UniProtKB - Q9BZJ0 (CRNL1_HUMAN)

>sp|Q9BZJ0|CRNL1_HUMAN Crooked neck-like protein 1 OS=Homo sapiens OX=9606 GN=CRNKL1 PE=1 SV=4
MTATVENLTFQKDTLGNAVDKNTSRLELRSYSLAGRHGSTEPLVLAWSSQFRRLTWGCAL
DALHRSPCVAASQHGVTHLIRSSRTPHSTRCRKEDAQPGHHGNGAASVTAQARGQRSVLQ
VPLPVPRSCLFSESFVVSVSSQSRFLASVPGTGVQRSTAADMAASTAAGKQRIPKVAKVK
NKAPAEVQITAEQLLREAKERELELLPPPPQQKITDEEELNDYKLRKRKTFEDNIRKNRT
VISNWIKYAQWEESLKEIQRARSIYERALDVDYRNITLWLKYAEMEMKNRQVNHARNIWD
RAITTLPRVNQFWYKYTYMEEMLGNVAGARQVFERWMEWQPEEQAWHSYINFELRYKEVD
RARTIYERFVLVHPDVKNWIKYARFEEKHAYFAHARKVYERAVEFFGDEHMDEHLYVAFA
KFEENQKEFERVRVIYKYALDRISKQDAQELFKNYTIFEKKFGDRRGIEDIIVSKRRFQY
EEEVKANPHNYDAWFDYLRLVESDAEAEAVREVYERAIANVPPIQEKRHWKRYIYLWINY
ALYEELEAKDPERTRQVYQASLELIPHKKFTFAKMWILYAQFEIRQKNLSLARRALGTSI
GKCPKNKLFKVYIELELQLREFDRCRKLYEKFLEFGPENCTSWIKFAELETILGDIDRAR
AIYELAISQPRLDMPEVLWKSYIDFEIEQEETERTRNLYRRLLQRTQHVKVWISFAQFEL
SSGKEGSLTKCRQIYEEANKTMRNCEEKEERLMLLESWRSFEEEFGTASDKERVDKLMPE
KVKKRRKVQTDDGSDAGWEEYFDYIFPEDAANQPNLKLLAMAKLWKKQQQEKEDAEHHPD
EDVDESES

Entry version 171 (12 Aug 2020)
Sequence version 4 (15 May 2007)
Previous versions | rss

Help video Add a publication Feedback

Protein

Crooked neck-like protein 1

Gene

CRNKL1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Involved in pre-mRNA splicing process.4 Publications

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- Ref.2
  "Crooked neck is a component of the human spliceosome and implicated in the splicing process."
  Chung S., Zhou Z., Huddleston K.A., Harrison D.A., Reed R., Coleman T.A., Rymond B.C.
  Biochim. Biophys. Acta 1576:287-297(2002) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, IDENTIFICATION IN SPLICEOSOMAL COMPLEX WITH HPRP8BP AND SNRPB2.

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	mRNA processing, mRNA splicing

Biological process

mRNA processing, mRNA splicing

Enzyme and pathway databases

PathwayCommonsⁱ	Q9BZJ0
Reactomeⁱ	R-HSA-72163, mRNA Splicing - Major Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Crooked neck-like protein 1 Alternative name(s): Crooked neck homolog Short name: hCrn
Gene namesⁱ	Name:CRNKL1 Synonyms:CRN ORF Names:CGI-201, MSTP021
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000101343.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15762, CRNKL1
MIMⁱ	610952, gene
neXtProtⁱ	NX_Q9BZJ0

Keywords - Cellular componentⁱ

Nucleus, Spliceosome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51340
Open Targets More...OpenTargetsⁱ	ENSG00000101343
PharmGKBⁱ	PA26886

