308.12; ENSP00000225308.8; ENSG00000013306.16 [Q9BZJ4-2] ENST00000377095.10; ENSP00000366299.4; ENSG00000013306.16 ENST00000590194.5; ENSP00000467681.1; ENSG00000013306.16 [Q9BZJ4-2] |
GeneIDi | 51629 |
KEGGi | hsa:51629 |
MANE-Selecti | ENST00000377095.10; ENSP00000366299.4; NM_001143780.3; NP_001137252.1 |
UCSCi | uc002igm.3, human [Q9BZJ4-1] |
Organism-specific databases
CTDi | 51629 |
DisGeNETi | 51629 |
GeneCardsi | SLC25A39 |
HGNCi | HGNC:24279, SLC25A39 |
HPAi | ENSG00000013306, Low tissue specificity |
MIMi | 610820, gene |
neXtProti | NX_Q9BZJ4 |
OpenTargetsi | ENSG00000013306 |
PharmGKBi | PA162403626 |
VEuPathDBi | HostDB:ENSG00000013306 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0761, Eukaryota |
GeneTreei | ENSGT00940000156382 |
HOGENOMi | CLU_015166_0_0_1 |
InParanoidi | Q9BZJ4 |
OMAi | DQTSVGA |
OrthoDBi | 1007936at2759 |
PhylomeDBi | Q9BZJ4 |
TreeFami | TF314720 |
Enzyme and pathway databases
PathwayCommonsi | Q9BZJ4 |
SignaLinki | Q9BZJ4 |
Miscellaneous databases
BioGRID-ORCSi | 51629, 18 hits in 1081 CRISPR screens |
ChiTaRSi | SLC25A39, human |
GeneWikii | SLC25A39 |
GenomeRNAii | 51629 |
Pharosi | Q9BZJ4, Tdark |
PROi | PR:Q9BZJ4 |
RNActi | Q9BZJ4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000013306, Expressed in blood and 205 other tissues |
ExpressionAtlasi | Q9BZJ4, baseline and differential |
Genevisiblei | Q9BZJ4, HS |
Family and domain databases
Gene3Di | 1.50.40.10, 2 hits |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf IPR045315, Mtm1-like |
PANTHERi | PTHR45760, PTHR45760, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | S2539_HUMAN | |
Accessioni | Q9BZJ4Primary (citable) accession number: Q9BZJ4 Secondary accession number(s): A8JZZ2 Q9Y379 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 11, 2002 |
Last sequence update: | January 11, 2011 | |
Last modified: | May 25, 2022 | |
This is version 182 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families