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UniProtKB - Q9BZJ0 (CRNL1_HUMAN)

Protein

Crooked neck-like protein 1

Gene

CRNKL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing process.4 Publications

GO - Molecular functioni

  • RNA binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Crooked neck-like protein 1
Alternative name(s):
Crooked neck homolog
Short name:
hCrn
Gene namesi
Name:CRNKL1
Synonyms:CRN
ORF Names:CGI-201, MSTP021
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101343.14
HGNCiHGNC:15762 CRNKL1
MIMi610952 gene
neXtProtiNX_Q9BZJ0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi51340
OpenTargetsiENSG00000101343
PharmGKBiPA26886

Polymorphism and mutation databases

BioMutaiCRNKL1
DMDMi147744555

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002057191 – 848Crooked neck-like protein 1Add BLAST848
Isoform 2 (identifier: Q9BZJ0-2)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei503PhosphoserineCombined sources1
Isoform 2 (identifier: Q9BZJ0-2)
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BZJ0
MaxQBiQ9BZJ0
PaxDbiQ9BZJ0
PeptideAtlasiQ9BZJ0
PRIDEiQ9BZJ0
ProteomicsDBi79851
79852 [Q9BZJ0-2]
79853 [Q9BZJ0-3]
79854 [Q9BZJ0-4]
79855 [Q9BZJ0-5]

PTM databases

iPTMnetiQ9BZJ0
PhosphoSitePlusiQ9BZJ0

Expressioni

Tissue specificityi

Widely expressed (PubMed:11342225). Highly expressed in testis (PubMed:12084575). Not detected in brain and lung (PubMed:12084575).2 Publications

Gene expression databases

BgeeiENSG00000101343 Expressed in 217 organ(s), highest expression level in heart
ExpressionAtlasiQ9BZJ0 baseline and differential
GenevisibleiQ9BZJ0 HS

Interactioni

Subunit structurei

Identified in the spliceosome C complex (PubMed:11991638, PubMed:28502770, PubMed:28076346). Present in a spliceosome complex assembled in vitro containing CRNKL1, HPRP8BP and SNRPB2 (PubMed:12084575). Isoform 2 seems to be predominant in the spliceosome complex (PubMed:12084575). Interacts with PPIL2 (via the PPIase cyclophilin-type domain); they may form a trimeric complex with HSP90 (PubMed:15189447).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC12Q8WUD42EBI-1049701,EBI-2557572

Protein-protein interaction databases

BioGridi119487, 71 interactors
CORUMiQ9BZJ0
IntActiQ9BZJ0, 19 interactors
MINTiQ9BZJ0
STRINGi9606.ENSP00000366557

Structurei

3D structure databases

ProteinModelPortaliQ9BZJ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati222 – 254HAT 1Add BLAST33
Repeati256 – 288HAT 2Add BLAST33
Repeati290 – 322HAT 3Add BLAST33
Repeati324 – 355HAT 4Add BLAST32
Repeati357 – 388HAT 5Add BLAST32
Repeati390 – 425HAT 6Add BLAST36
Repeati427 – 461HAT 7Add BLAST35
Repeati471 – 503HAT 8Add BLAST33
Repeati505 – 539HAT 9Add BLAST35
Repeati549 – 585HAT 10Add BLAST37
Repeati587 – 618HAT 11Add BLAST32
Repeati620 – 652HAT 12Add BLAST33
Repeati654 – 688HAT 13Add BLAST35
Repeati690 – 721HAT 14Add BLAST32
Repeati726 – 767HAT 15Add BLAST42
Repeati769 – 807HAT 16Add BLAST39
Repeati809 – 834HAT 17Add BLAST26

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni411 – 628Mediates interaction with HSP90By similarityAdd BLAST218