Miscellaneous databases

Pharosⁱ	Q9BZJ0, Tbio

Pharosⁱ

Q9BZJ0, Tbio

Polymorphism and mutation databases

BioMutaⁱ	CRNKL1
DMDMⁱ	147744555

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000205719	1 – 848	Crooked neck-like protein 1Add BLAST	848
Isoform 2 (identifier: Q9BZJ0-2)
Initiator methionineⁱ		RemovedCombined sources

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	503	PhosphoserineCombined sources	1
Isoform 2 (identifier: Q9BZJ0-2)
Modified residueⁱ	2	N-acetylalanineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9BZJ0
jPOSTⁱ	Q9BZJ0
MassIVEⁱ	Q9BZJ0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BZJ0
PaxDbⁱ	Q9BZJ0
PeptideAtlas More...PeptideAtlasⁱ	Q9BZJ0
PRIDEⁱ	Q9BZJ0
ProteomicsDBⁱ	79851 [Q9BZJ0-1] 79852 [Q9BZJ0-2] 79853 [Q9BZJ0-3] 79854 [Q9BZJ0-4] 79855 [Q9BZJ0-5]

PTM databases

iPTMnetⁱ	Q9BZJ0
PhosphoSitePlusⁱ	Q9BZJ0

Expressionⁱ

Tissue specificityⁱ

Widely expressed (PubMed:11342225). Highly expressed in testis (PubMed:12084575). Not detected in brain and lung (PubMed:12084575).2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000101343, Expressed in calcaneal tendon and 228 other tissues
ExpressionAtlasⁱ	Q9BZJ0, baseline and differential
Genevisibleⁱ	Q9BZJ0, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000101343, Low tissue specificity

HPAⁱ

ENSG00000101343, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Identified in the spliceosome C complex (PubMed:11991638, PubMed:28502770, PubMed:28076346). Present in a spliceosome complex assembled in vitro containing CRNKL1, HPRP8BP and SNRPB2 (PubMed:12084575). Isoform 2 seems to be predominant in the spliceosome complex (PubMed:12084575).

Interacts with PPIL2 (via the PPIase cyclophilin-type domain); they may form a trimeric complex with HSP90 (PubMed:15189447).

3 Publications

Binary interactionsⁱ

Q9BZJ0

With	#Exp.	IntAct
CCDC12 [Q8WUD4]	2	EBI-1049701,EBI-2557572

Protein-protein interaction databases

BioGRIDⁱ	119487, 83 interactors
CORUMⁱ	Q9BZJ0
IntActⁱ	Q9BZJ0, 45 interactors
Molecular INTeraction database More...MINTⁱ	Q9BZJ0
STRINGⁱ	9606.ENSP00000366557

Miscellaneous databases

RNActⁱ	Q9BZJ0, protein

RNActⁱ

Q9BZJ0, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	191 – 199	Combined sources	9
Helixⁱ	217 – 238	Combined sources	22
Beta strandⁱ	239 – 241	Combined sources	3
Helixⁱ	243 – 253	Combined sources	11
Turnⁱ	254 – 256	Combined sources	3
Helixⁱ	258 – 271	Combined sources	14
Helixⁱ	276 – 288	Combined sources	13
Helixⁱ	292 – 305	Combined sources	14
Helixⁱ	310 – 322	Combined sources	13
Helixⁱ	326 – 337	Combined sources	12
Helixⁱ	343 – 356	Combined sources	14
Helixⁱ	359 – 372	Combined sources	14
Helixⁱ	376 – 388	Combined sources	13
Helixⁱ	392 – 405	Combined sources	14
Beta strandⁱ	408 – 410	Combined sources	3
Helixⁱ	411 – 413	Combined sources	3
Helixⁱ	414 – 425	Combined sources	12
Helixⁱ	430 – 439	Combined sources	10
Turnⁱ	440 – 444	Combined sources	5
Helixⁱ	452 – 466	Combined sources	15
Helixⁱ	478 – 490	Combined sources	13
Helixⁱ	497 – 512	Combined sources	16
Helixⁱ	521 – 533	Combined sources	13
Turnⁱ	538 – 540	Combined sources	3
Helixⁱ	541 – 554	Combined sources	14
Helixⁱ	560 – 568	Combined sources	9
Helixⁱ	574 – 580	Combined sources	7
Turnⁱ	585 – 587	Combined sources	3
Turnⁱ	590 – 593	Combined sources	4
Helixⁱ	594 – 596	Combined sources	3
Helixⁱ	599 – 602	Combined sources	4
Helixⁱ	610 – 623	Combined sources	14
Turnⁱ	632 – 634	Combined sources	3
Helixⁱ	635 – 642	Combined sources	8
Helixⁱ	650 – 659	Combined sources	10
Helixⁱ	668 – 678	Combined sources	11
Helixⁱ	684 – 695	Combined sources	12
Helixⁱ	700 – 707	Combined sources	8
Helixⁱ	719 – 730	Combined sources	12
Helixⁱ	742 – 754	Combined sources	13
Helixⁱ	765 – 774	Combined sources	10
Helixⁱ	782 – 799	Combined sources	18

