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Entry version 166 (16 Oct 2019)
Sequence version 4 (15 May 2007)
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Protein

Crooked neck-like protein 1

Gene

CRNKL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in pre-mRNA splicing process.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-72163 mRNA Splicing - Major Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Crooked neck-like protein 1
Alternative name(s):
Crooked neck homolog
Short name:
hCrn
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CRNKL1
Synonyms:CRN
ORF Names:CGI-201, MSTP021
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15762 CRNKL1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610952 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BZJ0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51340

Open Targets

More...
OpenTargetsi
ENSG00000101343

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26886

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BZJ0

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CRNKL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
147744555

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002057191 – 848Crooked neck-like protein 1Add BLAST848
Isoform 2 (identifier: Q9BZJ0-2)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei503PhosphoserineCombined sources1
Isoform 2 (identifier: Q9BZJ0-2)
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BZJ0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BZJ0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BZJ0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BZJ0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BZJ0

PeptideAtlas

More...
PeptideAtlasi
Q9BZJ0

PRoteomics IDEntifications database

More...
PRIDEi
Q9BZJ0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79851 [Q9BZJ0-1]
79852 [Q9BZJ0-2]
79853 [Q9BZJ0-3]
79854 [Q9BZJ0-4]
79855 [Q9BZJ0-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BZJ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BZJ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed (PubMed:11342225). Highly expressed in testis (PubMed:12084575). Not detected in brain and lung (PubMed:12084575).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000101343 Expressed in 217 organ(s), highest expression level in heart

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BZJ0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BZJ0 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in the spliceosome C complex (PubMed:11991638, PubMed:28502770, PubMed:28076346). Present in a spliceosome complex assembled in vitro containing CRNKL1, HPRP8BP and SNRPB2 (PubMed:12084575). Isoform 2 seems to be predominant in the spliceosome complex (PubMed:12084575).

Interacts with PPIL2 (via the PPIase cyclophilin-type domain); they may form a trimeric complex with HSP90 (PubMed:15189447).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q8WUD42EBI-1049701,EBI-2557572

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119487, 76 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9BZJ0

Protein interaction database and analysis system

More...
IntActi
Q9BZJ0, 45 interactors

Molecular INTeraction database

More...
MINTi
Q9BZJ0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000366557

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1848
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BZJ0

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati222 – 254HAT 1Add BLAST33
Repeati256 – 288HAT 2Add BLAST33
Repeati290 – 322HAT 3Add BLAST33
Repeati324 – 355HAT 4Add BLAST32
Repeati357 – 388HAT 5Add BLAST32
Repeati390 – 425HAT 6Add BLAST36
Repeati427 – 461HAT 7Add BLAST35
Repeati471 – 503HAT 8Add BLAST33
Repeati505 – 539HAT 9Add BLAST35
Repeati549 – 585HAT 10Add BLAST37
Repeati587 – 618HAT 11Add BLAST32
Repeati620 – 652HAT 12Add BLAST33
Repeati654 – 688HAT 13Add BLAST35
Repeati690 – 721HAT 14Add BLAST32
Repeati726 – 767HAT 15Add BLAST42
Repeati769 – 807HAT 16Add BLAST39
Repeati809 – 834HAT 17Add BLAST26

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni411 – 628Mediates interaction with HSP90By similarityAdd BLAST218

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi207 – 210Poly-Pro4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the crooked-neck family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1915 Eukaryota
ENOG410XQJF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000074931

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BZJ0

KEGG Orthology (KO)

More...
KOi
K12869

Identification of Orthologs from Complete Genome Data

More...
OMAi
FTFSKIW

Database of Orthologous Groups

More...
OrthoDBi
355408at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BZJ0

TreeFam database of animal gene trees

More...
TreeFami
TF300305

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003107 HAT
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02184 HAT, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00386 HAT, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BZJ0-1) [UniParc]FASTAAdd to basket
Also known as: Type-II