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi207 – 210Poly-Pro4

Sequence similaritiesi

Belongs to the crooked-neck family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1915 Eukaryota
ENOG410XQJF LUCA
GeneTreeiENSGT00550000074931
HOVERGENiHBG051046
InParanoidiQ9BZJ0
KOiK12869
OMAiFTFSKIW
OrthoDBiEOG091G040G
PhylomeDBiQ9BZJ0
TreeFamiTF300305

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR003107 HAT
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF02184 HAT, 2 hits
SMARTiView protein in SMART
SM00386 HAT, 13 hits
SUPFAMiSSF48452 SSF48452, 2 hits

Sequences (5+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9BZJ0-1) [UniParc]FASTAAdd to basket
Also known as: Type-II

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTATVENLTF QKDTLGNAVD KNTSRLELRS YSLAGRHGST EPLVLAWSSQ 
        60         70         80         90        100
FRRLTWGCAL DALHRSPCVA ASQHGVTHLI RSSRTPHSTR CRKEDAQPGH 
       110        120        130        140        150
HGNGAASVTA QARGQRSVLQ VPLPVPRSCL FSESFVVSVS SQSRFLASVP 
       160        170        180        190        200
GTGVQRSTAA DMAASTAAGK QRIPKVAKVK NKAPAEVQIT AEQLLREAKE 
       210        220        230        240        250
RELELLPPPP QQKITDEEEL NDYKLRKRKT FEDNIRKNRT VISNWIKYAQ 
       260        270        280        290        300
WEESLKEIQR ARSIYERALD VDYRNITLWL KYAEMEMKNR QVNHARNIWD 
       310        320        330        340        350
RAITTLPRVN QFWYKYTYME EMLGNVAGAR QVFERWMEWQ PEEQAWHSYI 
       360        370        380        390        400
NFELRYKEVD RARTIYERFV LVHPDVKNWI KYARFEEKHA YFAHARKVYE 
       410        420        430        440        450
RAVEFFGDEH MDEHLYVAFA KFEENQKEFE RVRVIYKYAL DRISKQDAQE 
       460        470        480        490        500
LFKNYTIFEK KFGDRRGIED IIVSKRRFQY EEEVKANPHN YDAWFDYLRL 
       510        520        530        540        550
VESDAEAEAV REVYERAIAN VPPIQEKRHW KRYIYLWINY ALYEELEAKD 
       560        570        580        590        600
PERTRQVYQA SLELIPHKKF TFAKMWILYA QFEIRQKNLS LARRALGTSI 
       610        620        630        640        650
GKCPKNKLFK VYIELELQLR EFDRCRKLYE KFLEFGPENC TSWIKFAELE 
       660        670        680        690        700
TILGDIDRAR AIYELAISQP RLDMPEVLWK SYIDFEIEQE ETERTRNLYR 
       710        720        730        740        750
RLLQRTQHVK VWISFAQFEL SSGKEGSLTK CRQIYEEANK TMRNCEEKEE 
       760        770        780        790        800
RLMLLESWRS FEEEFGTASD KERVDKLMPE KVKKRRKVQT DDGSDAGWEE 
       810        820        830        840 
YFDYIFPEDA ANQPNLKLLA MAKLWKKQQQ EKEDAEHHPD EDVDESES
Length:848
Mass (Da):100,452
Last modified:May 15, 2007 - v4
Checksum:iE30A39E981BC50AC
GO
Isoform 2 (identifier: Q9BZJ0-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-161: Missing.

Show »
Length:687
Mass (Da):83,148
Checksum:iB370161134F63B1D
GO
Isoform 3 (identifier: Q9BZJ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-34: Missing.