Show more details

3D structure databases

SMRⁱ	Q9BZJ0
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	222 – 254	HAT 1Add BLAST	33
Repeatⁱ	256 – 288	HAT 2Add BLAST	33
Repeatⁱ	290 – 322	HAT 3Add BLAST	33
Repeatⁱ	324 – 355	HAT 4Add BLAST	32
Repeatⁱ	357 – 388	HAT 5Add BLAST	32
Repeatⁱ	390 – 425	HAT 6Add BLAST	36
Repeatⁱ	427 – 461	HAT 7Add BLAST	35
Repeatⁱ	471 – 503	HAT 8Add BLAST	33
Repeatⁱ	505 – 539	HAT 9Add BLAST	35
Repeatⁱ	549 – 585	HAT 10Add BLAST	37
Repeatⁱ	587 – 618	HAT 11Add BLAST	32
Repeatⁱ	620 – 652	HAT 12Add BLAST	33
Repeatⁱ	654 – 688	HAT 13Add BLAST	35
Repeatⁱ	690 – 721	HAT 14Add BLAST	32
Repeatⁱ	726 – 767	HAT 15Add BLAST	42
Repeatⁱ	769 – 807	HAT 16Add BLAST	39
Repeatⁱ	809 – 834	HAT 17Add BLAST	26

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	411 – 628	Mediates interaction with HSP90By similarityAdd BLAST		218

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	207 – 210	Poly-Pro		4

Sequence similaritiesⁱ

Belongs to the crooked-neck family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG1915, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074931
HOGENOMⁱ	CLU_2687132_0_0_1
InParanoidⁱ	Q9BZJ0
KEGG Orthology (KO) More...KOⁱ	K12869
OMAⁱ	FTFSKIW
PhylomeDBⁱ	Q9BZJ0
TreeFamⁱ	TF300305

Family and domain databases

Gene3Dⁱ	1.25.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR003107, HAT IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02184, HAT, 2 hits
SMARTⁱ	View protein in SMART SM00386, HAT, 13 hits
SUPFAMⁱ	SSF48452, SSF48452, 2 hits

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9BZJ0-1) [UniParc]FASTA Add to basket