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTATVENLTF QKDTLGNAVD KNTSRLELRS YSLAGRHGST EPLVLAWSSQ
60 70 80 90 100
FRRLTWGCAL DALHRSPCVA ASQHGVTHLI RSSRTPHSTR CRKEDAQPGH
110 120 130 140 150
HGNGAASVTA QARGQRSVLQ VPLPVPRSCL FSESFVVSVS SQSRFLASVP
160 170 180 190 200
GTGVQRSTAA DMAASTAAGK QRIPKVAKVK NKAPAEVQIT AEQLLREAKE
210 220 230 240 250
RELELLPPPP QQKITDEEEL NDYKLRKRKT FEDNIRKNRT VISNWIKYAQ
260 270 280 290 300
WEESLKEIQR ARSIYERALD VDYRNITLWL KYAEMEMKNR QVNHARNIWD
310 320 330 340 350
RAITTLPRVN QFWYKYTYME EMLGNVAGAR QVFERWMEWQ PEEQAWHSYI
360 370 380 390 400
NFELRYKEVD RARTIYERFV LVHPDVKNWI KYARFEEKHA YFAHARKVYE
410 420 430 440 450
RAVEFFGDEH MDEHLYVAFA KFEENQKEFE RVRVIYKYAL DRISKQDAQE
460 470 480 490 500
LFKNYTIFEK KFGDRRGIED IIVSKRRFQY EEEVKANPHN YDAWFDYLRL
510 520 530 540 550
VESDAEAEAV REVYERAIAN VPPIQEKRHW KRYIYLWINY ALYEELEAKD
560 570 580 590 600
PERTRQVYQA SLELIPHKKF TFAKMWILYA QFEIRQKNLS LARRALGTSI
610 620 630 640 650
GKCPKNKLFK VYIELELQLR EFDRCRKLYE KFLEFGPENC TSWIKFAELE
660 670 680 690 700
TILGDIDRAR AIYELAISQP RLDMPEVLWK SYIDFEIEQE ETERTRNLYR
710 720 730 740 750
RLLQRTQHVK VWISFAQFEL SSGKEGSLTK CRQIYEEANK TMRNCEEKEE
760 770 780 790 800
RLMLLESWRS FEEEFGTASD KERVDKLMPE KVKKRRKVQT DDGSDAGWEE
810 820 830 840
YFDYIFPEDA ANQPNLKLLA MAKLWKKQQQ EKEDAEHHPD EDVDESES
Length:848
Mass (Da):100,452
Last modified:May 15, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE30A39E981BC50AC
GO
Isoform 2 (identifier: Q9BZJ0-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-161: Missing.

Show »
Length:687
Mass (Da):83,148
Checksum:iB370161134F63B1D
GO
Isoform 3 (identifier: Q9BZJ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-34: Missing.

Show »
Length:836
Mass (Da):99,074
Checksum:i2ED68C036D071E71
GO
Isoform 4 (identifier: Q9BZJ0-4) [UniParc]FASTAAdd to basket
Also known as: Type-III

The sequence of this isoform differs from the canonical sequence as follows:
     23-34: Missing.
     117-848: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:104
Mass (Da):11,268
Checksum:iAF15BD5353314E12
GO
Isoform 5 (identifier: Q9BZJ0-5) [UniParc]FASTAAdd to basket
Also known as: type-IV

The sequence of this isoform differs from the canonical sequence as follows:
     23-74: TSRLELRSYS...RSPCVAASQH → ILASLLVSTA...SRLKREVKGQ
     75-848: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:74
Mass (Da):7,946
Checksum:i59162B429E1F0AF0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JY65Q5JY65_HUMAN
Crooked neck-like protein 1
CRNKL1
836Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGD7A0A0C4DGD7_HUMAN
Crooked neck-like protein 1
CRNKL1
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14303 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB14485 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti213K → R in AAF65571 (PubMed:11342225).Curated1
Sequence conflicti213K → R in AAK01924 (PubMed:11342225).Curated1
Sequence conflicti213K → R in AAK01925 (PubMed:11342225).Curated1
Sequence conflicti513V → A in BAB14659 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02499535G → R1 PublicationCorresponds to variant dbSNP:rs7508949Ensembl.1
Natural variantiVAR_04931851F → L. Corresponds to variant dbSNP:rs2273058Ensembl.1
Natural variantiVAR_049319111Q → H. Corresponds to variant dbSNP:rs2255258Ensembl.1
Natural variantiVAR_049320158T → A. Corresponds to variant dbSNP:rs2255255Ensembl.1
Natural variantiVAR_049321843V → I. Corresponds to variant dbSNP:rs35201190Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0020581 – 161Missing in isoform 2. 2 PublicationsAdd BLAST161
Alternative sequenceiVSP_00206023 – 74TSRLE…AASQH → ILASLLVSTALPTSSAAPGR RTPRAAARRTRSLVTMETVP PPSRLKREVKGQ in isoform 5. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_00205923 – 34Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_00206175 – 848Missing in isoform 5. 1 PublicationAdd BLAST774
Alternative sequenceiVSP_002062117 – 848Missing in isoform 4. 1 PublicationAdd BLAST732

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF255443 mRNA Translation: AAF65571.2
AF318302 mRNA Translation: AAK01924.1
AF318303 mRNA Translation: AAK01925.1
AF318304 mRNA Translation: AAK01926.1
AF318305 mRNA Translation: AAK01927.1
AF111802 mRNA Translation: AAL39004.1
AK023246 mRNA Translation: BAB14485.1 Different initiation.
AK023728 mRNA Translation: BAB14659.1
AK292799 mRNA Translation: BAF85488.1
AL035454 Genomic DNA No translation available.
AK022908 mRNA Translation: BAB14303.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS33446.1 [Q9BZJ0-1]
CCDS63238.1 [Q9BZJ0-2]
CCDS63239.1 [Q9BZJ0-3]