Show »
Length:836
Mass (Da):99,074
Checksum:i2ED68C036D071E71
GO
Isoform 4 (identifier: Q9BZJ0-4) [UniParc]FASTAAdd to basket
Also known as: Type-III

The sequence of this isoform differs from the canonical sequence as follows:
     23-34: Missing.
     117-848: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:104
Mass (Da):11,268
Checksum:iAF15BD5353314E12
GO
Isoform 5 (identifier: Q9BZJ0-5) [UniParc]FASTAAdd to basket
Also known as: type-IV

The sequence of this isoform differs from the canonical sequence as follows:
     23-74: TSRLELRSYS...RSPCVAASQH → ILASLLVSTA...SRLKREVKGQ
     75-848: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:74
Mass (Da):7,946
Checksum:i59162B429E1F0AF0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JY65Q5JY65_HUMAN
Crooked neck-like protein 1
CRNKL1
836Annotation score:
A0A0C4DGD7A0A0C4DGD7_HUMAN
Crooked neck-like protein 1
CRNKL1
104Annotation score:

Sequence cautioni

The sequence BAB14303 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14485 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti213K → R in AAF65571 (PubMed:11342225).Curated1
Sequence conflicti213K → R in AAK01924 (PubMed:11342225).Curated1
Sequence conflicti213K → R in AAK01925 (PubMed:11342225).Curated1
Sequence conflicti513V → A in BAB14659 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02499535G → R1 PublicationCorresponds to variant dbSNP:rs7508949Ensembl.1
Natural variantiVAR_04931851F → L. Corresponds to variant dbSNP:rs2273058Ensembl.1
Natural variantiVAR_049319111Q → H. Corresponds to variant dbSNP:rs2255258Ensembl.1
Natural variantiVAR_049320158T → A. Corresponds to variant dbSNP:rs2255255Ensembl.1
Natural variantiVAR_049321843V → I. Corresponds to variant dbSNP:rs35201190Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0020581 – 161Missing in isoform 2. 2 PublicationsAdd BLAST161
Alternative sequenceiVSP_00206023 – 74TSRLE…AASQH → ILASLLVSTALPTSSAAPGR RTPRAAARRTRSLVTMETVP PPSRLKREVKGQ in isoform 5. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_00205923 – 34Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_00206175 – 848Missing in isoform 5. 1 PublicationAdd BLAST774
Alternative sequenceiVSP_002062117 – 848Missing in isoform 4. 1 PublicationAdd BLAST732

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255443 mRNA Translation: AAF65571.2
AF318302 mRNA Translation: AAK01924.1
AF318303 mRNA Translation: AAK01925.1
AF318304 mRNA Translation: AAK01926.1
AF318305 mRNA Translation: AAK01927.1
AF111802 mRNA Translation: AAL39004.1
AK023246 mRNA Translation: BAB14485.1 Different initiation.
AK023728 mRNA Translation: BAB14659.1
AK292799 mRNA Translation: BAF85488.1
AL035454 Genomic DNA No translation available.
AK022908 mRNA Translation: BAB14303.1 Different initiation.
CCDSiCCDS33446.1 [Q9BZJ0-1]
CCDS63238.1 [Q9BZJ0-2]
CCDS63239.1 [Q9BZJ0-3]
RefSeqiNP_001265554.1, NM_001278625.1
NP_001265555.1, NM_001278626.1
NP_001265556.1, NM_001278627.1
NP_001265557.1, NM_001278628.1 [Q9BZJ0-2]
NP_057736.4, NM_016652.5 [Q9BZJ0-1]
UniGeneiHs.171342