Also known as: Type-II

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTATVENLTF QKDTLGNAVD KNTSRLELRS YSLAGRHGST EPLVLAWSSQ 
        60         70         80         90        100
FRRLTWGCAL DALHRSPCVA ASQHGVTHLI RSSRTPHSTR CRKEDAQPGH 
       110        120        130        140        150
HGNGAASVTA QARGQRSVLQ VPLPVPRSCL FSESFVVSVS SQSRFLASVP 
       160        170        180        190        200
GTGVQRSTAA DMAASTAAGK QRIPKVAKVK NKAPAEVQIT AEQLLREAKE 
       210        220        230        240        250
RELELLPPPP QQKITDEEEL NDYKLRKRKT FEDNIRKNRT VISNWIKYAQ 
       260        270        280        290        300
WEESLKEIQR ARSIYERALD VDYRNITLWL KYAEMEMKNR QVNHARNIWD 
       310        320        330        340        350
RAITTLPRVN QFWYKYTYME EMLGNVAGAR QVFERWMEWQ PEEQAWHSYI 
       360        370        380        390        400
NFELRYKEVD RARTIYERFV LVHPDVKNWI KYARFEEKHA YFAHARKVYE 
       410        420        430        440        450
RAVEFFGDEH MDEHLYVAFA KFEENQKEFE RVRVIYKYAL DRISKQDAQE 
       460        470        480        490        500
LFKNYTIFEK KFGDRRGIED IIVSKRRFQY EEEVKANPHN YDAWFDYLRL 
       510        520        530        540        550
VESDAEAEAV REVYERAIAN VPPIQEKRHW KRYIYLWINY ALYEELEAKD 
       560        570        580        590        600
PERTRQVYQA SLELIPHKKF TFAKMWILYA QFEIRQKNLS LARRALGTSI 
       610        620        630        640        650
GKCPKNKLFK VYIELELQLR EFDRCRKLYE KFLEFGPENC TSWIKFAELE 
       660        670        680        690        700
TILGDIDRAR AIYELAISQP RLDMPEVLWK SYIDFEIEQE ETERTRNLYR 
       710        720        730        740        750
RLLQRTQHVK VWISFAQFEL SSGKEGSLTK CRQIYEEANK TMRNCEEKEE 
       760        770        780        790        800
RLMLLESWRS FEEEFGTASD KERVDKLMPE KVKKRRKVQT DDGSDAGWEE 
       810        820        830        840 
YFDYIFPEDA ANQPNLKLLA MAKLWKKQQQ EKEDAEHHPD EDVDESES

Length:848

Mass (Da):100,452

Last modified:May 15, 2007 - v4

Checksum:ⁱE30A39E981BC50AC

Isoform 2 (identifier: Q9BZJ0-2) [UniParc]FASTA Add to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
1-161: Missing.

« Hide

        10         20         30         40         50
MAASTAAGKQ RIPKVAKVKN KAPAEVQITA EQLLREAKER ELELLPPPPQ 
        60         70         80         90        100
QKITDEEELN DYKLRKRKTF EDNIRKNRTV ISNWIKYAQW EESLKEIQRA 
       110        120        130        140        150
RSIYERALDV DYRNITLWLK YAEMEMKNRQ VNHARNIWDR AITTLPRVNQ 
       160        170        180        190        200
FWYKYTYMEE MLGNVAGARQ VFERWMEWQP EEQAWHSYIN FELRYKEVDR 
       210        220        230        240        250
ARTIYERFVL VHPDVKNWIK YARFEEKHAY FAHARKVYER AVEFFGDEHM 
       260        270        280        290        300
DEHLYVAFAK FEENQKEFER VRVIYKYALD RISKQDAQEL FKNYTIFEKK 
       310        320        330        340        350
FGDRRGIEDI IVSKRRFQYE EEVKANPHNY DAWFDYLRLV ESDAEAEAVR 
       360        370        380        390        400
EVYERAIANV PPIQEKRHWK RYIYLWINYA LYEELEAKDP ERTRQVYQAS 
       410        420        430        440        450
LELIPHKKFT FAKMWILYAQ FEIRQKNLSL ARRALGTSIG KCPKNKLFKV 
       460        470        480        490        500
YIELELQLRE FDRCRKLYEK FLEFGPENCT SWIKFAELET ILGDIDRARA 
       510        520        530        540        550
IYELAISQPR LDMPEVLWKS YIDFEIEQEE TERTRNLYRR LLQRTQHVKV 
       560        570        580        590        600
WISFAQFELS SGKEGSLTKC RQIYEEANKT MRNCEEKEER LMLLESWRSF 
       610        620        630        640        650
EEEFGTASDK ERVDKLMPEK VKKRRKVQTD DGSDAGWEEY FDYIFPEDAA 
       660        670        680 
NQPNLKLLAM AKLWKKQQQE KEDAEHHPDE DVDESES