NCBI Reference Sequences

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RefSeqi
NP_001265554.1, NM_001278625.1
NP_001265555.1, NM_001278626.1
NP_001265556.1, NM_001278627.1
NP_001265557.1, NM_001278628.1 [Q9BZJ0-2]
NP_057736.4, NM_016652.5 [Q9BZJ0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000377340; ENSP00000366557; ENSG00000101343 [Q9BZJ0-1]
ENST00000496549; ENSP00000428436; ENSG00000101343 [Q9BZJ0-5]
ENST00000536226; ENSP00000440733; ENSG00000101343 [Q9BZJ0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51340

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51340

UCSC genome browser

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UCSCi
uc002wrs.5 human [Q9BZJ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255443 mRNA Translation: AAF65571.2
AF318302 mRNA Translation: AAK01924.1
AF318303 mRNA Translation: AAK01925.1
AF318304 mRNA Translation: AAK01926.1
AF318305 mRNA Translation: AAK01927.1
AF111802 mRNA Translation: AAL39004.1
AK023246 mRNA Translation: BAB14485.1 Different initiation.
AK023728 mRNA Translation: BAB14659.1
AK292799 mRNA Translation: BAF85488.1
AL035454 Genomic DNA No translation available.
AK022908 mRNA Translation: BAB14303.1 Different initiation.
CCDSiCCDS33446.1 [Q9BZJ0-1]
CCDS63238.1 [Q9BZJ0-2]
CCDS63239.1 [Q9BZJ0-3]
RefSeqiNP_001265554.1, NM_001278625.1
NP_001265555.1, NM_001278626.1
NP_001265556.1, NM_001278627.1
NP_001265557.1, NM_001278628.1 [Q9BZJ0-2]
NP_057736.4, NM_016652.5 [Q9BZJ0-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MQFelectron microscopy5.90O1-848[»]
5XJCelectron microscopy3.60J1-848[»]
5YZGelectron microscopy4.10J1-848[»]
5Z56electron microscopy5.10J1-848[»]
5Z57electron microscopy6.50J1-848[»]
5Z58electron microscopy4.90J1-848[»]
6FF4electron microscopy16.00O1-848[»]
6FF7electron microscopy4.50O1-848[»]
6ICZelectron microscopy3.00J1-848[»]
6ID0electron microscopy2.90J1-848[»]
6ID1electron microscopy2.86J1-848[»]
6QDVelectron microscopy3.30S1-848[»]
SMRiQ9BZJ0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi119487, 76 interactors
CORUMiQ9BZJ0
IntActiQ9BZJ0, 45 interactors
MINTiQ9BZJ0
STRINGi9606.ENSP00000366557

PTM databases

iPTMnetiQ9BZJ0
PhosphoSitePlusiQ9BZJ0

Polymorphism and mutation databases

BioMutaiCRNKL1
DMDMi147744555

Proteomic databases

EPDiQ9BZJ0
jPOSTiQ9BZJ0
MassIVEiQ9BZJ0
MaxQBiQ9BZJ0
PaxDbiQ9BZJ0
PeptideAtlasiQ9BZJ0
PRIDEiQ9BZJ0
ProteomicsDBi79851 [Q9BZJ0-1]
79852 [Q9BZJ0-2]
79853 [Q9BZJ0-3]
79854 [Q9BZJ0-4]
79855 [Q9BZJ0-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51340

Genome annotation databases

EnsembliENST00000377340; ENSP00000366557; ENSG00000101343 [Q9BZJ0-1]
ENST00000496549; ENSP00000428436; ENSG00000101343 [Q9BZJ0-5]
ENST00000536226; ENSP00000440733; ENSG00000101343 [Q9BZJ0-2]
GeneIDi51340
KEGGihsa:51340
UCSCiuc002wrs.5 human [Q9BZJ0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51340
DisGeNETi51340

GeneCards: human genes, protein and diseases

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GeneCardsi
CRNKL1
HGNCiHGNC:15762 CRNKL1
MIMi610952 gene
neXtProtiNX_Q9BZJ0
OpenTargetsiENSG00000101343
PharmGKBiPA26886

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1915 Eukaryota
ENOG410XQJF LUCA
GeneTreeiENSGT00550000074931
InParanoidiQ9BZJ0
KOiK12869
OMAiFTFSKIW
OrthoDBi355408at2759
PhylomeDBiQ9BZJ0
TreeFamiTF300305

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CRNKL1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51340
PharosiQ9BZJ0

Protein Ontology

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PROi
PR:Q9BZJ0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000101343 Expressed in 217 organ(s), highest expression level in heart
ExpressionAtlasiQ9BZJ0 baseline and differential
GenevisibleiQ9BZJ0 HS

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR003107 HAT
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF02184 HAT, 2 hits
SMARTiView protein in SMART
SM00386 HAT, 13 hits
SUPFAMiSSF48452 SSF48452, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRNL1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BZJ0
Secondary accession number(s): A8K9T4
, Q5JY64, Q8WYI5, Q9BZI9, Q9BZJ1, Q9BZJ2, Q9GZW7, Q9H8F8, Q9NQH5, Q9NYD8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: May 15, 2007
Last modified: October 16, 2019
This is version 166 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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