Genome annotation databases

EnsembliENST00000377340; ENSP00000366557; ENSG00000101343 [Q9BZJ0-1]
ENST00000496549; ENSP00000428436; ENSG00000101343 [Q9BZJ0-5]
ENST00000536226; ENSP00000440733; ENSG00000101343 [Q9BZJ0-2]
GeneIDi51340
KEGGihsa:51340
UCSCiuc002wrs.5 human [Q9BZJ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255443 mRNA Translation: AAF65571.2
AF318302 mRNA Translation: AAK01924.1
AF318303 mRNA Translation: AAK01925.1
AF318304 mRNA Translation: AAK01926.1
AF318305 mRNA Translation: AAK01927.1
AF111802 mRNA Translation: AAL39004.1
AK023246 mRNA Translation: BAB14485.1 Different initiation.
AK023728 mRNA Translation: BAB14659.1
AK292799 mRNA Translation: BAF85488.1
AL035454 Genomic DNA No translation available.
AK022908 mRNA Translation: BAB14303.1 Different initiation.
CCDSiCCDS33446.1 [Q9BZJ0-1]
CCDS63238.1 [Q9BZJ0-2]
CCDS63239.1 [Q9BZJ0-3]
RefSeqiNP_001265554.1, NM_001278625.1
NP_001265555.1, NM_001278626.1
NP_001265556.1, NM_001278627.1
NP_001265557.1, NM_001278628.1 [Q9BZJ0-2]
NP_057736.4, NM_016652.5 [Q9BZJ0-1]
UniGeneiHs.171342

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MQFelectron microscopy5.90O1-848[»]
5XJCelectron microscopy3.60J1-848[»]
ProteinModelPortaliQ9BZJ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119487, 71 interactors
CORUMiQ9BZJ0
IntActiQ9BZJ0, 19 interactors
MINTiQ9BZJ0
STRINGi9606.ENSP00000366557

PTM databases

iPTMnetiQ9BZJ0
PhosphoSitePlusiQ9BZJ0

Polymorphism and mutation databases

BioMutaiCRNKL1
DMDMi147744555

Proteomic databases

EPDiQ9BZJ0
MaxQBiQ9BZJ0
PaxDbiQ9BZJ0
PeptideAtlasiQ9BZJ0
PRIDEiQ9BZJ0
ProteomicsDBi79851
79852 [Q9BZJ0-2]
79853 [Q9BZJ0-3]
79854 [Q9BZJ0-4]
79855 [Q9BZJ0-5]

Protocols and materials databases

DNASUi51340
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377340; ENSP00000366557; ENSG00000101343 [Q9BZJ0-1]
ENST00000496549; ENSP00000428436; ENSG00000101343 [Q9BZJ0-5]
ENST00000536226; ENSP00000440733; ENSG00000101343 [Q9BZJ0-2]
GeneIDi51340
KEGGihsa:51340
UCSCiuc002wrs.5 human [Q9BZJ0-1]

Organism-specific databases

CTDi51340
DisGeNETi51340
EuPathDBiHostDB:ENSG00000101343.14
GeneCardsiCRNKL1
H-InvDBiHIX0015678
HGNCiHGNC:15762 CRNKL1
MIMi610952 gene
neXtProtiNX_Q9BZJ0
OpenTargetsiENSG00000101343
PharmGKBiPA26886
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1915 Eukaryota
ENOG410XQJF LUCA
GeneTreeiENSGT00550000074931
HOVERGENiHBG051046
InParanoidiQ9BZJ0
KOiK12869
OMAiFTFSKIW
OrthoDBiEOG091G040G
PhylomeDBiQ9BZJ0
TreeFamiTF300305

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRSiCRNKL1 human
GenomeRNAii51340
PROiPR:Q9BZJ0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101343 Expressed in 217 organ(s), highest expression level in heart
ExpressionAtlasiQ9BZJ0 baseline and differential
GenevisibleiQ9BZJ0 HS

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR003107 HAT
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF02184 HAT, 2 hits
SMARTiView protein in SMART
SM00386 HAT, 13 hits
SUPFAMiSSF48452 SSF48452, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCRNL1_HUMAN
AccessioniPrimary (citable) accession number: Q9BZJ0
Secondary accession number(s): A8K9T4
, Q5JY64, Q8WYI5, Q9BZI9, Q9BZJ1, Q9BZJ2, Q9GZW7, Q9H8F8, Q9NQH5, Q9NYD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: May 15, 2007
Last modified: September 12, 2018
This is version 156 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health

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