Show »

Length:687

Mass (Da):83,148

Checksum:ⁱB370161134F63B1D

Isoform 3 (identifier: Q9BZJ0-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
23-34: Missing.

« Hide

        10         20         30         40         50
MTATVENLTF QKDTLGNAVD KNGRHGSTEP LVLAWSSQFR RLTWGCALDA 
        60         70         80         90        100
LHRSPCVAAS QHGVTHLIRS SRTPHSTRCR KEDAQPGHHG NGAASVTAQA 
       110        120        130        140        150
RGQRSVLQVP LPVPRSCLFS ESFVVSVSSQ SRFLASVPGT GVQRSTAADM 
       160        170        180        190        200
AASTAAGKQR IPKVAKVKNK APAEVQITAE QLLREAKERE LELLPPPPQQ 
       210        220        230        240        250
KITDEEELND YKLRKRKTFE DNIRKNRTVI SNWIKYAQWE ESLKEIQRAR 
       260        270        280        290        300
SIYERALDVD YRNITLWLKY AEMEMKNRQV NHARNIWDRA ITTLPRVNQF 
       310        320        330        340        350
WYKYTYMEEM LGNVAGARQV FERWMEWQPE EQAWHSYINF ELRYKEVDRA 
       360        370        380        390        400
RTIYERFVLV HPDVKNWIKY ARFEEKHAYF AHARKVYERA VEFFGDEHMD 
       410        420        430        440        450
EHLYVAFAKF EENQKEFERV RVIYKYALDR ISKQDAQELF KNYTIFEKKF 
       460        470        480        490        500
GDRRGIEDII VSKRRFQYEE EVKANPHNYD AWFDYLRLVE SDAEAEAVRE 
       510        520        530        540        550
VYERAIANVP PIQEKRHWKR YIYLWINYAL YEELEAKDPE RTRQVYQASL 
       560        570        580        590        600
ELIPHKKFTF AKMWILYAQF EIRQKNLSLA RRALGTSIGK CPKNKLFKVY 
       610        620        630        640        650
IELELQLREF DRCRKLYEKF LEFGPENCTS WIKFAELETI LGDIDRARAI 
       660        670        680        690        700
YELAISQPRL DMPEVLWKSY IDFEIEQEET ERTRNLYRRL LQRTQHVKVW 
       710        720        730        740        750
ISFAQFELSS GKEGSLTKCR QIYEEANKTM RNCEEKEERL MLLESWRSFE 
       760        770        780        790        800
EEFGTASDKE RVDKLMPEKV KKRRKVQTDD GSDAGWEEYF DYIFPEDAAN 
       810        820        830 
QPNLKLLAMA KLWKKQQQEK EDAEHHPDED VDESES

Show »

Length:836

Mass (Da):99,074

Checksum:ⁱ2ED68C036D071E71

Isoform 4 (identifier: Q9BZJ0-4) [UniParc]FASTA Add to basket

Also known as: Type-III

The sequence of this isoform differs from the canonical sequence as follows:
23-34: Missing.
117-848: Missing.

« Hide

        10         20         30         40         50
MTATVENLTF QKDTLGNAVD KNGRHGSTEP LVLAWSSQFR RLTWGCALDA 
        60         70         80         90        100
LHRSPCVAAS QHGVTHLIRS SRTPHSTRCR KEDAQPGHHG NGAASVTAQA 

RGQR

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated

Show »

Length:104

Mass (Da):11,268

Checksum:ⁱAF15BD5353314E12

Isoform 5 (identifier: Q9BZJ0-5) [UniParc]FASTA Add to basket

Also known as: type-IV

The sequence of this isoform differs from the canonical sequence as follows:
23-74: TSRLELRSYS...RSPCVAASQH → ILASLLVSTA...SRLKREVKGQ
75-848: Missing.

« Hide

        10         20         30         40         50
MTATVENLTF QKDTLGNAVD KNILASLLVS TALPTSSAAP GRRTPRAAAR 
        60         70 
RTRSLVTMET VPPPSRLKRE VKGQ

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated

Show »

Length:74

Mass (Da):7,946

Checksum:ⁱ59162B429E1F0AF0

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5JY65	Q5JY65_HUMAN	Crooked neck-like protein 1 Crooked neck-like protein 1	CRNKL1	836	Annotation score:
A0A0C4DGD7	A0A0C4DGD7_HUMAN	Crooked neck-like protein 1 Crooked neck-like protein 1	CRNKL1	104	Annotation score:

Sequence cautionⁱ

The sequence BAB14303 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

The sequence BAB14485 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	213	K → R in AAF65571 (PubMed:11342225).Curated	1
Sequence conflictⁱ	213	K → R in AAK01924 (PubMed:11342225).Curated	1
Sequence conflictⁱ	213	K → R in AAK01925 (PubMed:11342225).Curated	1
Sequence conflictⁱ	513	V → A in BAB14659 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_024995	35	G → R1 PublicationCorresponds to variant dbSNP:rs7508949Ensembl.	1
Natural variantⁱVAR_049318	51	F → L. Corresponds to variant dbSNP:rs2273058Ensembl.	1
Natural variantⁱVAR_049319	111	Q → H. Corresponds to variant dbSNP:rs2255258Ensembl.	1
Natural variantⁱVAR_049320	158	T → A. Corresponds to variant dbSNP:rs2255255Ensembl.	1
Natural variantⁱVAR_049321	843	V → I. Corresponds to variant dbSNP:rs35201190Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_002058	1 – 161	Missing in isoform 2. 2 PublicationsAdd BLAST	161
Alternative sequenceⁱVSP_002060	23 – 74	TSRLE…AASQH → ILASLLVSTALPTSSAAPGR RTPRAAARRTRSLVTMETVP PPSRLKREVKGQ in isoform 5. 1 PublicationAdd BLAST	52
Alternative sequenceⁱVSP_002059	23 – 34	Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST	12
Alternative sequenceⁱVSP_002061	75 – 848	Missing in isoform 5. 1 PublicationAdd BLAST	774
Alternative sequenceⁱVSP_002062	117 – 848	Missing in isoform 4. 1 PublicationAdd BLAST	732

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF255443 mRNA Translation: AAF65571.2 AF318302 mRNA Translation: AAK01924.1 AF318303 mRNA Translation: AAK01925.1 AF318304 mRNA Translation: AAK01926.1 AF318305 mRNA Translation: AAK01927.1 AF111802 mRNA Translation: AAL39004.1 AK023246 mRNA Translation: BAB14485.1 Different initiation. AK023728 mRNA Translation: BAB14659.1 AK292799 mRNA Translation: BAF85488.1 AL035454 Genomic DNA No translation available. AK022908 mRNA Translation: BAB14303.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33446.1 [Q9BZJ0-1] CCDS63238.1 [Q9BZJ0-2] CCDS63239.1 [Q9BZJ0-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001265554.1, NM_001278625.1 NP_001265555.1, NM_001278626.1 NP_001265556.1, NM_001278627.1 NP_001265557.1, NM_001278628.1 [Q9BZJ0-2] NP_057736.4, NM_016652.5 [Q9BZJ0-1]

Genome annotation databases

Ensemblⁱ	ENST00000377340; ENSP00000366557; ENSG00000101343 [Q9BZJ0-1] ENST00000496549; ENSP00000428436; ENSG00000101343 [Q9BZJ0-5] ENST00000536226; ENSP00000440733; ENSG00000101343 [Q9BZJ0-2]
GeneIDⁱ	51340
KEGGⁱ	hsa:51340
UCSC genome browser More...UCSCⁱ	uc002wrs.5, human [Q9BZJ0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BZJ0	Crooked neck pre-mRNA splicing factor 1		GORGO		687	UniRef100_Q9BZJ0
Isoform 2 of Crooked neck-like protein 1		HUMAN		687
+1

Protein	Similar proteins		Species	Score	Length	Source
Q9BZJ0	Crooked neck-like protein 1		MOUSE		690	UniRef90_Q9BZJ0
Crooked neck-like protein 1		RAT		690
Crooked neck pre-mRNA splicing factor 1		GORGO		687
Isoform 2 of Crooked neck-like protein 1		HUMAN		687
Uncharacterized protein		MACFA		850
+206
Q9BZJ0-5	CRNKL1 isoform 3		PONAB		74	UniRef90_Q9BZJ0-5
CRNKL1 isoform 3		PANTR		74

Protein	Similar proteins		Species	Score	Length	Source
Q9BZJ0	Crooked neck-like protein 1		MOUSE		690	UniRef50_Q9BZJ0
Crooked neck-like protein 1		RAT		690
Crooked neck pre-mRNA splicing factor 1		GORGO		687
Isoform 2 of Crooked neck-like protein 1		HUMAN		687
Uncharacterized protein		MACNE		850
+298
Q9BZJ0-5	CRNKL1 isoform 3		PONAB		74	UniRef50_Q9BZJ0-5
CRNKL1 isoform 3		PANTR		74

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF255443 mRNA Translation: AAF65571.2 AF318302 mRNA Translation: AAK01924.1 AF318303 mRNA Translation: AAK01925.1 AF318304 mRNA Translation: AAK01926.1 AF318305 mRNA Translation: AAK01927.1 AF111802 mRNA Translation: AAL39004.1 AK023246 mRNA Translation: BAB14485.1 Different initiation. AK023728 mRNA Translation: BAB14659.1 AK292799 mRNA Translation: BAF85488.1 AL035454 Genomic DNA No translation available. AK022908 mRNA Translation: BAB14303.1 Different initiation.
CCDSⁱ	CCDS33446.1 [Q9BZJ0-1] CCDS63238.1 [Q9BZJ0-2] CCDS63239.1 [Q9BZJ0-3]
RefSeqⁱ	NP_001265554.1, NM_001278625.1 NP_001265555.1, NM_001278626.1 NP_001265556.1, NM_001278627.1 NP_001265557.1, NM_001278628.1 [Q9BZJ0-2] NP_057736.4, NM_016652.5 [Q9BZJ0-1]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5MQF	electron microscopy	5.90	O	1-848	[»]
	5XJC	electron microscopy	3.60	J	1-848	[»]
	5YZG	electron microscopy	4.10	J	1-848	[»]
	5Z56	electron microscopy	5.10	J	1-848	[»]
	5Z57	electron microscopy	6.50	J	1-848	[»]
	5Z58	electron microscopy	4.90	J	1-848	[»]
	6FF4	electron microscopy	16.00	O	1-848	[»]
	6FF7	electron microscopy	4.50	O	1-848	[»]
	6ICZ	electron microscopy	3.00	J	1-848	[»]
	6ID0	electron microscopy	2.90	J	1-848	[»]
	6ID1	electron microscopy	2.86	J	1-848	[»]
	6QDV	electron microscopy	3.30	S	1-848	[»]
SMRⁱ	Q9BZJ0
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	119487, 83 interactors
CORUMⁱ	Q9BZJ0
IntActⁱ	Q9BZJ0, 45 interactors
MINTⁱ	Q9BZJ0
STRINGⁱ	9606.ENSP00000366557

PTM databases

iPTMnetⁱ	Q9BZJ0
PhosphoSitePlusⁱ	Q9BZJ0

Polymorphism and mutation databases

BioMutaⁱ	CRNKL1
DMDMⁱ	147744555

Proteomic databases

EPDⁱ	Q9BZJ0
jPOSTⁱ	Q9BZJ0
MassIVEⁱ	Q9BZJ0
MaxQBⁱ	Q9BZJ0
PaxDbⁱ	Q9BZJ0
PeptideAtlasⁱ	Q9BZJ0
PRIDEⁱ	Q9BZJ0
ProteomicsDBⁱ	79851 [Q9BZJ0-1] 79852 [Q9BZJ0-2] 79853 [Q9BZJ0-3] 79854 [Q9BZJ0-4] 79855 [Q9BZJ0-5]

Protocols and materials databases

Antibodypediaⁱ	9534, 64 antibodies
The DNASU plasmid repository More...DNASUⁱ	51340

Genome annotation databases

Ensemblⁱ	ENST00000377340; ENSP00000366557; ENSG00000101343 [Q9BZJ0-1] ENST00000496549; ENSP00000428436; ENSG00000101343 [Q9BZJ0-5] ENST00000536226; ENSP00000440733; ENSG00000101343 [Q9BZJ0-2]
GeneIDⁱ	51340
KEGGⁱ	hsa:51340
UCSCⁱ	uc002wrs.5, human [Q9BZJ0-1]

Organism-specific databases

CTDⁱ	51340
DisGeNETⁱ	51340
EuPathDBⁱ	HostDB:ENSG00000101343.14
GeneCardsⁱ	CRNKL1
HGNCⁱ	HGNC:15762, CRNKL1
HPAⁱ	ENSG00000101343, Low tissue specificity
MIMⁱ	610952, gene
neXtProtⁱ	NX_Q9BZJ0
OpenTargetsⁱ	ENSG00000101343
PharmGKBⁱ	PA26886
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1915, Eukaryota
GeneTreeⁱ	ENSGT00550000074931
HOGENOMⁱ	CLU_2687132_0_0_1
InParanoidⁱ	Q9BZJ0
KOⁱ	K12869
OMAⁱ	FTFSKIW
PhylomeDBⁱ	Q9BZJ0
TreeFamⁱ	TF300305

Enzyme and pathway databases

PathwayCommonsⁱ	Q9BZJ0
Reactomeⁱ	R-HSA-72163, mRNA Splicing - Major Pathway

Miscellaneous databases

BioGRID-ORCSⁱ	51340, 731 hits in 874 CRISPR screens
ChiTaRSⁱ	CRNKL1, human
GenomeRNAiⁱ	51340
Pharosⁱ	Q9BZJ0, Tbio
Protein Ontology More...PROⁱ	PR:Q9BZJ0
RNActⁱ	Q9BZJ0, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000101343, Expressed in calcaneal tendon and 228 other tissues
ExpressionAtlasⁱ	Q9BZJ0, baseline and differential
Genevisibleⁱ	Q9BZJ0, HS

Family and domain databases

Gene3Dⁱ	1.25.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR003107, HAT IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf
Pfamⁱ	View protein in Pfam PF02184, HAT, 2 hits
SMARTⁱ	View protein in SMART SM00386, HAT, 13 hits
SUPFAMⁱ	SSF48452, SSF48452, 2 hits
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CRNL1_HUMAN
Accessionⁱ	Q9BZJ0Primary (citable) accession number: Q9BZJ0 Secondary accession number(s): A8K9T4 Q9NYD8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 2003
	Last sequence update:	May 15, 2007
	Last modified:	August 12, 2020
	This is version 171 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9BZJ0 (CRNL1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Crooked neck-like protein 1

CRNKL1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q9BZJ0

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